Hip fracture risk and cadmium in erythrocytes: A nested case-control study with prospectively collected samples

Calcified Tissue International

Volumn 94, Issue 2, 2014, Pages 183-190

  Sommar, Johan Nilsson ^a   Pettersson Kymmer, Ulrika ^a   Lundh, Thomas ^b   Svensson, Olle ^a   Hallmans, Göran ^a   Bergdahl, Ingvar A ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Cadmium; Environmental exposure; Heavy metal; Hip fracture; Prospective

Indexed keywords

BIOLOGICAL MARKER; CADMIUM;

ADULT; AGE; AGED; ARTICLE; BODY HEIGHT; BODY MASS; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; ENVIRONMENTAL EXPOSURE; ERYTHROCYTE; FEMALE; GENDER; HEAVY METAL BLOOD LEVEL; HIGH RISK POPULATION; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SMOKING; URINALYSIS;

AGED; CADMIUM; CASE-CONTROL STUDIES; ENVIRONMENTAL POLLUTANTS; ERYTHROCYTES; FEMALE; HIP FRACTURES; HUMANS; MALE; MIDDLE AGED; OSTEOPOROSIS; OSTEOPOROTIC FRACTURES; RISK FACTORS; SWEDEN;

EID: 84893234806     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-013-9796-5     Document Type: Article

References (26)

1. Panel on Contaminants in the Food Chain (2009) Scientific opinion of the panel on contaminants in the food chain on a request from the European Commission on cadmium in food. EFSA J 980:1-139
2. Akesson A, Bjellerup P, Lundh T, Lidfeldt J, Nerbrand C, Samsioe G, Skerfving S, Vahter M (2006) Cadmium-induced effects on bone in a population-based study of women. Environ Health Perspect 114:830-834
3. Alfven T, Elinder CG, Carlsson MD, Grubb A, Hellstrom L, Persson B, Pettersson C, Spang G, Schutz A, Jarup L (2000) Low-level cadmium exposure and osteoporosis. J Bone Miner Res 15:1579-1586
4. Engstrom A, Michaelsson K, Suwazono Y, Wolk A, Vahter M, Akesson A (2011) Long-term cadmium exposure and the association with bone mineral density and fractures in a population-based study among women. J Bone Miner Res 26:486-495
5. Gallagher CM, Kovach JS, Meliker JR (2008) Urinary cadmium and osteoporosis in US women ≥50 years of age: NHANES 1988-1994 and 1999-2004. Environ Health Perspect 116:1338-1343
6. Jin T, Nordberg G, Ye T, Bo M, Wang H, Zhu G, Kong Q, Bernard A (2004) Osteoporosis and renal dysfunction in a general population exposed to cadmium in China. Environ Res 96:353-359
7. Schutte R, Nawrot TS, Richart T, Thijs L, Vanderschueren D, Kuznetsova T, Van Hecke E, Roels HA, Staessen JA (2008) Bone resorption and environmental exposure to cadmium in women: a population study. Environ Health Perspect 116:777-783
8. Wang H, Zhu G, Shi Y, Weng S, Jin T, Kong Q, Nordberg GF (2003) Influence of environmental cadmium exposure on forearm bone density. J Bone Miner Res 18:553-560
9. Cummings SR, Kelsey JL, Nevitt MC, O'Dowd KJ (1985) Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev 7:178-208
10. Staessen JA, Roels HA, Emelianov D, Kuznetsova T, Thijs L, Vangronsveld J, Fagard R (1999) Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Public Health and Environmental Exposure to Cadmium (PheeCad) Study Group. Lancet 353:1140-1144
11. Alfven T, Elinder CG, Hellstrom L, Lagarde F, Jarup L (2004) Cadmium exposure and distal forearm fractures. J Bone Miner Res 19:900-905
12. Engstrom A, Michaelsson K, Vahter M, Julin B, Wolk A, Akesson A (2012) Associations between dietary cadmium exposure and bone mineral density and risk of osteoporosis and fractures among women. Bone 50:1372-1378
13. Thomas LDK, Michaelsson K, Julin B, Wolk A, Akesson A (2011) Dietary cadmium exposure and fracture incidence among men: a population-based prospective cohort study. J Bone Miner Res 26:1601-1608
14. Englund U, Nordstrom P, Nilsson J, Bucht G, Bjornstig U, Hallmans G, Svensson O, Pettersson U (2011) Physical activity in middle-aged women and hip fracture risk: the UFO study. Osteoporos Int 22:499-505
15. Hallmans G, Agren A, Johansson G, Johansson A, Stegmayr B, Jansson JH, Lindahl B, Rolandsson O, Soderberg S, Nilsson M, Johansson I, Weinehall L (2003) Cardiovascular disease and diabetes in the Northern Sweden Health and Disease Study Cohort - evaluation of risk factors and their interactions. Scand J Public Health Suppl 61:18-24
16. Bergstrom U, Bjornstig U, Stenlund H, Jonsson H, Svensson O (2008) Fracture mechanisms and fracture pattern in men and women aged 50 years and older: a study of a 12-year population-based injury register, Umea, Sweden. Osteoporos Int 19:1267-1273
17. Nordberg GF, Fowler BA, Nordberg M, Friberg LT (2007) Handbook on the toxicology of metals, III edn. Elsevier/Academic Press, London
18. Sundkvist A (2011) Time trends of cadmium, lead and mercury in the population of northern Sweden 1990-2009 and blood levels of rhodium and platinum in 2009. Swedish Environmental Protection Agency. http://www.naturvardsverket. se/upload/02-tillstandet-i-miljon/Miljoovervakning/rapporter/halsa/ time-trends-Cd-Pb-Hg.pdf. Accessed 10 July 2011
19. Barany E, Bergdahl IA, Schutz A, Skerfving S, Oskarsson A (1997) Inductively coupled plasma mass spectrometry for direct multi-element analysis of diluted human blood and serum. J Anal At Spectrom 12:1005-1009
20. R Development Core Team (2010) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. http://www.R-project.org. Accessed 3 Oct 2013
21. Kjellstrom T (1992) Mechanism and epidemiology of bone effects of cadmium. IARC Sci Publ 118:301-310
22. Bhattacharyya MH (2009) Cadmium osteotoxicity in experimental animals: mechanisms and relationship to human exposures. Toxicol Appl Pharmacol 238:258-265
23. Kapoor D, Jones TH (2005) Smoking and hormones in health and endocrine disorders. Eur J Endocrinol 152:491-499
24. Johnson MD, Kenney N, Stoica A, Hilakivi-Clarke L, Singh B, Chepko G, Clarke R, Sholler PF, Lirio AA, Foss C, Reiter R, Trock B, Paik S, Martin MB (2003) Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland. Nat Med 9:1081-1084
25. Akesson A, Lundh T, Vahter M, Bjellerup P, Lidfeldt J, Nerbrand C, Samsioe G, Stromberg U, Skerfving S (2005) Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure. Environ Health Perspect 113:1627-1631
26. Thorngren KG, Hommel A, Norrman PO, Thorngren J, Wingstrand H (2002) Epidemiology of femoral neck fractures. Injury 33(Suppl 3):C1-C7