Hepatoprotective potential of Cassia auriculata roots on ethanol and antitubercular drug-induced hepatotoxicity in experimental models

Pharmaceutical Biology

Volumn 52, Issue 3, 2014, Pages 344-355

  Jaydeokar, Ashish V ^a   Bandawane, Deepti D ^a   Bibave, Kiran H ^a   Patil, Tushar V ^b  

^a Affiliated to Savitribai Phule Pune University   (India)

^b Pimpri Chinchwad Municipal Corporation   (India)

Author keywords

Antioxidant; Herb; Metabolic enzyme; Methanol extract; Prophylactic model; Silymarin; Therapeutic model

Indexed keywords

ANIMALS; ANTIOXIDANTS; ANTITUBERCULAR AGENTS; CASSIA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; ETHANOL; FEMALE; INDIA; ISONIAZID; MALE; MEDICINE, TRADITIONAL; PLANT EXTRACTS; PLANT ROOTS; PYRAZINAMIDE; RATS; RATS, WISTAR; RIFAMPIN; SILYMARIN;

EID: 84893220996     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2013.837075     Document Type: Article

References (51)

1. Adewusi EA, Afolayan AJ. (2010). A review of natural products with hepatoprotective activity. J Med Plants Res 4:1318-34.
2. Annie S, Rajagopal PL, Malini S. (2005). Effect of Cassia auriculata L. root extract on cisplatin and gentamicin-induced renal injury. Phytomedicine 12:555-60.
3. Arthika S, Shanthammal Y. (2011). Hepatoprotective activity of the ethanol extract of Azima tetracanth a against paracetamol induced hepatotoxicity in Wistar albino rats. J Adv Pharm Healthcare Res 1: 15-20.
4. Atta AH, Nasr SM, Mouneir SM. (2006). Potential protective effect of some plant extracts against carb on tetrachloride-induced hepatotoxicity. Afr J Trad Compl Alt Med 3:1-9.
5. Ayyanar M, Ignacimuthu S. (2008). Pharmacological actions of Cassia auriculata L. and Cissus quadrangularis Wall. A short review. J Pharmacol Toxicol 3:213-21.
6. Balakrishna RB, Patel JR, Prabhakaran V. (2011). Cassia auriculata-A phytopharmacological review. J Adv Drug Res 1:46-57.
7. Bandawane DD, Juvekar AR, Juvekar M. (2011). Antidiabetic and antihyperlipidemic effect of Alstonia scholaris Linn. bark in streptozotocin induced diabetic rats. Ind J Pharm Edu Res 5:114-20.
8. Bhadauria M. (2010). Dose-dependent hepatoprotective effect of emodin against acetaminophen induced acute damage in rats. Exp Toxicol Pathol 62:627-35.
9. Burstein M, Scholnick H, Morfin R. (1970). Rapid method fo r the isolation of lipoproteins from human serum by precipitation with polyanions. Lipid Res 11:583-95.
10. Chakraborthy GS. (2009). Evaluation of immunomodulatory activity of Cassia auriculata Linn. J Herbal Med Toxicol 3:111-13.
11. Dasgupta N, Bratati D. (2004). Antioxidant activity of Piper betle Linn. leaf extract in vitro. J Food Chem 88:219-24.
12. Deepa PR, Varalakshmi P. (2003). Protective effect of low molecular weight heparin on oxidative injury and cellular abnormalities in adriamycin-induced cardiac and hepatic toxicity. Chem Biol Interact 146:201-10.
13. Dhanasekaran J, Ganapathy M. (2011). Hepatoprotective effect of Cassia auriculata leaf extract on carbon tetrachloride induced hepatic damage in Wistar rats. Asian J Biochem 6:104-12.
14. Dharmananda S. (2012). Chinese herbal medicine for the treatment of hepatitis B infection. Available from: http://www.itmonline.org/arts/hepb.htm [last accessed 5 May 2012].
15. Doshi GV, Aggarval G, Shanbag PP, et al. (2011). Studies on Cassia auriculata plant parts by improved in vitro antioxidant models. J Pharm Biomed Sci 10:1-2.
16. Duh P, Lin S, She-Ching W. (2011). Hepatoprotection of Graptopetalum paraguayenese E. Walther on CCl4 induced liver damage and inflammation. J Ethnopharmacol 134:379-85.
17. Gaikwad SA, Kale AA, Jadhav BG, et al. (2011). Anthelmintic activity of Cassia auriculata L. extracts-in vivo study. J Nat Prod Plant Res 1:62-6.
18. Gramenzi A, Cap uto F, Biselli M, et al. (2006). Alcoholic liver disease-pathophysiological aspects and risk factors. Aliment Pharmacol Ther 24:1151-61.
19. Gupta SS, Sharma K, Bansal SK, Prabhu KM. (2009). Antihyperglycemic and hypolipidemic activity of aqueous extract of Cassia auriculata L. leaves in experimental diabetes. J Ethnopharmacol 123:499-503.
20. Gupta SS. (1994). Prospects and perspectives of natural plant products in medicine. Indian J Pharmacol 26:1-12.
21. Hussain T, Gupta RK, Sweety K, et al. (2012). Evaluation of antihepatotoxic potential of Solanum xanthocarpum fruit extract against antitubercular drugs induced hepatopathy in experimental rodents. Asian Pac J Trop Biomed 2012:454-60.
22. Janbaz KH, Saeed SA, Gilani AH. (2002). Protect ive effect of rutin on paracetamol and CCl4 induced hepatotoxicity in rodents. Fitoterapia 73:557-63.
23. Jendrassik L, Grof P. (1938). Spectrophotometric method for the estimation of blood bilirubins. Biochem J 297:81-9.
24. Kale BP, Kothekar MA, Tayade HP, et al. (2003). Effect of aqueous extract of Azadirakhta indica leaves on hepatotoxicity induced by antitubercular drugs in rats. Indian J Pharmacol 35:177-80.
25. Kaur G, Zoobi J, Mohammad A, Sarwar Alam M. (2006). Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice. Food Chem T oxicol 44:984-93.
26. Khandelwal KR. (2006). Practical Pharmacognosy. Pune, India: Nirali Publications.
27. Kind P, King E. (1954). Estimation of plasma phosphatase by determination of hydrolyzed phenol with aminopyrines. J Clin Pathol 7:322-6.
28. Kingsley S, Frankel S. (1939). The determination of serum total protein, albumin and globulin by the biuret reaction. J Biol Chem 128:131-7.
29. Kumar P, Devala Rao G, Lakshmayya M, Ramachandra SS. (2010). Ethanol extract of Momordica tuberosa tubers protects liver in paracetamol-induced damage. Arch Biol Sci, 62:999-1003.
30. Kumaran A, Karunakaran RJ. (2007). Antioxidant activity of Cassia auriculata flowers. Fitoterapia 78:46-7.
31. Lelbach WK. (1975). Cirrhosis in the alcoholic and its relation to the volume of alcohol abuse. Ann N Y Acad Sci 252:85-105.
32. Luna L. (1960). Manual of Histological Staining Methods of the Armed Forces Institute of Pathology. New York, USA: McGraw-Hill Publications.
33. Marklund SL. (1985). Pyrogallol autooxidation. In: Greenwald RA, ed. Handbook of Methods in Oxygen Radical Research. Boca Raton: CRC Press, 224-43.
34. Middleton E, Kandaswami C, Theoharis C. (2000). The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev 52:673-751.
35. Nadkarni KM. (2002). The Indian Materia Medica. Mumbai, India: Popular Publications.
36. Naik SR, Panda VS. (2008). Hepatoprotective effect of Ginkgo-select phytosome in rifampicin induced liver injury in rats: Evidence of antioxi dant activity. Fitoterapia 79:439-45.
37. Pralhad P, Ganesh S. (2009). Clinical evaluation of a herbal formulation in liver disorders. Aust J Med Herbalism 21:10-14.
38. Pramyothin P, Ngamtin C, Poungshompoob S, Chaichantipyuth C. (2007). Hepatoprotective activity of Phyllanthus amarus Schum. et. Thonn. extract in ethanol treated rats: In vitro and in vivo studies. J Ethnopharmacol 114:169-73.
39. Rai KN, Dasundhi RA. (1990). A new flavone glycoside from the roots of Cassia auriculata. J Bangladesh Acad Sci 14:57-61.
40. Ram VJ, Goel A. (1999). Past and present scenario of hepatoprotectants. Curr Med Chem 6:217-54.
41. Rao M, Rao C, Pushpangadan P, Shirwaikar A. (2006). Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol 103:484-90.
42. Reitman S, Frankel SA. (1957). Colorimetric method for the determination of serum glutamic oxoloacetic and glutamic pyruvic transaminase. Am J Clin Pathol 28:56-63.
43. Saha MR, Jahan gir R, Biva IJ. (2008). In vitro nitric oxide scavenging activity of ethanol leaf extracts of four Bangladeshi medicinal plants. S J Pharm Sci 1:57-62.
44. Sahreen S, Khan MR, Khan RA. (2011). Hepatoprotect ive effects of methanol extract of Carissa opaca leaves on CCl4 induced damage in rat. Compliment Alt Med 11:1-10.
45. Sayed A, Enayat A, Somaia A, Jame B. (2011). Flavone C-glycosides from Montanoa bipinnatifi da stems and evaluation of hepatoprotective activity of extract. J Med Plants Res 5:1291-6.
46. Swathi P, Jagadeesh Kumar T, Madhu Babu M, Vijay C. (2010). Protective response of dried stems of Cassia auriculat a against carbon tetrachloride induced liver damage in Wistar albino rats. Int J Adv Pharm Sci 1:274-80.
47. Thapa BR, Walia A. (2007). Liver function tests and their interpretation. Indian J Pediatr 74: 663-71.
48. Tondon VR, Kapoor B, Gupta S. (2008). Hepatoprotective activity of Vitex negundo leaf extract against antitubercular drugs induced hepatotoxicity. Fitoterpia 79:533-8.
49. Ubaid RS, Kothekar MA, Jaju JB, Mateenuddin MD. (2003). Effect of Ocimum sanctum (OS) leaf on hepatotoxicity induced by antitubercular drugs in rats. Indian J Physiol Pharmacol 47:465-70.
50. Wadekar J, Sawant R, Honde B. (2011). Anthelmintic and antibacterial potential of Cassia auriculata roots. Int J Pharm Front Res 1:93-8.
51. Woolson RF. (1987). Statistical Methods for the Analysis of Biomedical Data. New York, USA: John Wiley and Sons Publications