Ex vivo assessment of polyol coated-iron oxide nanoparticles for MRI diagnosis applications: Toxicological and MRI contrast enhancement effects

Journal of Nanoparticle Research

Volumn 16, Issue 3, 2014, Pages

  Bomati Miguel, Oscar ^a   Miguel Sancho, Nuria ^b,c   Abasolo, Ibane ^b,d   Candiota, Ana Paula ^b,d   Roca, Alejandro G ^b,c   Acosta, Milena ^b,d   Schwartz, Simó ^b,d   Arus, Carles ^b,d   Marquina, Clara ^c   Martinez, Gema ^b,c   Santamaria, Jesus ^b,c  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b BIOMATERIALES Y NANOMEDICINA CIBER BBN   (Spain)

^c UNIVERSITY OF ZARAGOZA   (Spain)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Contrast agents for nanoparticle enhanced magnetic resonance imaging; Hemolysis tests; In vitro cytotoxicity; Nanomedicine; Polyol mediated synthesis; Superparamagnetic iron oxide nanoparticles

Indexed keywords

ALCOHOLS; BIOCOMPATIBILITY; BLOOD; CELLS; CYTOTOXICITY; LANTHANUM COMPOUNDS; MAGNETIC RESONANCE IMAGING; MEDICAL NANOTECHNOLOGY; METAL NANOPARTICLES; NANOMAGNETICS; PARTICLE SIZE; SUPERPARAMAGNETISM; SYNTHESIS (CHEMICAL);

CONTRAST AGENT; CONTRAST AGENT FOR NANOPARTICLE-ENHANCED MAGNETIC RESONANCE IMAGING; DIMERCAPTOSUCCINIC ACIDS; HEMOLYSIS TEST; IN VITRO CYTOTOXICITY; IN-VITRO; POLYOL-MEDIATED SYNTHESIS; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES; TRIETHYLENE GLYCOL; VITRO CYTOTOXICITIES;

IRON OXIDES;

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CARBOXYL GROUP; POLYOL; SUCCIMER; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TRIETHYLENE GLYCOL;

ARTICLE; BIOCOMPATIBILITY; CELL ASSAY; CELL VIABILITY; COLLOID; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CYTOTOXICITY; DISPERSION; EX VIVO STUDY; HEMOLYSIS; HYDRODYNAMICS; MTT ASSAY; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; PRIORITY JOURNAL; SURFACE PROPERTY; TOXICOLOGY;

EID: 84893200750     PISSN: 13880764     EISSN: 1572896X     Source Type: Journal    
DOI: 10.1007/s11051-014-2292-7     Document Type: Article

References (45)

1. Anzai Y, Blackwell KE, Hirschowitz SL, Rogers JW, Sato Y, Yuh WT, Runge VM, Morris MR, McLachlan SJ, Lufkin RB (1994) Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node metastases in patients with head and neck cancer. Radiology 192:709-715 (Pubitemid 24266786)
2. 1H NMR relaxation enhancement produced by iron oxide and core-shell iron-iron oxide nanoparticles. Magn Reson Imaging 25:1437-1441
3. Cañete M, Soriano J, Villanueva A, Roca AG, Veintemillas S, Serna CJ, Miranda R, Morales MP (2010) The endocytic penetration mechanism of iron oxide magnetic nanoparticles with positively charged cover: a morphological approach. Int J Mol Med 26:533-539
4. Caravan P (2009) Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of action. Acc Chem Res 42:851-862
5. Coleman J, Nascimiento R, Solomon SB (2007) Advances in imaging for urologic procedures. Nat Clin Pract Urol 4:498-504 (Pubitemid 47377625)
6. Corot C, Robert P, Idée JM, Port M (2006) Recent advances in iron oxide nanocrystal technology for medical imaging. Adv Drug Deliv Rev 58(14):1471-1504 (Pubitemid 44820503)
7. Figuerola A, Di Corato R, Manna L, Pellegrino T (2010) From iron oxide nanoparticles towards advanced iron-based inorganic materials designed for biomedical applications. Pharm Res 62(2):126-143
8. Fröhlich E (2012) The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles. Int J Nanomedicine 7:5577-5591
9. Gossuin Y, Gillis P, Hocq A, Vuong Q, Roch A (2009) Magnetic resonance relaxation properties of superparamagnetic particles. Wires Nanomed Nanobiotechnol 1(3):299-310
10. Groman EV, Bouchard JC, Reinhardt CP, Vaccaro DE (2007) Ultrasmall mixed ferrite colloids as multidimensional magnetic resonance imaging, cell labeling, and cell sorting agents. Bioconjug Chem 18:1763-1771 (Pubitemid 350219973)
11. Gupta AK, Gupta M (2005) Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 26(18):3995-4021 (Pubitemid 40044762)
12. Hahn MA, Singh AK, Sharma P, Brown SC, Moudgil BM (2011) Nanoparticles as contrast agents for in vivo bioimaging: current status and future perspectives. Anal Bioanal Chem 399:3-27
13. Harisinghani MG, Saini S, Weissleder R, Hahn PF, Yantiss RK, Tempany C, Wood BJ, Mueller PR (1999) MR lymphangiography using ultrasmall superparamagnetic iron oxide in patients with primary abdominal and pelvic malignancies: radiographic-pathologic correlation. AJR Am J Roentgenol 172:1347-1351 (Pubitemid 29508795)
14. Huang J, Zhong X, Wang L, Yang L, Mao H (2012) Improving the magnetic resonance imaging contrast and detection methods with engineered magnetic nanoparticles. Theranostics 2(1):86-102
15. Jung CW, Jacobs P (1995) Physical and chemical properties of superparamagnetic iron oxide MR contrast agents: ferumoxides, ferumoxtran, ferumoxsil. Mag Reson Imaging 13(5):661-674
16. Kehagias DT, Gouliamos AD, Smyrniotis V, Vlahos LJ (2001) Diagnostic efficacy and safety of MRI of the liver with superparamagnetic iron oxide particles (SH U 555 A). J Magn Reson Imaging 14:595-601 (Pubitemid 33029546)
17. Kriege M et al (2004) Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med 351:427-437
18. Laurent S, Forge D, Port M, Roch A, Robic C, Vander Elst L, Muller RN (2008) Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem Rev 108:2064-2110
19. Maity D, Kale SN, Kaul-Ghanekar R, Xue JM, Ding J (2009) Studies of magnetite nanoparticles synthesized by thermal decomposition of iron(III) acetylacetonate in tri(ethyleneglycol). J Magn Magn Mater 321:3093-3098
20. Maity D, Chandrasekharan P, Yang CT, Chuang KH, Shuter B, Xue JM, Ding J, Feng SS (2010) Facile synthesis of water-stable magnetite nanoparticles for clinical MRI and magnetic hyperthermia applications. Nanomedicine 5(10): 1571-1584
21. McDermott S, Guimaraes AR (2012) Magnetic nanoparticles in the imaging of tumor angiogenesis. Appl Sci 2(2):525-534
22. Miguel-Sancho M, Bomati-Miguel O, Colom G, Pablo-Salvador J, Marco MP, Santamaría J (2011) Development of stable, water-dispersable, and biofunctionalizable super-paramagnetic iron oxide nanoparticles. Chem Mater 23:2795-2802
23. Miguel-Sancho M, Bomatí-Miguel O, Roca AG, Martínez G, Arruebo M, Santamaría J (2012) Synthesis of magnetic nanocrystals by thermal decomposition in glycol media: effect of process variables and mechanistic study. Ind Eng Chem Res 51:8348-8357
24. Mondini S, Cenedese S, Marioni G, Molteni G, Santo N, Bianchi CL, Ponti A (2008) One-step synthesis and functionalization of hydroxyl-decorated magnetite nanoparticles. J Colloid Interface Sci 322:173
25. Monet X, Weissleder R, Josephson L (2006) Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas. Bioconjug Chem 17(4):905-911 (Pubitemid 44162607)
26. Morales MP, Bomati-Miguel O, Perez de Alejo R, Ruiz-Cabello J, Veintemillas-Verdaguer S, O'Grady K (2003) Contrast agents for MRI based on iron oxide nanoparticles prepared by laser pyrolysis. J Magn Magn Mater 266:102-109
27. Pankhurst QA, Thanh NKT, Jones SK, Dobson J (2009) Progress in applications of magnetic nanoparticles in biomedicine. J Phys D 42:224001
28. Roca AG, Veintemillas-Verdaguer S, Port M, Robic C, Serna CJ, Morales MP (2009) Effect of nanoparticle and aggregate size on the relaxometric properties of MR contrast agents based on high quality magnetite nanoparticles. J Phys Chem B 113:7033-7039
29. Roca AG, Carmona D, Miguel-Sancho N, Bomati-Miguel O, Balas F, Piquer C, Santamaria J (2012) Surface functionalization for tailoring the aggregation and magnetic behaviour of silica-coated iron oxide nanostructures. Nanotechnology 23:155603
30. Rümenapp C, Gleich B, Haase A (2012) Magnetic nanoparticles in magnetic resonance imaging and diagnostics. Pharm Res 29(5):1165-1179
31. Sharma P, Brown S, Walter G, Santra S, Moudgil B (2006) Nanoparticles for bioimaging. Adv Colloid Interface Sci 123-126:471-485 (Pubitemid 44665822)
32. Shen T, Weissleder R, Papisov M, Bogdanov A Jr, Brady TJ (1993) Monocrystalline iron oxide nanocompounds (MION): physicochemical properties. Magn Reson Med 29(5):599-604 (Pubitemid 23138048)
33. Sun C, Sze R, Zhang M (2006) Folic acid-PEG conjugated superparamagnetic nanoparticles for targeted cellular uptake and detection by MRI. J Biomed Mater Res A 78(3):550-557 (Pubitemid 44253539)
34. Suzuki H, Tsurita G, Ishihara S, Akahane M, Kitayama J, Nagawa H (2008) Resovist-enhanced MRI for preoperative assessment of colorectal hepatic metastases: a case of multiple bile duct hamartomas associated with colon cancer. Case Rep Gastroenterol 2(3):509-516
35. Theppaleak T, Tumcharern G, Wichai U, Rutnakornpituk M (2009) Synthesis of water dispersible magnetite nanoparticles in the presence of hydrophilic polymers. Polym Bull 63:79-90
36. Thorek DLJ, Chen AK, Czupryna J, Tsourkas A (2006) Superparamagnetic iron oxide nanoparticle probes for molecular imaging. Ann Biomed Eng 34(1):23-28
37. Troprès I, Grimault S, Vaeth A, Grillon E, Julien C, Payen JF, Lamalle L, Décorps M (2001) Vessel size imaging. Magn Reson Med 45:397-408
38. Villanueva A, Cañete M, Roca AG, Calero M, Veintemillas- Verdagüer S, Serna CJ, Morales MP, Miranda R (2009) The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells. Nanotechnology 20:115103 (9 pp)
39. Wan J, Cai W, Meng X, Liu E (2007) Monodisperse water-soluble magnetite nanoparticles prepared by polyol process for high-performance magnetic resonance imaging. Chem Commun 47:5004-5006 (Pubitemid 350199436)
40. Wei C, Wan J (2007) Facile synthesis of superparamagnetic magnetite nanoparticles in liquid polyols. J Colloid Interface Sci 305:366-370
41. Weinreb JC, Abu-Alpha AK (2009) Gadolinium-based contrast agents and nephrogenic systemic fibrosis: why did it happen and what have we learned? J Magn Reson Imaging 30:1236-1239
42. Weissleder R, Hahn PF, Stark DD, Elizondo G, Saini S, Todd LE, Wittenberg J, Ferruci JT (1998) Superparamagnetic iron oxide: enhanced detection of splenic tumors with MR imaging. Radiology 169:399-403
43. Wu W, He Q, Jiang C (2008) Magnetic iron oxide nanoparticles: synthesis and surface functionalization strategies. Nanoscale Res Lett 3:397-415
44. Yan GP, Robinson L, Hogg P (2007) Magnetic resonance imaging contrast agents: overview and perspectives. Radiography 13:e5-e19
45. Yang WJ, Lee JH, Hong SC, Lee J, Lee J, Han DW (2013) Nanoparticles with various surface-functional groups against human normal fibroblast and fibrosarcoma cells. Materials 6:4689-4706