Resolution of the three dimensional structure of components of the glomerular filtration barrier

BMC Nephrology

Volumn 15, Issue 1, 2014, Pages

  Arkill, Kenton P ^a,d   Qvortrup, Klaus ^b   Starborg, Tobias ^c   Mantell, Judith M ^d   Knupp, Carlo ^e   Michel, C Charles ^f   Harper, Steve J ^d   Salmon, Andy H ^d   Squire, John M ^d   Bates, Dave O ^g   Neal, Chris R ^d  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e CARDIFF UNIVERSITY   (United Kingdom)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

^g UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

3D reconstruction; Electron microscopy; Focused ion beam (FIB); GFB; Glomerulus; Glycocalyx; Podocyte; Serial block face (SBF); Tomography; Urinary space

Indexed keywords

ANIMALS; GLOMERULAR FILTRATION BARRIER; GLYCOCALYX; IMAGING, THREE-DIMENSIONAL; MALE; MICROSCOPY, ELECTRON; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84893162062     PISSN: None     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/1471-2369-15-24     Document Type: Article

References (29)

1. Structural determinants of glomerular permeability. Deen WM, Lazzara MJ, Myers BD, Am J Physiol Renal Physiol 2001 281 579 F596 11553505
2. New aspects of glomerular filtration barrier structure and function: five layers (at least) not three. Salmon AHJ, Neal CR, Harper SJ, Curr Opin Nephrol Hypertens 2009 18 197 205 19365184
3. Glomerular endothelial glycocalyx. Avasthi PS, Koshy V, Contrib Nephrol 1988 68 104 113 3233988
4. The anionic Matrix at the rat glomerular enodothelial surface. Avasthi PS, Koshy V, Anat Rec 1988 220 258 266 10.1002/ar.1092200306 2966599
5. Sieve plugs in fenestrae of glomerular capillaries-site of the filtration barrier? Rostgaard J, Qvortrup K, Cells Tissues Organs 2002 170 132 138 10.1159/000046186 11731701 (Pubitemid 33151585)
6. Properties of the glomerular barrier and mechanisms of proteinuria. Haraldsson B, Nystrom J, Deen WM, Physiol Rev 2008 88 451 487 10.1152/physrev.00055.2006 18391170 (Pubitemid 351522745)
7. Glomerular size and charge selectivity in the mouse after exposure to glucosaminoglycan-degrading enzymes. Jeansson M, Haraldsson B, J Am Soc Nephrol 2003 14 1756 1765 10.1097/01.ASN.0000072742.02714.6E 12819235 (Pubitemid 36750471)
8. Morphological and functional evidence for an important role of the endothelial cell glycocalyx in the glomerular barrier. Jeansson M, Haraldsson B, Am J Physiol Renal Physiol 2006 290 111 F116 16091582
9. Loss of the Endothelial Glycocalyx Links Albuminuria and Vascular Dysfunction. Salmon AHJ, Ferguson JK, Burford JL, Gevorgyan H, Nakano D, Harper SJ, Bates DO, Peti-Peterdi J, J Am Soc Nephrol 2012 23 8 1339 1350 10.1681/ASN.2012010017 22797190
10. Three-dimensional reconstruction of glomeruli by electron microscopy reveals a distinct restrictive urinary subpodocyte space. Neal CR, Crook H, Bell E, Harper SJ, Bates DO, J Am Soc Nephrol 2005 16 1223 1235 10.1681/ASN. 2004100822 15829713 (Pubitemid 41716507)
11. Evidence for restriction of fluid and solute movement across the glomerular capillary wall by the subpodocyte space. Salmon AHJ, Toma I, Sipos A, Muston PR, Harper SJ, Bates DO, Neal CR, Peti-Peterdi J, Am J Physiol Renal Physiol 2007 293 1777 F1786 10.1152/ajprenal.00187.2007 17804486 (Pubitemid 350179602)
12. Glomerular filtration into the subpodocyte space is highly restricted under physiological perfusion conditions. Neal CR, Muston PR, Njegovan D, Verrill R, Harper SJ, Deen WM, Bates DO, Am J Physiol Renal Physiol 2007 293 1787 F1798 10.1152/ajprenal.00157.2007 17715264 (Pubitemid 350179603)
13. Sur lexistence dun appareil lacunaire peri-capillaire du glomerule de malpighi, revelee par le microscope electronique. Gautier A, Bernhard W, Oberling C, Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales 1950 144 1605 1607 14822344
14. The podocytes, re-examined. Elias H, Allara E, Elias PM, Murthy AS, Zeitschrift fur mikroskopisch-anatomische Forschung 1965 72 344 365
15. Abstract: 3-D reconstruction of the glomerular barrier and overlying podocyte reveals a sub-podocyte space: a new urinary space within the glomerulus? Neal CR, Harper SJ, Bates D, J Physiol 2003 552P 26
16. VEGF165b overexpression restores normal glomerular filtration barrier function in VEGF164-overexpressing adult mice. Oltean S, Neal CR, Sison K, Qui Y, Patel P, Ahad T, Alsop C, Lee T, Harper SJ, Bates DO, et al. Am J Physiol in review 2012 303 7 1026 F1036 10.1152/ajprenal.00410.2011
17. 3D reconstruction of the glycocalyx structure in mammalian capillaries using electron tomography. Arkill KP, Neal CR, Mantell JM, Michel CC, Qvortrup K, Rostgaard J, Bates DO, Knupp C, Squire JM, Microcirculation 2012 19 343 351 10.1111/j.1549-8719.2012.00168.x 22324320
18. Structure-function studies of blood and air capillaries in chicken lung using 3D electron microscopy. West JB, Fu ZX, Deerinck TJ, Mackey MR, Obayashi JT, Ellisman MH, Respir Physiol Neurobiol 2010 170 202 209 10.1016/j.resp.2009. 12.010 20038456
19. Serial block-face scanning electron microscopy to reconstruct three-dimensional tissue nanostructure. Denk W, Horstmann H, PLoS Biol 2004 2 1900 1909
20. Quantitative Biological Measurement In Transmission Electron Tomography. Mantell JM, Verkade P, Arkill KP, Electron Microscopy And Analysis Group Conference 2012 371 Journal of Physics Conference Series
21. A method for monitoring the collapse of plastic sections as a function of electron dose. Luther PK, Lawrence MC, Crowther RA, Ultramicroscopy 1988 24 7 18 10.1016/0304-3991(88)90322-1 3344552 (Pubitemid 18564554)
22. Computer visualization of three-dimensional image data using IMOD. Kremer JR, Mastronarde DN, McIntosh JR, J Struct Biol 1996 116 71 76 10.1006/jsbi.1996.0013 8742726 (Pubitemid 26093126)
23. Dual-axis tomography: an approach with alignment methods that preserve resolution. Mastronarde DN, J Struct Biol 1997 120 343 352 10.1006/jsbi.1997. 3919 9441937 (Pubitemid 28137307)
24. NIH Image to ImageJ: 25 years of image analysis. Schneider CA, Rasband WS, Eliceiri KW, Nature Methods 2012 9 671 675 10.1038/nmeth.2089 22930834
25. Fiji: an open-source platform for biological-image analysis. Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, et al. Nat Methods 2012 9 676 682 10.1038/nmeth.2019 22743772
26. Similar endothelial glycocalyx structures in microvessels from a range of mammalian tissues: evidence for a common filtering mechanism? Arkill KP, Knupp C, Michel CC, Neal CR, Qvortrup K, Rostgaard J, Squire JM, Biophys J 2011 101 1046 1056 10.1016/j.bpj.2011.07.036 21889441
27. Quasi-periodic substructure in the microvessel endothelial glycocalyx: a possible explanation for molecular filtering? Squire JM, Chew M, Nneji G, Neal C, Barry J, Michel C, J Struct Biol 2001 136 239 255 10.1006/jsbi.2002.4441 12051903
28. Rapid freeze-substitution preserves membranes in high-pressure frozen tissue culture cells. Hawes P, Netherton CL, Mueller M, Wileman T, Monaghan P, J Microsc-Oxford 2007 226 182 189 10.1111/j.1365-2818.2007.01767.x (Pubitemid 46625285)
29. Correlative light and volume electron microscopy: using focused ion beam scanning electron microscopy to image transient events in model organisms. Bushby A, Mariggi G, Armer H, Collinson L, Meth Cell Biol 2012 111 357 482