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Volumn 18, Issue 3, 2009, Pages 197-205

New aspects of glomerular filtration barrier structure and function: Five layers (at least) not three

Author keywords

Endothelial surface layer; Glomerulus; Permeability; Podocyte; Subpodocyte space

Indexed keywords

ELECTRON MICROSCOPY; ENDOTHELIAL SURFACE LAYER; ENDOTHELIUM CELL; GLOMERULAR ENDOTHELIAL FENESTRAE; GLOMERULAR STRUCTURE; GLOMERULUS; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION; HUMAN; HYDRAULIC PERMEABILITY; MEMBRANE PERMEABILITY; NONHUMAN; PODOCYTE INTERFOOT PROCESS; PRIORITY JOURNAL; REVIEW; SUBPODOCYTE SPACE; TRANSMISSION ELECTRON MICROSCOPY; ULTRAFILTRATION; ANIMAL; ENDOTHELIUM; GLOMERULUS FILTRATION RATE; HISTOLOGY; METABOLISM; PERMEABILITY; PHYSIOLOGY; PODOCYTE; SIGNAL TRANSDUCTION;

EID: 67049160811     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e328329f837     Document Type: Review
Times cited : (49)

References (56)
  • 1
    • 0028147336 scopus 로고
    • Transport of macromolecules across microvascular walls: The two-pore theory
    • Rippe B, Haraldsson B. Transport of macromolecules across microvascular walls: the two-pore theory. Physiol Rev 1994; 74:163-219.
    • (1994) Physiol Rev , vol.74 , pp. 163-219
    • Rippe, B.1    Haraldsson, B.2
  • 3
    • 42149122041 scopus 로고    scopus 로고
    • Properties of the glomerular barrier and mechanisms of proteinuria
    • This article reviews the structure and function of the glomerular filtration barrier, examines important controversies relating to the measurement of glomerular permselectivity, and argues for an integrative view of glomerular function in health and disease
    • Haraldsson B, Nystrom J, Deen WM. Properties of the glomerular barrier and mechanisms of proteinuria. Physiol Rev 2008; 88:451-487. This article reviews the structure and function of the glomerular filtration barrier, examines important controversies relating to the measurement of glomerular permselectivity, and argues for an integrative view of glomerular function in health and disease.
    • (2008) Physiol Rev , vol.88 , pp. 451-487
    • Haraldsson, B.1    Nystrom, J.2    Deen, W.M.3
  • 4
    • 23944442318 scopus 로고    scopus 로고
    • Three-dimensional reconstruction of glomeruli by electron microscopy reveals a distinct restrictive urinary subpodocyte space
    • Neal CR, Crook H, Bell E, et al. Three-dimensional reconstruction of glomeruli by electron microscopy reveals a distinct restrictive urinary subpodocyte space. J Am Soc Nephrol 2005; 16:1223-1235.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1223-1235
    • Neal, C.R.1    Crook, H.2    Bell, E.3
  • 5
    • 1442275722 scopus 로고    scopus 로고
    • Why do we not all have proteinuria? An update of our current understanding of the glomerular barrier
    • Haraldsson B, Sorensson J. Why do we not all have proteinuria? An update of our current understanding of the glomerular barrier. News Physiol Sci 2004; 19:7-10.
    • (2004) News Physiol Sci , vol.19 , pp. 7-10
    • Haraldsson, B.1    Sorensson, J.2
  • 6
    • 0016824003 scopus 로고
    • Permselectivity of the glomerular capillary wall to macromolecules. II. Experimental studies in rats using neutral dextran
    • Chang RL, Ueki IF, Troy JL, et al. Permselectivity of the glomerular capillary wall to macromolecules. II. Experimental studies in rats using neutral dextran. Biophys J 1975; 15:887-906.
    • (1975) Biophys J , vol.15 , pp. 887-906
    • Chang, R.L.1    Ueki, I.F.2    Troy, J.L.3
  • 7
    • 0037609543 scopus 로고    scopus 로고
    • Glomerular filtration rate dependence of sieving of albumin and some neutral proteins in rat kidneys
    • Lund U, Rippe A, Venturoli D, et al. Glomerular filtration rate dependence of sieving of albumin and some neutral proteins in rat kidneys. Am J Physiol Renal Physiol 2003; 284:F1226-F1234.
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Lund, U.1    Rippe, A.2    Venturoli, D.3
  • 8
    • 33646150223 scopus 로고    scopus 로고
    • Effects of glomerular filtration rate on Ficoll sieving coefficients (theta) in rats
    • Rippe C, Asgeirsson D, Venturoli D, et al. Effects of glomerular filtration rate on Ficoll sieving coefficients (theta) in rats. Kidney Int 2006; 69:1326-1332.
    • (2006) Kidney Int , vol.69 , pp. 1326-1332
    • Rippe, C.1    Asgeirsson, D.2    Venturoli, D.3
  • 9
    • 0023934274 scopus 로고
    • The anionic matrix at the rat glomerular endothelial surface
    • Avasthi PS, Koshy V. The anionic matrix at the rat glomerular endothelial surface. Anat Rec 1988; 220:258-266.
    • (1988) Anat Rec , vol.220 , pp. 258-266
    • Avasthi, P.S.1    Koshy, V.2
  • 10
    • 0031011040 scopus 로고    scopus 로고
    • Electron microscopic demonstrations of filamentous molecular sieve plugs in capillary fenestrae
    • Rostgaard J, Qvortrup K. Electron microscopic demonstrations of filamentous molecular sieve plugs in capillary fenestrae. Microvasc Res 1997; 53:1-13.
    • (1997) Microvasc Res , vol.53 , pp. 1-13
    • Rostgaard, J.1    Qvortrup, K.2
  • 11
    • 15044354909 scopus 로고    scopus 로고
    • Primary human glomerular endothelial cells produce proteoglycans, and puromycin affects their post-translational modification
    • Bjornson A, Moses J, Ingemansson A, et al. Primary human glomerular endothelial cells produce proteoglycans, and puromycin affects their post-translational modification. Am J Physiol Renal Physiol 2005; 288:F748-F756.
    • (2005) Am J Physiol Renal Physiol , vol.288
    • Bjornson, A.1    Moses, J.2    Ingemansson, A.3
  • 12
    • 0037303363 scopus 로고    scopus 로고
    • Synthesis of sulfated proteoglycans by bovine glomerular endothelial cells in culture
    • Sorensson J, Bjornson A, Ohlson M, et al. Synthesis of sulfated proteoglycans by bovine glomerular endothelial cells in culture. Am J Physiol Renal Physiol 2003; 284:F373-F380.
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Sorensson, J.1    Bjornson, A.2    Ohlson, M.3
  • 13
    • 0026597361 scopus 로고
    • Plasma proteins modify the endothelial cell glyco-calyx of frog mesenteric microvessels
    • Adamson RH, Clough G. Plasma proteins modify the endothelial cell glyco-calyx of frog mesenteric microvessels. J Physiol 1992; 445:473-486.
    • (1992) J Physiol , vol.445 , pp. 473-486
    • Adamson, R.H.1    Clough, G.2
  • 15
    • 0346728703 scopus 로고    scopus 로고
    • Electron microscopic evaluation of the endothelial surface layer of glomerular capillaries
    • Hjalmarsson C, Johansson BR, Haraldsson B. Electron microscopic evaluation of the endothelial surface layer of glomerular capillaries. Microvasc Res 2004; 67:9-17.
    • (2004) Microvasc Res , vol.67 , pp. 9-17
    • Hjalmarsson, C.1    Johansson, B.R.2    Haraldsson, B.3
  • 16
    • 0032772422 scopus 로고    scopus 로고
    • Microvascular permeability
    • Michel CC, Curry FE. Microvascular permeability. Physiol Rev 1999; 79:703-761.
    • (1999) Physiol Rev , vol.79 , pp. 703-761
    • Michel, C.C.1    Curry, F.E.2
  • 17
    • 0037530611 scopus 로고    scopus 로고
    • Glomerular size and charge selectivity in the mouse after exposure to glucosaminoglycan-degrading enzymes
    • Jeansson M, Haraldsson B. Glomerular size and charge selectivity in the mouse after exposure to glucosaminoglycan-degrading enzymes. J Am Soc Nephrol 2003; 14:1756-1765.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 1756-1765
    • Jeansson, M.1    Haraldsson, B.2
  • 18
    • 35848940725 scopus 로고    scopus 로고
    • Glomerular endothelial glycocalyx constitutes a barrier to protein permeability
    • Singh A, Satchell SC, Neal CR, et al. Glomerular endothelial glycocalyx constitutes a barrier to protein permeability. J Am Soc Nephrol 2007; 18: 2885-2893.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 2885-2893
    • Singh, A.1    Satchell, S.C.2    Neal, C.R.3
  • 19
    • 33646529152 scopus 로고    scopus 로고
    • Conditionally immortalized human glomerular endothelial cells expressing fenestrations in response to VEGF
    • Satchell SC, Tasman CH, Singh A, et al. Conditionally immortalized human glomerular endothelial cells expressing fenestrations in response to VEGF. Kidney Int 2006; 69:1633-1640.
    • (2006) Kidney Int , vol.69 , pp. 1633-1640
    • Satchell, S.C.1    Tasman, C.H.2    Singh, A.3
  • 20
    • 34248377676 scopus 로고    scopus 로고
    • The endothelial glycocalyx: Composition, functions, and visualization
    • Reitsma S, Slaaf DW, Vink H, et al. The endothelial glycocalyx: composition, functions, and visualization. Pflugers Arch 2007; 454:345-359.
    • (2007) Pflugers Arch , vol.454 , pp. 345-359
    • Reitsma, S.1    Slaaf, D.W.2    Vink, H.3
  • 21
    • 0020595324 scopus 로고
    • Endothelial characteristics of glomerular capillaries in normal, mercuric chloride-induced, and gentamicin-induced acute renal failure in the rat
    • Bulger RE, Eknoyan G, Purcell DJ 2nd, Dobyan DC. Endothelial characteristics of glomerular capillaries in normal, mercuric chloride-induced, and gentamicin-induced acute renal failure in the rat. J Clin Invest 1983; 72: 128-141.
    • (1983) J Clin Invest , vol.72 , pp. 128-141
    • Bulger, R.E.1    Eknoyan, G.2    Purcell 2nd, D.J.3    Dobyan, D.C.4
  • 22
    • 0021972672 scopus 로고
    • Endothelial fenestral diaphragms: A quick-freeze, deepetch study
    • Bearer EL, Orci L Endothelial fenestral diaphragms: a quick-freeze, deepetch study. J Cell Biol 1985; 100:418-428.
    • (1985) J Cell Biol , vol.100 , pp. 418-428
    • Bearer, E.L.1    Orci, L.2
  • 23
    • 0033539691 scopus 로고    scopus 로고
    • PV-1 is a component of the fenestral and stomatal diaphragms in fenestrated endothelia
    • Stan RV, Kubitza M, Palade GE. PV-1 is a component of the fenestral and stomatal diaphragms in fenestrated endothelia. Proc Natl Acad Sci USA 1999; 96:13203-13207.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13203-13207
    • Stan, R.V.1    Kubitza, M.2    Palade, G.E.3
  • 24
    • 0023225127 scopus 로고
    • An analysis of the permeability of a fenestra
    • Levick JR, Smaje LH. An analysis of the permeability of a fenestra. Microvasc Res 1987; 33:233-256.
    • (1987) Microvasc Res , vol.33 , pp. 233-256
    • Levick, J.R.1    Smaje, L.H.2
  • 25
    • 49649100466 scopus 로고    scopus 로고
    • Glomerular endothelial cells form diaphragms during development and pathologic conditions
    • Ichimura K, Stan RV, Kurihara H, Sakai T. Glomerular endothelial cells form diaphragms during development and pathologic conditions. J Am Soc Ne-phrol 2008; 19:1463-1471.
    • (2008) J Am Soc Ne-phrol , vol.19 , pp. 1463-1471
    • Ichimura, K.1    Stan, R.V.2    Kurihara, H.3    Sakai, T.4
  • 26
    • 49649100465 scopus 로고    scopus 로고
    • Fenestrated glomerular capillaries are unique
    • Kriz W. Fenestrated glomerular capillaries are unique. J Am Soc Nephrol 2008; 19:1439-1440.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1439-1440
    • Kriz, W.1
  • 27
    • 0024410191 scopus 로고
    • Glomerular basement membrane as a compressible ultrafilter
    • Robinson GB, Walton HA. Glomerular basement membrane as a compressible ultrafilter. Microvasc Res 1989; 38:36-48.
    • (1989) Microvasc Res , vol.38 , pp. 36-48
    • Robinson, G.B.1    Walton, H.A.2
  • 28
    • 33746730496 scopus 로고    scopus 로고
    • Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier
    • Jarad G, Cunningham J, Shaw AS, Miner JH. Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier. J Clin Invest 2006; 116:2272-2279.
    • (2006) J Clin Invest , vol.116 , pp. 2272-2279
    • Jarad, G.1    Cunningham, J.2    Shaw, A.S.3    Miner, J.H.4
  • 29
    • 8444221929 scopus 로고    scopus 로고
    • Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities
    • Zenker M, Aigner T, Wendler O, et al. Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities. Hum Mol Genet 2004; 13:2625-2632.
    • (2004) Hum Mol Genet , vol.13 , pp. 2625-2632
    • Zenker, M.1    Aigner, T.2    Wendler, O.3
  • 30
    • 33645746950 scopus 로고    scopus 로고
    • Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes
    • Jones N, Blasutig IM, Eremina V, et al. Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature 2006; 440:818-823.
    • (2006) Nature , vol.440 , pp. 818-823
    • Jones, N.1    Blasutig, I.M.2    Eremina, V.3
  • 31
    • 34249874096 scopus 로고    scopus 로고
    • Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine
    • Galeano B, Klootwijk R, Manoli I, et al. Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine. J Clin Invest 2007; 117:1585-1594.
    • (2007) J Clin Invest , vol.117 , pp. 1585-1594
    • Galeano, B.1    Klootwijk, R.2    Manoli, I.3
  • 32
    • 33846857348 scopus 로고    scopus 로고
    • Statin-sensitive endocytosis of albumin by glomerular podocytes
    • Eyre J, Ioannou K, Grubb BD, et al. Statin-sensitive endocytosis of albumin by glomerular podocytes. Am J Physiol Renal Physiol 2007; 292:F674-F681.
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Eyre, J.1    Ioannou, K.2    Grubb, B.D.3
  • 33
    • 36549089932 scopus 로고    scopus 로고
    • Glomerular filtration into the sub-podocyte space is highly restricted under physiological perfusion conditions
    • Neal CR, Muston PR, Njegovan D, et al. Glomerular filtration into the sub-podocyte space is highly restricted under physiological perfusion conditions. Am J Physiol Renal Physiol 2007; 293:F1787-F1798.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Neal, C.R.1    Muston, P.R.2    Njegovan, D.3
  • 34
    • 0002171228 scopus 로고
    • On the structure and use of the malpighian bodies of the kidney, with observations on the circulation through that gland
    • Bowman W. On the structure and use of the malpighian bodies of the kidney, with observations on the circulation through that gland. Phil Trans R Soc Lond 1842; 132:57-80.
    • (1842) Phil Trans R Soc Lond , vol.132 , pp. 57-80
    • Bowman, W.1
  • 36
    • 77049329168 scopus 로고
    • The existence of a pericapillary lacunar apparatus in the malpighian glomeruli revealed by electronic microscopy
    • Gautier A, Bernhard W, Oberling C. The existence of a pericapillary lacunar apparatus in the malpighian glomeruli revealed by electronic microscopy. C R Seances Soc Biol Fil 1950; 144:1605-1607.
    • (1950) C R Seances Soc Biol Fil , vol.144 , pp. 1605-1607
    • Gautier, A.1    Bernhard, W.2    Oberling, C.3
  • 38
  • 39
    • 36549030701 scopus 로고    scopus 로고
    • Evidence for restriction of fluid and solute movement across the glomerular capillary wall by the subpodocyte space
    • Salmon AH, Toma I, Sipos A, et al. Evidence for restriction of fluid and solute movement across the glomerular capillary wall by the subpodocyte space. Am J Physiol Renal Physiol 2007; 293:F1777-F1786.
    • (2007) Am J Physiol Renal Physiol , vol.293
    • Salmon, A.H.1    Toma, I.2    Sipos, A.3
  • 40
    • 9644264018 scopus 로고    scopus 로고
    • Human podocytes possess a stretch-sensitive, Ca2+-activated K+ channel: Potential implications for the control of glomerular filtration
    • Morton MJ, Hutchinson K, Mathieson PW, et al. Human podocytes possess a stretch-sensitive, Ca2+-activated K+ channel: potential implications for the control of glomerular filtration. J Am Soc Nephrol 2004; 15:2981-2987.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2981-2987
    • Morton, M.J.1    Hutchinson, K.2    Mathieson, P.W.3
  • 41
    • 0035126234 scopus 로고    scopus 로고
    • Podocytes respond to mechanical stress in vitro
    • Endlich N, Kress KR, Reiser J, et al. Podocytes respond to mechanical stress in vitro. J Am Soc Nephrol 2001; 12:413-422.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 413-422
    • Endlich, N.1    Kress, K.R.2    Reiser, J.3
  • 42
    • 0034004798 scopus 로고    scopus 로고
    • Angiotensin II increases the intracellular calcium activity in podocytes of the intact glomerulus
    • Nitschke R, Henger A, Ricken S, et al. Angiotensin II increases the intracellular calcium activity in podocytes of the intact glomerulus. Kidney Int 2000; 57:41-49.
    • (2000) Kidney Int , vol.57 , pp. 41-49
    • Nitschke, R.1    Henger, A.2    Ricken, S.3
  • 43
    • 58249123367 scopus 로고    scopus 로고
    • The insect nephrocyte is a podocyte-like cell with a filtration slitdiaphragm
    • Weavers H, Prieto-Sanchez S, Grawe F, et al. The insect nephrocyte is a podocyte-like cell with a filtration slitdiaphragm. Nature 2008; 457:322-326.
    • (2008) Nature , vol.457 , pp. 322-326
    • Weavers, H.1    Prieto-Sanchez, S.2    Grawe, F.3
  • 44
    • 34250374471 scopus 로고    scopus 로고
    • Role of the VEGF: A signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier
    • Eremina V, Baelde HJ, Quaggin SE. Role of the VEGF: a signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier. Nephron Physiol 2007; 106:32-37.
    • (2007) Nephron Physiol , vol.106 , pp. 32-37
    • Eremina, V.1    Baelde, H.J.2    Quaggin, S.E.3
  • 45
    • 54549123309 scopus 로고    scopus 로고
    • VEGF-A splicing: The key to antiangiogenic therapeutics?
    • Harper SJ, Bates DO. VEGF-A splicing: the key to antiangiogenic therapeutics? Nat Rev Cancer 2008; 8:880-887.
    • (2008) Nat Rev Cancer , vol.8 , pp. 880-887
    • Harper, S.J.1    Bates, D.O.2
  • 46
    • 0032888010 scopus 로고    scopus 로고
    • Vascular endothelial growth factor mRNA expression in minimal change, membranous, and diabetic nephropathy demonstrated by nonisotopic in situ hybridisation
    • Bailey E, Bottomley MJ, Westwell S, et al. Vascular endothelial growth factor mRNA expression in minimal change, membranous, and diabetic nephropathy demonstrated by nonisotopic in situ hybridisation. J Clin Pathol 1999; 52:735-738.
    • (1999) J Clin Pathol , vol.52 , pp. 735-738
    • Bailey, E.1    Bottomley, M.J.2    Westwell, S.3
  • 47
    • 0038623780 scopus 로고    scopus 로고
    • Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes
    • Foster RR, Hole R, Anderson K, et al. Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes. Am J Physiol Renal Physiol 2003; 284:F1263-F1273.
    • (2003) Am J Physiol Renal Physiol , vol.284
    • Foster, R.R.1    Hole, R.2    Anderson, K.3
  • 48
    • 11144287218 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes
    • Foster RR, Saleem MA, Mathieson PW, et al. Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes. Am J Physiol Renal Physiol 2005; 288:F48-F57.
    • (2005) Am J Physiol Renal Physiol , vol.288
    • Foster, R.R.1    Saleem, M.A.2    Mathieson, P.W.3
  • 49
    • 33846638744 scopus 로고    scopus 로고
    • Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: Systematic review and meta-analysis
    • Zhu X, Wu S, Dahut WL, Parikh CR. Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis. Am J Kidney Dis 2007; 49:186-193.
    • (2007) Am J Kidney Dis , vol.49 , pp. 186-193
    • Zhu, X.1    Wu, S.2    Dahut, W.L.3    Parikh, C.R.4
  • 50
    • 40849130173 scopus 로고    scopus 로고
    • VEGF inhibition and renal thrombotic microangiopathy
    • This paper reports that anti-VEGF antibody therapy in humans results in thrombotic microangiopathy, and that conditional deletion of VEGF from adult mouse podocytes elicits the same histological lesion, thereby demonstrating the importance of podocyte-derived VEGF for maintaining normal glomerular health and function
    • Eremina V, Jefferson JA, Kowalewska J, et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 2008; 358:1129-1136. This paper reports that anti-VEGF antibody therapy in humans results in thrombotic microangiopathy, and that conditional deletion of VEGF from adult mouse podocytes elicits the same histological lesion, thereby demonstrating the importance of podocyte-derived VEGF for maintaining normal glomerular health and function.
    • (2008) N Engl J Med , vol.358 , pp. 1129-1136
    • Eremina, V.1    Jefferson, J.A.2    Kowalewska, J.3
  • 51
    • 46949109391 scopus 로고    scopus 로고
    • VEGF inhibition and renal thrombotic microangiopathy
    • author reply 206-207
    • Katavetin P. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 2008; 359:205-206; author reply 206-207.
    • (2008) N Engl J Med , vol.359 , pp. 205-206
    • Katavetin, P.1
  • 52
    • 53149137800 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C, a potential paracrine regulator of glomerular permeability, increases glomerular endothelial cell monolayer integrity and intracellular calcium
    • This paper shows that VEGF-R3 is expressed by endothelial cells in mature adult glomeruli, and that VEGF-A and VEGF-C have opposing effects on glomerular endothelial cell monolayer permeability in vitro
    • Foster RR, Slater SC, Seckley J, et al. Vascular endothelial growth factor-C, a potential paracrine regulator of glomerular permeability, increases glomerular endothelial cell monolayer integrity and intracellular calcium. Am J Pathol 2008; 173:938-948. This paper shows that VEGF-R3 is expressed by endothelial cells in mature adult glomeruli, and that VEGF-A and VEGF-C have opposing effects on glomerular endothelial cell monolayer permeability in vitro.
    • (2008) Am J Pathol , vol.173 , pp. 938-948
    • Foster, R.R.1    Slater, S.C.2    Seckley, J.3
  • 53
    • 34547628176 scopus 로고    scopus 로고
    • Davis B, Dei Cas A, Long DA, et al. Podocyte-specific expression of angio- poietin-2 causes proteinuria and apoptosis of glomerular endothelia. J Am Soc Nephrol 2007; 18:2320-2329. This paper shows that overexpression of angiopoietin-2 in mature adult podocytes causes glomerular changes that are restricted to endothelia, and that result in proteinuria.
    • Davis B, Dei Cas A, Long DA, et al. Podocyte-specific expression of angio- poietin-2 causes proteinuria and apoptosis of glomerular endothelia. J Am Soc Nephrol 2007; 18:2320-2329. This paper shows that overexpression of angiopoietin-2 in mature adult podocytes causes glomerular changes that are restricted to endothelia, and that result in proteinuria.
  • 54
    • 1542349097 scopus 로고    scopus 로고
    • Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties
    • Satchell SC, Anderson KL, Mathieson PW. Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties. J Am Soc Nephrol 2004; 15:566-574.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 566-574
    • Satchell, S.C.1    Anderson, K.L.2    Mathieson, P.W.3
  • 55
    • 0025237845 scopus 로고
    • The pronephros of the early ammoncoete larva of lampreys (Cyclostomata Petromyzontes): Fine structure of the external glomus
    • Kluge B, Fischer A. The pronephros of the early ammoncoete larva of lampreys (Cyclostomata Petromyzontes): fine structure of the external glomus. Cell Tiss Res 1990; 260:249-259.
    • (1990) Cell Tiss Res , vol.260 , pp. 249-259
    • Kluge, B.1    Fischer, A.2
  • 56
    • 0027976510 scopus 로고
    • The cytoskeleton of the ventral nephro-cytes of Ceratitis capitata larva
    • Dallai R, Riparbelli MG, Callaini G. The cytoskeleton of the ventral nephro-cytes of Ceratitis capitata larva. Cell Tiss Res 1994; 275:9-536.
    • (1994) Cell Tiss Res , vol.275 , pp. 9-536
    • Dallai, R.1    Riparbelli, M.G.2    Callaini, G.3


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