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Volumn 4, Issue 1, 2014, Pages 14-25

Identification of metabolites of Radix Paeoniae Alba extract in rat bile, plasma and urine by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry

Author keywords

Metabolite profiling; Monoterpene glycosides; Radix Paeoniae Alba; UPLC Q TOF MS

Indexed keywords

PAEONIA RADIX; PAEONIAE ALBA EXTRACT; UNCLASSIFIED DRUG;

EID: 84893161754     PISSN: 20951779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpha.2013.06.004     Document Type: Article
Times cited : (27)

References (30)
  • 1
    • 34548114605 scopus 로고    scopus 로고
    • Active principles of Paeonia lactiflora Pall
    • X.Y. Gao, and G.Y. Tian Active principles of Paeonia lactiflora Pall Zhongguo Xinyao Zazhi 6 2006 416 418
    • (2006) Zhongguo Xinyao Zazhi , vol.6 , pp. 416-418
    • Gao, X.Y.1    Tian, G.Y.2
  • 3
    • 0842299125 scopus 로고    scopus 로고
    • Development of the study on chemical constituents of Paeonia lactiflora Pall
    • X.Y. Zhang, and X. Li Development of the study on chemical constituents of Paeonia lactiflora Pall Shenyang Yao Ke Da Xue Xue Bao 19 2002 70 73
    • (2002) Shenyang Yao Ke da Xue Xue Bao , vol.19 , pp. 70-73
    • Zhang, X.Y.1    Li, X.2
  • 4
    • 58049118322 scopus 로고    scopus 로고
    • Effects and mechanisms of total glucosides of paeony on synoviocytes activities in rat collagen-induced arthritis
    • Y. Chang, W. Wei, and L. Zhang et al. Effects and mechanisms of total glucosides of paeony on synoviocytes activities in rat collagen-induced arthritis J. Ethnopharmacol. 121 2009 43 48
    • (2009) J. Ethnopharmacol. , vol.121 , pp. 43-48
    • Chang, Y.1    Wei, W.2    Zhang, L.3
  • 5
    • 0034092941 scopus 로고    scopus 로고
    • The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan cortex and Paeoniae radix
    • T. Okubo, F. Nagai, and T. Seto et al. The inhibition of phenylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan cortex and Paeoniae radix Biol. Pharm. Bull. 23 2000 199 203
    • (2000) Biol. Pharm. Bull. , vol.23 , pp. 199-203
    • Okubo, T.1    Nagai, F.2    Seto, T.3
  • 6
    • 43049141859 scopus 로고    scopus 로고
    • Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol
    • B. Lee, Y.W. Shin, and E.A. Bae et al. Antiallergic effect of the root of Paeonia lactiflora and its constituents paeoniflorin and paeonol Arch. Pharm. Res. 31 2008 445 450
    • (2008) Arch. Pharm. Res. , vol.31 , pp. 445-450
    • Lee, B.1    Shin, Y.W.2    Bae, E.A.3
  • 7
    • 0034757170 scopus 로고    scopus 로고
    • Anti-thrombosis effect of paeoniflorin: Evaluated in a photochemical reaction thrombosis model in vivo
    • J. Ye, H. Duan, and X. Yang et al. Anti-thrombosis effect of paeoniflorin: evaluated in a photochemical reaction thrombosis model in vivo Planta Med. 67 2001 766 767
    • (2001) Planta Med. , vol.67 , pp. 766-767
    • Ye, J.1    Duan, H.2    Yang, X.3
  • 8
    • 33645022034 scopus 로고    scopus 로고
    • Protective effect of paeoniflorin on immunological liver injury induced by bacillus calmette-guerin plus lipopolysaccharide: Modulation of tumour necrosis factor-α and interleukin-6 mRNA
    • D.F. Liu, W. Wei, and L.H. Song Protective effect of paeoniflorin on immunological liver injury induced by bacillus calmette-guerin plus lipopolysaccharide: modulation of tumour necrosis factor-α and interleukin-6 mRNA Clin. Exp. Pharmacol. Physiol. 33 2006 332 339
    • (2006) Clin. Exp. Pharmacol. Physiol. , vol.33 , pp. 332-339
    • Liu, D.F.1    Wei, W.2    Song, L.H.3
  • 9
    • 0027192950 scopus 로고
    • Peony and its major constituent, paeoniflorin, improved radial maze performance impaired by scopolamine in rats
    • H. Ohta, J.W. Ni, and K. Matsumoto et al. Peony and its major constituent, paeoniflorin, improved radial maze performance impaired by scopolamine in rats Pharmacol. Biochem. Behav. 45 1993 719 723
    • (1993) Pharmacol. Biochem. Behav. , vol.45 , pp. 719-723
    • Ohta, H.1    Ni, J.W.2    Matsumoto, K.3
  • 10
    • 0030879256 scopus 로고    scopus 로고
    • Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora
    • F.L. Hsu, C.W. Lai, and J.T. Cheng Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora Planta Med. 63 1997 323 325
    • (1997) Planta Med. , vol.63 , pp. 323-325
    • Hsu, F.L.1    Lai, C.W.2    Cheng, J.T.3
  • 11
    • 65449119141 scopus 로고    scopus 로고
    • Effect of total glucosides of paeony on the expression of nephrin in the kidneys from diabetic rats
    • P. Zhang, J.J. Zhang, and J. Su et al. Effect of total glucosides of paeony on the expression of nephrin in the kidneys from diabetic rats Am. J. Chin. Med. 37 2010 295 307
    • (2010) Am. J. Chin. Med. , vol.37 , pp. 295-307
    • Zhang, P.1    Zhang, J.J.2    Su, J.3
  • 12
    • 38649116640 scopus 로고    scopus 로고
    • HPLC fingerprinting and LC-TOF-MS analysis of the extract of Pseudostellaria heterophylla (Miq.) Pax root
    • C. Han, Y. Shen, and J. Chen et al. HPLC fingerprinting and LC-TOF-MS analysis of the extract of Pseudostellaria heterophylla (Miq.) Pax root J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 862 2008 125 131
    • (2008) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.862 , pp. 125-131
    • Han, C.1    Shen, Y.2    Chen, J.3
  • 13
    • 60349107139 scopus 로고    scopus 로고
    • Differentiation of Herba Cistanches by fingerprint with high-performance liquid chromatography-diode array detection-mass spectrometry
    • Y. Jiang, S.P. Li, and Y.T. Wang et al. Differentiation of Herba Cistanches by fingerprint with high-performance liquid chromatography-diode array detection-mass spectrometry J. Chromatogr. A 1216 2009 2156 2162
    • (2009) J. Chromatogr. A , vol.1216 , pp. 2156-2162
    • Jiang, Y.1    Li, S.P.2    Wang, Y.T.3
  • 14
    • 60349120545 scopus 로고    scopus 로고
    • Quality evaluation of Rhizoma Belamcandae (Belamcanda chinensis (L.) DC) by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry
    • J. Li, W.Z. Li, and W. Huang et al. Quality evaluation of Rhizoma Belamcandae (Belamcanda chinensis (L.) DC.) by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry J. Chromatogr. A. 1216 2009 2071 2078
    • (2009) J. Chromatogr. A. , vol.1216 , pp. 2071-2078
    • Li, J.1    Li, W.Z.2    Huang, W.3
  • 15
    • 34548481329 scopus 로고    scopus 로고
    • Chromatographic fingerprint analysis of Cephalotaxus sinensis from various sources by high-performance liquid chromatography-diodearray detection-electrospray ionization-tandem mass spectrometry
    • W. Li, Y. Deng, and R. Dai et al. Chromatographic fingerprint analysis of Cephalotaxus sinensis from various sources by high-performance liquid chromatography-diodearray detection-electrospray ionization-tandem mass spectrometry J. Pharm. Biomed. Anal. 45 2007 38 46
    • (2007) J. Pharm. Biomed. Anal. , vol.45 , pp. 38-46
    • Li, W.1    Deng, Y.2    Dai, R.3
  • 16
    • 59049090924 scopus 로고    scopus 로고
    • Chemical profiling of Radix Paeoniae evaluated by ultra-performance liquid chromatography/photo-diode-array/quadrupole time-of-flight mass spectrometry
    • S.L. Li, J.Z. Song, and F.F.K. Choi et al. Chemical profiling of Radix Paeoniae evaluated by ultra-performance liquid chromatography/photo-diode-array/ quadrupole time-of-flight mass spectrometry J. Pharm. Biomed. Anal. 49 2009 253 266
    • (2009) J. Pharm. Biomed. Anal. , vol.49 , pp. 253-266
    • Li, S.L.1    Song, J.Z.2    Choi, F.F.K.3
  • 17
    • 77954953065 scopus 로고    scopus 로고
    • Pharmacokinetic properties of paeoniflorin, albiflorin and oxypaeoniflorin after oral gavage of extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba in rats
    • C. Feng, M. Liu, and X. Shi et al. Pharmacokinetic properties of paeoniflorin, albiflorin and oxypaeoniflorin after oral gavage of extracts of Radix Paeoniae Rubra and Radix Paeoniae Alba in rats J. Ethnopharmacol. 130 2010 407 413
    • (2010) J. Ethnopharmacol. , vol.130 , pp. 407-413
    • Feng, C.1    Liu, M.2    Shi, X.3
  • 18
    • 74049146364 scopus 로고    scopus 로고
    • Ultra-performance liquid chromatography-tandem mass spectrometry analysis of the bioactive components and their metabolites of Shaofu Zhuyu decoction active extract in rat plasma
    • S. Su, J. Guo, and J. Duan et al. Ultra-performance liquid chromatography-tandem mass spectrometry analysis of the bioactive components and their metabolites of Shaofu Zhuyu decoction active extract in rat plasma J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 878 2010 355 362
    • (2010) J. Chromatogr. B Anal. Technol. Biomed. Life Sci. , vol.878 , pp. 355-362
    • Su, S.1    Guo, J.2    Duan, J.3
  • 19
    • 0029591775 scopus 로고
    • Absorption and excretion of paeoniflorin in rats
    • S. Takeda, T. Isono, and Y. Wakui et al. Absorption and excretion of paeoniflorin in rats J. Pharm. Pharmacol. 47 1995 1036 1040
    • (1995) J. Pharm. Pharmacol. , vol.47 , pp. 1036-1040
    • Takeda, S.1    Isono, T.2    Wakui, Y.3
  • 20
    • 0031033144 scopus 로고    scopus 로고
    • In-vivo assessment of extrahepatic metabolism of paeoniflorin in rats: Relevance to intestinal floral metabolism
    • S. Takeda, T. Isono, and Y. Wakui et al. In-vivo assessment of extrahepatic metabolism of paeoniflorin in rats: relevance to intestinal floral metabolism J. Pharm. Pharmacol. 49 1997 35 39
    • (1997) J. Pharm. Pharmacol. , vol.49 , pp. 35-39
    • Takeda, S.1    Isono, T.2    Wakui, Y.3
  • 21
    • 42749096465 scopus 로고    scopus 로고
    • Comparative pharmacokinetic study of paeoniflorin after oral administration of decoction of Radix Paeoniae Rubra and Radix Paeoniae Alba in rats
    • C. Wang, R. Wang, and X. Cheng et al. Comparative pharmacokinetic study of paeoniflorin after oral administration of decoction of Radix Paeoniae Rubra and Radix Paeoniae Alba in rats J. Ethnopharmacol. 117 2008 467 472
    • (2008) J. Ethnopharmacol. , vol.117 , pp. 467-472
    • Wang, C.1    Wang, R.2    Cheng, X.3
  • 22
    • 1242284441 scopus 로고    scopus 로고
    • A deglucosylated metabolite of paeoniflorin of the root of Paeonia lactiflora and its pharmacokinetics in rats
    • S.L. Hsiu, Y.T. Lin, and K.C. Wen et al. A deglucosylated metabolite of paeoniflorin of the root of Paeonia lactiflora and its pharmacokinetics in rats Planta Med. Nat. Prod. Med. Plant Res. 69 2003 1113 1118
    • (2003) Planta Med. Nat. Prod. Med. Plant Res. , vol.69 , pp. 1113-1118
    • Hsiu, S.L.1    Lin, Y.T.2    Wen, K.C.3
  • 23
    • 0022365954 scopus 로고
    • Metabolism of paeoniflorin and related compounds by human intestinal bacteria
    • M. Hattori, Y.Z. Shu, and M. Shimizu et al. Metabolism of paeoniflorin and related compounds by human intestinal bacteria Chem. Pharm. Bull. (Tokyo) 33 1985 3838 3846
    • (1985) Chem. Pharm. Bull. (Tokyo) , vol.33 , pp. 3838-3846
    • Hattori, M.1    Shu, Y.Z.2    Shimizu, M.3
  • 25
    • 14844293921 scopus 로고    scopus 로고
    • Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer
    • J. Castro-Perez, R. Plumb, and J.H. Granger et al. Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer Rapid Commun. Mass Spectrom. 19 2005 843 848
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 843-848
    • Castro-Perez, J.1    Plumb, R.2    Granger, J.H.3
  • 26
    • 25144438177 scopus 로고    scopus 로고
    • Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis
    • R.J. Mortishire-Smith, D. O'Connor, and J.M. Castro-Perez et al. Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis Rapid Commun. Mass Spectrom. 19 2005 2659 2670
    • (2005) Rapid Commun. Mass Spectrom. , vol.19 , pp. 2659-2670
    • Mortishire-Smith, R.J.1    O'Connor, D.2    Castro-Perez, J.M.3
  • 27
    • 0027818680 scopus 로고
    • Modeling oil-water partitioning and membrane permeation using reversed-phase chromatography
    • W.J. Lambert Modeling oil-water partitioning and membrane permeation using reversed-phase chromatography J. Chromatogr. A 656 1993 469 484
    • (1993) J. Chromatogr. A , vol.656 , pp. 469-484
    • Lambert, W.J.1
  • 28
    • 0002690622 scopus 로고
    • Modeling octanol-water partition coefficients by reversed-phase liquid chromatography
    • D.J. Minick, D.A. Brent, and J. Frenz Modeling octanol-water partition coefficients by reversed-phase liquid chromatography J. Chromatogr. A. 461 1989 177 191
    • (1989) J. Chromatogr. A. , vol.461 , pp. 177-191
    • Minick, D.J.1    Brent, D.A.2    Frenz, J.3
  • 29
    • 77955925853 scopus 로고    scopus 로고
    • Identification of chemicals and their metabolites from PHY906, a Chinese medicine formulation, in the plasma of a patient treated with irinotecan and PHY906 using liquid chromatography/tandem mass spectrometry (LC/MS/MS)
    • W. Zhang, M.W. Saif, and G.E. Dutschman et al. Identification of chemicals and their metabolites from PHY906, a Chinese medicine formulation, in the plasma of a patient treated with irinotecan and PHY906 using liquid chromatography/tandem mass spectrometry (LC/MS/MS) J. Chromatogr. A 1217 2010 5785 5793
    • (2010) J. Chromatogr. A , vol.1217 , pp. 5785-5793
    • Zhang, W.1    Saif, M.W.2    Dutschman, G.E.3
  • 30
    • 84925835392 scopus 로고    scopus 로고
    • Liquid chromatography coupled with time-of-flight and ion trap mass spectrometry for qualitative analysis of herbal medicines
    • X.F. Chen, H.T Wu, and G.G. Tan et al. Liquid chromatography coupled with time-of-flight and ion trap mass spectrometry for qualitative analysis of herbal medicines J. Pharm. Anal. 1 2011 235 245
    • (2011) J. Pharm. Anal. , vol.1 , pp. 235-245
    • Chen, X.F.1    Wu, H.T.2    Tan, G.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.