Effect of total glucosides of paeony on the expression of nephrin in the kidneys from diabetic rats

American Journal of Chinese Medicine

Volumn 37, Issue 2, 2009, Pages 295-307

  Zhang, Pei ^a   Zhang, Jing Jing ^a   Su, Jing ^a   Qi, Xiang Ming ^a   Wu, Yong Gui ^a   Shen, Ji Jia ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Diabetic nephropathy; Nephrin; Total glucosides of paeony; Tumor necrosis Factor

Indexed keywords

3 NITROTYROSINE; ALBUMIN; GLUCOSE; GLUCOSIDE; MEMBRANE PROTEIN; NEPHRIN; PAEONIA EXTRACT; STREPTOZOCIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DRUG MECHANISM; DRUG STRUCTURE; GLUCOSE BLOOD LEVEL; IMMUNOFLUORESCENCE; KIDNEY; MALE; NEPHRON; NONHUMAN; PAEONIA; PAEONIA LACTIFLORA; PATHOGENESIS; PLANT ROOT; PODOCYTE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN URINE LEVEL; RAT; REGULATORY MECHANISM; RISK REDUCTION; STREPTOZOCIN DIABETES; STRUCTURE ACTIVITY RELATION; UPREGULATION; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; BLOTTING, WESTERN; DIABETES MELLITUS, EXPERIMENTAL; FLUORESCENT ANTIBODY TECHNIQUE; GLUCOSIDES; KIDNEY; MALE; MEMBRANE PROTEINS; PAEONIA; RATS; RATS, WISTAR;

EID: 65449119141     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X09006850     Document Type: Article

References (34)

1. Aaltonen, P., P. Luimula, E. Astrom, T. Palmen, T. Gronholm, E. Palojoki, I. Jaakkola, H. Ahola, I. Tikkanen and H. Holthofer. Changes in the expression of nephrin gene and protein in experimental diabetic nephropathy. Lab Invest. 81: 1185-1190, 2001.
2. Doublier, S., V. Ruotsalainen, G. Salvidio, E. Lupia, L. Biancone, P.G. Conaldi, P. Reponen, K. Tryggvason and G. Camussi. Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephritic syndrome. Am. J. Pathol. 158: 1723-1731, 2001.
3. Doublier, S., G. Salvidio, E. Lupia, V. Ruotsalainen, D. Verzola, G. Deferrari and G. Camussil. Nephrin expression is reduced in human diabetic nephropathy: Evidence for a distinct role for glycated albumin and angiotensin II. Diabetes 52: 1023-1030, 2003.
4. Estacio, R.O. and R.W. Schrier. Diabetic nephropathy: Pathogenesis, diagnosis, and prevention of progression. Adv. Intern. Med. 46: 359-408, 2001.
5. Fang, F., Y.G. Wu, J. Dong, K.J Reng, X.M. Qi, C. Liang and W. Zhang. Effect of total glucosides of paeony on the oxidative stress in the kidney from diabetic rats. Chin. J. Pharmaco. Toxico. 22: 199-204, 2008.
6. Forbes, J.M., F. Bonnet, L.M. Russo, W.C. Burns, Z. Cao, R. Candido, H. Kawachi, T.J. Allen, M.E. Cooper, G. Jerums and T.M. Osicka. Modulation of nephrin in the diabetic kidney: Association with systemic hypertension and increasing albuminuria. J. Hypertens. 20: 9850-9992, 2002.
7. Holdsworth, S.R. and T.J. Neale. Macrophage-induced glomerular injury. Cell transfer studies in passive autologous antiglomerular basement membrane antibody-initiated experimental glomerulonephritis. Lab. Invest. 51: 172-180, 1984.
8. Huang, L.M., P. Shi and X.X. Wang. The effect of the extract from Radix Paeoniae Alba on IgA glomerulonephritis in mice. Chin. Tradit. Herb. Drugs 26: 109-111, 2003.
9. Jin, J.S., S.H. Dou and M.C. Zhong. Isolation of paeoniflorin with macroreticular absorption resin. China J. Chin. Mat. Med. 19: 31, 1994.
10. Kestila, M., U. Lenkkeri, M. Mannikko, J. Lamerdin, P. McCready, H. Putaala, V. Ruotsalainen, T. Morita, M. Nissinen, R. Herva, C.E. Kashtan, L. Peltonen, C. Holmberg, A. Olsen and K. Tryggvason.\ Positionally cloned gene for a novel glomerular protein nephrin is mutated in congenital nephritic syndrome. Mol. Cell 1: 575-582, 1998.
11. Lemley, K.V., K. Blouth, I. Abdullah, D.B. Boothroyd, P.H. Bennett, B.D. Myers and R.G. Nelson. Glomerular permselectivity at the onset of nephropathy in type 2 diabetes mellitus. J. Am. Soc. Nephrol. 11: 2095-2105, 2000.
12. Lenkkeri, U., M. Mannikko, P. McCready, J. Lamerdin, O. Gribouval, P. Niaudet, C. Antignac, C.E. Kashtan, C. Holmberg, A. Olsen, M. Kestila and K. Tryggvason. Structure of the gene for congenital nephritic syndrome of the Finnish type (NPHS1) and characterization of mutations. Am. J. Hum. Genet. 64: 51-61, 1999.
13. Le Hir, M., C. Haas, M. Marino and B. Ryffel. Prevention of crescentic glomerulonephritis induced by anti-glomerular membrane antibody in tumor necrosis factor-deficient mice. Lab Invest. 78: 1625-1631, 1998.
14. Marshall, S.M. The podocyte: A potential therapeutic target in diabetic nephropathy? Curr. Pharm. Des. 13: 2713-2720, 2007.
15. Menne, J., J.K. Park,M. Boehne, M. Elger, C. Lindschau, T. Kirsch, M. Meier, F. Gueler, A. Fiebeler, F.H. Bahlmann, M. Leitges and H. Haller. Diminished loss of proteoglycans and lack of albiminuria in protein kinase C-alpha-deficient diabetic mice. Diabetes 53: 2101-2109, 2004.
16. Moeller, M.J., A. Soofi, I. Hartmann, M. Le Hir, R. Wiggins, W. Kriz and L.B. Holzman. Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis. J. Am. Soc. Nephrol. 15: 61-67, 2004.
17. Nagai, R., Y. Unno, M.C. Hayashi, S. Masuda, F. Hayase, N. Kinae and S. Horiuchi. Peroxynitrite induces formation of N(epsilon)-(carboxymethyl) lysine by the cleavage of amadori product and generation of glucosone and glyoxal from glucose: Novel pathways for protein modification by peroxynitrite. Diabetes 51: 2833-2839, 2002.
18. Narita, T., J. Koshimura, K. Suzuki, M. Murata, H. Meguro, H. Fujila, H. Kitazato and S. Ito. Effects of short-term glycemic control, low protein diet and administration of enalapril on renal hemodynamics and protein permselectivity in type 2 diabetic patients with microalbuminuria. Tohoku J. Exp. Med. 189: 117-133, 1999.
19. Ruotsalainen, V., P. Ljungberg and J. Wartiovaara. Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc. Natl. Acad. Sci. USA 96: 7962-7967, 1999.
20. Shi, P. Effects of total glucosides of paeony on active Heymann nephritis in rats. J. Fourth Mil. Med. Univ. 26: 1661-1663, 2005.
21. Takano, Y., K. Yamauchi, K. Hayakawa, N. Hiramatsu, A. Kasai, M. Okamura, M. Yokouchi, A. Shitamura, J. Yao and M. Kitamura. Transcriptional suppression of nephrin in podocytes by macrophages: roles of inflammatory cytokines and involvement of the PI3K/Akt pathway. FEBS Lett. 581: 421-426, 2007.
22. Tang, C.F. Extraction and isolation of effective parts from Paeonia lactiflora Pall. Guangdong Pharmace. J. 5: 28, 1995.
23. Tang, W.W., L. Feng, J.L. Vannice and C.B. Wilson. Interleukin-1 receptor antagonist ameliorates experimental antiglomerular basement membrane antibody-associated experimental glomerulonephritis. J. Clin. Invest. 93: 273-279, 1994.
24. Tryggvason, K. Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm. J. Am. Soc. Nephrol. 10: 2440-2445, 1999.
25. Tryggvason, K. and J. Wartiovaara. Molecular basis of glomerular permselectivity. Curr. Opin. Nephrol. Hypertens. 10: 543-549, 2001.
26. Wei, W., J.S. Liang, A.W. Zhou, M.Z. Chen and S.Y. Xu. Effects of total glucosides of paeony on interleukin 2 production. Chin. Pharmacol. Bull. 5: 176-179, 1989.
27. Wang, B., Y.Y. Yao, A.W. Zhou, Z.D. Ge, M.Z. Chen and S.Y. Xu. Protective effects of total glucosides of paeony on joint damage in adjuvant arthritis rats. Chin. J. Pharmaco. Toxico. 10: 211-214, 1996a.
28. Wang, B., Y.Y. Yao, A.W. Zhou, M.Z. Chen and S.Y. Xu. Study on immunomodulatory effect of total glucosides of paeony and its relationship with nitric oxide in adjuvant arthritis rats. Chin. J. Immunol. 12: 104-106, 1996b.
29. Wang, B., M.Z. Chen and S.Y. Xu. Regulatory mechanism of total glucosides of paeony on tumor necrosis factor production by peritoneal macrophages in rats. Chin. Pharmacol. Bull. 13: 255-257, 1997.
30. Whaley-Connell, A., J. Habibi, R. Nistala, S.A. Cooper, P.R. Karuparthi, M.R. Hayden, N. Rehmer, V.G. DeMarco, B.T. Andresen, Y. Wei, C. Ferrario and J.R. Sowers. Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment. Hypertension 51: 474-480, 2008.
31. Xu, S.Y., M.Z. Chen and W. Wei. Immunopharmacology and clinic. In: J.H. Zhou and G.Z. Liu (eds.). Progress in Pharmacology and Clinics of Chinese Materia Medical Research, 1st ed. Science and Technology of China Press, Beijing. 1992, pp. 49-59.
32. Xu, S.Y., Y.X. Shen, D.J. Xu, W. Wei and J.S Liang. Effects of total glucosides of paeony and moutan cortex on the functions of pineal gland in inflammatory-immune regulation in rats. Chin. J. Pharmacol Toxicol. 8: 161-165, 1994.
33. Yuan, L., Y.G. Wu, L. Hao, C., Liang, J., Dong, K.J., Reng, W. Zhang and F. Fang. Renoprotective effect of total glucosides of paeony and its mechanism in experimental diabetes. Chin. Pharmacol. Bull. 23: 421-426, 2007.
34. Zhou, L.L., W. Wei, Y.X. Shen and S.Y Xu. The effects of TGP on CJS131-induced systemic lupus erythematosus-like model in mice. Chin Pharmacol. Bull. 18: 175-177, 2002.