Severe bereavement stress during the prenatal and childhood periods and risk of psychosis in later life: Population based cohort study

BMJ (Online)

Volumn 348, Issue , 2014, Pages

  Abel, K M ^a   Heuvelman, H P ^a   Jorgensen L ^b   Magnusson, C ^b   Wicks, S ^b   Susser, E ^c   Hallkvist, J ^b,d   Dalman, C ^b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENCE; ADOLESCENT; ADULT; ARTICLE; BEREAVEMENT; CAUSE OF DEATH; CHILDHOOD; COHORT ANALYSIS; CONCEPTION; DISEASE ASSOCIATION; FEMALE; FIRST TRIMESTER PREGNANCY; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL STRESS; NUCLEAR FAMILY; PERINATAL PERIOD; POPULATION RISK; PRENATAL PERIOD; PRIORITY JOURNAL; PROGENY; PSYCHOSIS; RISK ASSESSMENT; SECOND TRIMESTER PREGNANCY; SUICIDE; THIRD TRIMESTER PREGNANCY; CHILD; COMPLICATION; EPIDEMIOLOGY; INFANT; MOTHER; NEWBORN; PREGNANCY; PRENATAL EXPOSURE; PRESCHOOL CHILD; PSYCHOLOGY; PSYCHOTIC DISORDERS; RISK FACTOR; STATISTICAL MODEL; SWEDEN; YOUNG ADULT;

ADOLESCENT; ADULT; BEREAVEMENT; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; LOGISTIC MODELS; MALE; MOTHERS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PSYCHOTIC DISORDERS; RISK FACTORS; STRESS, PSYCHOLOGICAL; SUICIDE; SWEDEN; YOUNG ADULT;

EID: 84893090200     PISSN: None     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.f7679     Document Type: Article

References (46)

1. Barker D J P. Mothers, babies and health in later life. Churchill Livingstone, 1998.
2. Mousseau TA, Fox CW. The adaptive significance of maternal effects. Trends Ecol Evol 1998;13:403-7. (Pubitemid 28430680)
3. Garcia-Moreno C. Intimate partner violence and fetal loss. Lancet 2009;373:278-9.
4. Beydoun H, Saftlas AF. Physical and mental health outcomes of prenatal maternal stress in human and animal studies: a review of recent evidence. Paediatr Perinat Epidemiol 2008;22:438-66.
5. Khashan AS, McNamee R, Abel KM, Mortensen PB, Kenny LC, Pedersen MG, et al. Rates of preterm birth following antenatal maternal exposure to severe life events: a population-based cohort study. Hum Reprod 2009;24:429-37.
6. Khashan AS, McNamee R, Abel KM, Pedersen MG, Webb RT, Kenny LC, et al. Reduced infant birthweight consequent upon maternal exposure to severe life events. Psychosom Med 2008;70:688-94.
7. Class QA, Lichtenstein P, Langstrom N, D'Onofrio BM. Timing of prenatal maternal severe life events and adverse pregnancy outcomes: a population study of 2.6 million pregnancies. Psychosom Med 2011;73:234-41.
8. Buss C, Davis EP, Muftuler LT, Head K, Sandman CA. High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. Psychoneuroendocrinology 2010;35:141-53.
9. Buss C, Davis EP, Shahbaba B, Pruessner JC, Head K, Sandman CA. Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems. Proc Natl Acad Sci 2012;109:E1312-9.
10. King S, Laplante DP. The effects of prenatal maternal stress on children's cognitive development: Project Ice Storm. Stress 2005;8:35-45. (Pubitemid 40776471)
11. Meijer A. Child psychiatric sequelae of maternal war stress. Acta Psych Scand 1985;72:505-11.
12. Van Os J, Selten J-P. Prenatal exposure to maternal stress and subsequent schizophrenia. The May 1940 invasion of The Netherlands. Br J Psychiatry 1998;172:324-6. (Pubitemid 28183858)
13. Selten J-P, Cantor-Graae E, Nahon D Levav I, Aleman A, Kahn RS. No relationship between risk of schizophrenia and prenatal exposure to stress during the Six-Day War or Yom Kippur War in Israel. Schizophr Res 2003;63:131-5. (Pubitemid 36929855)
14. Imamura Y, Nakane Y, Ohta Y, Kondo H. Life time prevalence of schizophrenia in individuals prenatally exposed to atomic bomb radiation in Nagasaki City. Acta Psych Scand 1999;100:344-9. (Pubitemid 29493640)
15. Selten J-P, Van Der Graaf Y, Van Duursen R, Gispen-de-Wied CC, RS Kahn. Psychotic illness after prenatal exposure to the 1953 Dutch Flood Disaster. Schizophr Res 1999;5:243-5. (Pubitemid 29112976)
16. Huttunen MO, Niskanen P. Prenatal loss of father and psychiatric disorders. Arch Gen Psych 1978;35:429-31. (Pubitemid 8337034)
17. Myhrman A, Rantakallio P, Isohanni M, Jones P, Partanen U. Unwantedness of a pregnancy and schizophrenia in the child. Br J Psychiatry 1996;169:637-40.
18. Herman DB, Brown AS, Opler MS, Desai M, Malaspina D, Bresnahan M, et al. Does unwantedness of pregnancy predict schizophrenia in the offspring? Soc Psychiatry Psychiatr Epidemiol 2006;41:605-10.
19. Weinstock M. Alterations induced by gestational stress in brain morphology and behaviour of the offspring. Prog Neurobiol 2001;65:427-51. (Pubitemid 33016408)
20. Khashan A, Abel KM, McNamee R, Pedersen MG, Webb RT, Baker PN, et al. Higher risk of offspring schizophrenia following prenatal exposure to severe life events. Arch Gen Psychiatry 2008;65:146-52. (Pubitemid 351214313)
21. Khashan A, McNamee R, Henriksen TB, Pedersen MG, Kenny LC, Abel KM, et al. Risk of affective disorders following prenatal exposure to severe life events: a Danish population-based cohort study. J Psychiatr Res 2011;45:879-85.
22. Class Q, Abel KM, Khashan AS, Rickert ME, Dalman C, Larsson H, et al. Offspring psychopathology following preconception, prenatal, and postnatal maternal bereavement stress. Psychol Med 2013;17:1-14.
23. Luoma JB, Martin CE, Pearson JL. Contact with mental health and primary care providers before suicide: a review of the evidence. Am J Psychiatry 2002;159:909-16. (Pubitemid 34586933)
24. Tidemalm D, Runeson B, Waern M, Frisell T, Carlström E, Lichtenstein P, et al. Familial clustering of suicide risk: a total population study of 11.4 million individuals. Psychol Med 2011;41:2527-34.
25. Agid O, Shapira B, Zislin J, Ritsner M, Hanin B, Murad H, et al. Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia. Mol Psychiatry 1999;4:163-72. (Pubitemid 29163979)
26. Furukawa TA, Ogura A, Hirai T, Fujihara S, Kitamura T, Takahashi K. Early parental separation experiences among patients with bipolar disorder and major depression: a case-control study. J Affect Disord 1999;52:85-91. (Pubitemid 29232037)
27. Morgan C, Kirkbride JS, Leff J, Craig T, Hutchinson G, McKenzie K, et al. Parental separation, loss and psychosis in different ethnic groups: a case-control study. Psychol Med 2006;37:495-503. (Pubitemid 46359597)
28. Crump C, Sundquist K, Winkleby MA, Sundquist J. Mental disorders and risk of accidental death. Br J Psychiatry 2013;203:297-302.
29. Kessing LV, Agerbo E, Mortensen PB Major stressful life events and other risk factors for first admission with mania. Bipolar Disord 2004;6:122-129. (Pubitemid 38443565)
30. Tsuchiya KJ, Agerbo E, Mortensen PB. Parental death and bipolar disorder: a robust association was found in early maternal suicide. J Affect Disord 2005;86:151-9. (Pubitemid 40780027)
31. Mortensen PB, Pedersen CB, Melbye M, Mors O, Ewald H. Individual and familial risk factors for bipolar affective disorder. Arch Gen Psychiatry 2003;60:1209-15. (Pubitemid 37494074)
32. Kuramoto SJ, Runeson B, Stuart EA, Lichtenstein P, Wilcox HC. Time to hospitalization for suicide attempt by the timing of parental suicide during offspring early development. JAMA Psychiatry 2013;70:149-57.
33. Wilcox HC, Kuramoto SJ, Lichtenstein P, Långström N, Brent DA, Runeson B. Psychiatric morbidity, violent crime, and suicide among children and adolescents exposed to parental death. J Am Acad Child Adolesc Psychiatry 2010;49:514-23.
34. Conwell Y, Duberstein PR, Cox C, Herrmann JH, Forbes NT, Caine ED. Relationships of age and axis I diagnoses in victims of completed suicide: a psychological autopsy study. Am J Psychiatry 1996;153:1001-8. (Pubitemid 26264699)
35. Maier EH, Lachman ME. The consequences of early parental loss and separation for health and well-being in midlife. Int J Behav Develop 2000;24:183-9.
36. Parsons S. Long-term impact of childhood bereavement: preliminary analysis of the 1970 British Cohort Study (BCS70). 2011. www.education. gov. uk/publications/eOrderingDownload/LongTermOutcomesOfParentalBereavement.pdf
37. Rogers CH, Floyd FJ, Seltzer MM, Greenberg J, Hong J. Long term effects of the death of a child on parents' adjustment in midlife. J Fam Psychol 2008;22:203-11.
38. Wicks S, Hjern A, Gunnel D, Lewis G, Dalman C. Social adversity in childhood and the risk of developing psychosis: a national cohort study. Am J Psychiatry 2005;162:1652-7. (Pubitemid 41318234)
39. Cantor-Graae E. The contribution of social factors to the development of schizophrenia: a review of recent findings. Can J Psychiatry 2007;52:277-86. (Pubitemid 46743456)
40. Jorgensen L, Ahlbom A, Allebeck P, Dalman C. The Stockholm non-affective psychoses study (snaps): the importance of including out-patient data in incidence studies. Acta Psych Scand 2010;121:389-92.
41. Liu J, Dietz K, Deloyht JM, Pedre X, Kelkar D, Kaur J, et al. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat Neurosci 2012;15:1621-3.
42. Fish EW, Shahrokh D, Bagot R, Caldji C, Bredy T, Szyf M, et al. Epigenetic programming of stress responses through variations in maternal care. Ann NY Acad Sci 2004;1036:167-80. (Pubitemid 40576094)
43. Del Guidice M. Fetal programming by maternal stress: insights from a conflict perspective. Psychoneuroendocrinology 2012;37:1614-29.
44. Lin KK, Sandler IN, Ayers TS, Wolchik SA, Luecken LJ. Resilience in parentally bereaved children and adolescents seeking preventive services. J Clin Child Adolesc Psychol 2004;33:673-83. (Pubitemid 39603907)
45. Fauth B, Thompson M, Penny A. Associations between childhood bereavement and children's background, experiences and outcomes. Secondary analysis of the 2004 Mental Health of Children and Young People in Great Britain. National Children's Bureau, 2009.
46. Susser E, Widom CS. Still searching for lost truths about the bitter sorrows of childhood. Schizophr Bull 2012;38:672-5.