Microbiological diagnosis of prosthetic joint infection

Infected Total Joint Arthroplasty: The Algorithmic Approach

Volumn , Issue , 2013, Pages 165-179

  Esteban, Jaime ^a   Pérez Jorge, Concepción ^a   Pérez Tanoira, Ramón ^a   Gómez Barrena, Enrique ^b  

^a 28400 Madrid   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Aspiration; Cultures; Imaging; Sonication

Indexed keywords

EID: 84893066658     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4471-2482-5_17     Document Type: Chapter

References (67)

1. Gomez E, Patel R. Laboratory diagnosis of prosthetic joint infection, part I. Clin Microbiol Newslett. 2011;33(8):55-60. doi: 10.1016/j.clinmicnews.2011.03.004 .
2. Darouiche RO. Treatment of infections associated with surgical implants. N Engl J Med. 2004;350:1422-9.
3. Kurtz SM, Lau E, Schmier J, Ong KL, Zhao K, Parvizi J. Infection burden for hip and knee arthroplasty in the United States. J Arthroplasty. 2008;23(7):984-91.
4. Del Pozo JL, Patel R. Clinical practice. Infection associated with prosthetic joints. N Engl J Med. 2009;361(8):787-94.
5. Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med. 2004; 351(16):1645-54.
6. Trampuz A, Widmer AF. Infections associated with orthopedic implants. Curr Opin Infect Dis. 2006;19:349-56.
7. Nelson CL, McLaren AC, McLaren SG, Johnson JW, Smeltzer MS. Is aseptic loosening truly aseptic? Clin Orthop Relat Res. 2005;437:25-30.
8. Esteban J, Cordero-Ampuero J. Treatment of prosthetic osteoarticular infections. Expert Opin Pharmacother. 2011;12(6):899-912.
9. Mirra JM, Amstutz HC, Matos M, Gold R. The pathology of the joint tissues and its clinical relevance in prosthesis failure. Clin Orthop Relat Res. 1976;117:221-40.
10. Trampuz A, Zimmerli W. Prosthetic joint infections: Update in diagnosis and treatment. Swiss Med Wkly. 2005;135(17-18):243-51.
11. Zimmerli W. Prosthetic-joint-associated infections. Best Pract Res Clin Rheumatol. 1996;20(6):1045-63.
12. Lonner JH, Desai P, Dicesare PE, Steiner G, Zuckerman JD. The reliability of analysis of intraoperative frozen sections for identifying active infection during revision hip or knee arthroplasty. J Bone Joint Surg Am. 1996;78(10):1553-8.
13. Bori G, Soriano A, Garcia S, Mallofre C, Riba J, Mensa J. Usefulness of histological analysis for predicting the presence of microorganisms at the time of reimplantation after hip resection arthroplasty for the treatment of infection. J Bone Joint Surg Am. 2007;89(6):1232-7.
14. Della Valle CJ, Bogner E, Desai P, Lonner JH, Adler E, Zuckerman JD, et al. Analysis of frozen sections of intraoperative specimens obtained at the time of reoperation after hip or knee resection arthroplasty for the treatment of infection. J Bone Joint Surg Am. 1999;81:684-9.
15. Widmer AF. New developments in diagnosis and treatment of infection in orthopedic implants. Clin Infect Dis. 2001;33 Suppl 2:S94-106.
16. Atlas RM, Snyder JW. Reagents, stains and media: bacteriology. In: Versalovic J, Carroll KC, Funke G, Jorgensen JH, Landry ML, Warnock DW, editors. Manual of clinical microbiology. 10th ed. Washington, DC: ASM Press; 2011. p. 272-303.
17. Atkins BL, Athanasou N, Deeks JJ, Crook DW, Simpson H, Peto TE, et al. Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty. The OSIRIS Collaborative Study Group. J Clin Microbiol. 1998;36(10):2932-9.
18. Ghanem E, Ketonis C, Restrepo C, Joshi A, Barrack R, Parvizi J. Periprosthetic infection: Where do we stand with regard to Gram stain? Acta Orthop. 2009;80(1):37-40.
19. Chimento GF, Finger S, Barrack RL. Gram stain detection of infection during revision arthroplasty. J Bone Joint Surg Br. 1996;78(5):838-9.
20. Bauer TW, Parvizi J, Kobayashi N, Krebs V. Diagnosis of periprosthetic infection. J Bone Joint Surg Am. 2006;88(4):869-82.
21. Tunney MM, Patrick S, Curran MD, Ramage G, Hanna D, Nixon JR, et al. Detection of prosthetic hip infection at revision arthroplasty by immuno fl uorescence microscopy and PCR amplification of the bacterial 16S rRNA gene. J Clin Microbiol. 1999;37(10):3281-90.
22. Piper KE, Jacobson MJ, Cofield RH, Sperling JW, Sanchez-Sotelo J, Osmon DR, et al. Microbiologic diagnosis of prosthetic shoulder infection by use of implant sonication. J Clin Microbiol. 2009;47(6):1878-84.
23. McDowell A, Patrick S. Evaluation of nonculture methods for the detection of prosthetic hip bio films. Clin Orthop Relat Res. 2005;437:74-82.
24. Stoodley P, Nistico L, Johnson S, Lasko LA, Baratz M, Gahlot V, et al. Direct demonstration of viable Staphylococcus aureus bio fi lms in an infected total joint arthroplasty. A case report. J Bone Joint Surg Am. 2008;90(8):1751-8.
25. Neut D, van Horn JR, van Kooten TG, van der Mei HC, Busscher HJ. Detection of biomaterialassociated infections in orthopaedic joint implants. Clin Orthop Relat Res. 2003;413:261-8.
26. Stoodley P, Kathju S, Hu FZ, Erdos G, Levenson JE, Mehta N, et al. Molecular and imaging techniques for bacterial bio fi lms in joint arthroplasty infections. Clin Orthop Relat Res. 2005; 437:31-40.
27. Moran E, Byren I, Atkins BL. The diagnosis and management of prosthetic joint infections. J Antimicrob Chemother. 2010;65 Suppl 3:45-54.
28. Virolainen P, Lahteenmaki H, Hiltunen A, Sipola E, Meurman O, Nelimarkka O. The reliability of diagnosis of infection during revision arthroplasties. Scand J Surg. 2002;91(2):178-81.
29. Patel R, Osmon DR, Hanssen AD. The diagnosis of prosthetic joint infection: current techniques and emerging technologies. Clin Orthop Relat Res. 2005;437:55-8.
30. Hughes JG, Vetter EA, Patel R, Schleck CD, Harmsen S, Turgeant LT, et al. Culture with BACTEC Peds Plus/F bottle compared with conventional methods for detection of bacteria in synovial fluid. J Clin Microbiol. 2001;39(12):4468-71.
31. Fink B, Makowiak C, Fuerst M, Berger I, Schafer P, Frommelt L. The value of synovial biopsy, joint aspiration and C-reactive protein in the diagnosis of late peri-prosthetic infection of total knee replacements. J Bone Joint Surg Br. 2008;90(7):874-8.
32. Font-Vizcarra L, Garcia S, Martinez-Pastor JC, Sierra JM, Soriano A. Blood culture flasks for culturing synovial fl uid in prosthetic joint infections. Clin Orthop Relat Res. 2010;468(8): 2238-43.
33. Yagupsky P, Dagan R, Howard CW, Einhorn M, Kassis I, Simu A. High prevalence of Kingella kingae in joint fluid from children with septic arthritis revealed by the BACTEC blood culture system. J Clin Microbiol. 1992;30(5):1278-81.
34. Costerton JW, Montanaro L, Arciola CR. Bio film in implant infections: Its production and regulation. Int J Artif Organs. 2005;28:1062-8.
35. Mackowiak PA, Jones SR, Smith JW. Diagnostic value of sinus-tract cultures in chronic osteomyelitis. JAMA. 1978;239(26):2772-5.
36. Cune J, Soriano A, Martinez JC, Garcia S, Mensa J. A super ficial swab culture is useful for microbiologic diagnosis in acute prosthetic joint infections. Clin Orthop Relat Res. 2009; 467(2):531-5.
37. Sadiq S, Wootton JR, Morris CA, Northmore-Ball MD. Application of core biopsy in revision arthroplasty for deep infection. J Arthroplasty. 2005;20(2):196-201.
38. Spangehl MJ, Masri BA, O'Connell JX, Duncan CP. Prospective analysis of preoperative and intraoperative investigations for the diagnosis of infection at the sites of two hundred and two revision total hip arthroplasties. J Bone Joint Surg Am. 1999;81(5):672-83.
39. Meermans G, Haddad FS. Is there a role for tissue biopsy in the diagnosis of periprosthetic infection? Clin Orthop Relat Res. 2010;468(5):1410-7.
40. Trampuz A, Piper KE, Jacobson MJ, Hanssen AD, Unni KK, Osmon DR, et al. Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med. 2007; 357(7):654-63.
41. Kamme C, Lindberg L. Aerobic and anaerobic bacteria in deep infections after total hip arthroplasty: Differential diagnosis between infectious and non-infectious loosening. Clin Orthop Relat Res. 1981;154:201-7.
42. Roux AL, Sivadon-Tardy V, Bauer T, Lortat-Jacob A, Herrmann JL, Gaillard JL, et al. Diagnosis of prosthetic joint infection by beadmill processing of a periprosthetic specimen. Clin Microbiol Infect. 2011;17(3):447-50.
43. Schafer P, Fink B, Sandow D, Margull A, Berger I, Frommelt L. Prolonged bacterial culture to identify late periprosthetic joint infection: A promising strategy. Clin Infect Dis. 2008;47(11): 1403-9.
44. Berbari EF, Marculescu C, Sia I, Lahr BD, Hanssen AD, Steckelberg JM, et al. Culturenegative prosthetic joint infection. Clin Infect Dis. 2007;45(9):1113-9.
45. Malekzadeh D, Osmon DR, Lahr BD, Hanssen AD, Berbari EF. Prior use of antimicrobial therapy is a risk factor for culture-negative prosthetic joint infection. Clin Orthop Relat Res. 2010;468(8):2039-45.
46. Costerton JW. Bio film theory can guide the treatment of device-related orthopaedic infections. Clin Orthop Relat Res. 2005;437:7-11.
47. Costerton JW, Post JC, Ehrlich GD, Hu FZ, Kreft R, Nistico L, et al. New methods for the detection of orthopedic and other bio fi lm infections. FEMS Immunol Med Microbiol. 2011; 61(2):133-40.
48. Gristina AG. Biomaterial-centered infection: Microbial adhesion versus tissue integration. Science. 1987;237:1588-95.
49. Donlan RM, Costerton JW. Biofilms: Survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev. 2002;15(2):167-93.
50. Trampuz A, Osmon DR, Hanssen AD, Steckelberg JM, Patel R. Molecular and antibio fi lm approaches to prosthetic joint infection. Clin Orthop Relat Res. 2003;414:69-88.
51. Monsen T, Lovgren E, Widerstrom M, Wallinder L. In vitro effect of ultrasound on bacteria and suggested protocol for sonication and diagnosis of prosthetic infections. J Clin Microbiol. 2009;47(8):2496-501.
52. Nguyen LL, Nelson CL, Saccente M, Smeltzer MS, Wassell DL, McLaren SG. Detecting bacterial colonization of implanted orthopaedic devices by ultrasonication. Clin Orthop Relat Res. 2002;403:29-37.
53. Trampuz A, Piper KE, Hanssen AD, Osmon DR, Cockerill FR, Steckelberg JM, et al. Sonication of explanted prosthetic components in bags for diagnosis of prosthetic joint infection is associated with risk of contamination. J Clin Microbiol. 2006;44(2):628-31.
54. Esteban J, Gomez-Barrena E, Cordero J, Martin-de-Hijas NZ, Kinnari TJ, Fernandez-Roblas R. Evaluation of quantitative analysis of cultures from sonicated retrieved orthopedic implants in diagnosis of orthopedic infection. J Clin Microbiol. 2008;46(2):488-92.
55. Dora C, Altwegg M, Gerber C, Bottger EC, Zbinden R. Evaluation of conventional microbiological procedures and molecular genetic techniques for diagnosis of infections in patients with implanted orthopedic devices. J Clin Microbiol. 2008;46(2):824-5.
56. Sampedro MF, Huddleston PM, Piper KE, Karau MJ, Dekutoski MB, Yaszemski MJ, et al. A bio film approach to detect bacteria on removed spinal implants. Spine (Phila Pa 1976). 2010; 12:1218-24.
57. Holinka J, Bauer L, Hirschl AM, Graninger W, Windhager R, Presterl E. Sonication cultures of explanted components as an add-on test to routinely conducted microbiological diagnostics improve pathogen detection. J Orthop Res. 2011;29(4):617-22.
58. Achermann Y, Vogt M, Leunig M, Wust J, Trampuz A. Improved diagnosis of periprosthetic joint infection by multiplex PCR of sonication fluid from removed implants. J Clin Microbiol. 2010;48(4):1208-14.
59. Fehring TK, McAlister JA Jr. Frozen histologic section as a guide to sepsis in revision joint arthroplasty. Clin Orthop Relat Res. 1994;(304):229-37.
60. Athanasou NA, Pandey R, de Steiger R, Crook D, Smith PM. Diagnosis of infection by frozen section during revision arthroplasty. J Bone Joint Surg Br. 1995;77(1):28-33.
61. Pandey R, Berendt AR, Athanasou NA. Histological and microbiological findings in noninfected and infected revision arthroplasty tissues. The OSIRIS Collaborative Study Group. Oxford Skeletal Infection Research and Intervention Service. Arch Orthop Trauma Surg. 2000;120(10):570-4.
62. Banit DM, Kaufer H, Hartford JM. Intraoperative frozen section analysis in revision total joint arthroplasty. Clin Orthop Relat Res. 2002;(401):230-8.
63. Feldman DS, Lonner JH, Desai P, Zuckerman JD. The role of intraoperative frozen sections in revision total joint arthroplasty. J Bone Joint Surg Am. 1995;77(12):1807-13.
64. Della Valle CJ, Scher DM, Kim YH, Oxley CM, Desai P, Zuckerman JD, et al. The role of intraoperative Gram stain in revision total joint arthroplasty. J Arthroplasty. 1999;14(4):500-4.
65. Spangehl MJ, Masri BA, O'Connell JX, Duncan CP. Prospective analysis of preoperative and intraoperative investigations for the diagnosis of infection at the sites of two hundred and two revision total hip arthroplasties. J Bone Joint Surg Am. 1999;81(5):672-83.
66. Parvizi J, Ghanem E, Sharkey P, Aggarwal A, Burnett RS, Barrack RL. Diagnosis of infected total knee: findings of a multicenter database. Clin Orthop Relat Res. 2008;466(11):2628-33.
67. Levine BR, Evans BG. Use of blood culture vial specimens in intraoperative detection of infection. Clin Orthop Relat Res. 2001;(382):222-31.