Differential sensitivity to prevention programming: A dopaminergic polymorphism-enhanced prevention effect on protective parenting and adolescent substance use

Health Psychology

Volumn 33, Issue 2, 2014, Pages 182-191

  Brody, Gene H ^a,b   Chen, Yi fu ^a,d   Beach, Steven R H ^a   Kogan, Steven M ^a   Yu, Tianyi ^a   DiClemente, Ralph J ^b   Wingood, Gina M ^b   Windle, Michael ^b   Philibert, Robert A ^c  

^a UNIVERSITY OF GEORGIA   (United States)

^b EMORY UNIVERSITY   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d NATIONAL TAIPEI UNIVERSITY   (Taiwan)

Author keywords

African american; Genetics; Intervention; Prevention; Substance use

Indexed keywords

DOPAMINE RECEPTOR; DOPAMINE RECEPTOR 4; UNCLASSIFIED DRUG;

ADOLESCENT; AFRICAN AMERICAN; ALLELE; ARTICLE; CAREGIVER; CHILD PARENT RELATION; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; PREVENTION; RANDOMIZED CONTROLLED TRIAL; SUBSTANCE USE;

ADOLESCENT; AFRICAN AMERICANS; ALLELES; FAMILY RELATIONS; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GEORGIA; HEALTH PROMOTION; HUMANS; IOWA; MALE; MODELS, STATISTICAL; PARENTING; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D4; SEX FACTORS; SOCIOECONOMIC FACTORS; SUBSTANCE-RELATED DISORDERS;

EID: 84893030444     PISSN: 02786133     EISSN: 19307810     Source Type: Journal    
DOI: 10.1037/a0031253     Document Type: Article

References (49)

1. Asghari, V., Sanyal, S., Buchwaldt, S., Paterson, A., Jovanovic, V., & Van Tol, H. H. M. (1995). Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. Journal of Neurochemistry, 65, 1157-1165. doi:10.1046/j.1471-4159.1995.65031157.x
2. Asghari, V., Schoots, O., Vankats, S., Ohara, K., Jovanovic, V., Guan, H. C., . . . Van Tol, H. H. M. (1994). Dopamine D4 receptor repeat: Analysis of different native and mutant forms of the human and rat genes. Molecular Pharmacology, 46, 364-373. Retrieved from http:// molpharm.aspetjournals.org/content/46/2/364.abstract
3. Bakermans-Kranenburg, M. J., van IJzendoorn, M. H., Pijlman, F. T. A., Mesman, J., & Juffer, F. (2008). Experimental evidence for differential susceptibility: Dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers' externalizing behavior in a randomized controlled trial. Developmental Psychology, 44, 293-300. doi:10.1037/0012-1649.44.1.293
4. Beach, S. R. H., Brody, G. H., Lei, M.-K., & Philibert, R. A. (2010). Differential susceptibility to parenting among African American youths: Testing the DRD4 hypothesis. Journal of Family Psychology, 24, 513-521. doi:10.1037/a0020835
5. Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 300-304. doi:10.1111/j.1467-8721.2007.00525.x
6. Belsky, J., Jonassaint, C. R., Pluess, M., Stanton, M., Brummett, B., & Williams, R. (2009). Vulnerability genes or plasticity genes?. Molecular Psychiatry, 14, 746-754. doi:10.1038/mp.2009.44
7. Brody, G. H., Chen, Y.-f., & Kogan, S. M. (2010). A cascade model connecting life stress to risk behavior among rural African American emerging adults. Development and Psychopathology, 22, 667-678. doi: 10.1017/S0954579410000350
8. Brody, G. H., Chen, Y.-f., Kogan, S. M., Smith, K., & Brown, A. C. (2010). Buffering effects of a family-based intervention for African American emerging adults. Journal of Marriage and Family, 72, 1426-1435. doi:10.1111/j.1741-3737.2010.00774.x
9. Brody, G. H., Chen, Y.-f., Kogan, S. M., Yu, T., Molgaard, V. K., DiClemente, R. J., & Wingood, G. M. (2012). Family-centered program to prevent substance use, conduct problems, and depressive symptoms in Black adolescents. Pediatrics, 129, 108-115. doi:10.1542/peds.2011-0623
10. Brody, G. H., Chen, Y.-f., Murry, V. M., Ge, X., Simons, R. L., Gibbons, F. X., . . . Cutrona, C. E. (2006). Perceived discrimination and the adjustment of African American youths: A five-year longitudinal analysis with contextual moderation effects. Child Development, 77, 1170-1189. doi:10.1111/j.1467-8624.2006.00927.x
11. Brody, G. H., Chen, Y.-f., Yu, T., Beach, S. R. H., Kogan, S. M., Simons, R. L., . . . Philibert, R. A. (2012). Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: A longitudinal, multilevel, mediated moderation analysis. Development and Psychopathology, 24, 941-951. doi:10.1017/S0954579412000466
12. Brody, G. H., & Ge, X. (2001). Linking parenting processes and selfregulation to psychological functioning and alcohol use during early adolescence. Journal of Family Psychology, 15, 82-94. doi: 10.1037/0893-3200.15.1.82
13. Brody, G. H., Murry, V. M., Gerrard, M., Gibbons, F. X., McNair, L. D., Brown, A. C., . . . Chen, Y.-f. (2006). The Strong African American Families program: Prevention of youths' high-risk behavior and a test of a model of change. Journal of Family Psychology, 20, 1-11. doi: 10.1037/0893-3200.20.1.1
14. Brody, G. H., Murry, V. M., Gerrard, M., Gibbons, F. X., Molgaard, V., McNair, L. D., . . . Neubaum-Carlan, E. (2004). The Strong African American Families program: Translating research into prevention programming. Child Development, 75, 900-917. doi:10.1111/j.1467-8624 .2004.00713.x
15. Cameron, A. C., & Trivedi, P. K. (1998). Regression analysis of count data. New York, NY: Cambridge University Press.
16. Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010). Genetic sensitivity to the environment: The case of the serotonin transporter gene and its implications for studying complex diseases and traits. American Journal of Psychiatry, 167, 509-527. doi:10.1176/appi.ajp .2010.09101452
17. Chang, F.-M., Kidd, J. R., Livak, K. J., Pakstis, A. J., & Kidd, K. K. (1996). The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Human Genetics, 98, 91-101. doi:10.1007/ s004390050166
18. Chen, C., Burton, M., Greenberger, E., & Dmitrieva, J. (1999). Population migration and the variation of dopamine D4 receptor (DRD4) allele frequencies around the globe. Evolution and Human Behavior, 20, 309-324. doi:10.1016/S1090-5138(99)00015-X
19. Cicchetti, D., & Blender, J. A. (2006). A multiple-levels-of-analysis perspective on resilience: Implications for the developing brain, neural plasticity, and preventive interventions. Annals of the New York Academy of Sciences, 1094, 248-258. doi:10.1196/annals.1376.029
20. Conger, R. D., & Elder, G. H., Jr. (1994). Families in troubled times: Adaptation to change in rural America. New York, NY: Aldine de Gruyter.
21. Ding, Y.-C., Chi, H-C., Grady, D. L., Morishima, A., Kidd, J. R., Kidd, K. K., . . . Moyzis, R. K. (2002). Evidence of positive selection acting at the human dopamine receptor D4 locus. Proceedings of the National Academy of Sciences, USA, 99, 309-314. doi:10.1073/pnas.012464099
22. Eisenberg, D. T. A., MacKillop, J., Modi, M., Beauchemin, J., Dang, D., Lisman, S. A., . . . Wilson, D. S. (2007). Examining impulsivity as an endophenotype using a behavioral approach: A DRD2 TaqI A and DRD4 48-bp VNTR association study. Behavioral and Brain Functions, 3(Article 2). doi:10.1186/1744-9081-3-2
23. Fisher, J. D., Fisher, W. A., Bryan, A. D., & Misovich, S. J. (2002). Information-motivation-behavioral skills model-based HIV risk behavior change intervention for inner-city high school youth. Health Psychology, 21, 177-186. doi:10.1037/0278-6133.21.2.177
24. Grady, D. L., Chi, H. C., Ding, Y. C., Smith, M., Wang, E., Schuck, S., . . . Moyzis, R. K. (2003). High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder. Molecular Psychiatry, 8, 536-545. doi:10.1038/sj.mp.4001350
25. Hetherington, E. M. (1989). Coping with family transitions: Winners, losers, and survivors. Child Development, 60, 1-14. doi:10.2307/ 1131066
26. Hopfer, C. J., Timberlake, D., Haberstick, B. C., Lessem, J. M., Ehringer, M. A., Smolen, A., & Hewitt, J. K. (2005). Genetic influences on quantity of alcohol consumed by adolescents and young adults. Drug and Alcohol Dependence, 78, 187-193. doi:10.1016/j.drugalcdep.2004 .11.003
27. Johnston, L. D., O'Malley, P. M., & Bachman, J. G. (2000). Monitoring the Future national survey results on drug use 1975-1999. Volume I: Secondary school students (NIH Publication No. 00-4802). Bethesda, MD: National Institute on Drug Abuse.
28. Johnston, L. D., O'Malley, P. M., Bachman, J. G., & Schulenberg, J. E. (2004). Monitoring the Future national results on adolescent drug use: Overview of key findings, 2003 (NIH Publication No. 04 -5506). Bethesda, MD: National Institute on Drug Abuse.
29. Kegel, C. A. T., Bus, A. G., & van IJzendoorn, M. H. (2011). Differential susceptibility in early literacy instruction through computer games: The role of the dopamine D4 receptor gene (DRD4). Mind, Brain and Education, 5, 71-78. doi:10.1111/j.1751-228X.2011.01112.x
30. Kogan, S. M., Berkel, C., Chen, Y.-f., Brody, G. H., & Murry, V. M. (2006). Metro status and African-American adolescents' risk for substance use. Journal of Adolescent Health, 38, 454-457. doi:10.1016/j .jadohealth.2005.05.024
31. Kogan, S. M., Brody, G. H., Molgaard, V. K., Grange, C. M., Oliver, D. A. H., Anderson, T. N., . . . Sperr, M. C. (2012). The Strong African American Families-Teen trial: Rationale, design, engagement processes, and family-specific effects. Prevention Science, 13, 206-217. doi:10 .1007/s11121-011-0257-y
32. Laucht, M., Becker, K., Blomeyer, D., & Schmidt, M. H. (2007). Novelty seeking involved in mediating the association between the dopamine D4 receptor gene exon III polymorphism and heavy drinking in male adolescents: Results from a high-risk community sample. Biological Psychiatry, 61, 87-92. doi:10.1016/j.biopsych.2006.05.025
33. Lichter, J. B., Barr, C. L., Kennedy, J. L., Van Tol, H. H. M., Kidd, K. K., & Livak, K. J. (1993). A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Human Molecular Genetics, 2, 767-773. doi:10.1093/hmg/2.6.767
34. Luan, J. A., Wong, M. Y., Day, N. E., & Wareham, N. J. (2001). Sample size determination for studies of gene-environment interaction. International Journal of Epidemiology, 30, 1035-1040. doi:10.1093/ije/30.5 .1035
35. McGeary, J. (2009). The DRD4 exon 3 VNTR polymorphism and addiction-related phenotypes: A review. Pharmacology, Biochemistry and Behavior, 93, 222-229. doi:10.1016/j.pbb.2009.03.010
36. Milhausen, R. R., Crosby, R., Yarber, W. L., DiClemente, R. J., Wingood, G. M., & Ding, K. (2003). Rural and nonrural African American high school students and STD/HIV sexual-risk behaviors. American Journal of Health Behavior, 27, 373-379. doi:10.5555/ajhb.2003.27.4.373
37. Muthén, L. K., & Muthén, B. O. (1998 -2010). Mplus user's guide (6th ed.). Los Angeles, CA: Authors.
38. Ṕerez de Castro, I., Ibáñez, A., Torres, P., Sáiz-Ruiz, J., & Fernández-Piqueras, J. (1997). Genetic association study between pathological gambling and a functional DNA polymorphism at the D4 receptor gene. Pharmacogenetics, 7, 345-348.
39. Rutter, M. L. (1990). Commentary: Some focus and process considerations regarding effects of parental depression on children. Developmental Psychology, 26, 60-67. doi:10.1037/h0092669
40. Rutter, M. L. (2005). Environmentally mediated risks for psychopathology: Research strategies and findings. Journal of the American Academy of Child & Adolescent Psychiatry, 44, 3-18. doi:10.1097/01.chi .0000145374.45992.c9
41. Sampson, R. J., Raudenbush, S. W., & Earls, F. (1997, August 15). Neighborhoods and violent crime: A multilevel study of collective efficacy. Science, 277, 918-924. doi:10.1126/science.277.5328.918
42. Schoots, O., & Van Tol, H. H. M. (2003). The human dopamine D4 receptor repeat sequences modulate expression. Pharmacogenomics Journal, 3, 343-348. doi:10.1038/sj.tpj.6500208
43. Shanahan, M. J., & Hofer, S. M. (2005). Social context in geneenvironment interactions: Retrospect and prospect. Journals of Gerontology: Series B. Psychological Sciences and Social Sciences, 60B (Suppl. 1), 65-76. doi:10.1093/geronb/60.Special_Issue_1.65
44. Shields, P. C., Lerman, C., Audrain, J., Bowman, E. D., Main, D., Boyd, N. R., & Caporaso, N. E. (1998). Dopamine D4 receptors and the risk of cigarette smoking in African-Americans and Caucasians. Cancer Epidemiology, Biomarkers and Prevention, 7, 453-458. Retrieved from http://cebp.aacrjournals.org/content/7/6/453.full.pdf html
45. Simons, R. L., Lin, K.-H., Gordon, L. C., Brody, G. H., Murry, V. M., & Conger, R. D. (2002). Community differences in the association between parenting practices and child conduct problems. Journal of Marriage and Family, 64, 331-345. doi:10.1111/j.1741-3737.2002.00331.x
46. StataCorp. (2011). Stata statistical software: Release 12. College Station, TX: Author.
47. van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., & Ebstein, R. P. (2011). Methylation matters in child development: Toward developmental behavioral epigenetics. Child Development Perspectives, 5, 305-310. doi:10.1111/j.1750-8606.2011.00202.x
48. Wald, A. (1947). Sequential analysis. Oxford, United Kingdom: Wiley.
49. Wang, X., Zhong, P., & Yan, Z. (2002). Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex. The Journal of Neuroscience, 22, 9185-9193. Retrieved from http://www .jneurosci.org/content/22/21/9185.abstract