Pathogens of bovine respiratory disease in North American feedlots conferring multidrug resistance via integrative conjugative elements

Journal of Clinical Microbiology

Volumn 52, Issue 2, 2014, Pages 438-448

  Klima, Cassidy L ^a,b   Zaheer, Rahat ^a   Cook, Shaun R ^a   Booker, Calvin W ^c   Hendrick, Steve ^b   Alexander, Trevor W ^a   McAllister, Tim A ^a  

^a AGRICULTURE AND AGRI FOOD CANADA   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c Feedlot Health Management Services Alberta   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; CHLORTETRACYCLINE; COTRIMOXAZOLE; DANOFLOXACIN; ENROFLOXACIN; FLORFENICOL; GENTAMICIN; LINCOSAMIDE; MACROLIDE; NEOMYCIN; OXYTETRACYCLINE; PENICILLIN DERIVATIVE; PLEUROMUTILIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPECTINOMYCIN; TILMICOSIN; TULATHROMYCIN;

ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM CONJUGATION; BACTERIUM DETECTION; BACTERIUM ISOLATE; BOVINE HERPES VIRUS; BOVINE RESPIRATORY DISEASE; BOVINE RESPIRATORY SYNCYTIAL PNEUMOVIRUS; BOVINE VIRAL DIARRHEA VIRUS 1; BOVINE VIRAL DIARRHEA VIRUS 2; CATTLE DISEASE; CONTROLLED STUDY; DNA STRUCTURE; FEEDLOT; GENETIC ANALYSIS; HISTOPHILUS SOMNI; INTEGRATIVE CONJUGATIVE ELEMENT; LIVESTOCK; MANNHEIMIA HAEMOLYTICA; MINIMUM INHIBITORY CONCENTRATION; MIXED INFECTION; MULTIDRUG RESISTANCE; MYCOPLASMA BOVIS; NONHUMAN; NORTH AMERICA; NOSE SMEAR; PARAINFLUENZA VIRUS 3; PASTEURELLA MULTOCIDA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY TRACT DISEASE; SEROTYPE; THROAT CULTURE; VIRUS DETECTION;

ALBERTA; ANIMALS; BACTERIA; BACTERIAL INFECTIONS; CATTLE; CATTLE DISEASES; DRUG RESISTANCE, MULTIPLE, BACTERIAL; INTERSPERSED REPETITIVE SEQUENCES; NEBRASKA; PREVALENCE; RESPIRATORY TRACT INFECTIONS; TEXAS; VIRUS DISEASES; VIRUSES;

EID: 84893030140     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.02485-13     Document Type: Article

References (50)

1. Larson RL. 2005. Effect of cattle disease on carcass trait. J. Anim. Sci. 83:37-47.
2. Snowder GD, Van Vleck LD, Cundiff LV, Bennett GL, Koohmaraie M, Dikeman ME. 2007. Bovine respiratory disease in feedlot cattle: phenotypic, environmental, and genetic correlations with growth, carcass, and longissimus muscle palatability traits. J. Anim. Sci. 85:1885-1892. http://dx.doi.org/10. 2527/jas.2007-0008.
3. Rice JA, Carrasco-Medina L, Hodgins DC, Shewen PE. 2007. Mannheimia haemolytica and bovine respiratory disease. Anim. Health Res. Rev. 8:117-128. http://dx.doi.org/10.1017/S1466252307001375.
4. Booker CW, Abutarbush SM, Morely PS, Jim GK, Pittman TJ, Schunicht OC, Perrett T, Wildman BK, Fenton RK, Guichon PT, Janzen ED. 2008. Microbiological and histopathological findings in cases of fatal bovine respiratory disease of feedlot cattle in western Canada. Can. Vet. J. 49:473-481.
5. Gagea MI, Bateman KG, Shanahan RA, van Dreumel T, McEwen BJ, Carman S, Archambault M, Caswell JL. 2006. Naturally occurring Mycoplasma bovis-associated pneumonia and polyarthritis in feedlot beef calves. J. Vet. Diagn. Invest. 18:29-40. http://dx.doi.org/10.1177/104063870601800105.
6. Woolums AR. 2010. Feedlot BRD: is the disease changing? p 16-20. In Proceedings of the North American Veterinary Conference, Orlando, FL.
7. Larson RL, Step DL. 2012. Evidence-based effectiveness of vaccination against Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni in feedlot cattle for mitigating the incidence and effect of bovine respiratory disease complex. Vet. Clin. North Am. Food Anim. Pract. 28:97-106. http://dx.doi.org/10.1016/j.cvfa.2011.12.005.
8. Checkley SL, Campbell JR, Chirino-Trejo M, Janzen ED, Waldner CL. 2010. Associations between antimicrobial use and the prevalence of antimicrobial resistance in fecal Escherichia coli from feedlot cattle in western Canada. Can. Vet. J. 51:853-861.
9. United States Department of Agriculture (USDA) Economic Research Service. 2012. Statistics & information: U.S. cattle and beef industry, 2002-2011. U.S. Department of Agriculture Economic Research Service, Washington, DC. http://www.ers.usda.gov/topics/animal-products/cattle-beef/statistics- information.aspx#.UdcdGW22BOT.
10. Silbergeld EK, Graham J, Price LB. 2008. Industrial food animal production, antimicrobial resistance, and human health. Annu. Rev. Public Health 29:151-169. http://dx.doi.org/10.1146/annurev.publhealth.29.020907.090904.
11. Call DR, Davis MA, Sawant AA. 2008. Antimicrobial resistance in beef and dairy cattle production. Anim. Health Res. Rev. 9:159-167. http://dx.doi.org/10. 1017/S1466252308001515.
12. Catry B, Laevens H, Devriese LA, Opsomer G, De Kruif A. 2003. Antimicrobial resistance in livestock. J. Vet. Pharmacol. Ther. 26:81-93. http://dx.doi.org/10.1046/j.1365-2885.2003.00463.x.
13. McEwen SA, Fedorka-Cray PJ. 2002. Antimicrobial use and resistance in animals. Clin. Infect. Dis. 4:S93-S106. http://dx.doi.org/10.1086/340246.
14. Wozniak RAF, Waldor MK. 2010. Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow. Nat. Rev. Microbiol. 8:552-563. http://dx.doi.org/10.1038/nrmicro2382.
15. Watts JL, Sweeney MT. 2010. Antimicrobial resistance in bovine respiratory disease pathogens: measures, trends, and impact on efficacy. Vet. Clin. North Am. Food Anim. Pract. 26:79-88. http://dx.doi.org/10.1016/j.cvfa. 2009.10.009.
16. Alexander TW, Cook SR, Yanke LJ, Booker CW, Morley PS, Read RR, Gow SP, McAllister TA. 2008. A multiplex polymerase chain reaction assay for the identification of Mannheimia haemolytica, Mannheimia glucosida and Mannheimia ruminalis. Vet. Microbiol. 130:165-175. http://dx.doi.org/10.1016/j.vetmic.2008. 01.001.
17. Sachse K, Salam HS, Diller R, Schubert E, Hoffmann B, Hotzel H. 2010. Use of a novel real-time PCR technique to monitor and quantitate Mycoplasma bovis infection in cattle herds with mastitis and respiratory disease. Vet. J. 186:299-303. http://dx.doi.org/10.1016/j.tvjl.2009.10.008.
18. Klima CL, Alexander TW, Read RR, Gow SP, Booker CW, Hannon S, Sheedy C, McAllister TA, Selinger LB. 2011. Genetic characterization and antimicrobial susceptibility of Mannheimia haemolytica isolated from the nasopharynx of feedlot cattle. Vet. Microbiol. 149:390-398. http://dx.doi.org/10.1016/j.vetmic. 2010.11.018.
19. Klima CK, Alexander TW, Hendrick S, McAllister TA. 2013. Characterization of Mannheimia haemolytica isolated from feedlot cattle that were healthy or treated for bovine respiratory disease. Can. J. Vet. Res., in press.
20. Clinical and Laboratory Standards Institute. 2008. Performance standards for antimicrobial disk and dilution susceptibility tests for bacteria collected from animals; approved standard-3rd ed. CLSI document M31-A3. Clinical and Laboratory Standards Institute, Wayne, PA.
21. Michael GB, Kadlec K, Sweeney MT, Brzuszkiewicz E, Liesegang H, Daniel R, Murray RW, Watts JL, Schwarz S. 2012. ICEPmu1, an integrative conjugative element (ICE) of Pasteurella multocida: structure and transfer. J. Antimicrob. Chemother. 67:91-100. http://dx.doi.org/10.1093/jac/dkr411.
22. Fulton RW, Purdy CW, Confer AW, Saliki JT, Loan RW, Briggs RE, Burge LJ. 2000. Bovine viral diarrhea viral infections in feeder calves with respiratory disease: interactions with Pasteurella spp., parinfluenza-3 virus, and bovine respiratory syncytial virus. Can. J. Vet. Res. 64:151-159.
23. Fulton RW, Blood KS, Panciera RJ, Payton ME, Ridpath JF, Confer AW, Saliki JT, Burge LT, Welsh RD, Johnson BJ, Reck A. 2009. Lung pathology and infectious agents in fatal feedlot pneumonias and relationship with mortality, disease onset, and treatments. J. Vet. Diagn. Invest. 21:464-477. http://dx.doi.org/10.1177/104063870902100407.
24. Lamm CG, Love BC, Krehbiel CR, Johnson NJ, Step DL. 2012. Comparison of antemortem antimicrobial treatment regimens to antimicrobial susceptibility patterns of postmortem lung isolates from feedlot cattle with bronchopneumonia. J. Vet. Diagn. Invest. 24:277-282. http://dx.doi.org/10.1177/1040638711428149.
25. Fulton RW, Briggs RE, Ridpath JF, Saliki JT, Confer AW, Payton ME, Duff GC, Step DL, Walker DA. 2005. Transmission of bovine viral diarrhea virus 1b to susceptible and vaccinated calves by exposure to persistently infected calves. Can. J. Vet. Res. 69:161-169.
26. Ridpath JF, Neill JD, Frey M, Landgraf JG. 2000. Phylogenetic, antigenic and clinical characterization of type 2 BVDV from North America. Vet. Microbiol. 77:145-155. http://dx.doi.org/10.1016/S0378-1135(00)00271-6.
27. Welsh RD, Dye LB, Payton ME, Confer AW. 2004. Isolation and antimicrobial susceptibilities of bacterial pathogens from bovine pneumonia: 1994-2002. J. Vet. Diagn. Invest. 16:426-431. http://dx.doi.org/10.1177/104063870401600510.
28. Panciera RJ, Confer AW. 2010. Pathogenesis and pathology of bovine pneumonia. Vet. Clin. North Am. Food Anim. Pract. 26:191-214. http://dx.doi.org/10.1016/j.cvfa.2010.04.001.
29. Dabo SM, Taylor JD, Confer AW. 2007. Pasteurella multocida and bovine respiratory disease. Anim. Health Res. Rev. 8:129-150. http://dx.doi.org/10. 1017/S1466252307001399.
30. Ellis JA. 2009. Update on viral pathogenesis in BRD. Anim. Health Res. Rev. 10:149-153. http://dx.doi.org/10.1017/S146625230999020X.
31. Pastoret PP, Thiry E. 1985. Diagnosis and prophylaxis of infectious bovine rhinotracheitis: the role of virus latency. Comp. Immunol. Microbiol. Infect. Dis. 8:35-42. http://dx.doi.org/10.1016/0147-9571(85)90052-9.
32. DeRosa DC, Mechor GD, Staats JJ, Chengappa MM, Shryock TR. 2000. Comparison of Pasteurella spp. simultaneously isolated from nasal and transtracheal swabs from cattle with clinical signs of bovine respiratory disease. J. Clin. Microbiol. 38:327-332.
33. Timsit E, Christensen H, Bareille N, Seegers H, Bisgaard M, Assié S. 2013. Transmission dynamics of Mannheimia haemolytica in newlyreceived beef bulls at fattening operations. Vet. Microbiol. 161:295-304. http://dx.doi.org/ 10.1016/j.vetmic.2012.07.044.
34. Portis E, Lindeman C, Johansen L, Stoltman G. 2012. A ten-year (2000-2009) study of antimicrobial susceptibility of bacteria that cause bovine respiratory disease complex-Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni-in the United States and Canada. J. Vet. Diagn. Invest. 24:932-944. http://dx.doi.org/10.1177/1040638712457559.
35. Lubbers BV, Hanzlicek GA. 2013. Antimicrobial multi-drug resistance and coresistance patterns of Mannheimia haemolytica isolated from bovine respiratory disease cases-a three-year (2009-2011) retrospective analysis. J. Vet. Diagn. Invest. 25:413-417. http://dx.doi.org/10.1177/1040638713485227.
36. Esaki H, Asai T, Kojima A, Ishihara K, Morioka A, Tamura Y, Takahashi T. 2005. Antimicrobial susceptibility of Mannheimia haemolytica isolates from cattle in Japan from 2001 to 2002. J. Vet. Med. Sci. 67:75-77. http://dx.doi.org/10.1292/jvms.67.75.
37. Tang X, Zhao Z, Hu J, Wu B, Cai X, He Q, Chen H. 2009. Isolation, antimicrobial resistance, and virulence genes of Pasteurella multocida strains from swine in China. J. Clin. Microbiol. 47:951-958. http://dx.doi.org/10.1128/ JCM.02029-08.
38. Michael GB, Kadlec K, Sweeney MT, Brzuszkiewicz E, Liesegang H, Daniel R, Murray RW, Watts JL, Schwarz S. 2012. ICEPmu1, an integrative conjugative element (ICE) of Pasteurella multocida: analysis of the regions that comprise 12 antimicrobial resistance genes. J. Antimicrob. Chemother. 67:84-90. http://dx.doi.org/10.1093/jac/dkr406.
39. Bi D, Xu Z, Harrison EM, Tai C, Wei Y, He X, Jia S, Deng Z, Rajakumar K, Ou HY. 2012. ICEberg: a web-based resource for integrative and conjugative elements found in bacteria. Nucleic Acids Res. 40:D621-D626. http://dx.doi.org/10.1093/nar/gkr846.
40. Wozniak RA, Waldor MK. 2009. A toxin-antitoxin system promotes the maintenance of an integrative conjugative element. PLoS Genet. 5:e1000439. http://dx.doi.org/10.1371/journal.pgen.1000439.
41. Eidam C, Poehlein A, Brenner Michael G, Kadlec K, Liesegang H, Brzuszkiewicz E, Daniel R, Sweeney MT, Murray RW, Watts JL, Schwarz S. 2013. Complete genome sequence of Mannheimia haemolytica strain 42548 from a case of bovine respiratory disease. Genome Announc. 30:e00318-13. http://dx.doi.org/10. 1128/genomeA.00318-13.
42. Galyean ML, Ponce C, Schutz J. 2011. The future of beef production in North America. Anim. Front. 1:29-36. http://dx.doi.org/10.2527/af.2011-0013.
43. Aarestrup FM, Oliver Duran C, Burch DG. 2008. Antimicrobial resistance in swine production. Anim. Health Res. Rev. 9:135-148. http://dx.doi.org/10.1017/ S1466252308001503.
44. Angen O, Thomsen J, Larsen LE, Larsen J, Kokotovic B, Heegaard PM, Enemark JM. 2009. Respiratory disease in calves: microbiological investigations on trans-tracheally aspirated bronchoalveolar fluid and acute phase protein response. Vet. Microbiol. 137:165-171. http://dx.doi.org/10.1016/j.vetmic.2008. 12.024.
45. Angen O, Ahrens P, Tegtmeier C. 1998. Development of a PCR test for identification of Haemophilus somnus in pure and mixed cultures. Vet. Microbiol. 63:39-48. http://dx.doi.org/10.1016/S0378-1135(98)00222-3.
46. Miflin JK, Blackall PJ. 2001. Development of a 23S rRNA-based PCR assay for the identification of Pasteurella multocida. Lett. Appl. Microbiol. 33:216-221. http://dx.doi.org/10.1046/j.1472-765x.2001.00985.x.
47. Zaheer R, Cook SR, Klima CL, Stanford K, Alexander T, Topp E, Read RR, McAllister TA. 2013. Effect of subtherapeutic vs. Therapeutic administration of macrolides on antimicrobial resistance in Mannheimia haemolytica and enterococci isolated from beef cattle. Front. Microbiol. 4:133. http://dx.doi.org/10.3389/ fmicb.2013.00133.
48. Horwood PF, Mahony TJ. 2011. Multiplex real-time RT-PCR detection of three viruses associated with the bovine respiratory disease complex. J. Virol. Methods 171:360-363. http://dx.doi.org/10.1016/j.jviromet.2010.11.020.
49. Kadlec K, Brenner Michael G, Sweeney MT, Brzuszkiewicz E, Liesegang H, Daniel R, Watts JL, Schwarz S. 2011. Molecular basis of macrolide, triamilide, and lincosamide resistance in Pasteurella multocida from bovine respiratory disease. Antimicrob. Agents Chemother. 55:2475-2477. http://dx.doi.org/10.1128/ AAC.00092-11.
50. Poppe C, Ziebell K, Martin L, Allen K. 2002. Diversity in antimicrobial resistance and other characteristics among Salmonella Typhimurium DT104 isolates. Microb. Drug Resist. 8:107-122. http://dx.doi.org/10.1089/ 107662902760190653.