Medication adherence, knowledge about psychosis, and insight among patients with a schizophrenia-spectrum disorder

Journal of Nervous and Mental Disease

Volumn 202, Issue 1, 2014, Pages 25-29

  Chan, Kit Wa Sherry ^a   Hui, Lai Ming Christy ^a   Wong, Hoi Yan Gloria ^a   Lee, Ho Ming Edwin ^a   Chang, Wing Chung ^a   Chen, Yu Hai Eric ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Insight; Knowledge about psychosis; Medication adherence; Schizophrenia spectrum disorder

Indexed keywords

ADULT; ARTICLE; CLINICAL ASSESSMENT TOOL; FEMALE; HUMAN; INTROSPECTION; KNOWLEDGE; MAJOR CLINICAL STUDY; MALE; MEDICATION ADHERENCE RATING SCALE; MEDICATION COMPLIANCE; MODIFIED KNOWLEDGE ABOUT SCHIZOPHRENIA TEST; OUTPATIENT DEPARTMENT; PSYCHOEDUCATION; PSYCHOSIS; SCALE TO ASSESS UNAWARENESS OF MENTAL DISORDER; SCHIZOPHRENIA; SCORING SYSTEM; YOUNG ADULT;

EID: 84893022537     PISSN: 00223018     EISSN: 1539736X     Source Type: Journal    
DOI: 10.1097/NMD.0000000000000068     Document Type: Article

References (48)

1. Alenius M, Hammarlund-Udenaes M, Hartivig P, Lindström L (2010) Knowledge and insight in relation to functional remission in patients with long term psychotic disorders. Soc Psychiatry Psychiatr Epidemiol. 45:523-529
2. Amador XF, Flaum M, Andreasen NC, Strauss DH, Yale SA, Clark SC, Gorman JM (1994) Awareness of illness in schizophrenia and schizoaffective and mood disorders. Arch Gen Psychiatry. 51:826-836
3. Amador XF, Strauss DH (1993) Poor insight in schizophrenia. Psychiatr Q. 64: 305-318
4. Ascher-Svanum H, Faries DE, Zhu B, Ernst FR, Swartz MS, Swanson JW (2006) Medication adherence and long-Term functional outcomes in the treatment of schizophrenia in usual care. J Clin Psychiatry. 67:453-460
5. Baloush-Kleinman V, Levine SZ, Roe D, Shnitt D, Weizman A, Poyurovsky M (2011) Adherence to antipsychotic drug treatment in early-episode schizophrenia: A six-month naturalistic follow-up study. Schizophr Res. 130:176-181
6. Baron RM, Kenny DA (1986) The moderatorYmediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 51:1173-1182
7. Bodén R, Brandt L, Kieler H, Andersen M, Reutfors J (2011) Early non-Adherence to medication and other risk factors for rehospitalization in schizophrenia and schizoaffective disorder. Schizophr Res. 133:36-41
8. Chan SK, Chan KK, Lam MM, Chiu CP, Hui CL, Wong GH, Chang WC, Chen EY (2012) Clinical and cognitive correlates of insight in first-episode schizophrenia. Schizophr Res. 135:40-45
9. Chen EYH, Tam DKP, Wong JWS, Law CW, Chiu CPY (2005) Self administered instrument to measure the patient's experience of recovery after first episode psychosis: Development and validation of the Psychosis Recovery Inventory. Aust N Z J Psychiatry. 39:493-499
10. Coldham EL, Addington J, Addington D (2002) Medication adherence of individuals with a first episode of psychosis. Acta Psychiatr Scand. 106:286-290
11. Compton MT, Quintero L, Esterberg ML (2007) Assessing knowledge of schizophrenia: Development and psychometric properties of a brief, multiple-choice knowledge test for use across various samples. Psychiatry Res. 151:87-95
12. Cooke M, Peters E, Kuipers E, Kumari V (2005) Disease, deficit or denial? Models of poor insight in psychosis. Acta Psychiatr Scand. 112:4-17
13. Cuffel BJ, Alford J, Fischer EP, Owen RR (1996) Awareness of illness in schizophrenia and outpatient treatment adherence. J Nerv Ment Dis. 184:653-659
14. David AS (1990) Insight and psychosis. Br J Psychiatry. 156:798-808
15. Fenton WS, Blyler CR, Heinssen RK (1997) Determinants of medication compliance in schizophrenia: Empirical and clinical findings. Schizophr Bull. 23: 637-651
16. First MB (1997) User's guide for the Structured Clinical Interview for DSM-IVAxis I Disorders SCID-I: Clinician version. Arlington, VA: American Psychiatric Publishing Inc
17. Gitlin M, Nuechterlein K, Subotnik KL, Ventura J, Mintz J, Fogelson DL, Bartzokis G, Aravagiri, M (2001) Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia. Am J Psychiatry. 158:1835-1842
18. Giugiario M, Crivelli B, Mingrone C, Montemagni C, Scalese M, Sigaudo M, Rocca G, Rocca P (2012) Cognitive function and competitive employment in schizophrenia: Relative contribution of insight and psychopathology. Soc Psychiatry Psychiatr Epidemiol. 47:553-561
19. Hill M, Crumlish N, Whitty P, Clarke M, Browne S, Kamali M, Kinsella A, Waddington JL, Larkin C, O'Callaghan E (2010) Nonadherence to medication four years after a first episode of psychosis and associated risk factors. Psychiatr Serv. 61:189-192
20. Hogan TP, Awad AG, Eastwood R (1983) A self-report scale predictive of drug compliance in schizophrenics: Reliability and discriminative validity. Psychol Med. 13:177-183
21. Hui CLM, Chen EYH, Kan CS, Yip KC, Law CW, Chiu CPY (2006) Anti-psychotics adherence among out-patients with schizophrenia in Hong Kong. Keio J Med. 55:9-14
22. Jónsdó ttir H, Opjordsmoen S, Birkenaes AB, Simonsen C, Engh JA, Ringen PA, Vaskinn A, Friis S, Sundet K, Andreassen OA (2012) Predictors of medication adherence in patients with schizophrenia and bipolar disorder [published online ahead of print]. Acta Psychiatr Scand. 127:23-33
23. Kamali M, Kelly BD, Clarke M, Browne S, Gervin M, Kinsella A, Lane A, Larkin C, O'Callaghan E (2006) A prospective evaluation of adherence to medication in first episode schizophrenia. Eur Psychiatry. 21:29-33
24. Kampman O, Laippala P, Väänänen J, Koivisto E, Kiviniemi P, Kilkku N, Lehtinen K (2002) Indicators of medication compliance in first-episode psychosis. Psychiatry Res. 110:39-48
25. Karow A, Pajonk FG, Reimer J, Hirdes F, Osterwald C, Naber D, Moritz S (2008 The dilemma of insight into illness in schizophrenia: Self-And expert-rated insight and quality of life. Eur Arch Psychiatry Clin Neurosci. 258:152-159
26. Kay SR, Flszbein A, Opfer LA (1987) The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull. 13:261-276
27. Kelly GR, Mamon JA, Scott JE (1987) Utility of the health belief model in examining medication compliance among psychiatric outpatients. Soc Sci Med. 25: 1205-1211
28. Ko NY, Yeh ML, Hsu ST, Chung HH, Yen CF (2006) Investigation of insight formation using narrative analyses of people with schizophrenia in remission. J Nerv Ment Dis. 194:124-127
29. Lacro JP, Dunn LB, Dolder CR, Leckband SG, Jeste DV (2002) Prevalence of and risk factors for medication nonadherence in patients with schizophrenia: A comprehensive review of recent literature. J Clin Psychiatry. 63:892-909
30. Lincoln TM, Wilhelm K, Nestoriuc Y (2007) Effectiveness of psychoeducation for relapse, symptoms, knowledge, adherence and functioning in psychotic disorders: A meta-Analysis. Schizophr Res. 96:232-245
31. Lysaker PH, Tsai J, Maulucci AM, Stanghellini G (2008) Narrative accounts of illness in schizophrenia: Association of different forms of awareness with neurocognition and social function over time. Conscious Cogn. 17:1143-1151
32. Mintz A, Dobson K, Romney D (2003) Insight in schizophrenia: A meta-Analysis. Schizophr Res. 61:75-88
33. Misdrahi D, Petit M, Blanc O, Bayle F, Llorca PM (2001) The influence of therapeutic alliance and insight on medication adherence in schizophrenia. Nord J Psychiatry. 66:49-54
34. Morken G,Widen J, Grawe R (2008) Non-Adherence to antipsychotic medication, relapse and rehospitalisation in recent-onset schizophrenia. BMC Psychiatry. 8:32
35. Novick D, Haro JM, Suarez D, Perez V, Dittmann RW, Haddad PM (2010) Predictors and clinical consequences of non-Adherence with antipsychotic medication in the outpatient treatment of schizophrenia. Psychiatry Res. 176:109-113
36. Olfson M, Marcus SC, Wilk J, West JC (2006) Awareness of illness and nonadherence to antipsychotic medications among persons with schizophrenia. Psychiatr Serv. 57:205-211
37. Osatuke K, Ciesla J, Kasckow J, Zisook S, Mohamed S (2008) Insight in schizophrenia: A review of etiological models and supporting research. Compr Psychiatry. 49:70-77
38. Pyne JM, Bean D, Sullivan G (2001) Characteristics of patients with schizophrenia who do not believe they are mentally ill. J Nerv Ment Dis. 189:146-153
39. Quillams L, Addington J (2003) Insight, knowledge, and beliefs about illness in first-episode psychosis. Can J Psychiatry. 48:350
40. Rabinovitch M, Béchard-Evans L, Schmitz N, Joober R, Malla A (2009) Early predictors of nonadherence to antipsychotic therapy in first-episode psychosis. 54:28-35
41. Robinson DG (2011) Medication adherence and relapse in recent-onset psychosis. Am J Psychiatry. 168:240-242
42. Rocca P, Castagna F, Mongini T, Montemagni C, Bogetto F (2010) Relative contributions of psychotic symptoms and insight to quality of life in stable schizophrenia. Psychiatry Res. 177:71-76
43. Subotnik KL, Nuechterlein KH, Ventura J, Gitlin MJ, Marder S, Mintz J, Hellemann GS, Thornton LA, Singh IR (2011) Risperidone nonadherence and return of positive symptoms in the early course of schizophrenia. Am J Psychiatry. 168:286-292
44. Süllwold L, Herrlich J (1992) Providing schizophrenic patients with a concept of illness: An essential element of therapy. Br J Psychiatry Suppl. 18:129-132
45. Tang JYM, Wong GHY, Hui CLM, Lam MML, Chiu CPY, Chan SKW, Chung DWS, Tso S, Chan KPM, Yip KC, Hung SF, Chen EYH (2010) Early intervention for psychosis in Hong KongVThe EASY programme. Early Interv Psychiatry. 4:214-219
46. Thompson K, Kulkarni J, Sergejew AA (2000) Reliability and validity of a new Medication Adherence Rating Scale (MARS) for the psychoses. Schizophr Res. 42:241-247
47. Velligan DI, Lam YWF, Glahn DC, Barrett JA, Maples NJ, Ereshefsky L, Miller AL (2006) Defining and assessing adherence to oral antipsychotics: A review of the literature. Schizophr Bull. 32:724-742
48. Wong DFK, Tsui HKP, Pearson V, Chen EYH, Chiu SN (2004) Family burdens, Chinese health beliefs, and the mental health of Chinese caregivers in Hong Kong. Transcult Psychiatry. 41:497-513