Steroid hormones in 2013: Glucocorticoids - Timing, binding and environment

Nature Reviews Endocrinology

Volumn 10, Issue 2, 2014, Pages 71-72

  Lightman, Stafford L ^a   George, Charlotte L ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR; GLUCOCORTICOID; LIM KINASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; THYMIC STROMAL LYMPHOPOIETIN;

CIRCADIAN RHYTHM; DEMETHYLATION; DEPRESSION; DNA BINDING; DNA HELIX; DNA METHYLATION; DNA SEQUENCE; ENVIRONMENT; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PERSONAL EXPERIENCE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

BASE SEQUENCE; CIRCADIAN RHYTHM; ENVIRONMENT; GLUCOCORTICOIDS; HUMANS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84893019013     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2013.257     Document Type: Review

References (9)

1. Hudson, W. H., Youn, C. & Ortlund, E. A. The structural basis of direct glucocorticoid-mediated transrepression. Nat. Struct. Mol. Biol. 20, 53-58 (2013).
2. Surjit, M. et al. Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell 145, 224-241 (2011).
3. Miranda, T. B. et al. Reprogramming the chromatin landscape: Interplay of the estrogen and glucocorticoid receptors at the genomic level. Cancer Res. 73, 5130-5139 (2013).
4. Lightman, S. L. & Conway-Campbell, B. L. The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration. Nat. Rev. Neurosci. 11, 710-718 (2010).
5. Liston, C. et al. Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance. Nat. Neurosci. 16, 698-705 (2013).
6. Sahay, A. & Hen, R. Adult hippocampal neurogenesis in depression. Nat. Neurosci. 10, 1110-1115 (2007).
7. Anacker, C. et al. Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis. Proc. Natl Acad. Sci. USA 110, 8708-8713 (2013).
8. Wu, C. et al. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 496, 513-517 (2013).
9. Klengel, T. et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat. Neurosci. 16, 33-41 (2013).