Biomechanical characteristics of bone in streptozotocin-induced diabetic rats: An in-vivo randomized controlled experimental study

World Journal of Orthopedics

Volumn 4, Issue 3, 2013, Pages 124-129

  Korres, Nektarios ^a   Tsiridis, Eleftherios ^b   Pavlou, George ^c   Mitsoudis, Athanasios ^d   Perrea, Despina N ^e   Zoumbos, Aristedes B ^e  

^a KAT First Department of Orthopaedics and Trauma   (Greece)

^b ARISTOTLE UNIVERSITY MEDICAL SCHOOL   (Greece)

^c ROBERT JONES AND AGNES HUNT ORTHOPAEDIC HOSPITAL   (United Kingdom)

^d NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

^e UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Biomechanics; Bone; Rodent; Streptozotocin

Indexed keywords

EID: 84892973615     PISSN: None     EISSN: 22185836     Source Type: Journal    
DOI: 10.5312/wjo.v4.i3.124     Document Type: Article

References (23)

1. Gevins AS, Zeitlin GM, Yingling CD, Doyle JC, Dedon MF, Schaffer RE, Roumasset JT, Yeager CL. EEG patterns during 'cognitive' tasks. I. Methodology and analysis of complex behaviors. Electroencephalogr Clin Neurophysiol 1979; 47: 693-703 [PMID: 91498].
2. Fiorelli G, Orlando C, Benvenuti S, Franceschelli F, Bianchi S, Pioli P, Tanini A, Serio M, Bartucci F, Brandi ML. Characterization, regulation, and function of specific cell membrane receptors for insulin-like growth factor I on bone endothelial cells. J Bone Miner Res 1994; 9: 329-337 [PMID:8191926 DOI: 10.1002/jbmr.5650090307].
3. Hickman J, McElduff A. Insulin promotes growth of the cultured rat osteosarcoma cell line UMR-106-01: an osteoblastlike cell. Endocrinology 1989; 124: 701-706 [PMID: 2536316 DOI: 10.1210/endo-124-2-701].
4. Peck WA, Messinger K. Nucleoside and ribonucleic acid metabolism in isolated bone cells. Effects of insulin and cortisol in vitro. J Biol Chem 1970; 245: 2722-2729 [PMID: 5464041].
5. Levy JR, Murray E, Manolagas S, Olefsky JM. Demonstration of insulin receptors and modulation of alkaline phosphatase activity by insulin in rat osteoblastic cells. Endocrinology 1986; 119: 1786-1792 [PMID: 3530724 DOI: 10.1210/ endo-119-4-1786].
6. Garnero P, Borel O, Gineyts E, Duboeuf F, Solberg H, Bouxsein ML, Christiansen C, Delmas PD. Extracellular posttranslational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bone. Bone 2006; 38: 300-309 [PMID: 16271523 DOI: 10.1016/ j.bone.2005.09.014].
7. Vashishth D, Gibson GJ, Khoury JI, Schaffler MB, Kimura J, Fyhrie DP. Influence of nonenzymatic glycation on biomechanical properties of cortical bone. Bone 2001; 28: 195-201 [PMID: 11182378 DOI: 10.1016/S8756-3282(00)00434-8].
8. Armas LA, Akhter MP, Drincic A, Recker RR. Trabecular bone histomorphometry in humans with Type 1 Diabetes Mellitus. Bone 2012; 50: 91-96 [PMID: 22001578 DOI: 10.1016/ j.bone.2011.09.055].
9. Funk JR, Hale JE, Carmines D, Gooch HL, Hurwitz SR. Biomechanical evaluation of early fracture healing in normal and diabetic rats. J Orthop Res 2000; 18: 126-132 [PMID:10716288 DOI: 10.1002/jor.1100180118].
10. Schwartz AV. Diabetes Mellitus: Does it Affect Bone? Calcif Tissue Int 2003; 73: 515-519 [PMID: 14517715 DOI: 10.1007/ s00223-003-0023-7].
11. Räkel A, Sheehy O, Rahme E, LeLorier J. Osteoporosis among patients with type 1 and type 2 diabetes. Diabetes Metab 2008; 34: 193-205 [PMID: 18308607 DOI: 10.1016/j.diabet.2007.10.008].
12. Fleischli JG, Laughlin TJ, Lavery LA, Shah B, Lanctot D, Agrawal CM, Athanasiou K. The effects of diabetes mellitus on the material properties of human metatarsal bones. J Foot Ankle Surg 1998; 37: 195-198 [PMID: 9638543 DOI: 10.1016/ S1067-2516(98)80110-5].
13. Fleischli JG, Laughlin TJ, Athanasiou K, Lanctot DR, Lavery L, Wang X, Agrawal CM. Effect of diabetes mellitus on the material properties of the distal tibia. J Am Podiatr Med Assoc 2006; 96: 91-95 [PMID: 16546944].
14. Silva MJ, Brodt MD, Lynch MA, McKenzie JA, Tanouye KM, Nyman JS, Wang X. Type 1 diabetes in young rats leads to progressive trabecular bone loss, cessation of cortical bone growth, and diminished whole bone strength and fatigue life. J Bone Miner Res 2009; 24: 1618-1627 [PMID: 19338453 DOI: 10.1359/jbmr.090316].
15. Reddy GK, Stehno-Bittel L, Hamade S, Enwemeka CS. The biomechanical integrity of bone in experimental diabetes. Diabetes Res Clin Pract 2001; 54: 1-8 [PMID: 11532324 DOI: 10.1016/S0168-8227(01)00273-X].
16. Einhorn TA, Boskey AL, Gundberg CM, Vigorita VJ, Devlin VJ, Beyer MM. The mineral and mechanical properties of bone in chronic experimental diabetes. J Orthop Res 1988; 6: 317-323 [PMID: 3258636 DOI: 10.1002/jor.1100060303].
17. Erdal N, Gürgül S, Kavak S, Yildiz A, Emre M. Deterioration of bone quality by streptozotocin (STZ)-induced type 2 diabetes mellitus in rats. Biol Trace Elem Res 2011; 140: 342-353 [PMID: 20446056 DOI: 10.1007/s12011-010-8703-4].
18. Verhaeghe J, Suiker AM, Einhorn TA, Geusens P, Visser WJ, Van Herck E, Van Bree R, Magitsky S, Bouillon R. Brittle bones in spontaneously diabetic female rats cannot be predicted by bone mineral measurements: studies in diabetic and ovariectomized rats. J Bone Miner Res 1994; 9: 1657-1667 [PMID: 7817814 DOI: 10.1002/jbmr.5650091021].
19. Beam HA, Parsons JR, Lin SS. The effects of blood glucose control upon fracture healing in the BB Wistar rat with diabetes mellitus. J Orthop Res 2002; 20: 1210-1216 [PMID:12472231 DOI: 10.1016/S0736-0266(02)00066-9].
20. Facchini DM, Yuen VG, Battell ML, McNeill JH, Grynpas MD. The effects of vanadium treatment on bone in diabetic and non-diabetic rats. Bone 2006; 38: 368-377 [PMID:16256449 DOI: 10.1016/j.bone.2005.08.015].
21. Macey LR, Kana SM, Jingushi S, Terek RM, Borretos J, Bolander ME. Defects of early fracture-healing in experimental diabetes. J Bone Joint Surg Am 1989; 71: 722-733 [PMID: 2659600].
22. Zhang SQ, Chen GH, Lu WL, Zhang Q. Effects on the bones of vanadyl acetylacetonate by oral administration: a comparison study in diabetic rats. J Bone Miner Metab 2007; 25: 293-301 [PMID: 17704994 DOI: 10.1007/s00774-007-0759-7].
23. Nyman JS, Even JL, Jo CH, Herbert EG, Murry MR, Cockrell GE, Wahl EC, Bunn RC, Lumpkin CK, Fowlkes JL, Thrailkill KM. Increasing duration of type 1 diabetes perturbs the strength-structure relationship and increases brittleness of bone. Bone 2011; 48: 733-740 [PMID: 21185416 DOI: 10.1016/ j.bone.2010.12.016].