Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria

Malaria Journal

Volumn 13, Issue 1, 2014, Pages

  Muhindo, Mary K ^a   Kakuru, Abel ^a   Jagannathan, Prasanna ^b   Talisuna, Ambrose ^a,c   Osilo, Emmanuel ^a   Orukan, Francis ^a   Arinaitwe, Emmanuel ^a   Tappero, Jordan W ^d   Kaharuza, Frank ^d   Kamya, Moses R ^e   Dorsey, Grant ^b  

^a INFECTIOUS DISEASES RESEARCH COLLABORATION   (Uganda)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^e MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

Author keywords

Artemether lumefantrine; Artemisinin based combination therapy; Dihydroartemisin piperaquine; Malaria; Parasite clearance; Plasmodium falciparum

Indexed keywords

ANTIMALARIALS; ARTEMISININS; CHILD, PRESCHOOL; DRUG COMBINATIONS; DRUG RESISTANCE; ETHANOLAMINES; FLUORENES; HUMANS; KINETICS; LONGITUDINAL STUDIES; MALARIA, FALCIPARUM; PARASITEMIA; PLASMODIUM FALCIPARUM; QUINOLINES; RISK FACTORS; UGANDA;

EID: 84892943195     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-13-32     Document Type: Article

References (23)

1. WHO, Guidelines for the treatment of malaria Geneva, Switzerland: World Health Organization Second 2010
2. WHO, World Malaria Report 2011 Geneva, Switzerland: World Health Organization 2011
3. Artesunate dose escalation for the treatment of uncomplicated malaria in a region of reported artemisinin resistance: a randomized clinical trial. Bethell D, Se Y, Lon C, Tyner S, Saunders D, Sriwichai S, Darapiseth S, Teja-Isavadharm P, Khemawoot P, Schaecher K, PLoS One 2011 6 19283 10.1371/journal.pone.0019283 21603629
4. Artemisinin resistance in Plasmodium falciparum malaria. Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, Lwin KM, Ariey F, Hanpithakpong W, Lee SJ, N Engl J Med 2009 361 455 467 10.1056/NEJMoa0808859 19641202
5. Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast Asia. Noedl H, Se Y, Sriwichai S, Schaecher K, Teja-Isavadharm P, Smith B, Rutvisuttinunt W, Bethell D, Surasri S, Fukuda MM, Clin Infect Dis 2010 51 82 e89 10.1086/657120 21028985
6. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Phyo AP, Nkhoma S, Stepniewska K, Ashley EA, Nair S, McGready R, ler Moo C, Al-Saai S, Dondorp AM, Lwin KM, Lancet 2012 379 1960 1966 10.1016/S0140-6736(12)60484-X 22484134
7. Invasion of Africa by a single pfcrt allele of South East Asian type. Ariey F, Fandeur T, Durand R, Randrianarivelojosia M, Jambou R, Legrand E, Ekala MT, Bouchier C, Cojean S, Duchemin JB, Malar J 2006 5 34 10.1186/1475-2875-5-34 16638153 (Pubitemid 43742435)
8. Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations. Mita T, Venkatesan M, Ohashi J, Culleton R, Takahashi N, Tsukahara T, Ndounga M, Dysoley L, Endo H, Hombhanje F, J Infect Dis 2011 204 1980 1988 10.1093/infdis/jir664 22021623
9. Intercontinental spread of pyrimethamine-resistant malaria. Roper C, Pearce R, Nair S, Sharp B, Nosten F, Anderson T, Science 2004 305 1124 10.1126/science.1098876 15326348 (Pubitemid 39100317)
10. Artemisinin-resistant malaria: research challenges, opportunities, and public health implications. Fairhurst RM, Nayyar GM, Breman JG, Hallett R, Vennerstrom JL, Duong S, Ringwald P, Wellems TE, Plowe CV, Dondorp AM, Am J Trop Med Hyg 2012 87 231 241 10.4269/ajtmh.2012.12-0025 22855752
11. Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator. Flegg JA, Guerin PJ, White NJ, Stepniewska K, Malar J 2011 10 339 10.1186/1475-2875-10-339 22074219
12. Early parasitological response following artemisinin-containing regimens: a critical review of the literature. Das D, Price RN, Bethell D, Guerin PJ, Stepniewska K, Malar J 2013 12 125 10.1186/1475-2875-12-125 23602021
13. In vivo parasitological measures of artemisinin susceptibility. Stepniewska K, Ashley E, Lee SJ, Anstey N, Barnes KI, Binh TQ, D'Alessandro U, Day NP, de Vries PJ, Dorsey G, J Infect Dis 2010 201 570 579 10.1086/650301 20085495
14. Variation in malaria transmission intensity in seven sites throughout Uganda. Okello PE, Van Bortel W, Byaruhanga AM, Correwyn A, Roelants P, Talisuna A, D'Alessandro U, Coosemans M, Am J Trop Med Hyg 2006 75 219 225 16896122 (Pubitemid 46941334)
15. Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Arinaitwe E, Sandison TG, Wanzira H, Kakuru A, Homsy J, Kalamya J, Kamya MR, Vora N, Greenhouse B, Rosenthal PJ, Tappero J, Dorsey G, Clin Infect Dis 2009 49 1629 1637 10.1086/647946 19877969
16. Protective efficacy of co-trimoxazole prophylaxis against malaria in HIV exposed children in rural Uganda: a randomised clinical trial. Sandison TG, Homsy J, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Kalamya J, Vora N, Kublin J, Kamya MR, Dorsey G, Tappero JW, BMJ 2011 342 1617 10.1136/bmj.d1617 21454456
17. Antimalarial drug resistance and combination chemotherapy. White N, Philos Trans R Soc Lond B Biol Sci 1999 354 739 749 10.1098/rstb.1999.0426 10365399 (Pubitemid 29365622)
18. Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. White NJ, Antimicrob Agents Chemother 1997 41 1413 1422 9210658 (Pubitemid 27289660)
19. Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast. Borrmann S, Sasi P, Mwai L, Bashraheil M, Abdallah A, Muriithi S, Fruhauf H, Schaub B, Pfeil J, Peshu J, Hanpithakpong W, Rippert A, Juma E, Tsofa B, Mosobo M, Lowe B, Osier F, Fegan G, Lindegårdh N, Nzila A, Peshu N, Mackinnon M, Marsh K, PLoS One 2011 6 26005 10.1371/journal.pone.0026005 22102856
20. Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study. Whitworth J, Morgan D, Quigley M, Smith A, Mayanja B, Eotu H, Omoding N, Okongo M, Malamba S, Ojwiya A, Lancet 2000 356 1051 1056 10.1016/S0140-6736(00)02727-6 11009139
21. Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study. Kamya MR, Gasasira AF, Yeka A, Bakyaita N, Nsobya SL, Francis D, Rosenthal PJ, Dorsey G, Havlir D, J Infect Dis 2006 193 9 15 10.1086/498577 16323126 (Pubitemid 43032494)
22. Delayed clearance of Plasmodium falciparum in patients with human immunodeficiency virus co-infection treated with artemisinin. Birku Y, Mekonnen E, Bjorkman A, Wolday D, Ethiop Med J 2002 40 Suppl 1 17 26 12802828
23. Plasmodium falciparum clearance rates in response to artesunate in malian children with malaria: effect of acquired immunity. Lopera-Mesa TM, Doumbia S, Chiang S, Zeituni AE, Konate DS, Doumbouya M, Keita AS, Stepniewska K, Traore K, Diakite SA, Ndiaye D, Sa JM, Anderson JM, Fay MP, Long CA, Diakite M, Fairhurst RM, J Infect Dis 2013 207 1655 1663 10.1093/infdis/jit082 23448727