Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone

Epilepsia

Volumn 55, Issue 1, 2014, Pages 103-107

  Hussain, Shaun A ^a   Shinnar, Shlomo ^b   Kwong, Grace ^a   Lerner, Jason T ^a   Matsumoto, Joyce H ^a   Wu, Joyce Y ^a   Shields, W Donald ^a   Sankar, Raman ^a  

^a MATTEL CHILDREN S HOSPITAL   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

ACTHar; Corticosteroids; Corticotropin; Hypsarrhythmia; West syndrome

Indexed keywords

CORTICOTROPIN; PREDNISOLONE;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL PROTOCOL; DRUG MEGADOSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAPHY; FEMALE; FOLLOW UP; HORMONAL THERAPY; HUMAN; HYPSARRHYTHMIA; INFANTILE SPASM; MALE; MEDICAL RECORD REVIEW; MUSCLE SPASM; PRIORITY JOURNAL; RELAPSE; RETROSPECTIVE STUDY; SCHOOL CHILD; TREATMENT OUTCOME;

ACTHAR; CORTICOSTEROIDS; CORTICOTROPIN; HYPSARRHYTHMIA; WEST SYNDROME;

ADOLESCENT; ADRENOCORTICOTROPIC HORMONE; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; INFANT; MALE; MONITORING, PHYSIOLOGIC; PREDNISOLONE; SPASMS, INFANTILE; TREATMENT OUTCOME;

EID: 84892935682     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/epi.12460     Document Type: Article

References (14)

1. Arya R, Shinnar S, Glauser TA,. (2012) Corticosteroids for the treatment of infantile spasms a systematic review. J Child Neurol 27: 1284-1288.
2. Baram TZ, Mitchell WG, Tournay A, Snead OC, Hanson RA, Horton EJ,. (1996) High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics 97: 375-379.
3. Bitton JY, Sauerwein HC, Weiss SK, Donner EJ, Whiting S, Dooley JM, Snead C, Farrell K, Wirrell EC, Mohamed IS, Ronen GM, Salas-Prato M, Amre D, Lassonde M, Carmant L,. (2012) A randomized controlled trial of flunarizine as add-on therapy and effect on cognitive outcome in children with infantile spasms. Epilepsia 53: 1570-1576.
4. Go CY, Mackay MT, Weiss SK, Stephens D, Adams-Webber T, Ashwal S, Snead OC III,. (2012) Evidence-based guideline update: medical treatment of infantile spasms: report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 78: 1974-1980.
5. Hrachovy RA, Frost J, Kellaway P, Zion TE,. (1983) Double-blind study of ACTH vs prednisone therapy in infantile spasms. J Pediatr 103: 641-645.
6. Hrachovy RA, Frost JD, Kellaway P,. (1984) Hypsarrhythmia: variations on the theme. Epilepsia 25: 317-325.
7. Hrachovy RA, Frost J, Glaze DG,. (1994) High-dose, long-duration versus low-dose, short-duration corticotropin therapy for infantile spasms. J Pediatr 124: 803-806.
8. Kossoff EH, Hartman AL, Rubenstein JE, Vining EPG,. (2009) High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH. Epilepsy Behav 14: 674-676.
9. Lux AL, Edwards SW, Hancock E, Johnson AL, Kennedy CR, Newton RW, O'Callaghan FJK, Verity CM, Osborne JP,. (2004) The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trial. Lancet 364: 1773-1778.
10. O'Callaghan FJK, Lux AL, Darke K, Edwards SW, Hancock E, Johnson AL, Kennedy CR, Newton RW, Verity CM, Osborne JP,. (2011) The effect of lead time to treatment and of age of onset on developmental outcome at 4 years in infantile spasms: evidence from the United Kingdom Infantile Spasms Study. Epilepsia 52: 1359-1364.
11. Pellock JM, Hrachovy R, Shinnar S, Baram TZ, Bettis D, Dlugos DJ, Gaillard WD, Gibson PA, Holmes GL, Nordl DR, O'Dell C, Shields WD, Trevathan E, Wheless JW,. (2010) Infantile spasms: a U.S. consensus report. Epilepsia 51: 2175-2189.
12. Shields WD,. (2006) Infantile spasms: little seizures, BIG consequences. Epilepsy Curr 6: 63-69.
13. Snead OC, Benton JW, Hosey LC, Swann JW, Spink D, Martin D, Rej R,. (1989) Treatment of infantile spasms with high-dose ACTH: efficacy and plasma levels of ACTH and cortisol. Neurology 39: 1027-1031.
14. Ware TL, Mackay MT, Harvey AS, Freeman JL,. (2012) Epileptic spasms: experience with a high-dose oral corticosteroid protocol. J Paediatr Child Health 48: 985-989.