Corticosteroids for the treatment of infantile spasms: A systematic review

Journal of Child Neurology

Volumn 27, Issue 10, 2012, Pages 1284-1288

  Arya, Ravindra ^a   Shinnar, Shlomo ^b   Glauser, Tracy A ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

ACTH; adrenocorticotropic hormone; corticosteroids; infantile spasms; systematic review

Indexed keywords

METHYLPREDNISOLONE; PREDNISOLONE; PREDNISONE;

APPETITE; ARTICLE; BRAIN ATROPHY; CLINICAL TRIAL (TOPIC); CUSHINGOID SYNDROME; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG TOLERABILITY; ELECTROENCEPHALOGRAPHY; HUMAN; HYPERTENSION; HYPSARRHYTHMIA; INFANTILE SPASM; IRRITABILITY; LETHARGY; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; SIDE EFFECT; SYSTEMATIC REVIEW; TREATMENT OUTCOME; VOMITING; WEIGHT GAIN;

ADRENAL CORTEX HORMONES; HUMANS; INFANT; INFANT, NEWBORN; SPASMS, INFANTILE;

EID: 84866849830     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073812453203     Document Type: Article

References (30)

1. Stafstrom CE, Arnason BG, Baram TZ, et al. Treatment of infantile spasms: emerging insights from clinical and basic science perspectives. J Child Neurol. 2011 ; 26: 1411-1421
2. Hrachovy RA, Frost JD Epilepsy: A Comprehensive Textbook. 2. 2nd ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2008:1519-1530. Engel J Pedley TA, ed. Philadelphia, PA: Lippincott, Williams & Wilkins ; 2008: 1519-1530.
3. Huttenlocher PR, Amemiya IM. Effects of adrenocortical steroids and of adrenocorticotrophic hormone on (Na+-K+)-ATPase in immature cerebral cortex. Pediatr Res. 1978 ; 12: 104-107
4. Molteni R, Fumagalli F, Magnaghi V, et al. Modulation of fibroblast growth factor-2 by stress and corticosteroids: from developmental events to adult brain plasticity. Brain Res Brain Res Rev. 2001 ; 37: 249-258
5. Vreugdenhil E, de Kloet ER, Schaaf M, Datson NA. Genetic dissection of corticosterone receptor function in the rat hippocampus. Eur Neuropsychopharmacol. 2001 ; 11: 423-430
6. Vidal C, Jordan W, Zieglgansberger W. Corticosterone reduces the excitability of hippocampal pyramidal cells in vitro. Brain Res. 1986 ; 383: 54-59
7. Kendall DA, McEwen BS, Enna SJ. The influence of ACTH and corticosterone on [3H]GABA receptor binding in rat brain. Brain Res. 1982 ; 236: 365-374
8. Klawans HL, Goetz C. Weiner WJ. 5-Hydroxytryptophan-induced myoclonus in guinea pigs and the possible role of serotonin in infantile myoclonus. Neurology. 1973 ; 23: 1234-1240
9. Baram TZ, Mitchell WG, Hanson RA, Snead OC, Horton EJ. Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms. Pediatr Neurol. 1995 ; 13: 108-110
10. Baram TZ. Pathophysiology of massive infantile spasms: perspective on the putative role of the brain adrenal axis. Ann Neurol. 1993 ; 33: 231-236
11. Brunson KL, Avishai-Eliner S, Baram TZ. ACTH treatment of infantile spasms: mechanisms of its effects in modulation of neuronal excitability. Int Rev Neurobiol. 2002 ; 49: 185-197
12. Baram TZ, Mitchell WG, Brunson K, Haden E. Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonists. Dev Neurosci. 1999 ; 21: 281-289
13. Mackay MT, Weiss SK, Adams-Webber T, et al. Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society. Neurology. 2004 ; 62: 1668-1681
14. Pellock JM, Hrachovy R, Shinnar S, et al. Infantile spasms: a U.S. consensus report. Epilepsia. 2010 ; 51: 2175-2189
15. Baram TZ, Mitchell WG, Tournay A, Snead OC, Hanson RA, Horton EJ. High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics. 1996 ; 97: 375-379
16. Hrachovy RA, Frost JD, Kellaway P, Zion TE. Double-blind study of ACTH vs prednisone therapy in infantile spasms. J Pediatr. 1983 ; 103: 641-645
17. Kossoff EH, Hartman AL, Rubenstein JE, Vining EP. High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH. Epilepsy Behav. 2009 ; 14: 674-676
18. Mytinger JR, Quigg M, Taft WC, Buck ML, Rust RS. Outcomes in treatment of infantile spasms with pulse methylprednisolone. J Child Neurol. 2010 ; 25: 948-953
19. Snead OC, Benton JW, Myers GJ. ACTH and prednisone in childhood seizure disorders. Neurology. 1983 ; 33: 966-970
20. Azam M, Bhatti N, Krishin J. Use of ACTH and prednisolone in infantile spasms: experience from a developing country. Seizure. 2005 ; 14: 552-556
21. Lux AL, Edwards SW, Hancock E, et al. The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trial. Lancet. 2004 ; 364: 1773-1778
22. Noureen N, Rana MT. Clinical profile and response to oral prednisolone in infantile spasm. J Coll Physicians Surg Pak. 2010 ; 20: 186-189
23. Glaze DG, Hrachovy RA, Frost JD, Kellaway P, Zion TE. Prospective study of outcome of infants with infantile spasms treated during controlled studies of ACTH and prednisone. J Pediatr. 1988 ; 112: 389-396
24. Hrachovy RA, Glaze DG, Frost JD. A retrospective study of spontaneous remission and long-term outcome in patients with infantile spasms. Epilepsia. 1991 ; 32: 212-214
25. Hrachovy RA, Frost JD, Kellaway P, Zion T. A controlled study of prednisone therapy in infantile spasms. Epilepsia. 1979 ; 20: 403-407
26. Hrachovy RA, Frost JD, Kellaway P, Zion T. A controlled study of ACTH therapy in infantile spasms. Epilepsia. 1980 ; 21: 631-636
27. Hrachovy RA, Frost JD Intractable Epilepsy: Experimental and Clinical Aspects. Schmidt D Morselli PL, ed. New York: Raven Press ; 1986: 87-97.
28. Frost JD, Hrachovy RA Infantile Spasms: Diagnosis, Management and Prognosis. Boston: Kluwer Academic ; 2003:
29. Riikonen R, Donner M. ACTH therapy in infantile spasms: side effects. Arch Dis Child. 1980 ; 55: 664-672
30. Hishitani T, Hoshino K, Ogawa K, et al. Rapid enlargement of cardiac rhabdomyoma during corticotropin therapy for infantile spasms. Can J Cardiol. 1997 ; 13: 72-74