Structural insights into the recognition of β3 integrin cytoplasmic tail by the SH3 domain of Src kinase

Protein Science

Volumn 22, Issue 10, 2013, Pages 1358-1365

  Katyal, Priya ^a   Puthenveetil, Robbins ^a   Vinogradova, Olga ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Integrin; NMR; Src kinase

Indexed keywords

BETA3 INTEGRIN; PROTEIN SH3; PROTEIN TYROSINE KINASE;

ALPHA HELIX; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; MOLECULAR DOCKING; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE;

INTEGRIN; NMR; SRC-KINASE;

CIRCULAR DICHROISM; HUMANS; INTEGRIN BETA3; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SRC HOMOLOGY DOMAINS; TYROSINE;

EID: 84892935412     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2323     Document Type: Article

References (27)

1. Hynes RO (2002) Integrins: Bidirectional, allosteric signaling machines. Cell 110:673-687.
2. Vinogradova O, Velyvis A, Velyviene A, Hu B, Haas T, Plow E, Qin J (2002) A structural mechanism of integrin alpha(IIb)beta(3) "inside-Out" activation as regulated by its cytoplasmic face. Cell 110:587-597.
3. Liu S, Calderwood DA, Ginsberg MH (2000) Integrin cytoplasmic domain-Binding proteins. J Cell Sci 113: 3563-3571.
4. Arias-Salgado EG, Lizano S, Shattil SJ, Ginsberg MH (2005) Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J Biol Chem 280:29699-29707.
5. Arias-Salgado EG Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ (2003) Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci USA 100:13298-13302.
6. Roskoski Jr R (2005) Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys Res Commun 331:1-14.
7. Shattil SJ (2005) Integrins and Src: Dynamic duo of adhesion signaling. Trends Cell Biol 15:399-403.
8. Cordier F, Wang C, Grzesiek S, Nicholson LK (2000) Ligand-Induced strain in hydrogen bonds of the c-Src SH3 domain detected by NMR. J Mol Biol 304:497-505.
9. Yu H, Rosen MK, Schreiber SL (1993) 1H and 15N assignments and secondary structure of the Src SH3 domain. FEBS Lett 324:87-92.
10. Mayer BJ (2001) SH3 domains: Complexity in moderation. J Cell Sci 114:1253-1263.
11. Zarrinpar A, Bhattacharyya RP, Lim WA (2003) The structure and function of proline recognition domains. Sciences STKE:RE8.
12. Feng S, Chen JK, Yu H, Simon JA, Schreiber SL (1994) Two binding orientations for peptides to the Src SH3 domain: Development of a general model for SH3- ligand interactions. Science 266:1241-1247.
13. Kang H, Freund C, Duke-Cohan JS, Musacchio A, Wagner G, Rudd CE (2000) SH3 domain recognition of a proline-Independent tyrosine-Based RKxxYxxY motif in immune cell adaptor SKAP55. EMBO J 19:2889-2899.
14. Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME (1997) The SH3 domain of Eps8 exists as a novel intertwined dimer. Nat Struct Biol 4:739-743.
15. Mongiovi AM, Romano PR, Panni S, Mendoza M, Wong WT, Musacchio A, Cesareni G, Di Fiore PP (1999) A novel peptide-SH3 interaction. EMBO J 18:5300-5309.
16. Kami K, Takeya R, Sumimoto H, Kohda D (2002) Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p. EMBO J 21:4268-4276.
17. Xiao R, Xi XD, Chen Z, Chen SJ, Meng G (2013) Structural framework of c-Src activation by integrin beta3. Blood 121:700-706.
18. Ablooglu AJ Kang J, Petrich BG, Ginsberg MH, Shattil SJ (2009) Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. Blood 113:3585-3592.
19. Phillips DR, Prasad KS, Manganello J, Bao M, Nannizzi-Alaimo L (2001) Integrin tyrosine phosphorylation in platelet signaling. Curr Opin Cell Biol 13:546-554.
20. Kelly MA, Chellgren BW, Rucker AL, Troutman JM, Fried MG, Miller AF, Creamer TP (2001) Host-Guest study of left-Handed polyproline II helix formation. Biochemistry 40:14376-14383.
21. Rucker AL, Creamer TP (2002) Polyproline II helical structure in protein unfolded states: Lysine peptides revisited. Protein Sci 11:980-985.
22. Dominguez C, Boelens R, Bonvin AM (2003) HADDOCK: A protein-Protein docking approach based on biochemical or biophysical information. J Am Chem Soc 125:1731-1737.
23. De Vries SJ, van Dijk M, Bonvin AM (2010) The HADDOCK web server for data-Driven biomolecular docking. Nat Protoc 5:883-897.
24. Xu W, Doshi A, Lei M, Eck MJ, Harrison SC (1999) Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Mol Cell 3:629-638.
25. Delaglio F, Grzesiek S, Vuister GW, Zhu G, Pfeifer J, Bax A (1995) NMRPipe: A multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 6:277-293.
26. Vranken WF, Boucher W, Stevens TJ, Fogh RH, Pajon A, Llinas M, Ulrich EL, Markley JL, Ionides J, Laue ED (2005) The CCPN data model for NMR spectroscopy: Development of a software pipeline. Proteins 59: 687-696.
27. Baker NA, Sept D, Joseph S, Holst MJ, McCammon MJ (2001) Electrostatics of nanosystems: Application to microtubules and the ribosome. Proc Natl Acad Sci USA 98:10037-10041.