Characterisation of the metabolism of pogostone in vitro and in vivo using liquid chromatography with mass spectrometry

Phytochemical Analysis

Volumn 25, Issue 2, 2014, Pages 97-105

  Li, Yucui ^a   Su, Ziren ^a   Lin, Shuhai ^b   Li, Chuwen ^a   Zhao, Ya ^a   Gao, Xiang ^b   Lai, Yongquan ^b   Wu, Xiaoli ^a   Wu, Hanzhi ^b   Cai, Zongwei ^b   Lai, Xiaoping ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

hydroxylation; LC MS; metabolites; orbitrap; oxidation; pogostone; rat liver

Indexed keywords

BIOMOLECULES; ESSENTIAL OILS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; RATS;

ANTI-BACTERIAL; ANTIFUNGAL ACTIVITIES; IN-VITRO; LIQUID CHROMATOGRAPHY COUPLED WITH MASS SPECTROMETRY; ORAL ADMINISTRATION; ORBITRAP; POGOSTEMON CABLIN; POGOSTONE; RAT LIVERS; VITRO AND IN VIVO;

METABOLITES;

PLANT MEDICINAL PRODUCT; POGOSTONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG FECES LEVEL; DRUG HYDROLYSIS; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; LIVER MICROSOME; MALE; METABOLITE; NEWBORN; NONHUMAN; OXYGENATION; RAT; SENSITIVITY ANALYSIS; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY;

BACTERIA (MICROORGANISMS); MAMMALIA; POGOSTEMON CABLIN; RATTUS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROXYLATION; LAMIACEAE; MALE; METABOLIC NETWORKS AND PATHWAYS; MICROSOMES, LIVER; OILS, VOLATILE; OXIDATION-REDUCTION; PLANT OILS; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84892932701     PISSN: 09580344     EISSN: 10991565     Source Type: Journal    
DOI: 10.1002/pca.2471     Document Type: Article

References (31)

1. Actis-Goretta L, Lévèques A, Giuffrida F, Destaillats F, Nagy K,. 2012. Identification of O-methyl-(-)-epicatechin-O-sulphate metabolites by mass-spectrometry after O-methylation with trimethylsilyldiazomethane. J Chromatogr A 1245: 150-157.
2. Chandrani G,. 2000. Drug metabolism and pharmacokinetics in drug discovery a primer for bioanalytical chemists, Part I. Curr Sep 19: 17-23.
3. Chen H, Li Y, Wu X, Li C, Li Q, Qin Z, Yi Y, Chen J, Lai X, Su Z,. 2013. LC-MS/MS determination of pogostone in rat plasma and its application in pharmacokinetic studies. Biomed Chromatogr 27: 1092-1099.
4. Chen X, Zhao Y, Yao S, Li X, Jin M,. 2011. Simultaneous determination of nine preservatives and sweeteners in yellow wine and wine by ultrafast liquid chromatography-tandem mass spectrometry. Se Pu 29: 1147-1154.
5. China Pharmacopoeia Committee. 2010. Pharmacopoeia of the People's Republic of China, Vol. 1. China Medical Science Press: Beijing.
6. Guo DA, Lu A, Liu L,. 2012. Modernization of traditional Chinese medicine. J Ethnopharmacol 141: 547-548.
7. Hui JP, Stuart Grossert J, Cutler MJ, Melanson JE,. 2012. Strategic identification of in vitro metabolites of 13-desmethyl spirolide C using liquid chromatography/high-resolution mass spectrometry. Rapid Commun Mass Spectrom 26: 345-54.
8. Hung HY, Qian K, Morris-Natschke SL, Hsu CS, Lee KH,. 2012. Recent discovery of plant-derived anti-diabetic natural products. Nat Prod Rep 29: 580-606.
9. Jemal M, Ouyang Z, Zhao W, Zhu M, Wu WW,. 2003. A strategy for metabolite identification using triple-quadrupole mass spectrometry with enhanced resolution and accurate mass capability. Rapid Commun Mass Spectrom 17: 2732-2740.
10. Kong GX,. 1986. The isolation and application in pharmaceutics of pogostone. Chin J Hosp Pharm 6: 32-33.
11. Kumar D, Kumar A, Prakash O,. 2012. Potential antifertility agents from plants a comprehensive review. J Ethnopharmacol 140: 1-32.
12. Lai Y, Cai Z,. 2012. In vitro metabolism of hydroxylated polybrominated diphenyl ethers and their inhibitory effects on 17 β-estradiol metabolism in rat liver microsomes. Environ Sci Pollut Res Int 19: 3219-27.
13. Li YC, Xian YF, Ip SP, Su ZR, Su JY, He JJ, Xie QF, Lai XP, Lin ZX,. 2011. Anti-inflammatory activity of patchouli alcohol isolated from Pogostemonis Herba in animal models. Fitoterapia 82: 1295-1301.
14. Li YC, Peng SZ, Chen HM, Zhang FX, Xu PP, Xie JH, He JJ, Chen JN, Lai XP, Su ZR,. 2012a. Oral administration of patchouli alcohol isolated from Pogostemonis Herba augments protection against influenza viral infection in mice. Int Immunopharmacol 12: 294-301.
15. Li YC, Liang HC, Chen HM, Tan LR, Yi YY, Qin Z, Zhang WM, Wu DW, Li CW, Lin RF, Su ZR, Lai XP,. 2012b. Anti-Candida albicans activity and pharmacokinetics of pogostone isolated from Pogostemonis Herba. Phytomedicine 20: 77-83.
16. Liu H, Luo J, Lai P,. 1999. Studies on the anti-enteropathogenic bacteria action of Herba Pogostemonis extracts. Zhong Yao Cai 22: 408-411.
17. Lu TC, Liao JC, Huang TH, Lin YC, Liu CY, Chiu YJ, Peng WH,. 2011. Analgesic and anti-inflammatory activities of the methanol extract from Pogostemon cablin. Evid Based Complement Alternat Med 6717: 1-9.
18. Markwell MA, Haas SM, Bieber LL, Tolbert NE,. 1978. A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem 87: 206-210.
19. Mo XL, Yan Z, Wang YS, Wang XG,. 2004. Antifungal activity of essential oil of Pogostemonis Herba against plant pathogenic fungi. J Chin Med Mater 27: 805-807.
20. Omura T, Sato R,. 1964. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239: 2370-2378.
21. Osawa K, Matsumoto T, Maruyama T, Takiguchi T, Okuda K, Takazoe I,. 1990. Studies of the antibacterial activity of plant extracts and their constituents against periodontopathic bacteria. Bull Tokyo Dent Coll 31: 17-21.
22. 2 extract of Chrysanthemum indicum, patchouli oil and Zedoary turmeric oil in vivo. J Ethnopharmacol 141: 608-614.
23. Sumitomo patent: US 20020197294 A1. 2002. Pyrone compounds and their use. Sumitomo Chemical Company. Filed date 02.05.2001. Priority 08.06.2001.
24. Van Meulebroek L, Bussche JV, Steppe K, Vanhaecke L,. 2012. Ultra-high performance liquid chromatography coupled to high resolution orbitrap mass spectrometry for metabolomic profiling of the endogenous phytohormonal status of the tomato plant. J Chromatogr A 1260: 67-80.
25. Wu HQ, Li L, Li J, He ZD, Liu ZG, Zeng QQ, Wang YS,. 2012. Acaricidal activity of DHEMH, derived from patchouli oil, against house dust mite, Dermatophagoides farinae. Chem Pharm Bul 60: 178-182.
26. Xian YF, Li YC, Ip SP, Lin ZX, Lai XP, Su ZR,. 2011. Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophages. Exp Ther Med 2: 545-550.
27. Xian YF, Lin ZX, Mao QQ, Ip SP, Su ZR, Lai XP,. 2012. Protective effect of isorhynchophylline against β-amyloid-induced neurotoxicity in PC12 cells. Cell Mol Neurobiol 32: 353-360.
28. Yang DP, Chaumont JP, Millet J,. 2000. Antifungal activity of the essential oils from Agastache rugosa and Pogostemon cablin against dermatophytes and opportunistic fungi. Chin Pharm J 35: 9-11.
29. Yang M, Sun J, Lu Z, Chen G, Guan S, Liu X, Jiang B, Ye M, Guo DA,. 2009. Phytochemical analysis of traditional Chinese medicine using liquid chromatography coupled with mass spectrometry. J Chromatogr A 1216: 2045-2062.
30. Zhang NR, Yu S, Tiller P, Yeh S, Mahan E, Emary WB,. 2009. Quantitation of small molecules using high-resolution accurate mass spectrometers-a different approach for analysis of biological samples. Rapid Commun Mass Spectrom 23: 1085-1094.
31. Zhou JL, Qi LW, Li P,. 2009. Herbal medicine analysis by liquid chromatography/time-of-flight mass spectrometry. J Chromatogr A 1216: 7582-7594.