Adrenal signaling in heart failure: Something more than a distant ship's smoke on the horizon

Hypertension

Volumn 63, Issue 2, 2014, Pages 215-216

  Santulli, Gaetano ^a  

^a New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ALDOSTERONE; BETA ADRENERGIC RECEPTOR; BETA ARRESTIN 1; BETA ARRESTIN 2; CATECHOLAMINE; G PROTEIN COUPLED RECEPTOR KINASE; NORADRENALIN;

ADRENAL GLAND; DIABETES MELLITUS; DISEASE COURSE; EDITORIAL; GENE DELETION; HEART FAILURE; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE METABOLISM; HEART OUTPUT; INSULIN RESISTANCE; INSULIN SENSITIVITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 84892905831     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.113.02382     Document Type: Editorial

References (10)

1. Santulli G. Epidemiology of cardiovascular disease in the 21st century: updated numbers and updated facts. JCvD. 2013;1:1-2.
2. Lymperopoulos A, Rengo G, Funakoshi H, Eckhart AD, Koch WJ. Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. Nat Med. 2007;13:315-323.
3. Santulli G, Campanile A, Spinelli L, Assante di Panzillo E, Ciccarelli M, Trimarco B, Iaccarino G. G protein-coupled receptor kinase 2 in patients with acute myocardial infarction. Am J Cardiol. 2011;107: 1125-1130.
4. Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ. beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem. 2006;281:1261-1273.
5. Bathgate-Siryk A, Dabul S, Pandya K, Walklett K, Rengo G, Cannavo A, de Lucia C, Liccardo D, Gao E, Leosco D, Koch WJ, Lymperopoulos A. Negative impact of ?-arrestin-1 on post-myocardial infarction heart failure via both cardiac and adrenal-dependent neurohormonal mechanisms. Hypertension. 2014;63:404-412.
6. Sorriento D, Santulli G, Del Giudice C, Anastasio A, Trimarco B, Iaccarino G. Endothelial cells are able to synthesize and release catecholamines both in vitro and in vivo. Hypertension. 2012;60:129-136.
7. Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G. CaMK4 gene deletion induces hypertension. J Am Heart Assoc. 2012;1:e001081.
8. Wang WC, Juan AH, Panebra A, Liggett SB. MicroRNA let-7 establishes expression of beta2-adrenergic receptors and dynamically downregulates agonist-promoted down-regulation. Proc Natl Acad Sci USA. 2011;108:6246-6251.
9. Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, Formisano P, Béguinot F, Trimarco B, Miele C, Iaccarino G. Age-related impairment in insulin release: the essential role of ?(2)-adrenergic receptor. Diabetes. 2012;61:692-701.
10. Zhang M, Zhu Y, Mu K, Li L, Lu J, Zhao J, Huang X, Wang C, Jia W. Loss of ?-arrestin2 mediates pancreatic-islet dysfunction in mice. Biochem Biophys Res Commun. 2013;435:345-349.