Patterns of medication exposures in hospitalized pediatric patients with acute renal failure requiring intermittent or continuous hemodialysis

Pediatric Critical Care Medicine

Volumn 14, Issue 9, 2013, Pages

  Rizkalla, Nicole A ^a   Feudtner, Chris ^b   Dai, Dingwei ^b   Zuppa, Athena F ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Acute renal failure; Drug utilization; Hemodialysis; Pediatrics pharmacoepidemiology; Prescribing practices; Renal replacement therapy

Indexed keywords

ACICLOVIR; ADRENALIN; AMPICILLIN; ANTICONVULSIVE AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; CARDIOVASCULAR AGENT; CORTICOSTEROID; DIURETIC AGENT; DOPAMINE; FENTANYL; GASTROINTESTINAL AGENT; GENTAMICIN; HEMATOLOGIC AGENT; HYDROCORTISONE; LORAZEPAM; MIDAZOLAM; MILRINONE; MORPHINE; OPIATE; PIPERACILLIN PLUS TAZOBACTAM; VACCINE;

ACUTE KIDNEY FAILURE; ADOLESCENT; ARTICLE; CHILD; CONTINUOUS HEMODIALYSIS; DRUG EXPOSURE; DRUG THERAPY; DRUG UTILIZATION; FEMALE; HEMODIALYSIS; HOSPITAL; HOSPITAL PATIENT; HUMAN; INFANT; INFORMATION; MAJOR CLINICAL STUDY; MALE; MEDICAL INFORMATION SYSTEM; PRESCHOOL CHILD; PRIORITY JOURNAL; PSYCHOTHERAPY; RETROSPECTIVE STUDY; SCHOOL CHILD; UNITED STATES;

ACUTE KIDNEY INJURY; ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; HOSPITALIZATION; HUMANS; INFANT; INFANT, NEWBORN; MALE; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; POLYPHARMACY; RENAL DIALYSIS; RETROSPECTIVE STUDIES;

EID: 84892818676     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e31829f5bc8     Document Type: Article

References (38)

1. Pea F, Viale P, Pavan F., et al.: Pharmacokinetic considerations for antimicrobial therapy in patients receiving renal replacement therapy. Clin Pharmacokinet 2007; 46:997-1038
2. Awdishu L, Bouchard J: How to optimize drug delivery in renal replacement therapy. Semin Dial 2011; 24:176-182
3. Roberts R, Rodriguez W, Murphy D., et al.: Pediatric drug labeling: Improving the safety and efficacy of pediatric therapies. JAMA 2003; 290:905-911
4. Lasky T, Lawless ST, Greenspan J: Quality care for children: Inpatient medication use in a mid-Atlantic hospital system 2000-2003. Am J Med Qual 2010; 25:225-231
5. Lasky T, Ernst FR, Greenspan J, et al.: Estimating pediatric inpatient medication use in the United States. Pharmacoepidemiol Drug Saf 2011; 20:76-82
6. Feudtner C, Dai D, Hexem K.R., et al.: Prevalence of polypharmacy exposure among hospitalized children in the United States. Arch Pediatr Adolesc Med 2012; 166:9-16
7. Moffett BS, Goldstein SL: Acute kidney injury and increasing nephro-toxic-medication exposure in noncritically-ill children. Clin J Am Soc Nephrol 2011; 6:856-863
8. US Department of Health and Human Services: Best Pharmaceuticals for Children Act Literature Reviews and Assessments. Available at: http://www.bpca.nichd.nih.gov/resources/reviews/index.cfm. Accessed June 12, 2012
9. Kweder S: Programs Affecting Safety and Innovation in Pediatric Therapies. Available at: http://www.fda.gov/NewsEvents/Testimony/ucm153848.htm. Accessed June 12, 2012
10. Waikar SS, Wald R, Chertow G.M., et al.: Validity of International Classification of Diseases, Ninth Revision, Clinical Modification Codes for Acute Renal Failure. J Am Soc Nephrol 2006; 17:1688-1694
11. Takemoto C, Hodding JH, Kraus DM: Pediatric and Neonatal Dosage Handbook. Nineteenth Edition. Hudson, Lexi-Comp, 2012
12. Slonim AD, Khandelwal S, He J., et al.: Characteristics associated with pediatric inpatient death. Pediatrics 2010; 125:1208-1216
13. Aronoff GR, Bennett WM, Berns JS: Drug Prescribing in Renal Failure: Dosing Guidelines for Adults and Children. Fifth Edition. Philadelphia, Scribe, 2007
14. Bailey D, Phan V, Litalien C., et al.: Risk factors of acute renal failure in critically ill children: A prospective descriptive epidemiological study. Pediatr Crit Care Med 2007; 8:29-35
15. Medina Villanueva A., López-Herce Cid J, López Fernández Y, et al.: [Acute renal failure in critically-ill children. A preliminary study]. An Pediatr (Barc) 2004; 61:509-514
16. Williams DM, Sreedhar SS, Mickell J.J., et al.: Acute kidney failure: A pediatric experience over 20 years. Arch Pediatr Adolesc Med 2002; 156:893-900
17. Moghal NE, Brocklebank JT, Meadow SR: A review of acute renal failure in children: Incidence, etiology and outcome. Clin Nephrol 1998; 49:91-95
18. Bunchman TE, McBryde KD, Mottes T.E., et al.: Pediatric acute renal failure: Outcome by modality and disease. Pediatr Nephrol 2001; 16:1067-1071
19. Zappitelli M, Bernier PL, Saczkowski R.S., et al.: A small post-operative rise in serum creatinine predicts acute kidney injury in children undergoing cardiac surgery. Kidney Int 2009; 76:885-892
20. Ozçakar Z.B., Yalçinkaya F, Altas B., et al.: Application of the new classification criteria of the Acute Kidney Injury Network: A pilot study in a pediatric population. Pediatr Nephrol 2009; 24: 1379-1384
21. Schneider J, Khemani R, Grushkin C., et al.: Serum creatinine as strati-fied in the RIFLE score for acute kidney injury is associated with mortality and length of stay for children in the pediatric intensive care unit. Crit Care Med 2010; 38:933-939
22. Plötz F.B., Bouma AB, van Wijk JA, et al.: Pediatric acute kidney injury in the ICU: An independent evaluation of pRIFLE criteria. Intensive Care Med 2008; 34:1713-1717
23. Vachvanichsanong P, Dissaneewate P, Lim A., et al.: Childhood acute renal failure: 22-Year experience in a university hospital in southern Thailand. Pediatrics 2006; 118:e786-e791
24. Heintz BH, Matzke GR, Dager WE: Antimicrobial dosing concepts and recommendations for critically ill adult patients receiving continuous renal replacement therapy or intermittent hemodialysis. Pharmacotherapy 2009; 29:562-577
25. Choi G, Gomersall CD, Tian Q, et al.: Principles of antibacterial dosing in continuous renal replacement therapy. Crit Care Med 2009; 37:2268-2282
26. Bauer SR, Salem C, Connor MJ Jr, et al.: Pharmacokinetics and phar-macodynamics of piperacillin-tazobactam in 42 patients treated with concomitant CRRT. Clin J Am Soc Nephrol 2012; 7:452-457
27. Seyler L, Cotton F, Taccone F.S., et al.: Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy. Crit Care 2011; 15:R137
28. Connor MJ J.r., Salem C, Bauer S.R., et al.: Therapeutic drug monitoring of piperacillin-tazobactam using spent dialysate effluent in patients receiving continuous venovenous hemodialysis. Antimicrob Agents Chemother 2011; 55:557-560
29. Goldstein SL, Somers MJ, Brophy P.D., et al.: The Prospective Pediatric Continuous Renal Replacement Therapy (ppCRRT) Registry: Design, development and data assessed. Int J Artif Organs 2004; 27:9-14
30. Goldstein SL, Somers MJ, Baum M.A., et al.: Pediatric patients with multi-organ dysfunction syndrome receiving continuous renal replacement therapy. Kidney Int 2005; 67:653-658
31. Flores FX, Brophy PD, Symons J.M., et al.: Continuous renal replacement therapy (CRRT) after stem cell transplantation. A report from the prospective pediatric CRRT Registry Group. Pediatr Nephrol 2008; 23:625-630
32. Goldstein SL: Advances in pediatric renal replacement therapy for acute kidney injury. Semin Dial 2011; 24:187-191
33. Hui-Stickle S., Brewer ED, Goldstein SL: Pediatric ARF epidemiology at a tertiary care center from 1999 to 2001. Am J Kidney Dis 2005; 45:96-101
34. Zuppa AF, Adamson PC, Mondick J.T., et al.: Drug utilization in the pediatric intensive care unit: Monitoring prescribing trends and establishing prioritization of pharmacotherapeutic evaluation of critically ill children. J Clin Pharmacol 2005; 45:1305-1312
35. Nguyen JK, Fouts MM, Kotabe S.E., et al.: Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am J Geriatr Pharmacother 2006; 4:36-41
36. Joshua L, Devi P, Guido S: Adverse drug reactions in medical intensive care unit of a tertiary care hospital. Pharmacoepidemiol Drug Saf 2009; 18:639-645
37. Papadopoulos J, Smithburger PL: Common drug interactions leading to adverse drug events in the intensive care unit: Management and pharmacokinetic considerations. Crit Care Med 2010; 38:S126-S135
38. Stone BL, Boehme S, Mundorff M.B., et al.: Hospital admission medication reconciliation in medically complex children: An observational study. Arch Dis Child 2010; 95:250-255