Prevalence of polypharmacy exposure among hospitalized children in the United States

Archives of Pediatrics and Adolescent Medicine

Volumn 166, Issue 1, 2012, Pages 9-16

  Feudtner, Chris ^a,b   Dai, Dingwei ^a   Hexem, Kari R ^a   Luan, Xianqun ^a   Metjian, Talene A ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; AMPICILLIN; AZITHROMYCIN; CEFAZOLIN; CEFOTAXIME; CEFTRIAXONE; DIPHENHYDRAMINE; ERYTHROMYCIN; FENTANYL; FUROSEMIDE; GENTAMICIN; GLUCONATE CALCIUM; HEPARIN; HEPATITIS B VACCINE; IBUPROFEN; IPRATROPIUM BROMIDE; KETOROLAC; LIDOCAINE; METHYLPREDNISOLONE; MIDAZOLAM; MORPHINE; ONDANSETRON; PARACETAMOL; POTASSIUM CHLORIDE; PREDNISOLONE; PROPOFOL; RANITIDINE; SALBUTAMOL; UNINDEXED DRUG; VITAMIN K GROUP;

ADOLESCENT; ARTICLE; CHILD; COHORT ANALYSIS; DRUG EXPOSURE; FEMALE; GENERAL HOSPITAL; HOSPITALIZED CHILD; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; PEDIATRIC HOSPITAL; POLYPHARMACY; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; UNITED STATES; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; CHILD; CHILD, HOSPITALIZED; CHILD, PRESCHOOL; COHORT STUDIES; DRUG UTILIZATION; FEMALE; HUMANS; INFANT; MALE; POLYPHARMACY; PREVALENCE; RETROSPECTIVE STUDIES; UNITED STATES;

EID: 84855336780     PISSN: 10724710     EISSN: 15383628     Source Type: Journal    
DOI: 10.1001/archpediatrics.2011.161     Document Type: Article

References (33)

1. Aspden P, Wolcott J, Bootman JL, Cronenwett LR; Committee on Identifying and Preventing Medication Errors. Preventing Medication Errors: Quality Chasm Series. Washington, DC: National Academies Press; 2006.
2. Best Pharmaceuticals for Children Act of 2002, Pub L 107-109, 107th Congress (January 4, 2002).
3. Steinbrook R. Testing medications in children. N Engl JMed. 2002;347(18):1462-1470. (Pubitemid 35239728)
4. Food and Drug Administration Modernization Act of 1997, Pub L 105-115, 105th Congress (November 21, 1997).
5. Committee on Drugs, American Academy of Pediatrics. Guidelines for the ethical conduct of studies to evaluate drugs in pediatric populations. Pediatrics. 1995;95(2):286-294.
6. Shah SS, Hall M, Goodman DM, et al. Off-label drug use in hospitalized children. Arch Pediatr Adolesc Med. 2007;161(3):282-290. (Pubitemid 46364332)
7. Wang JK, Herzog NS, Kaushal R, Park C, Mochizuki C, Weingarten SR. Prevention of pediatric medication errors by hospital pharmacists and the potential benefit of computerized physician order entry. Pediatrics. 2007;119(1):e77-e85. (Pubitemid 46397809)
8. Holdsworth MT, Fichtl RE, Raisch DW, et al. Impact of computerized prescriber order entry on the incidence of adverse drug events in pediatric inpatients. Pediatrics. 2007;120(5):1058-1066. (Pubitemid 350085540)
9. Walsh KE, Landrigan CP, Adams WG, et al. Effect of computer order entry on prevention of serious medication errors in hospitalized children. Pediatrics. 2008;121(3):e421-e427.
10. Ghaleb MA, Barber N, Franklin BD, Wong IC. The incidence and nature of prescribing and medication administration errors in paediatric inpatients. Arch Dis Child. 2010;95(2):113-118.
11. Pediatric Research Equity Act of 2003, Pub L 108-155, 108th Congress (December 3, 2003).
12. US Department of Health and Human Services, National Institutes of Health. List of drugs for which pediatric studies are needed [January 21, 2003]. http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/ DevelopmentResources/UCM077742.pdf. Accessed July 12, 2011.
13. US Department of Health and Human Services, National Institutes of Health. List of drugs for which pediatric studies are needed [April 26, 2006]. http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/ DevelopmentResources/UCM077708.pdf. Accessed July 12, 2011.
14. Hsien L, Breddemann A, Frobel AK, Heusch A, Schmidt KG, Läer S. Off-label drug use among hospitalised children: identifying areas with the highest need for research. Pharm World Sci. 2008;30(5):497-502.
15. Roberts R, Rodriguez W, Murphy D, Crescenzi T. Pediatric drug labeling: improving the safety and efficacy of pediatric therapies. JAMA. 2003;290(7):905-911. (Pubitemid 37430462)
16. Kweder S. Programs affecting safety and innovation in pediatric therapies. http://www.fda.gov/NewsEvents/Testimony/ucm153848.htm. Accessed July 12, 2011.
17. Lasky T. Estimates of pediatric medication use in the United States: current abilities and limitations. Clin Ther. 2009;31(2):436-445.
18. Neubert A, Wong IC, Bonifazi A, et al. Defining off-label and unlicensed use of medicines for children: results of a Delphi survey. Pharmacol Res. 2008;58(5-6):316-322.
19. Neubert A, Sturkenboom MC, Murray ML, et al. TEDDY Network of Excellence. Databases for pediatric medicine research in Europe: assessment and critical appraisal. Pharmacoepidemiol Drug Saf. 2008;17(12):1155-1167.
20. Nguyen JK, Fouts MM, Kotabe SE, Lo E. Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am J Geriatr Pharmacother. 2006;4(1):36-41.
21. Joshua L, Devi P, Guido S. Adverse drug reactions in medical intensive care unit of a tertiary care hospital. Pharmacoepidemiol Drug Saf. 2009;18(7):639-645.
22. American Hospital Formulary System. AHFS Pharmacologic-Therapeutic Classification System, 2010. http://www.ahfsdruginformation.com/class/index. aspx. Accessed 14 Dec, 2010.
23. Lasky T, Lawless ST, Greenspan J. Quality care for children: inpatient medication use in a mid-Atlantic hospital system 2000-2003. Am J Med Qual. 2010;25(3):225-231.
24. Lasky T, Ernst FR, Greenspan J, Wang S, Gonzalez L. Estimating pediatric inpatient medication use in the United States. Pharmacoepidemiol Drug Saf. 2011;20(1):76-82.
25. Sturkenboom MC, Verhamme KM, Nicolosi A, et al. TEDDY European Network of Excellence. Drug use in children: cohort study in three European countries. BMJ. 2008;337:a2245.
26. Clavenna A, Bonati M. Drug prescriptions to outpatient children: a review of the literature. Eur J Clin Pharmacol. 2009;65(8):749-755.
27. Takata GS, Mason W, Taketomo C, Logsdon T, Sharek PJ. Development, testing, and findings of a pediatric-focused trigger tool to identify medication-related harm in US children's hospitals. Pediatrics. 2008;121(4):e927-e935.
28. Bertsche T, Bertsche A, Krieg EM, et al. Prospective pilot intervention study to prevent medication errors in drugs administered to children by mouth or gastric tube: a programme for nurses, physicians and parents. Qual Saf Health Care. 2010;19(5):e26.
29. Stone BL, Boehme S, Mundorff MB, Maloney CG, Srivastava R. Hospital admission medication reconciliation in medically complex children: an observational study. Arch Dis Child. 2010;95(4):250-255.
30. Rosenbaum PR. Observational Studies. 2nd ed. New York, NY: Springer; 2002.
31. Zaoutis T, Localio AR, Leckerman K, Saddlemire S, Bertoch D, Keren R. Prolonged intravenous therapy versus early transition to oral antimicrobial therapy for acute osteomyelitis in children. Pediatrics. 2009;123(2):636-642.
32. Weiss PF, Klink AJ, Localio R, et al. Corticosteroids may improve clinical outcomes during hospitalization for Henoch-Schönlein purpura. Pediatrics. 2010;126(4):674-681.
33. Lindenauer PK, Pekow PS, Lahti MC, Lee Y, Benjamin EM, Rothberg MB. Association of corticosteroid dose and route of administration with risk of treatment failure in acute exacerbation of chronic obstructive pulmonary disease. JAMA. 2010;303(23):2359-2367.