Genetic evidence for a pathogenic role for the vitamin D3 metabolizing enzyme CYP24A1 in multiple sclerosis

Multiple Sclerosis and Related Disorders

Volumn 3, Issue 2, 2014, Pages 211-219

  Ramasamy, Adaikalavan ^a,b   Trabzuni, Daniah ^b,c   Forabosco, Paola ^d   Smith, Colin ^e   Walker, Robert ^e   Dillman, Allissa ^f   Sveinbjornsdottir, Sigurlaug ^g,h   Hardy, John ^b   Weale, Michael E ^a   Ryten, Mina ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^d CNR   (Italy)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f NATIONAL INSTITUTE ON AGING   (United States)

^g BROOMFIELD HOSPITAL   (United Kingdom)

^h QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

CYP24A1; Expression quantitative trait loci; Genetics; Genome wide association studies; Multiple sclerosis; Vitamin D

Indexed keywords

COLECALCIFEROL; TACALCITOL; VITAMIN D;

ADULT; ALLELE; ARTICLE; AUTOPSY; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; CYP24A1 GENE; ENZYME DEGRADATION; FRONTAL CORTEX; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC DATABASE; GENETIC RISK; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOMODULATION; MULTIPLE SCLEROSIS; PATHOGENESIS; UPREGULATION; VITAMIN D METABOLISM;

EID: 84892809390     PISSN: 22110348     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.msard.2013.08.009     Document Type: Article

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