Risk factors associated with adverse drug events among older adults in emergency department

European Journal of Internal Medicine

Volumn 25, Issue 1, 2014, Pages 49-55

  Chen, Yen Chia ^a,b,c   Fan, Ju Sing ^a,b   Chen, Min Hui ^d   Hsu, Teh Fu ^a,b   Huang, Hsien Hao ^a,b   Cheng, Kuo Wei ^a,b   Yen, David Hung Tsang ^b   Huang, Chun I ^a,b   Chen, Liang Kung ^a   Yang, Chen Chang ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c ROCKY MOUNTAIN POISON AND DRUG CENTER   (United States)

^d Vigor Medical Institute   (Taiwan)

Author keywords

Adverse drug event (ADE); Emergency department; Risk factors

Indexed keywords

ACETYLSALICYLIC ACID; ALANINE AMINOTRANSFERASE; ANALGESIC AGENT; ANTIARRHYTHMIC AGENT; ANTIASTHMATIC AGENT; ANTICOAGULANT AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTIINFECTIVE AGENT; ANTILIPEMIC AGENT; ANTINEOPLASTIC AGENT; ANTIRHEUMATIC AGENT; CARDIOVASCULAR AGENT; CONTRAST MEDIUM; CREATININE; DIURETIC AGENT; HYPNOTIC AGENT; LAXATIVE; NARCOTIC AGENT; NEUROLEPTIC AGENT; NON PRESCRIPTION DRUG; NONSTEROID ANTIINFLAMMATORY AGENT; STEROID; TICLOPIDINE; TOPICAL AGENT; UNINDEXED DRUG; VACCINE; VITAMIN;

ABDOMINAL PAIN; ABNORMAL FECES; ADVERSE DRUG REACTION; AGE DISTRIBUTION; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ATRIOVENTRICULAR BLOCK; BLOOD CLOTTING DISORDER; BRADYCARDIA; CASE CONTROL STUDY; CHARLSON COMORBIDITY INDEX; CHEST TIGHTNESS; CHRONIC KIDNEY FAILURE; COLD SWEAT; CONFUSION; CONSTIPATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIARRHEA; DIET SUPPLEMENTATION; DIZZINESS; DYSPNEA; ELECTROLYTE DISTURBANCE; EMERGENCY HEALTH SERVICE; EMERGENCY WARD; FATIGUE; FEMALE; FEVER; HEART PALPITATION; HOSPITAL ADMISSION; HOSPITAL PATIENT; HOSPITALIZATION; HUMAN; HYPERKALEMIA; HYPOGLYCEMIA; HYPOKALEMIA; HYPONATREMIA; HYPOTENSION; LOSS OF APPETITE; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PHYSICIAN; RASH; RHABDOMYOLYSIS; RISK FACTOR; SEX DIFFERENCE; STEVENS JOHNSON SYNDROME; TAIWAN; TERTIARY CARE CENTER; TOXIC HEPATITIS; UPPER GASTROINTESTINAL BLEEDING; URINE RETENTION; VERY ELDERLY; VOMITING;

ADVERSE DRUG EVENT (ADE); EMERGENCY DEPARTMENT; RISK FACTORS;

AGE FACTORS; AGED; AGED, 80 AND OVER; ALANINE TRANSAMINASE; ANALGESICS; ANTICOAGULANTS; CARDIOVASCULAR AGENTS; CASE-CONTROL STUDIES; CREATININE; DIURETICS; DRUG-INDUCED LIVER INJURY; DRUG-RELATED SIDE EFFECTS AND ADVERSE REACTIONS; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; LOGISTIC MODELS; MALE; POLYPHARMACY; PROSPECTIVE STUDIES; RENAL INSUFFICIENCY; RISK FACTORS; SEX FACTORS; TAIWAN;

EID: 84892798394     PISSN: 09536205     EISSN: 18790828     Source Type: Journal    
DOI: 10.1016/j.ejim.2013.10.006     Document Type: Article

References (42)

1. J.R. Nebeker, P. Barach, and M.H. Samore Clarifying adverse drug events: a clinician's guide to terminology, documentation, and reporting Ann Intern Med 140 2004 795 801
2. J.W. Hafner Jr., S.M. Belknap, M.D. Squillante, and K.A. Bucheit Adverse drug events in emergency department patients Ann Emerg Med 39 2002 258 267
3. L. Juntti-Patinen, and P.J. Neuvonen Drug-related deaths in a university central hospital Eur J Clin Pharmacol 58 2002 479 482
4. U. Sarkar, A. Lopez, J.H. Maselli, and R. Gonzales Adverse drug events in U.S. adult ambulatory medical care Health Serv Res 46 2011 1517 1533
5. M. Zhang, C.D. Holman, D.B. Preen, and K. Brameld Repeat adverse drug reactions causing hospitalization in older Australians: a population-based longitudinal study 1980-2003 Br J Clin Pharmacol 63 2007 163 170
6. J.H. Gurwitz, T.S. Field, L.R. Harrold, J. Rothschild, K. Debellis, and A.C. Seger et al. Incidence and preventability of adverse drug events among older persons in the ambulatory setting JAMA 289 2003 1107 1116
7. G. Trifiro, G. Calogero, F.M. Ippolito, M. Cosentino, R. Giuliani, and A. Conforti et al. Adverse drug events in emergency department population: a prospective Italian study Pharmacoepidemiol Drug Saf 14 2005 333 340
8. A Capuano, A. Irpino, M. Gallo, L. Ferrante, M.L. Illiano, and B. Rinaldi et al. Regional surveillance of emergency-department visits for outpatient adverse drug events Eur J Clin Pharmacol 65 2009 721 728
9. S.I. Haider, K. Johnell, M. Thorslund, and J. Fastbom Trends in polypharmacy and potential drug-drug interactions across educational groups in elderly patients in Sweden for the period 1992-2002 Int J Clin Pharmacol Ther 45 2007 643 653
10. K. Johnell, J. Fastbom, M. Rosen, and A. Leimanis Inappropriate drug use in the elderly: a nationwide register-based study Ann Pharmacother 41 2007 1243 1248
11. E.S. ElDesoky Pharmacokinetic-pharmacodynamic crisis in the elderly Am J Ther 14 2007 488 498
12. A.J. McLean, and D.G. Le Couteur Aging biology and geriatric clinical pharmacology Pharmacol Rev 56 2004 163 184
13. B. Reason, M. Terner, A. Moses McKeag, B. Tipper, and G. Webster The impact of polypharmacy on the health of Canadian seniors Fam Pract 29 2012 427 432
14. T.S. Field, J.H. Gurwitz, J. Avorn, D. McCormick, S. Jain, and M. Eckler et al. Risk factors for adverse drug events among nursing home residents Arch Intern Med 161 2001 1629 1634
15. J.H. Gurwitz, and P. Rochon Improving the quality of medication use in elderly patients: a not-so-simple prescription Arch Intern Med 162 2002 1670 1672
16. R.S. Evans, J.F. Lloyd, G.J. Stoddard, J.R. Nebeker, and M.H. Samore Risk factors for adverse drug events: a 10-year analysis Ann Pharmacother 39 2005 1161 1168
17. A. Hellden, U. Bergman, M. von Euler, M. Hentschke, I. Odar-Cederlof, and G. Ohlen Adverse drug reactions and impaired renal function in elderly patients admitted to the emergency department: a retrospective study Drugs Aging 26 2009 595 606
18. T. Egger, H. Dormann, G. Ahne, A. Pahl, U. Runge, and T. Azaz-Livshits et al. Cytochrome P450 polymorphisms in geriatric patients: impact on adverse drug reactions - a pilot study Drugs Aging 22 2005 265 272
19. U.A. Meyer Pharmacogenetics and adverse drug reactions Lancet 356 2000 1667 1671
20. K.A. Phillips, D.L. Veenstra, E. Oren, J.K. Lee, and W. Sadee Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review JAMA 286 2001 2270 2279
21. Y.C. Chen, J.S. Fan, T.F. Hsu, M.H. Chen, H.H. Huang, and K.W. Cheng et al. Detection of patients presenting with adverse drug events in the emergency department Intern Med J 42 2012 651 657
22. D.S. Budnitz, D.A. Pollock, A.B. Mendelsohn, K.N. Weidenbach, A.K. McDonald, and J.L. Annest Emergency department visits for outpatient adverse drug events: demonstration for a national surveillance system Ann Emerg Med 45 2005 197 206
23. C.A. Naranjo, U. Busto, E.M. Sellers, P. Sandor, I. Ruiz, and A.E. Roberts et al. A method for estimating the probability of adverse drug reactions Clin Pharmacol Ther 30 1981 239 245
24. I.R. Edwards, and J.K. Aronson Adverse drug reactions: definitions, diagnosis, and management Lancet 356 2000 1255 1259
25. C. Benichou Criteria of drug-induced liver disorders. Report of an international consensus meeting J Hepatol 11 1990 272 276
26. J.F. Mann, H.C. Gerstein, J. Pogue, J. Bosch, and S. Yusuf Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial Ann Intern Med 134 2001 629 636
27. C. Benichou, G. Danan, and A. Flahault Causality assessment of adverse reactions to drugs - II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge J Clin Epidemiol 46 1993 1331 1336
28. S. Wacholder, D.T. Silverman, J.K. McLaughlin, and J.S. Mandel Selection of controls in case-control studies. III. Design options Am J Epidemiol 135 1992 1042 1050
29. M.E. Charlson, P. Pompei, K.L. Ales, and C.R. MacKenzie A new method of classifying prognostic comorbidity in longitudinal studies: development and validation J Chronic Dis 40 1987 373 383
30. D.S. Budnitz, M.C. Lovegrove, N. Shehab, and C.L. Richards Emergency hospitalizations for adverse drug events in older Americans N Engl J Med 365 2011 2002 2012
31. C.M. Hohl, C. Robitaille, V. Lord, J. Dankoff, A. Colacone, and L. Pham et al. Emergency physician recognition of adverse drug-related events in elder patients presenting to an emergency department Acad Emerg Med 12 2005 197 205
32. T.S. Field, J.H. Gurwitz, L.R. Harrold, J. Rothschild, K.R. DeBellis, and A.C. Seger et al. Risk factors for adverse drug events among older adults in the ambulatory setting J Am Geriatr Soc 52 2004 1349 1354
33. C.M. Chang, P.Y. Liu, Y.H. Yang, Y.C. Yang, C.F. Wu, and F.H. Lu Use of the Beers criteria to predict adverse drug reactions among first-visit elderly outpatients Pharmacotherapy 25 2005 831 838
34. D.M. Fick, J.W. Cooper, W.E. Wade, J.L. Waller, J.R. Maclean, and M.H. Beers Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts Arch Intern Med 163 2003 2716 2724
35. D.S. Budnitz, N. Shehab, S.R. Kegler, and C.L. Richards Medication use leading to emergency department visits for adverse drug events in older adults Ann Intern Med 147 2007 755 765
36. S.L. Kane-Gill, L. Kirisci, M.M. Verrico, and J.M. Rothschild Analysis of risk factors for adverse drug events in critically ill patients Crit Care Med 40 2012 823 828
37. M.P. Ducharme, M. Smythe, and G. Strohs Drug-induced alterations in serum creatinine concentrations Ann Pharmacother 27 1993 622 633
38. G. Onder, M. Petrovic, B. Tangiisuran, M.C. Meinardi, W.P. Markito-Notenboom, and A. Somers et al. Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older: the GerontoNet ADR risk score Arch Intern Med 170 2010 1142 1148
39. D.E. Everitt, and J. Avorn Drug prescribing for the elderly Arch Intern Med 146 1986 2393 2396
40. B. Begaud, K. Martin, A. Fourrier, and F. Haramburu Does age increase the risk of adverse drug reactions? Br J Clin Pharmacol 54 2002 550 552
41. J.H. Wasson, H.C. Sox, R.K. Neff, and L. Goldman Clinical prediction rules. Applications and methodological standards N Engl J Med 313 1985 793 799
42. E. Seevak, D.J. Kent, and E. Wagner A pharmacist-based screening program of octogenarians starting new medications J Manag Care Pharm 9 2003 13 18