Immunohistochemical study of 36 cases of pulmonary sarcomatoid carcinoma - Sensitivity of TTF-1 is superior to napsin

Human Pathology

Volumn 45, Issue 2, 2014, Pages 294-302

  Terra, Simone B S P ^a   Aubry, Marie Christine ^a   Yi, Eunhee S ^a   Boland, Jennifer M ^a  

^a MAYO CLINIC   (United States)

Author keywords

Lung sarcomatoid carcinoma; Napsin; TTF 1

Indexed keywords

CALRETININ; CYTOKERATIN AE1; CYTOKERATIN AE3; DESMIN; KERATIN; KERATIN CAM5.2; KERATIN OSCAR; MONOCLONAL ANTIBODY D2-40; NAPSIN A; PROTEIN S 100; THYROID TRANSCRIPTION FACTOR 1; TUMOR MARKER; UNCLASSIFIED DRUG; WT1 PROTEIN;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CARCINOMA; CARCINOSARCOMA; CLINICAL ARTICLE; FEMALE; FOLLOW UP; GIANT CELL CARCINOMA; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG CARCINOMA; MALE; MIDDLE AGED; PLEOMORPHIC CARCINOMA; PULMONARY SARCOMATOID CARCINOMA; SARCOMATOID CARCINOMA; SPINDLE CELL CARCINOMA; VERY ELDERLY;

LUNG SARCOMATOID CARCINOMA; NAPSIN; TTF-1;

AGED; AGED, 80 AND OVER; ASPARTIC ACID ENDOPEPTIDASES; CARCINOMA; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOSARCOMA; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 84892796582     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2013.09.005     Document Type: Article

References (32)

1. Travis W.D., Brambilla E., Muller-Hermelink H.K., and Harris C.C., eds. Pathology & Genetics, Tumors of the the Lung, Pleura, Thymus and Heart. World Health Organization Classification of Tumours 2004, IARC Press: Lyon.
2. N.F. Fishback, W.D. Travis, C.A. Moran, D.G. Guinee Jr., W.F. McCarthy, and M.N. Koss Pleomorphic (spindle/giant cell) carcinoma of the lung. A clinicopathologic correlation of 78 cases Cancer 73 1994 2936 2945
3. G. Rossi, A. Cavazza, and N. Sturm et al. Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases Am J Surg Pathol 27 2003 311 324
4. M. Nakajima, T. Kasai, H. Hashimoto, Y. Iwata, and H. Manabe Sarcomatoid carcinoma of the lung: a clinicopathologic study of 37 cases Cancer 86 1999 608 616
5. W.D. Travis, L.B. Travis, and S.S. Devesa Lung cancer Cancer 75 1995 191 202
6. J.Y. Ro, J.L. Chen, J.S. Lee, A.A. Sahin, N.G. Ordonez, and A.G. Ayala Sarcomatoid carcinoma of the lung. Immunohistochemical and ultrastructural studies of 14 cases Cancer 69 1992 376 386
7. O. Nappi, S.D. Glasner, P.E. Swanson, and M.R. Wick Biphasic and monophasic sarcomatoid carcinomas of the lung. A reappraisal of "carcinosarcomas" and "spindle-cell carcinomas" Am J Clin Pathol 102 1994 331 340
8. Y.L. Chang, Y.C. Lee, J.Y. Shih, and C.T. Wu Pulmonary pleomorphic (spindle) cell carcinoma: peculiar clinicopathologic manifestations different from ordinary non-small cell carcinoma Lung Cancer 34 2001 91 97
9. D.R. Lucas, H.I. Pass, and S.K. Madan et al. Sarcomatoid mesothelioma and its histological mimics: a comparative immunohistochemical study Histopathology 42 2003 270 279
10. Y. Takeshima, V.J. Amatya, K. Kushitani, M. Kaneko, and K. Inai Value of immunohistochemistry in the differential diagnosis of pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma Histopathology 54 2009 667 676
11. K. Mori, Y. Ogawa, and N. Tamura et al. Molecular cloning of a novel mouse aspartic protease-like protein that is expressed abundantly in the kidney FEBS Letters 401 1997 218 222
12. P.J. Tatnell, D.J. Powell, J. Hill, T.S. Smith, D.G. Tew, and J. Kay Napsins: new human aspartic proteinases. Distinction between two closely related genes FEBS Letters 441 1998 43 48
13. Y. Chuman, A. Bergman, and T. Ueno et al. Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas FEBS lett 462 1999 129 134
14. V. Schauer-Vukasinovic, D. Bur, D. Kling, F. Gruninger, and T. Giller Human napsin A: expression, immunochemical detection, and tissue localization FEBS Letters 462 1999 135 139
15. T. Hirano, G. Auer, and M. Maeda et al. Human tissue distribution of TA02, which is homologous with a new type of aspartic proteinase, napsin A Jpn J Cancer Res 91 2000 1015 1021
16. K. Mori, Y. Kon, A. Konno, and T. Iwanaga Cellular distribution of napsin (kidney-derived aspartic protease-like protein, KAP) mRNA in the kidney, lung and lymphatic organs of adult and developing mice Arch Histol Cytol 64 2001 319 327
17. F. Brasch, M. Ochs, and T. Kahne et al. Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung J Biol Chem 278 2003 49006 49014
18. T. Ueno, S. Linder, C.L. Na, W.R. Rice, J. Johansson, and T.E. Weaver Processing of pulmonary surfactant protein B by napsin and cathepsin H J Biol Chem 279 2004 16178 16184
19. B.M. Turner, P.T. Cagle, I.M. Sainz, J. Fukuoka, S.S. Shen, and J. Jagirdar Napsin A, a new marker for lung adenocarcinoma, is complementary and more sensitive and specific than thyroid transcription factor 1 in the differential diagnosis of primary pulmonary carcinoma: evaluation of 1674 cases by tissue microarray Arch Pathol Lab Med 136 2012 163 171
20. J.A. Bishop, R. Sharma, and P.B. Illei Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma Hum Pathol 41 2010 20 25
21. J. Ye, J.J. Findeis-Hosey, and Q. Yang et al. Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung Appl Immunohistochem Mol Morphol 19 2011 313 317
22. N.G. Ordonez A word of caution regarding napsin A expression in squamous cell carcinomas of the lung Am J Surg Pathol 36 2012 396 401
23. N.G. Ordonez Napsin A expression in lung and kidney neoplasia: a review and update Adv Anat Pathol 19 2012 66 73
24. W.D. Travis Sarcomatoid neoplasms of the lung and pleura Arch Pathol Lab Med 134 2010 1645 1658
25. L.A. Litzky Pulmonary sarcomatous tumors Arch Pathol Lab Med 132 2008 1104 1117
26. K. Kushitani, Y. Takeshima, V.J. Amatya, O. Furonaka, A. Sakatani, and K. Inai Differential diagnosis of sarcomatoid mesothelioma from true sarcoma and sarcomatoid carcinoma using immunohistochemistry Pathol Int 58 2008 75 83
27. D.M. Padgett, H.P. Cathro, M.R. Wick, and S.E. Mills Podoplanin is a better immunohistochemical marker for sarcomatoid mesothelioma than calretinin Am J Surg Pathol 32 2008 123 127
28. R.L. Attanoos, S.D. Dojcinov, R. Webb, and A.R. Gibbs Anti-mesothelial markers in sarcomatoid mesothelioma and other spindle cell neoplasms Histopathol 37 2000 224 231
29. J. Terry, T. Saito, and S. Subramanian et al. TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies Am J Surg Pathol 31 2007 240 246
30. A. Matsuyama, M. Hisaoka, M. Iwasaki, M. Iwashita, S. Hisanaga, and H. Hashimoto TLE1 expression in malignant mesothelioma Virchows Arch 457 2010 577 583
31. H. Kenmotsu, G. Ishii, and K. Nagai et al. Pleomorphic carcinoma of the lung expressing podoplanin and calretinin Pathology Int 58 2008 771 774
32. S. Haraguchi, Y. Fukuda, Y. Sugisaki, and N. Yamanaka Pulmonary carcinosarcoma: immunohistochemical and ultrastructural studies Pathol Int 49 1999 903 908