Pleomorphic carcinoma of the lung expressing podoplanin and calretinin

Pathology International

Volumn 58, Issue 12, 2008, Pages 771-774

  Kenmotsu, Hirotsugu ^a,b   Ishii, Genichiro ^a   Nagai, Kanji ^b   Nakao, Masayuki ^a,b   Kawase, Akikazu ^a,b   Kojika, Masakazu ^a,b   Murata, Yukinori ^a   Nishiwaki, Yutaka ^b   Ochiai, Atsushi ^a,b  

^a Research Center for Innovative Oncology   (Japan)

^b NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

Author keywords

Calretinin; Differential diagnosis; Malignant mesothelioma; Pleomorphic carcinoma of the lung; Podoplanin; Sarcomatoid component

Indexed keywords

CALRETININ; PODOPLANIN;

AGED; ARTICLE; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC APPROACH ROUTE; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST; DIFFERENTIAL DIAGNOSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENT CELL; LUNG ALVEOLUS CELL CARCINOMA; LUNG BIOPSY; LUNG CARCINOMA; MALE; MEDICAL EXAMINATION; NEEDLE BIOPSY; PLEOMORPHIC CARCINOMA OF THE LUNG; PLEURA MESOTHELIOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINDLE CELL CARCINOMA; THORAX RADIOGRAPHY; TISSUE SECTION; UNDIFFERENTIATED CARCINOMA;

AGED, 80 AND OVER; BIOPSY, NEEDLE; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CARCINOMA; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MEMBRANE GLYCOPROTEINS; MESOTHELIOMA; TUMOR MARKERS, BIOLOGICAL;

EID: 56049121224     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2008.02309.x     Document Type: Article

References (18)

1. Travis WD, Brambilla E, Muller-Hermelink HK et al. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Lyon : IARCPress, 2003.
2. Travis WD. Pathology of lung cancer. Clin Chest Med 2002 23 : 65 81, viii.
3. Hinterberger M, Reineke T, Storz M et al. D2-40 and calretinin: A tissue microarray analysis of 341 malignant mesotheliomas with emphasis on sarcomatoid differentiation. Mod Pathol 2007 20 : 248 55.
4. Ordonez NG. What are the current best immunohistochemical markers for the diagnosis of epithelioid mesothelioma? A review and update. Hum Pathol 2007 38 : 1 16.
5. Padgett DM, Cathro HP, Wick MR et al. Podoplanin is a better immunohistochemical marker for sarcomatoid mesothelioma than calretinin. Am J Surg Pathol 2008 32 : 123 7.
6. Doglioni C, Tos AP, Laurino L et al. Calretinin: A novel immunocytochemical marker for mesothelioma. Am J Surg Pathol 1996 20 : 1037 46.
7. Marks A, Sutherland DR, Bailey D et al. Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours. Br J Cancer 1999 80 : 569 78.
8. Breiteneder-Geleff S, Soleiman A, Kowalski H et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: Podoplanin as a specific marker for lymphatic endothelium. Am J Pathol 1999 154 : 385 94.
9. Ordonez NG. Podoplanin: A novel diagnostic immunohistochemical marker. Adv Anat Pathol 2006 13 : 83 8.
10. Schacht V, Dadras SS, Johnson LA et al. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol 2005 166 : 913 21.
11. Lugli A, Forster Y, Haas P et al. Calretinin expression in human normal and neoplastic tissues: A tissue microarray analysis on 5233 tissue samples. Hum Pathol 2003 34 : 994 1000.
12. Naito Y, Ishii G, Kawai O et al. D2-40-positive solitary fibrous tumors of the pleura: Diagnostic pitfall of biopsy specimen. Pathol Int 2007 57 : 618 21.
13. Rossi G, Cavazza A, Sturm N et al. Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: A clinicopathologic and immunohistochemical study of 75 cases. Am J Surg Pathol 2003 27 : 311 24.
14. Fishback NF, Travis WD, Moran CA et al. Pleomorphic (spindle/giant cell) carcinoma of the lung. A clinicopathologic correlation of 78 cases. Cancer 1994 73 : 2936 45.
15. Chu AY, Litzky LA, Pasha TL et al. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol 2005 18 : 105 10.
16. Lucas DR, Pass HI, Madan SK et al. Sarcomatoid mesothelioma and its histological mimics: A comparative immunohistochemical study. Histopathology 2003 42 : 270 79.
17. Miettinen M, Sarlomo-Rikala M. Expression of calretinin, thrombomodulin, keratin 5, and mesothelin in lung carcinomas of different types: An immunohistochemical analysis of 596 tumors in comparison with epithelioid mesotheliomas of the pleura. Am J Surg Pathol 2003 27 : 150 58.
18. Kushitani K, Takeshima Y, Amatya VJ et al. Differential diagnosis of sarcomatoid mesothelioma from true sarcoma and sarcomatoid carcinoma using immunohistochemistry. Pathol Int 2008 58 : 75 83.