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Volumn 120, Issue SUPPL. 1, 2013, Pages

Biotherapeutics for the treatment of multiple sclerosis: Hopes and hazards

Author keywords

Benefit; Immunotherapy; Multiple sclerosis; Relapsing remitting MS; Risk; Treatment choices

Indexed keywords

ALEMTUZUMAB; MONOCLONAL ANTIBODY; NATALIZUMAB;

EID: 84892782483     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-013-1055-4     Document Type: Review
Times cited : (5)

References (42)
  • 1
    • 77954864204 scopus 로고    scopus 로고
    • Fingolimod is a potential novel therapy for multiple sclerosis
    • Aktas O, Küry P, Kieseier B, Hartung HP (2010) Fingolimod is a potential novel therapy for multiple sclerosis. Nat Rev Neurol 6:373-382
    • (2010) Nat Rev Neurol , vol.6 , pp. 373-382
    • Aktas, O.1    Küry, P.2    Kieseier, B.3    Hartung, H.P.4
  • 6
    • 70350041408 scopus 로고    scopus 로고
    • Natalizumab: A double-edged sword?
    • doi:10.1002/ana.21813
    • DeAngelis LM (2009) Natalizumab: a double-edged sword? Ann Neurol 66(3):262-263. doi:10.1002/ana.21813
    • (2009) Ann Neurol , vol.66 , Issue.3 , pp. 262-263
    • Deangelis, L.M.1
  • 7
    • 84869885852 scopus 로고    scopus 로고
    • Capture, crawl, cross: The T cell code to breach the blood-brain barriers
    • doi:10.1016/j.it.2012.07.004
    • Engelhardt B, Ransohoff RM (2012) Capture, crawl, cross: the T cell code to breach the blood-brain barriers. Trends Immunol 33(12):579-589. doi:10.1016/j.it.2012.07.004
    • (2012) Trends Immunol , vol.33 , Issue.12 , pp. 579-589
    • Engelhardt, B.1    Ransohoff, R.M.2
  • 8
    • 57149117126 scopus 로고    scopus 로고
    • New cases of progressive multifocal leukoencephalopathy after treatment with natalizumab
    • doi:10.1016/S1474-4422(08)70281-3
    • Hartung HP (2009) New cases of progressive multifocal leukoencephalopathy after treatment with natalizumab. Lancet Neurol 8(1):28-31. doi:10.1016/S1474-4422(08)70281-3
    • (2009) Lancet Neurol , vol.8 , Issue.1 , pp. 28-31
    • Hartung, H.P.1
  • 10
    • 79952660229 scopus 로고    scopus 로고
    • Principles of a new treatment algorithm in multiple sclerosis
    • doi:10.1586/ern. 11.15
    • Hartung HP, Montalban X, Sorensen PS, Vermersch P, Olsson T (2011) Principles of a new treatment algorithm in multiple sclerosis. Expt Rev Neurother 11(3):351-362. doi:10.1586/ern. 11.15
    • (2011) Expt Rev Neurother , vol.11 , Issue.3 , pp. 351-362
    • Hartung, H.P.1    Montalban, X.2    Sorensen, P.S.3    Vermersch, P.4    Olsson, T.5
  • 12
    • 60049089535 scopus 로고    scopus 로고
    • Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: A retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study
    • doi:10.1016/S1474-4422(09)70021-3
    • Havrdova E, Galetta S, Hutchinson M, Stefoski D, Bates D, Polman CH, O'Connor PW, Giovannoni G, Phillips JT, Lublin FD, Pace A, Kim R, Hyde R (2009) Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study. Lancet Neurol 8(3):254-260. doi:10.1016/S1474-4422(09)70021-3
    • (2009) Lancet Neurol , vol.8 , Issue.3 , pp. 254-260
    • Havrdova, E.1    Galetta, S.2    Hutchinson, M.3    Stefoski, D.4    Bates, D.5    Polman, C.H.6    O'connor, P.W.7    Giovannoni, G.8    Phillips, J.T.9    Lublin, F.D.10    Pace, A.11    Kim, R.12    Hyde, R.13
  • 13
    • 33744487388 scopus 로고    scopus 로고
    • Central nervous system infections: A potential complication of systemic immunotherapy
    • Hemmer B, Frohman E, Hartung H-P, Stüve O (2006) Central nervous system infections: a potential complication of systemic immunotherapy. Curr Opin Neurol 19:271-276
    • (2006) Curr Opin Neurol , vol.19 , pp. 271-276
    • Hemmer, B.1    Frohman, E.2    Hartung, H.-P.3    Stüve, O.4
  • 16
    • 0029082566 scopus 로고
    • Copolymer 1 reduces relapse rate and improves disability in relapsingremitting multiple sclerosis: Results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group
    • Johnson KP, Brooks BR, Cohen JA, Ford CC, Goldstein J, Lisak RP, Myers LW, Panitch HS, Rose JW, Schiffer RB (1995) Copolymer 1 reduces relapse rate and improves disability in relapsingremitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group. Neurology 45(7):1268-1276
    • (1995) Neurology , vol.45 , Issue.7 , pp. 1268-1276
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3    Ford, C.C.4    Goldstein, J.5    Lisak, R.P.6    Myers, L.W.7    Panitch, H.S.8    Rose, J.W.9    Schiffer, R.B.10
  • 18
    • 81555202418 scopus 로고    scopus 로고
    • Ocrelizumab in relapsing-remitting multiple sclerosis: A phase 2, randomised, placebo-controlled, multicentre trial
    • doi:10.1016/S0140-6736(11)61649-8
    • Kappos L, Li D, Calabresi PA, O'Connor P, Bar-Or A, Barkhof F, Yin M, Leppert D, Glanzman R, Tinbergen J, Hauser SL (2011) Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial. Lancet 378(9805):1779-1787. doi:10.1016/S0140-6736(11)61649-8
    • (2011) Lancet , vol.378 , Issue.9805 , pp. 1779-1787
    • Kappos, L.1    Li, D.2    Calabresi, P.A.3    O'connor, P.4    Bar-Or, A.5    Barkhof, F.6    Yin, M.7    Leppert, D.8    Glanzman, R.9    Tinbergen, J.10    Hauser, S.L.11
  • 19
    • 79955573527 scopus 로고    scopus 로고
    • Risks and benefits of multiple sclerosis therapies: Need for continual assessment?
    • doi: 10.1097/WCO.0b013e32834696dd
    • Kieseier BC, Wiendl H, Hartung HP, Leussink VI, Stuve O (2011) Risks and benefits of multiple sclerosis therapies: need for continual assessment? Curr Opin Neurol 24(3):238-243. doi: 10.1097/WCO.0b013e32834696dd
    • (2011) Curr Opin Neurol , vol.24 , Issue.3 , pp. 238-243
    • Kieseier, B.C.1    Wiendl, H.2    Hartung, H.P.3    Leussink, V.I.4    Stuve, O.5
  • 20
    • 84862861720 scopus 로고    scopus 로고
    • Update on PML and PML-IRIS occurring in multiple sclerosis patients treated with natalizumab
    • doi:10.1097/NEN.0b013e 31825caf2c
    • Kleinschmidt-De Masters BK, Miravalle A, Schowinsky J, Corboy J, Vollmer T (2012) Update on PML and PML-IRIS occurring in multiple sclerosis patients treated with natalizumab. J Neuropathol Exp Neurol 71(7):604-617. doi:10.1097/NEN.0b013e 31825caf2c
    • (2012) J Neuropathol Exp Neurol , vol.71 , Issue.7 , pp. 604-617
    • Kleinschmidt-De Masters, B.K.1    Miravalle, A.2    Schowinsky, J.3    Corboy, J.4    Vollmer, T.5
  • 21
    • 22844445230 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy in a patient treated with natalizumab
    • doi:10.1056/ NEJMoa051847
    • Langer-Gould A, Atlas SW, Green AJ, Bollen AW, Pelletier D (2005) Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 353(4):375-381. doi:10.1056/ NEJMoa051847
    • (2005) N Engl J Med , vol.353 , Issue.4 , pp. 375-381
    • Langer-Gould, A.1    Atlas, S.W.2    Green, A.J.3    Bollen, A.W.4    Pelletier, D.5
  • 22
    • 84993741950 scopus 로고    scopus 로고
    • Innovative monoclonal antibody therapies in multiple sclerosis
    • doi:10.1177/1756285608093945
    • Linker RA, Kieseier BC (2008) Innovative monoclonal antibody therapies in multiple sclerosis. Therap Adv Neurol Disorders 1(1):43-52. doi:10.1177/1756285608093945
    • (2008) Therap Adv Neurol Disorders , vol.1 , Issue.1 , pp. 43-52
    • Linker, R.A.1    Kieseier, B.C.2
  • 24
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group
    • PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group (1998) Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. Lancet 352(9139):1498-1504
    • (1998) Lancet , vol.352 , Issue.9139 , pp. 1498-1504
  • 27
    • 84868198919 scopus 로고    scopus 로고
    • Signals of progressive multifocal leukoencephalopathy for immunosuppressants: A disproportionality analysis of spontaneous reports within the US Adverse Event Reporting System (AERS)
    • doi:10.1002/pds.3320
    • Schmedt N, Andersohn F, Garbe E (2012) Signals of progressive multifocal leukoencephalopathy for immunosuppressants: a disproportionality analysis of spontaneous reports within the US Adverse Event Reporting System (AERS). Pharmacoepidemiol Drug Safety 21(11):1216-1220. doi:10.1002/pds.3320
    • (2012) Pharmacoepidemiol Drug Safety , vol.21 , Issue.11 , pp. 1216-1220
    • Schmedt, N.1    Andersohn, F.2    Garbe, E.3
  • 28
    • 84892827183 scopus 로고    scopus 로고
    • Genetic influence on anti-JC-virus antibody seropositivity in MS patients and controls
    • Sundqvist E, Warnke C, Khademi M (2011) Genetic influence on anti-JC-virus antibody seropositivity in MS patients and controls. Multi Scler 17(Suppl 10):S358
    • (2011) Multi Scler , vol.17 , Issue.SUPPL. 10
    • Sundqvist, E.1    Warnke, C.2    Khademi, M.3
  • 29
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomized controlled trial
    • The IFNB Multiple Sclerosis Study Group, The University of British Columbia MS/MRI Analysis Group
    • The IFNB Multiple Sclerosis Study Group, The University of British Columbia MS/MRI Analysis Group (1995) Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurology 45(7):1277-1285
    • (1995) Neurology , vol.45 , Issue.7 , pp. 1277-1285
  • 33
    • 79955717389 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy under natalizumab. Initial possibilities for risk stratification?
    • doi:10.1007/s00115-010-3091-8
    • Warnke C, Adams O, Gold R, Hartung HP, Hohlfeld R, Wiendl H, Kieseier BC (2011a) Progressive multifocal leukoencephalopathy under natalizumab. Initial possibilities for risk stratification? Der Nervenarzt 82(4):475-480. doi:10.1007/s00115-010-3091-8
    • (2011) Der Nervenarzt , vol.82 , Issue.4 , pp. 475-480
    • Warnke, C.1    Adams, O.2    Gold, R.3    Hartung, H.P.4    Hohlfeld, R.5    Wiendl, H.6    Kieseier, B.C.7
  • 34
    • 80755130444 scopus 로고    scopus 로고
    • Risk stratification of progressive multifocal leukoencephalopathy under natalizumab: Recommendations for JC virus serology
    • doi:10.1007/s00115-011-3319-2
    • Warnke C, Adams O, Hartung HP, Gold R, Hemmer B, Hohlfeld R, Stangel M, Zipp F, Wiendl H, Kieseier BC (2011b) Risk stratification of progressive multifocal leukoencephalopathy under natalizumab: recommendations for JC virus serology. Der Nervenarzt 82(10):1314-1319. doi:10.1007/s00115-011-3319-2
    • (2011) Der Nervenarzt , vol.82 , Issue.10 , pp. 1314-1319
    • Warnke, C.1    Adams, O.2    Hartung, H.P.3    Gold, R.4    Hemmer, B.5    Hohlfeld, R.6    Stangel, M.7    Zipp, F.8    Wiendl, H.9    Kieseier, B.C.10
  • 35
    • 80955160568 scopus 로고    scopus 로고
    • Critical appraisal of the role of fingolimod in the treatment of multiple sclerosis
    • doi:10.2147/NDT.S10481
    • Warnke C, Stuve O, Hartung HP, Fogdell-Hahn A, Kieseier BC (2011c) Critical appraisal of the role of fingolimod in the treatment of multiple sclerosis. Neuropsychiatr Dis Treatm 7:519-527. doi:10.2147/NDT.S10481
    • (2011) Neuropsychiatr Dis Treatm , vol.7 , pp. 519-527
    • Warnke, C.1    Stuve, O.2    Hartung, H.P.3    Fogdell-Hahn, A.4    Kieseier, B.C.5
  • 39
    • 84874948941 scopus 로고    scopus 로고
    • Multiple sclerosis: Reprogramming the immune repertoire with alemtuzumab in MS
    • doi:10.1038/nrneurol.2013.2
    • Wiendl H, Kieseier B (2013) Multiple sclerosis: reprogramming the immune repertoire with alemtuzumab in MS. Nat Rev Neurol 9(3):125-126. doi:10.1038/nrneurol.2013.2
    • (2013) Nat Rev Neurol , vol.9 , Issue.3 , pp. 125-126
    • Wiendl, H.1    Kieseier, B.2
  • 40
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
    • doi:10.1038/356063a0
    • Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N (1992) Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 356(6364):63-66. doi:10.1038/356063a0
    • (1992) Nature , vol.356 , Issue.6364 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3    Sanchez-Madrid, F.4    Steinman, L.5    Karin, N.6
  • 42
    • 84871961775 scopus 로고    scopus 로고
    • Magnetic resonance imaging pattern in natalizumab-associated progressive multifocal leukoencephalopathy
    • doi:10.1002/ana.23676
    • Yousry TA, Pelletier D, Cadavid D, Gass A, Richert ND, Radue EW, Filippi M (2012) Magnetic resonance imaging pattern in natalizumab-associated progressive multifocal leukoencephalopathy. Ann Neurol 72(5):779-787. doi:10.1002/ana.23676
    • (2012) Ann Neurol , vol.72 , Issue.5 , pp. 779-787
    • Yousry, T.A.1    Pelletier, D.2    Cadavid, D.3    Gass, A.4    Richert, N.D.5    Radue, E.W.6    Filippi, M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.