-
1
-
-
77954243341
-
Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms
-
Akinc A, Querbes W, De S, Qin J, Frank-Kamenetsky M, Jayaprakash KN, Jayaraman M, Rajeev KG, Cantley WL, Dorkin JR, et al. 2010. Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms. Mol Ther 18:1357-1364.
-
(2010)
Mol Ther
, vol.18
, pp. 1357-1364
-
-
Akinc, A.1
Querbes, W.2
De, S.3
Qin, J.4
Frank-Kamenetsky, M.5
Jayaprakash, K.N.6
Jayaraman, M.7
Rajeev, K.G.8
Cantley, W.L.9
Dorkin, J.R.10
-
2
-
-
84864459298
-
Hepatocellualar carcinoma serum markers
-
Bertino G, Ardiri A, Malaguarnera M, Malaguarnera G, Bertino N, Calvagno GS. 2012. Hepatocellualar carcinoma serum markers. Semin Oncol 39:410-433.
-
(2012)
Semin Oncol
, vol.39
, pp. 410-433
-
-
Bertino, G.1
Ardiri, A.2
Malaguarnera, M.3
Malaguarnera, G.4
Bertino, N.5
Calvagno, G.S.6
-
3
-
-
0037351819
-
Cell-free nucleic acids in plasma, serum and urine: A new tool in molecular diagnosis
-
Chan AK, Chiu RW, Lo YM. 2003. Cell-free nucleic acids in plasma, serum and urine: A new tool in molecular diagnosis. Ann Clin Biochem 40 Pt 2:122-130.
-
(2003)
Ann Clin Biochem
, vol.40 PT. 2
, pp. 122-130
-
-
Chan, A.K.1
Chiu, R.W.2
Lo, Y.M.3
-
4
-
-
84883118140
-
Safety and efficacy of RNAi therapy for transthyretin amyloidosis
-
Coelho T, Adams D, Silva A, Lozeron P, Hawkins PN, Mant T, Perez J, Chiesa J, Warrington S, Tranter E, et al. 2013. Safety and efficacy of RNAi therapy for transthyretin amyloidosis. N Engl J Med 369:819-829.
-
(2013)
N Engl J Med
, vol.369
, pp. 819-829
-
-
Coelho, T.1
Adams, D.2
Silva, A.3
Lozeron, P.4
Hawkins, P.N.5
Mant, T.6
Perez, J.7
Chiesa, J.8
Warrington, S.9
Tranter, E.10
-
5
-
-
61349173156
-
Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes
-
Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, Valle M, Elortza F, Lu SC, Mato JM, Falcon-Perez JM. 2008. Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J Proteome Res 7:5157-5166.
-
(2008)
J Proteome Res
, vol.7
, pp. 5157-5166
-
-
Conde-Vancells, J.1
Rodriguez-Suarez, E.2
Embade, N.3
Gil, D.4
Matthiesen, R.5
Valle, M.6
Elortza, F.7
Lu, S.C.8
Mato, J.M.9
Falcon-Perez, J.M.10
-
6
-
-
77951132901
-
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
-
Davis ME, Zuckerman JE, Choi CH, Seligson D, Tolcher A, Alabi CA, Yen Y, Heidel JD, Ribas A. 2010. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 464:1067-1070.
-
(2010)
Nature
, vol.464
, pp. 1067-1070
-
-
Davis, M.E.1
Zuckerman, J.E.2
Choi, C.H.3
Seligson, D.4
Tolcher, A.5
Alabi, C.A.6
Yen, Y.7
Heidel, J.D.8
Ribas, A.9
-
7
-
-
33645075443
-
MiR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
-
Esau C, Davis S, Murray SF, Yu XX, Pandey SK, Pear M, Watts L, Booten SL, Graham M, McKay R, et al. 2006. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 3:87-98.
-
(2006)
Cell Metab
, vol.3
, pp. 87-98
-
-
Esau, C.1
Davis, S.2
Murray, S.F.3
Yu, X.X.4
Pandey, S.K.5
Pear, M.6
Watts, L.7
Booten, S.L.8
Graham, M.9
McKay, R.10
-
8
-
-
42649118442
-
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia IRIDA
-
Finberg KE, Heeney MM, Campagna DR, Aydinok Y, Pearson HA, Hartman KR, Mayo MM, Samuel SM, Strouse JJ, Markianos K, et al. 2008. Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia IRIDA. Nat Genet 40:569-571.
-
(2008)
Nat Genet
, vol.40
, pp. 569-571
-
-
Finberg, K.E.1
Heeney, M.M.2
Campagna, D.R.3
Aydinok, Y.4
Pearson, H.A.5
Hartman, K.R.6
Mayo, M.M.7
Samuel, S.M.8
Strouse, J.J.9
Markianos, K.10
-
9
-
-
50149101511
-
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
-
Frank-Kamenetsky M, Grefhorst A, Anderson NN, Racie TS, Bramlage B, Akinc A, Butler D, Charisse K, Dorkin R, Fan Y, et al. 2008. Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci 105:11915-11920.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 11915-11920
-
-
Frank-Kamenetsky, M.1
Grefhorst, A.2
Anderson, N.N.3
Racie, T.S.4
Bramlage, B.5
Akinc, A.6
Butler, D.7
Charisse, K.8
Dorkin, R.9
Fan, Y.10
-
10
-
-
76749115747
-
The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid
-
Harrington MG, Fonteh AN, Oborina E, Liao P, Cowan RP, McComb G, Chavez JN, Rush J, Biringer RG, Huhmer AF. 2009. The morphology and biochemistry of nanostructures provide evidence for synthesis and signaling functions in human cerebrospinal fluid. Cerebrospinal Fluid Res 6:10.
-
(2009)
Cerebrospinal Fluid Res
, vol.6
, pp. 10
-
-
Harrington, M.G.1
Fonteh, A.N.2
Oborina, E.3
Liao, P.4
Cowan, R.P.5
McComb, G.6
Chavez, J.N.7
Rush, J.8
Biringer, R.G.9
Huhmer, A.F.10
-
11
-
-
2642564039
-
Comparative analysis of adenoviral transgene delivery via tail or portal vein into rat liver
-
Herrmann J, Abriss B, Van De Leur E, Weiskirchen S, Gressner AM, Weiskirchen R. 2004. Comparative analysis of adenoviral transgene delivery via tail or portal vein into rat liver. Arch Virol 149:1611-1617.
-
(2004)
Arch Virol
, vol.149
, pp. 1611-1617
-
-
Herrmann, J.1
Abriss, B.2
Van De Leur, E.3
Weiskirchen, S.4
Gressner, A.M.5
Weiskirchen, R.6
-
12
-
-
79957879331
-
Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis
-
Hood JL, San RS, Wickline SA. 2011. Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res 71:3792-3801.
-
(2011)
Cancer Res
, vol.71
, pp. 3792-3801
-
-
Hood, J.L.1
San, R.S.2
Wickline, S.A.3
-
13
-
-
57849130395
-
Detection of microRNA expression in human peripheral blood microvesicles
-
Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, Yu L, Xiao T, Schafer J, Lee ML, Schmittgen TD, et al. 2008. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One 3:e3694.
-
(2008)
PLoS One
, vol.3
-
-
Hunter, M.P.1
Ismail, N.2
Zhang, X.3
Aguda, B.D.4
Lee, E.J.5
Yu, L.6
Xiao, T.7
Schafer, J.8
Lee, M.L.9
Schmittgen, T.D.10
-
14
-
-
0015350817
-
Nucleic acid concentrations in normal human plasma
-
Kamm RC, Smith AG. 1972. Nucleic acid concentrations in normal human plasma. Clin Chem 18:519-522.
-
(1972)
Clin Chem
, vol.18
, pp. 519-522
-
-
Kamm, R.C.1
Smith, A.G.2
-
15
-
-
28444469246
-
Silencing of microRNAs in vivo with 'antagomirs'
-
Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, Stoffel M. 2005. Silencing of microRNAs in vivo with 'antagomirs.' Nature 438:685-689.
-
(2005)
Nature
, vol.438
, pp. 685-689
-
-
Krutzfeldt, J.1
Rajewsky, N.2
Braich, R.3
Rajeev, K.G.4
Tuschl, T.5
Manoharan, M.6
Stoffel, M.7
-
16
-
-
58149269261
-
In vivo silencing of α-synuclein using naked siRNA
-
Lewis J, Melrose H, Bumcrot D, Hope A, Zehr C, Lincoln S, Braithwaite A, He Z, Ogholikhan S, Hinkle K, et al. 2008. In vivo silencing of α-synuclein using naked siRNA. Mol Neurodegener 3:19.
-
(2008)
Mol Neurodegener
, vol.3
, pp. 19
-
-
Lewis, J.1
Melrose, H.2
Bumcrot, D.3
Hope, A.4
Zehr, C.5
Lincoln, S.6
Braithwaite, A.7
He, Z.8
Ogholikhan, S.9
Hinkle, K.10
-
17
-
-
76649098887
-
Lipid-like materials for low-dose, in vivo gene silencing
-
Love KT, Mahon KP, Levins CG, Whitehead KA, Querbes W, Dorkin JR, Qin J, Cantley W, Qin LL, Racie T, et al. 2010. Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci 107:1864-1869.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 1864-1869
-
-
Love, K.T.1
Mahon, K.P.2
Levins, C.G.3
Whitehead, K.A.4
Querbes, W.5
Dorkin, J.R.6
Qin, J.7
Cantley, W.8
Qin, L.L.9
Racie, T.10
-
18
-
-
34249335372
-
Extracellular nucleic acids and their potential as diagnostic, prognostic and predictive biomarkers
-
O'Driscoll L. 2007. Extracellular nucleic acids and their potential as diagnostic, prognostic and predictive biomarkers. Anticancer Res 27:1257-1265.
-
(2007)
Anticancer Res
, vol.27
, pp. 1257-1265
-
-
O'Driscoll, L.1
-
19
-
-
61349120741
-
Direct CNS delivery of siRNA mediates robust silencing in oligodendrocytes
-
Querbes W, Ge P, Zhang W, Fan Y, Costigan J, Charisse K, Maier M, Nechev L, Manoharan M, Kotelianski V, et al. 2009. Direct CNS delivery of siRNA mediates robust silencing in oligodendrocytes. Oligonucleotides 19:23-29.
-
(2009)
Oligonucleotides
, vol.19
, pp. 23-29
-
-
Querbes, W.1
Ge, P.2
Zhang, W.3
Fan, Y.4
Costigan, J.5
Charisse, K.6
Maier, M.7
Nechev, L.8
Manoharan, M.9
Kotelianski, V.10
-
20
-
-
79551475841
-
Advances in membranous vesicle and exosome proteomics improving biological understanding and biomarker discovery
-
Raimondo F, Morosi L, Chinello C, Magni F, Pitto M. 2011. Advances in membranous vesicle and exosome proteomics improving biological understanding and biomarker discovery. Proteomics 11:709-720.
-
(2011)
Proteomics
, vol.11
, pp. 709-720
-
-
Raimondo, F.1
Morosi, L.2
Chinello, C.3
Magni, F.4
Pitto, M.5
-
22
-
-
0028969996
-
Transthyretin mutations in health and disease
-
Saraiva MJ. 1995. Transthyretin mutations in health and disease. Hum Mutat 5:191-196.
-
(1995)
Hum Mutat
, vol.5
, pp. 191-196
-
-
Saraiva, M.J.1
-
23
-
-
38949191397
-
Exosomal transfer of proteins and RNAs at synapses in the nervous system
-
Smalheiser NR. 2007. Exosomal transfer of proteins and RNAs at synapses in the nervous system. Biol Direct 2:35.
-
(2007)
Biol Direct
, vol.2
, pp. 35
-
-
Smalheiser, N.R.1
-
24
-
-
0030882856
-
α-Synuclein in Lewy bodies
-
Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. 1997. α-Synuclein in Lewy bodies. Nature 388:839-840.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
25
-
-
34249302620
-
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
-
Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. 2007. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9:654-659.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 654-659
-
-
Valadi, H.1
Ekstrom, K.2
Bossios, A.3
Sjostrand, M.4
Lee, J.J.5
Lotvall, J.O.6
-
26
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann TS, Lee AC, Akinc A, Bramlage B, Bumcrot D, Fedoruk MN, Harborth J, Heyes JA, Jeffs LB, John M, et al. 2006. RNAi-mediated gene silencing in non-human primates. Nature 441:111-114.
-
(2006)
Nature
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.2
Akinc, A.3
Bramlage, B.4
Bumcrot, D.5
Fedoruk, M.N.6
Harborth, J.7
Heyes, J.A.8
Jeffs, L.B.9
John, M.10
|