메뉴 건너뛰기




Volumn 9, Issue 12, 2013, Pages

Phenome-Wide Association Studies on a Quantitative Trait: Application to TPMT Enzyme Activity and Thiopurine Therapy in Pharmacogenomics

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATICS; CODES (SYMBOLS); DATA WAREHOUSES; PATIENT MONITORING; PATIENT TREATMENT; TESTING;

EID: 84892743778     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003405     Document Type: Article
Times cited : (43)

References (53)
  • 2
    • 77952786822 scopus 로고    scopus 로고
    • Genomic medicine-an updated primer
    • doi:10.1056/NEJMra0907175
    • Feero WG, Guttmacher AE, Collins FS, (2010) Genomic medicine-an updated primer. N Engl J Med 362: 2001-2011 doi:10.1056/NEJMra0907175.
    • (2010) N Engl J Med , vol.362 , pp. 2001-2011
    • Feero, W.G.1    Guttmacher, A.E.2    Collins, F.S.3
  • 3
    • 20244380171 scopus 로고    scopus 로고
    • Complement Factor H Polymorphism in Age-Related Macular Degeneration
    • doi:10.1126/science.1109557
    • Klein RJ, Zeiss C, Chew EY, Tsai J-Y, Sackler RS, et al. (2005) Complement Factor H Polymorphism in Age-Related Macular Degeneration. Science 308: 385-389 doi:10.1126/science.1109557.
    • (2005) Science , vol.308 , pp. 385-389
    • Klein, R.J.1    Zeiss, C.2    Chew, E.Y.3    Tsai, J.-Y.4    Sackler, R.S.5
  • 5
    • 35348983887 scopus 로고    scopus 로고
    • A second generation human haplotype map of over 3.1 million SNPs
    • doi:10.1038/nature06258
    • Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, et al. (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature 449: 851-861 doi:10.1038/nature06258.
    • (2007) Nature , vol.449 , pp. 851-861
    • Frazer, K.A.1    Ballinger, D.G.2    Cox, D.R.3    Hinds, D.A.4    Stuve, L.L.5
  • 6
    • 85135546679 scopus 로고    scopus 로고
    • Hindorff LA, MacArthur J (European Bioinformatics Institute), Morales J (European Bioinformatics Institute), Junkins HA, Hall PN, et al. (n.d.) A Catalog of Published Genome-Wide Association Studies. Available:. Accessed 9 April 2013
    • Hindorff LA, MacArthur J (European Bioinformatics Institute), Morales J (European Bioinformatics Institute), Junkins HA, Hall PN, et al. (n.d.) A Catalog of Published Genome-Wide Association Studies. Available: http://www.genome.gov/gwastudies/. Accessed 9 April 2013.
  • 7
    • 77952822074 scopus 로고    scopus 로고
    • PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations
    • doi:10.1093/bioinformatics/btq126
    • Denny JC, Ritchie MD, Basford MA, Pulley JM, Bastarache L, et al. (2010) PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics 26: 1205-1210 doi:10.1093/bioinformatics/btq126.
    • (2010) Bioinformatics , vol.26 , pp. 1205-1210
    • Denny, J.C.1    Ritchie, M.D.2    Basford, M.A.3    Pulley, J.M.4    Bastarache, L.5
  • 8
    • 80053896220 scopus 로고    scopus 로고
    • Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies
    • doi:10.1016/j.ajhg.2011.09.008
    • Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, et al. (2011) Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. American journal of human genetics 89: 529-542 doi:10.1016/j.ajhg.2011.09.008.
    • (2011) American Journal of Human Genetics , vol.89 , pp. 529-542
    • Denny, J.C.1    Crawford, D.C.2    Ritchie, M.D.3    Bielinski, S.J.4    Basford, M.A.5
  • 10
    • 49949093313 scopus 로고    scopus 로고
    • Development of a large-scale de-identified DNA biobank to enable personalized medicine
    • doi:10.1038/clpt.2008.89
    • Roden DM, Pulley JM, Basford MA, Bernard GR, Clayton EW, et al. (2008) Development of a large-scale de-identified DNA biobank to enable personalized medicine. ClinPharmacolTher 84: 362-369 doi:10.1038/clpt.2008.89.
    • (2008) ClinPharmacolTher , vol.84 , pp. 362-369
    • Roden, D.M.1    Pulley, J.M.2    Basford, M.A.3    Bernard, G.R.4    Clayton, E.W.5
  • 11
    • 84874435155 scopus 로고    scopus 로고
    • Autoantibodies, autoimmune risk alleles and clinical associations in rheumatoid arthritis cases and non-RA controls in the electronic medical records
    • doi:10.1002/art.37801
    • Liao KP, Kurreeman F, Li G, Duclos G, Murphy S, et al. (2012) Autoantibodies, autoimmune risk alleles and clinical associations in rheumatoid arthritis cases and non-RA controls in the electronic medical records. Arthritis Rheum doi:10.1002/art.37801.
    • (2012) Arthritis Rheum
    • Liao, K.P.1    Kurreeman, F.2    Li, G.3    Duclos, G.4    Murphy, S.5
  • 13
    • 79955035027 scopus 로고    scopus 로고
    • Electronic medical records for genetic research: results of the eMERGE consortium
    • doi:10.1126/scitranslmed.3001807
    • Kho AN, Pacheco JA, Peissig PL, Rasmussen L, Newton KM, et al. (2011) Electronic medical records for genetic research: results of the eMERGE consortium. SciTransl Med 3: 79re1 doi:10.1126/scitranslmed.3001807.
    • (2011) SciTransl Med , vol.3
    • Kho, A.N.1    Pacheco, J.A.2    Peissig, P.L.3    Rasmussen, L.4    Newton, K.M.5
  • 14
    • 79958154438 scopus 로고    scopus 로고
    • The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery
    • doi:10.1002/gepi.20589
    • Pendergrass SA, Brown-Gentry K, Dudek SM, Torstenson ES, Ambite JL, et al. (2011) The use of phenome-wide association studies (PheWAS) for exploration of novel genotype-phenotype relationships and pleiotropy discovery. Genetic epidemiology 35: 410-422 doi:10.1002/gepi.20589.
    • (2011) Genetic Epidemiology , vol.35 , pp. 410-422
    • Pendergrass, S.A.1    Brown-Gentry, K.2    Dudek, S.M.3    Torstenson, E.S.4    Ambite, J.L.5
  • 15
    • 84873488838 scopus 로고    scopus 로고
    • Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network
    • doi:10.1371/journal.pgen.1003087
    • Pendergrass SA, Brown-Gentry K, Dudek S, Frase A, Torstenson ES, et al. (2013) Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network. PLoS Genet 9: e1003087 doi:10.1371/journal.pgen.1003087.
    • (2013) PLoS Genet , vol.9
    • Pendergrass, S.A.1    Brown-Gentry, K.2    Dudek, S.3    Frase, A.4    Torstenson, E.S.5
  • 16
    • 85135546738 scopus 로고    scopus 로고
    • Ritchie MD, Denny JC, Zuvich RL, Crawford DC, Schildcrout JS, et al. (2013) Genome- and Phenome-Wide Analysis of Cardiac Conduction Identifies Markers of Arrhythmia Risk. Circulation. Available:. Accessed 20 March 2013
    • Ritchie MD, Denny JC, Zuvich RL, Crawford DC, Schildcrout JS, et al. (2013) Genome- and Phenome-Wide Analysis of Cardiac Conduction Identifies Markers of Arrhythmia Risk. Circulation. Available: http://circ.ahajournals.org/content/early/2013/03/05/CIRCULATIONAHA.112.000604. Accessed 20 March 2013.
  • 17
    • 84863553057 scopus 로고    scopus 로고
    • The coming age of data-driven medicine: translational bioinformatics' next frontier
    • doi:10.1136/amiajnl-2012-000969
    • Shah NH, Tenenbaum JD, (2012) The coming age of data-driven medicine: translational bioinformatics' next frontier. J Am Med Inform Assoc 19: e2-4 doi:10.1136/amiajnl-2012-000969.
    • (2012) J Am Med Inform Assoc , vol.19
    • Shah, N.H.1    Tenenbaum, J.D.2
  • 19
    • 77958007735 scopus 로고    scopus 로고
    • STRIDE-An integrated standards-based translational research informatics platform
    • Lowe HJ, Ferris TA, Hernandez PM, Weber SC, (2009) STRIDE-An integrated standards-based translational research informatics platform. AMIA AnnuSympProc 2009: 391-395.
    • (2009) AMIA AnnuSympProc , vol.2009 , pp. 391-395
    • Lowe, H.J.1    Ferris, T.A.2    Hernandez, P.M.3    Weber, S.C.4
  • 21
    • 77954661651 scopus 로고    scopus 로고
    • Effective knowledge management in translational medicine
    • doi:10.1186/1479-5876-8-68
    • Szalma S, Koka V, Khasanova T, Perakslis ED, (2010) Effective knowledge management in translational medicine. J Transl Med 8: 68 doi:10.1186/1479-5876-8-68.
    • (2010) J Transl Med , vol.8 , pp. 68
    • Szalma, S.1    Koka, V.2    Khasanova, T.3    Perakslis, E.D.4
  • 22
    • 84871682979 scopus 로고    scopus 로고
    • A glimpse of the next 100 years in medicine
    • doi:10.1056/NEJMe1213371
    • Kohane IS, Drazen JM, Campion EW, (2012) A glimpse of the next 100 years in medicine. N Engl J Med 367: 2538-2539 doi:10.1056/NEJMe1213371.
    • (2012) N Engl J Med , vol.367 , pp. 2538-2539
    • Kohane, I.S.1    Drazen, J.M.2    Campion, E.W.3
  • 23
    • 84861338882 scopus 로고    scopus 로고
    • Translational Bioinformatics: Linking the Molecular World to the Clinical World
    • doi:10.1038/clpt.2012.49
    • Altman RB, (2012) Translational Bioinformatics: Linking the Molecular World to the Clinical World. Clinical Pharmacology & Therapeutics 91: 994-1000 doi:10.1038/clpt.2012.49.
    • (2012) Clinical Pharmacology & Therapeutics , vol.91 , pp. 994-1000
    • Altman, R.B.1
  • 24
    • 84872022133 scopus 로고    scopus 로고
    • Chapter 13: Mining Electronic Health Records in the Genomics Era
    • doi:10.1371/journal.pcbi.1002823
    • Denny JC, (2012) Chapter 13: Mining Electronic Health Records in the Genomics Era. PLoSComputBiol 8: e1002823 doi:10.1371/journal.pcbi.1002823.
    • (2012) PLoSComputBiol , vol.8
    • Denny, J.C.1
  • 25
    • 80052329143 scopus 로고    scopus 로고
    • Using Electronic Patient Records to Discover Disease Correlations and Stratify Patient Cohorts
    • doi:10.1371/journal.pcbi.1002141
    • Roque FS, Jensen PB, Schmock H, Dalgaard M, Andreatta M, et al. (2011) Using Electronic Patient Records to Discover Disease Correlations and Stratify Patient Cohorts. PLoSComputBiol 7: e1002141 doi:10.1371/journal.pcbi.1002141.
    • (2011) PLoSComputBiol , vol.7
    • Roque, F.S.1    Jensen, P.B.2    Schmock, H.3    Dalgaard, M.4    Andreatta, M.5
  • 26
    • 84875042177 scopus 로고    scopus 로고
    • Clinical Bioinformatics: challenges and opportunities
    • doi:10.1186/1471-2105-13-S14-S1
    • Bellazzi R, Masseroli M, Murphy S, Shabo A, Romano P, (2012) Clinical Bioinformatics: challenges and opportunities. BMC Bioinformatics 13 Suppl 14: S1 doi:10.1186/1471-2105-13-S14-S1.
    • (2012) BMC Bioinformatics , vol.13 , Issue.SUPPL.
    • Bellazzi, R.1    Masseroli, M.2    Murphy, S.3    Shabo, A.4    Romano, P.5
  • 27
    • 84863432324 scopus 로고    scopus 로고
    • TPMT status determination: the simplest is the most effective?
    • doi:10.1016/j.crohns.2012.04.003, author reply 808. doi
    • Chouchana L, Narjoz C, Loriot M-A, (2012) TPMT status determination: the simplest is the most effective? J Crohns Colitis 6: 807 author reply 808. doi:10.1016/j.crohns.2012.04.003.
    • (2012) J Crohns Colitis , vol.6 , pp. 807
    • Chouchana, L.1    Narjoz, C.2    Loriot, M.-A.3
  • 28
    • 3242762099 scopus 로고    scopus 로고
    • Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants
    • Schaeffeler E, Fischer C, Brockmeier D, Wernet D, Moerike K, et al. (2004) Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants. Pharmacogenetics 14: 407-417.
    • (2004) Pharmacogenetics , vol.14 , pp. 407-417
    • Schaeffeler, E.1    Fischer, C.2    Brockmeier, D.3    Wernet, D.4    Moerike, K.5
  • 29
    • 83555174812 scopus 로고    scopus 로고
    • Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease
    • doi:10.1111/j.1365-2036.2011.04905.x
    • Chouchana L, Narjoz C, Beaune P, Loriot MA, Roblin X, (2012) Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease. Alimentary pharmacology & therapeutics 35: 15-36 doi:10.1111/j.1365-2036.2011.04905.x.
    • (2012) Alimentary Pharmacology & Therapeutics , vol.35 , pp. 15-36
    • Chouchana, L.1    Narjoz, C.2    Beaune, P.3    Loriot, M.A.4    Roblin, X.5
  • 30
    • 79951809968 scopus 로고    scopus 로고
    • Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing
    • doi:10.1038/clpt.2010.320
    • Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, et al. (2011) Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing. Clinical pharmacology and therapeutics 89: 387-391 doi:10.1038/clpt.2010.320.
    • (2011) Clinical Pharmacology and Therapeutics , vol.89 , pp. 387-391
    • Relling, M.V.1    Gardner, E.E.2    Sandborn, W.J.3    Schmiegelow, K.4    Pui, C.H.5
  • 31
    • 33644873301 scopus 로고    scopus 로고
    • TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease
    • doi:10.1016/j.dld.2005.08.003
    • Stocco G, Martelossi S, Barabino A, Fontana M, Lionetti P, et al. (2005) TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease. Dig Liver Dis 37: 940-945 doi:10.1016/j.dld.2005.08.003.
    • (2005) Dig Liver Dis , vol.37 , pp. 940-945
    • Stocco, G.1    Martelossi, S.2    Barabino, A.3    Fontana, M.4    Lionetti, P.5
  • 32
    • 0036278519 scopus 로고    scopus 로고
    • The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review
    • Fraser AG, Orchard TR, Jewell DP, (2002) The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review. Gut 50: 485-489.
    • (2002) Gut , vol.50 , pp. 485-489
    • Fraser, A.G.1    Orchard, T.R.2    Jewell, D.P.3
  • 33
    • 0036202803 scopus 로고    scopus 로고
    • 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease
    • Dubinsky MC, Yang H, Hassard PV, Seidman EG, Kam LY, et al. (2002) 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease. Gastroenterology 122: 904-915.
    • (2002) Gastroenterology , vol.122 , pp. 904-915
    • Dubinsky, M.C.1    Yang, H.2    Hassard, P.V.3    Seidman, E.G.4    Kam, L.Y.5
  • 34
    • 0023119219 scopus 로고
    • Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations
    • Lennard L, Van Loon JA, Lilleyman JS, Weinshilboum RM, (1987) Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations. ClinPharmacolTher 41: 18-25.
    • (1987) ClinPharmacolTher , vol.41 , pp. 18-25
    • Lennard, L.1    Van Loon, J.A.2    Lilleyman, J.S.3    Weinshilboum, R.M.4
  • 35
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum RM, Sladek SL, (1980) Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 32: 651-662.
    • (1980) Am J Hum Genet , vol.32 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 36
    • 84874931583 scopus 로고    scopus 로고
    • Nomenclature for alleles of the thiopurine methyltransferase gene
    • doi:10.1097/FPC.0b013e32835f1cc0
    • Appell ML, Berg J, Duley J, Evans WE, Kennedy MA, et al. (2013) Nomenclature for alleles of the thiopurine methyltransferase gene. Pharmacogenet Genomics 23: 242-248 doi:10.1097/FPC.0b013e32835f1cc0.
    • (2013) Pharmacogenet Genomics , vol.23 , pp. 242-248
    • Appell, M.L.1    Berg, J.2    Duley, J.3    Evans, W.E.4    Kennedy, M.A.5
  • 37
    • 0036790212 scopus 로고    scopus 로고
    • Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease
    • Ansari A, Hassan C, Duley J, Marinaki A, Shobowale-Bakre E-M, et al. (2002) Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease. Aliment PharmacolTher 16: 1743-1750.
    • (2002) Aliment PharmacolTher , vol.16 , pp. 1743-1750
    • Ansari, A.1    Hassan, C.2    Duley, J.3    Marinaki, A.4    Shobowale-Bakre, E.-M.5
  • 38
    • 84879724086 scopus 로고    scopus 로고
    • Poor response to thiopurine in inflammatory bowel disease: how to overcome therapeutic resistance?
    • Chouchana L, Roche D, Jian R, Beaune P, Loriot MA, (2013) Poor response to thiopurine in inflammatory bowel disease: how to overcome therapeutic resistance? Clin Chem 59: 1023-6.
    • (2013) Clin Chem , vol.59 , pp. 1023-1026
    • Chouchana, L.1    Roche, D.2    Jian, R.3    Beaune, P.4    Loriot, M.A.5
  • 39
    • 78649493608 scopus 로고    scopus 로고
    • Methodology of integration of a clinical data warehouse with a clinical information system: the HEGP case
    • Zapletal E, Rodon N, Grabar N, Degoulet P, (2010) Methodology of integration of a clinical data warehouse with a clinical information system: the HEGP case. Studies in health technology and informatics 160: 193-197.
    • (2010) Studies in Health Technology and Informatics , vol.160 , pp. 193-197
    • Zapletal, E.1    Rodon, N.2    Grabar, N.3    Degoulet, P.4
  • 40
    • 84892745857 scopus 로고    scopus 로고
    • Mapping between ICD-10 and ICD-9, Available:. Accessed 8 February 2013
    • Mapping between ICD-10 and ICD-9 (2000). Ministry of Health of New Zealand. Available: http://www.health.govt.nz/nz-health-statistics/data-references/mapping-tools/mapping-between-icd-10-and-icd-9. Accessed 8 February 2013.
    • (2000) Ministry of Health of New Zealand
  • 41
    • 0032240835 scopus 로고    scopus 로고
    • Beyond synonymy: exploiting the UMLS semantics in mapping vocabularies
    • Bodenreider O, Nelson SJ, Hole WT, Chang HF, (1998) Beyond synonymy: exploiting the UMLS semantics in mapping vocabularies. Proc AMIA Symp pp. 815-819.
    • (1998) Proc AMIA Symp , pp. 815-819
    • Bodenreider, O.1    Nelson, S.J.2    Hole, W.T.3    Chang, H.F.4
  • 42
    • 84892687327 scopus 로고    scopus 로고
    • Vanderbilt University. Available:. Accessed 8 January 2013
    • Denny J (2013) ICD9 to PheWAS: Code translation map. Vanderbilt University. Available: http://knowledgemap2.mc.vanderbilt.edu/research/sites/default/files/code_translation.txt. Accessed 8 January 2013.
    • (2013) ICD9 to PheWAS: Code translation map
    • Denny, J.1
  • 43
    • 0037172935 scopus 로고    scopus 로고
    • Thiopurine methyltransferase activity: new conditions for reversed-phase high-performance liquid chromatographic assay without extraction and genotypic-phenotypic correlation
    • Anglicheau D, Sanquer S, Loriot MA, Beaune P, Thervet E, (2002) Thiopurine methyltransferase activity: new conditions for reversed-phase high-performance liquid chromatographic assay without extraction and genotypic-phenotypic correlation. J Chromatogr B AnalytTechnol Biomed Life Sci 773: 119-127.
    • (2002) J Chromatogr B AnalytTechnol Biomed Life Sci , vol.773 , pp. 119-127
    • Anglicheau, D.1    Sanquer, S.2    Loriot, M.A.3    Beaune, P.4    Thervet, E.5
  • 45
    • 84889676637 scopus 로고    scopus 로고
    • Applying semantic web technologies for phenome-wide scan using an electronic health record linked Biobank
    • doi:10.1186/2041-1480-3-10
    • Pathak J, Kiefer RC, Bielinski SJ, Chute CG, (2012) Applying semantic web technologies for phenome-wide scan using an electronic health record linked Biobank. J Biomed Semantics 3: 10 doi:10.1186/2041-1480-3-10.
    • (2012) J Biomed Semantics , vol.3 , pp. 10
    • Pathak, J.1    Kiefer, R.C.2    Bielinski, S.J.3    Chute, C.G.4
  • 46
    • 76549094518 scopus 로고    scopus 로고
    • Prevalence and pathogenesis of anemia in inflammatory bowel disease.Influence of anti-tumor necrosis factor-alpha treatment
    • doi:10.3324/haematol.2009.009985
    • Bergamaschi G, Di Sabatino A, Albertini R, Ardizzone S, Biancheri P, et al. (2010) Prevalence and pathogenesis of anemia in inflammatory bowel disease.Influence of anti-tumor necrosis factor-alpha treatment. Haematologica 95: 199-205 doi:10.3324/haematol.2009.009985.
    • (2010) Haematologica , vol.95 , pp. 199-205
    • Bergamaschi, G.1    Di Sabatino, A.2    Albertini, R.3    Ardizzone, S.4    Biancheri, P.5
  • 47
    • 0025837127 scopus 로고
    • Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia
    • Evans WE, Horner M, Chu YQ, Kalwinsky D, Roberts WM, (1991) Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia. J Pediatr 119: 985-989.
    • (1991) J Pediatr , vol.119 , pp. 985-989
    • Evans, W.E.1    Horner, M.2    Chu, Y.Q.3    Kalwinsky, D.4    Roberts, W.M.5
  • 48
    • 0009663357 scopus 로고
    • A Multiple Comparison Procedure for Comparing Several Treatments with a Control
    • doi:10.1080/01621459.1955.10501294
    • Dunnett CW, (1955) A Multiple Comparison Procedure for Comparing Several Treatments with a Control. Journal of the American Statistical Association 50: 1096-1121 doi:10.1080/01621459.1955.10501294.
    • (1955) Journal of the American Statistical Association , vol.50 , pp. 1096-1121
    • Dunnett, C.W.1
  • 49
    • 0037433040 scopus 로고    scopus 로고
    • Identifying differentially expressed genes using false discovery rate controlling procedures
    • Reiner A, Yekutieli D, Benjamini Y, (2003) Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics 19: 368-375.
    • (2003) Bioinformatics , vol.19 , pp. 368-375
    • Reiner, A.1    Yekutieli, D.2    Benjamini, Y.3
  • 50
    • 84893752804 scopus 로고    scopus 로고
    • Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease
    • doi:10.1136/gutjnl-2012-303615
    • Jharap B, de Boer NKH, Stokkers P, Hommes DW, Oldenburg B, et al. (2013) Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease. Gut doi:10.1136/gutjnl-2012-303615.
    • (2013) Gut
    • Jharap, B.1    de Boer, N.K.H.2    Stokkers, P.3    Hommes, D.W.4    Oldenburg, B.5
  • 51
    • 34247251970 scopus 로고    scopus 로고
    • Prevalence of Neutropenia in the U.S. Population: Age, Sex, Smoking Status, and Ethnic Differences
    • doi:10.7326/0003-4819-146-7-200704030-00004
    • Hsieh MM, Everhart JE, Byrd-Holt DD, Tisdale JF, Rodgers GP, (2007) Prevalence of Neutropenia in the U.S. Population: Age, Sex, Smoking Status, and Ethnic Differences. Ann Intern Med 146: 486-492 doi:10.7326/0003-4819-146-7-200704030-00004.
    • (2007) Ann Intern Med , vol.146 , pp. 486-492
    • Hsieh, M.M.1    Everhart, J.E.2    Byrd-Holt, D.D.3    Tisdale, J.F.4    Rodgers, G.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.