Vitamin D-binding protein haplotype is associated with hospitalization for RSV bronchiolitis

Clinical and Experimental Allergy

Volumn 44, Issue 2, 2014, Pages 231-237

  Randolph, A G ^a,b,c   Yip, W K ^d   Falkenstein Hagander, K ^a,c,e   Weiss, S T ^b,c,f   Janssen, R ^g   Keisling, S ^a   Bont, L ^h  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e LUND UNIVERSITY HOSPITAL   (Sweden)

^f LABORATORY FOR MOLECULAR MEDICINE   (United States)

^g NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^h UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Asthma; Bronchiolitis; Children; GC; Haplotype; Infants; Polymorphisms; RSV; Vitamin D; Vitamin D binding protein

Indexed keywords

VITAMIN D BINDING PROTEIN;

ADOLESCENT; ALLELE; ARTICLE; ASTHMA; CHILD; CHILD HOSPITALIZATION; CHILDHOOD DISEASE; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FEMALE; FOLLOW UP; GENE FREQUENCY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; OXYGEN THERAPY; PRESCHOOL CHILD; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY SYNCYTIAL PNEUMOVIRUS BRONCHIOLITIS; RETROSPECTIVE STUDY; SCHOOL CHILD; VENTILATED PATIENT; VIRAL BRONCHIOLITIS;

ASTHMA; BRONCHIOLITIS; CHILDREN; GC; HAPLOTYPE; INFANTS; POLYMORPHISMS; RSV; VITAMIN D; VITAMIN D-BINDING PROTEIN;

BRONCHIOLITIS, VIRAL; CHILD, PRESCHOOL; FEMALE; FOLLOW-UP STUDIES; HAPLOTYPES; HOSPITALIZATION; HUMANS; INFANT; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUS, HUMAN; RETROSPECTIVE STUDIES; VITAMIN D; VITAMIN D-BINDING PROTEIN;

EID: 84892728968     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12247     Document Type: Article

References (56)

1. Leader S, Kohlhase K. Respiratory syncytial virus-coded pediatric hospitalizations, 1997 to 1999. Pediatr Infect Dis J 2002; 21:629-32.
2. Hall CB, Weinberg GA, Iwane MK et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009; 360:588-98.
3. McConnochie KM, Roghmann KJ. Bronchiolitis as a possible cause of wheezing in childhood: new evidence. Pediatrics 1984; 74:1-10.
4. Sigurs N, Gustafsson PM, Bjarnason R et al. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am J Respir Crit Care Med 2005; 171:137-41.
5. Piippo-Savolainen E, Korppi M. Wheezy babies-wheezy adults? Review on long-term outcome until adulthood after early childhood wheezing. Acta Paediatr 2008; 97:5-11.
6. Blanken M, Rovers MM, Molenaar JM et al. Respiratory syncytial virus and recurrent wheeze in healthy preterm infants. N Engl J Med 2013; 368:1791-9.
7. Sorensen TI, Nielsen GG, Andersen PK, Teasdale TW. Genetic and environmental influences on premature death in adult adoptees. N Engl J Med 1988; 318:727-32.
8. Goetghebuer T, Kwiatkowski D, Thomson A, Hull J. Familial susceptibility to severe respiratory infection in early life. Pediatr Pulmonol 2004; 38:321-8.
9. Cook PM, Eglin RP, Easton AJ. Pathogenesis of pneumovirus infections in mice: detection of pneumonia virus of mice and human respiratory syncytial virus mRNA in lungs of infected mice by in situ hybridization. J Gen Virol 1998; 79:2411-7.
10. Stark JM, McDowell SA, Koenigsknecht V et al. Genetic susceptibility to respiratory syncytial virus infection in inbred mice. J Med Virol 2002; 67:92-100.
11. Anh DB, Faisca P, Desmecht DJ. Differential resistance/susceptibility patterns to pneumovirus infection among inbred mouse strains. Am J Physiol Lung Cell Mol Physiol 2006; 291:L426-35.
12. Domachowske JB, Bonville CA, Rosenberg HF. Animal models for studying respiratory syncytial virus infection and its long term effects on lung function. Pediatr Infect Dis J 2004; 23:S228-34.
13. Drysdale SB, Milner AD, Greenough A. Respiratory syncytial virus infection and chronic respiratory morbidity - is there a functional or genetic predisposition? Acta Paediatr 2012; 101:1114-20.
14. Gupta A, Sjoukes A, Richards D et al. Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med 2011; 184:1342-9.
15. Zosky GR, Berry LJ, Elliot JG, James AL, Gorman S, Hart PH. Vitamin D deficiency causes deficits in lung function and alters lung structure. Am J Respir Crit Care Med 2011; 183:1336-43.
16. Zanetti M. The role of cathelicidins in the innate host defenses of mammals. Curr Issues Mol Biol 2005; 7:179-96.
17. Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1, 25-dihydroxyvitamin D3. FASEB J 2005; 19:1067-77.
18. Maruotti N, Cantatore FP. Vitamin D and the immune system. J Rheumatol 2010; 37:491-5.
19. Jeffery LE, Burke F, Mura M et al. 1, 25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol 2009; 183:5458-67.
20. Hansdottir S, Monick MM, Hinde SL, Lovan N, Look DC, Hunninghake GW. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol 2008; 181:7090-9.
21. Hansdottir S, Monick MM, Lovan N, Powers L, Gerke A, Hunninghake GW. Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol 2010; 184:965-74.
22. Belderbos ME, Houben ML, Wilbrink B et al. Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Pediatrics 2011; 127:e1513-20.
23. Sabetta JR, DePetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML. Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults. PLoS One 2010; 5:e11088.
24. Ginde AA, Mansbach JM, Camargo CA Jr. Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med 2009; 169:384-90.
25. Roth DE, Jones AB, Prosser C, Robinson JL, Vohra S. Vitamin D receptor polymorphisms and the risk of acute lower respiratory tract infection in early childhood. J Infect Dis 2008; 197:676-80.
26. Kresfelder TL, Janssen R, Bont L, Pretorius M, Venter M. Confirmation of an association between single nucleotide polymorphisms in the VDR gene with respiratory syncytial virus related disease in South African children. J Med Virol 2011; 83:1834-40.
27. Kamboh MI, Ferrell RE. Ethnic variation in vitamin D-binding protein (GC): a review of isoelectric focusing studies in human populations. Hum Genet 1986; 72:281-93.
28. Chishimba L, Thickett DR, Stockley RA, Wood AM. The vitamin D axis in the lung: a key role for vitamin D-binding protein. Thorax 2010; 65:456-62.
29. Janssen R, Bont L, Siezen CLE et al. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J Infect Dis 2007; 196:826-34.
30. Schuurhof A, Bont L, Hodemaekers HM et al. Proteins involved in extracellular matrix dynamics are associated with respiratory syncytial virus disease severity. Eur Respir J 2012; 39:1475-81.
31. Viet A, vanGils HWV, de Melker H et al. Risk factors and health in the Netherlands, a survey by municipal health centres: annual report 1998. RIVM Report 2000:266807003.
32. A language and environment for statistical computing. Vienna: R Core Team; 2012. Available from http://www.R-project.org/. (Last accessed 16 August 2013).
33. Family-based association test toolkit. 2004. Available from http://www.biostat.harvard.edu/fbat/. (Last accessed 11 August 2013).
34. Horvath S, Xu X, Laird NM. The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 2001; 9:301-6.
35. Horvath S, Xu X, Lake SL, Silverman EK, Weiss ST, Laird NM. Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol 2004; 26:61-9.
36. Malik S, Fu L, Juras DJ et al. Common variants of the vitamin D binding protein gene and adverse health outcomes. Crit Rev Clin Lab Sci 2013; 50:1-22.
37. Ginde AA, Mansbach JM, Camargo CA Jr. Vitamin D respiratory infections, and asthma. Curr Allergy Asthma Rep 2009; 9:81-7.
38. Wang TJ, Zhang F, Richards JB et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 2010; 376:180-8.
39. Lasky-Su J, Lange N, Brehm JM et al. Genome-wide association analysis of circulating vitamin D levels in children with asthma. Hum Genet 2012; 131:1495-505.
40. Ahn J, Yu K, Stolzenberg-Solomon R et al. Genome-wide association study of circulating vitamin D levels. Hum Mol Genet 2010; 19:2739-45.
41. Li F, Jiang L, Willis-Owen SA, Zhang Y, Gao J. Vitamin D binding protein variants associate with asthma susceptibility in the Chinese Han population. BMC Med Genet 2011; 12:103.
42. Laufs J, Andrason H, Sigvaldason A et al. Association of vitamin D binding protein variants with chronic mucus hypersecretion in Iceland. Am J Pharmacogenomics 2004; 4:63-8.
43. Janssens W, Bouillon R, Claes B et al. Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D-binding gene. Thorax 2010; 65:215-20.
44. Fu L, Yun F, Oczak M, Wong BY, Vieth R, Cole DE. Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation. Clin Biochem 2009; 42:1174-7.
45. Chun RF, Peercy BE, Adams JS, Hewison M. Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1, 25-dihydroxyvitamin D: analysis by mathematical modeling. PLoS One 2012; 7:e30773.
46. Gozdzik A, Zhu J, Wong BY, Fu L, Cole DE, Parra EJ. Association of vitamin D binding protein (VDBP) polymorphisms and serum 25(OH)D concentrations in a sample of young Canadian adults of different ancestry. J Steroid Biochem Mol Biol 2011; 127:405-12.
47. Puthothu B, Forster J, Heinze J, Heinzmann A, Krueger M. Surfactant protein B polymorphisms are associated with severe respiratory syncytial virus infection, but not with asthma. BMC Pulm Med 2007; 7:6.
48. Nuolivirta K, He Q, Vuononvirta J, Koponen P, Helminen M, Korppi M. Toll-like receptor 3 L412F polymorphisms in infants with bronchiolitis and postbronchiolitis wheezing. Pediatr Infect Dis J 2012; 31:920-3.
49. Forton JT, Rowlands K, Rockett K et al. Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster. Thorax 2009; 64:345-52.
50. Faber TE, Schuurhof A, Vonk A et al. IL1RL1 gene variants and nasopharyngeal IL1RL-a levels are associated with severe RSV bronchiolitis: a multicenter cohort study. PLoS One 2012; 7:e34364.
51. Tal G, Mandelberg A, Dalal I et al. Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease. J Infect Dis 2004; 189:2057-63.
52. Amanatidou V, Sourvinos G, Apostolakis S, Tsilimigaki A, Spandidos DA. T280M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis. Pediatr Infect Dis J 2006; 25:410-4.
53. Choi EH, Lee HJ, Yoo T, Chanock SJ. A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in Korean children. J Infect Dis 2002; 186:1207-11.
54. Tian M, Liu F, Wen GY, Shi SY, Chen RH, Zhao DY. Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China. Eur J Pediatr 2009; 168:963-7.
55. Lauridsen AL, Vestergaard P, Nexo E. Mean serum concentration of vitamin D-binding protein (Gc globulin) is related to the Gc phenotype in women. Clin Chem 2001; 47:753-6.
56. Speeckaert M, Huang G, Delanghe JR, Taes YE. Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chem Acta 2006; 372:33-42.