IL1RL1 gene variants and nasopharyngeal IL1RL-a levels are associated with severe RSV bronchiolitis: A multicenter cohort study

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Faber, Tina E ^a   Schuurhof, Annemieke ^b   Vonk, Annelies ^a   Koppelman, Gerard H ^c   Hennus, Marije P ^d   Kimpen, Jan L L ^d   Janssen, Riny ^b   Bont, Louis J ^d  

^a MEDICAL CENTER LEEUWARDEN   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; PROTEIN IL1RL A; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; IL1RL1 PROTEIN, HUMAN;

ARTICLE; ARTIFICIAL VENTILATION; ATOPY; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE; GENE CLUSTER; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIABILITY; GENOTYPE; GESTATIONAL AGE; HUMAN; IL1RL1 GENE; INFANT; INTRON; MAJOR CLINICAL STUDY; MALE; NONHUMAN; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; VIRAL BRONCHIOLITIS; BLOOD; CLINICAL TRIAL; GENETICS; METABOLISM; MULTICENTER STUDY; NASOPHARYNX; PATHOGENICITY; PREGNANCY; RESPIRATORY SYNCYTIAL VIRUS INFECTION; VIROLOGY;

RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

BRONCHIOLITIS, VIRAL; COHORT STUDIES; FEMALE; HUMANS; INFANT; MALE; NASOPHARYNX; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; RECEPTORS, CELL SURFACE; RESPIRATION, ARTIFICIAL; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES;

EID: 84860506235     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0034364     Document Type: Article

References (42)

1. Behrendt CE, Decker MD, Burch DJ, Watson PH, (1998) International variation in the management of infants hospitalized with respiratory syncytial virus. Eur J Pediatr 157: 215-220.
2. Stein RT, Sherill D, Morgan WJ, Holberg CJ, Halonen M, et al. (1999) Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13. Lancet 354: 541-545.
3. Perez-Yarza EG, Moreno A, Lazaro P, Mejias A, Ramilio O, (2007) The association between respiratory syncytial virus infection and the development of childhood asthma: a systematic review of the literature. Pediatr Infect Dis J 26: 733-739.
4. Henderson J, Hilliard TN, Sherriff A, Stalker D, Al Shammari N, et al. (2005) Hospitalization for RSV bronchiolitis before 12 months of age and subsequent asthma, atopy and wheeze: a longitudinal birth cohort study. Pediatr Allergy Immunol. 16: 386-392.
5. Thorburn K, Harigopal S, Reddy V, Taylor N, van Saene HK, (2006) High incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitis. Thorax 61: 611-615.
6. Levin D, Tribuzio M, Green-Wrzesinki T, Ames B, Radwan S, et al. (2010) Empiric antibiotics are justified for infants with respiratory syncytial virus lower respiratory tract infection presenting with respiratory failure: a prospective study and evidence review. Pediatr Crit Care Med 11: 390-395.
7. Duttweiler L, Nadal D, Frey B, (2004) Pulmonary and systemic bacterial co-infections in severe RSV bronchiolitis. Arch Dis Child 89: 1155-1157.
8. Thorburn K, van Saene H, (2007) Pulmonary bacterial co-infections in children ventilated for severe respiratory syncytial virus bronchiolitis is common. Intensive Care Med 33: 565.
9. Spurling GK, Doust J, Del Mar CB, Eriksson L, (2011) Antibiotics for bronchiolitis in children. Cochrane Database Syst Rev 15: CD005189.
10. Resch B, Gusenleitner W, Mueller WD, (2007) Risk of concurrent bacterial infection in preterm infants hospitalized due to respiratory syncytial virus infection. Acta Paediatr 96: 495-498.
11. Ralston S, Hill V, Waters A, (2011) Occult serious bacterial infection in infants younger than 60 to 90 days with bronchiolitis: a systematic review. Pediatr Adolesc Med 165: 951-956.
12. Kabir AR, Mollah AH, Anwar KS, Rahman AK, Amin R, et al. (2009) Management of bronchiolitis without antibiotics: a multicentre randomized control trial in Bangladesh. Acta Paediatr 98: 1593-1599.
13. Lenney W, Boner AL, Bont L, Bush A, Carlsen KH, et al. (2009) Medicines used in respiratory diseases only seen in children. Eur Respir J 34: 531-551.
14. Reijmerink NE, Postma DS, Bruinenberg M, Nolte IM, Meyers DA, et al. (2008) Association of IL1RL1, IL18R1, and IL18RAP gene cluster polymorphisms with asthma and atopy. J Allergy Clin Immunol 122: 651-654.
15. Ali M, Zhang G, Thomas WR, McLean CJ, Bizzintino JA, et al. (2009) Investigations into the role of ST2 in acute asthma in children. Tissue Antigens 73: 206-212.
16. Wu H, Romieu I, Shi M, Hancock DB, Li H, et al. (2010) Evaluation of candidate genes in a genome-wide association study of childhood asthma in Mexicans. J Allergy Clin Immunol. 125: 321-327.
17. Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, et al. (2010) A Large-Scale, Consortium-Based Genomewide Association Study of Asthma. N Engl J Med 363: 1211-1221.
18. Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, et al. (2009) Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet.41: 342-347.
19. Kumar S, Tzimas MN, Griswold DE, Young PR, (1997) Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuli. Biochem Biophys Res Commun 235: 474-478.
20. Löhning M, Stroehmann A, Coyle AJ, Grogan JL, Lin S, et al. (1998) T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function. Proc Natl Acad Sci USA. 95: 6930-6935.
21. Dale M, Nicklin MJ, (1999) Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. Genomics 57: 177-179.
22. Hayakawa H, Hayakawa M, Kume A, Tominaga S, (2007) Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J Biol Chem 282: 26369-26380.
23. Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, (2005) IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23: 479-490.
24. Eggers KM, Armstrong PW, Califf RM, Simoons ML, Venge P, et al. (2010) ST2 and mortality in non-ST-segment elevation acute coronary syndrome. Am Heart J. 159: 788-794.
25. Näkki A, Kouhia ST, Saarela J, Harilainen A, Tallroth K, et al. (2010) Allelic variants of IL1R1 gene associate with severe hand osteoarthritis. BMC Med Genet. 11: 50.
26. Hacker S, Lambers C, Pollreisz A, Hoetzenecker K, Lichtenauer M, et al. (2009) Increased soluble serum markers caspase-cleaved cytokeratin-18, histones, and ST2 indicate apoptotic turnover and chronic immune response in COPD. J Clin Lab Anal. 23: 372-379.
27. Szerafin T, Niederpold T, Mangold A, Hoetzenecker K, Hacker S, et al. (2009) Secretion of soluble ST2- possible explanation for systemic immunosuppression after heart surgery. Thorac Cardiovasc Surg. 57: 25-29.
28. Martinez-Rumayor A, Camargo CA, Green SM, Baggish AL, O'Donoghue M, et al. (2008) Soluble ST2 plasma concentrations predict 1-year mortality in acutely dyspneic emergency department patients with pulmonary disease. Am J Clin Pathol. 130: 578-584.
29. Schuurhof A, Janssen R, de Groot H, Hodemaekers HM, de Klerk A, et al. (2011) Local interleukin-10 production during respiratory syncytial virus bronchiolitis is associated with post-bronchiolitis wheeze. Respir Res 12: 121.
30. Schuurhof A, Bont L, Hodemaekers HM, de Klerk A, de Groot H, et al. (2012) Proteins involved in extracellular matrix dynamics are associated with RSV disease severity. Eur Respir J, in press.
31. Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, (2007) Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. J Infect Dis 196: 826-834.
32. Savenije OE, Kerkhof M, Reijmerink NE, Brunekreef B, de Jongste JC, et al. (2011) Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol 127: 750-756.
33. Reijmerink NE, Bottema RW, Kerkhof M, Gerritsen J, Stelma FF, et al. (2010) TLR-related pathway analysis: novel gene-gene interactions in the development of asthma and atopy. Allergy 65: 199-207.
34. Hayakawa H, Hayakawa M, Kume A, Tominaga S, (2007) Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J Biol Chem 282: 26369-26380.
35. Brint EK, Xu D, Liu H, Dunne A, McKenzie AN, et al. (2004) ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol 5: 373-379.
36. Mangan NE, Dasvarma A, McKenzie AN, Fallon PG, (2007) T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation. Eur J Immunol 37: 1302-1312.
37. Kakkar R, Lee RT, (2008) The IL-33/ST2 pathway: therapeutic target and novel biomarker. Nat Rev Drug Discov 2008 827-40 pp. 827-40.
38. Xu D, Chan WL, Leung BP, Huang F, Wheeler R, et al. (1998) Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J Exp Med 187: 787-794.
39. McGuirk P, McCann C, Mills KH, (2002) Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med 195: 221-231.
40. Lecart S, Lecointe N, Subramaniam A, Alkan S, Ni D, et al. (2002) Activated, but not resting human Th2 cells, in contrast to Th1 and T regulatory cells, produce soluble ST2 and express low levels of ST2L at the cell surface. Eur J Immunol 32: 2979-2987.
41. Walzl G, Matthews S, Kendall S, Gutierrez-Ramoz JC, Coyle AJ, et al. (2001) Inhibition of T1/ST 2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology. J Exp Med 193: 785-792.
42. Thorburn K, Shetty N, Darbyshire AP, (2011) Concomitant bacterial pneumonia and empirical antibiotics in severe respiratory syncytial virus infection. Pediatr Crit Care Med 12: 119-120.