Elevated serotonin and 5-HIAA in the brainstem and lower serotonin turnover in the prefrontal cortex of suicides

Synapse

Volumn 68, Issue 3, 2014, Pages 127-130

  Bach, Helene ^a,b   Huang, Yung Yu ^a,b   Underwood, Mark D ^a,b   Dwork, Andrew J ^a,b,c   Mann, J John ^a,b   Arango, Victoria ^a,b  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^c MACEDONIAN ACADEMY OF SCIENCES AND ARTS   (Macedonia)

Author keywords

5 HIAA; Brainstem; Prefrontal cortex; Raphe; Serotonin; Suicide

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; MESSENGER RNA; SEROTONIN; SEROTONIN AGONIST; TRYPTOPHAN HYDROXYLASE 2;

ARTICLE; AUTOPSY; BRAIN LEVEL; BRAIN STEM; DEPRESSION; DORSAL RAPHE NUCLEUS; FOREBRAIN; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MEDIAN RAPHE NUCLEUS; NEUROTRANSMISSION; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; SEROTONIN BRAIN LEVEL; SEROTONIN METABOLISM; SEROTONINERGIC NERVE CELL; SEROTONINERGIC SYSTEM; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS; SUDDEN DEATH; SUICIDE; SUICIDE ATTEMPT; TURNOVER TIME;

5-HIAA; BRAINSTEM; PREFRONTAL CORTEX; RAPHE; SEROTONIN; SUICIDE;

ADOLESCENT; ADULT; AGED; ANALYSIS OF VARIANCE; BRAIN STEM; FEMALE; HUMANS; HYDROXYINDOLEACETIC ACID; MALE; MIDDLE AGED; PILOT PROJECTS; PREFRONTAL CORTEX; RAPHE NUCLEI; SEROTONIN; SUICIDE; YOUNG ADULT;

EID: 84892679588     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.21695     Document Type: Article

References (37)

1. Alenina N, Kikic D, Todiras M, Mosienko V, Qadri F, Plehm R, Boye P, Vilianovitch L, Sohr R, Tenner K, Hortnagl H, Bader M. 2009. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc Natl Acad Sci USA 106:10332-10337.
2. Andrews PW, Thomson JA Jr. 2009. The bright side of being blue: Depression as an adaptation for analyzing complex problems. Psychol Rev 116:620-654.
3. Arango V, Mann JJ. 1992. Relevance of serotonergic postmortem studies to suicidal behavior. Int Rev Psychiatry 4:131-140.
4. Arato M, Tekes K, Tothfalusi L, Magyar K, Palkovits M, Demeter E, Falus A. 1987. Serotonergic split brain and suicide. Psychiatry Res 21:355-356.
5. Arranz B, Blennow K, Eriksson A, Mansson JE, Marcusson J. 1997. Serotonergic, noradrenergic, and dopaminergic measures in suicide brains. Biol Psychiatry 41:1000-1009.
6. Bach H, Arango V. 2012. Neuroanatomy of serotonergic abnormalities in suicide. In: Dwivedi, Y, editor. The Neurobiological Basis of Suicide. New York: Taylor and Francis. p. 11-27.
7. Bach-Mizrachi H, Underwood MD, Kassir SA, Bakalian MJ, Sibille E, Tamir H, Mann JJ, Arango V. 2006. Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. Neuropsychopharmacology 31:814-824.
8. Bach-Mizrachi H, Underwood MD, Tin A, Ellis SP, Mann JJ, Arango V. 2008. Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Mol Psychiatry 13:507-513.
9. Barton DA, Esler MD, Dawood T, Lambert EA, Haikerwal D, Brenchley C, Socratous F, Hastings J, Guo L, Wiesner G, Kaye DM, Bayles R, Schlaich MP, Lambert GW. 2008. Elevated brain serotonin turnover in patients with depression: effect of genotype and therapy. Arch Gen Psychiatry 65:38-46.
10. Beskow J, Gottfries CG, Roos BE, Winblad B. 1976. Determination of monoamine and monoamine metabolites in the human brain: Post mortem studies in a group of suicides and in a control group. Acta Psychiatr Scand 53:7-20.
11. Boldrini M, Underwood MD, Mann JJ, Arango V. 2005. More tryptophan hydroxylase in the brainstem dorsal raphe nucleus in depressed suicides. Brain Res 1041:19-28.
12. Bourne HR, Bunney WE Jr, Colburn RW, Davis JM, Shaw DM, Coppen AJ. 1968. Noradrenaline, 5-hydroxytryptamine, and 5-hydroxy-indoleacetic acid in hindbrains of suicidal patients. Lancet ii:805-808.
13. Cheetham SC, Crompton MR, Czudek C, Horton RW, Katona CLE, Reynolds GP. 1989. Serotonin concentrations and turnover in brains of depressed suicides. Brain Res 502:332-340.
14. Cochran E, Robins E, Grote S. 1976. Regional serotonin levels in brain: A comparison of depressive suicides and alcoholic suicides with controls. Biol Psychiatry 11:283-294.
15. Crow TJ, Cross AJ, Cooper SJ, Deakin JFW, Ferrier IN, Johnson JA, Joseph MH, Owen F, Poulter M, Lofthouse R, Corsellis JAN, Chambers DR, Blessed G, Perry EK, Perry RH, Tomlinson BE. 1984. Neurotransmitter receptors and monoamine metabolites in the brains of patients with Alzheimer-type dementia and depression, and suicides. Neuropharmacology 23:1561-1569.
16. Gjerris A, Srensen AS, Rafaelsen OJ, Werdelin L, Alling C, Linnoila M. 1987. 5-HT and 5-HIAA in cerebrospinal fluid in depression. J Affect Disord 12:13-22.
17. Harrison PJ, Heath PR, Eastwood SL, Burnet PWJ, McDonald B, Pearson RCA. 1995. The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: Selective mRNA vulnerability and comparison with their encoded proteins. Neurosci Lett 200:151-154.
18. Kelly TM, Mann JJ. 1996. Validity of DSM-III-R diagnosis by psychological autopsy: A comparison with clinician ante-mortem diagnosis. Acta Psychiatr Scand 94:337-343.
19. Kontur PJ, Al-Tikriti MS, Innis RB, Roth RH. 1994. Postmortem stability of monoamines, their metabolites, and receptor binding in rat brain regions. J Neurochem 62:282-290.
20. Lidberg L, Belfrage H, Bertilsson L, Evenden MM, Åsberg M. 2000. Suicide attempts and impulse control disorder are related to low cerebrospinal fluid 5-HIAA in mentally disordered violent offenders. Acta Psychiatr Scand 101:395-402.
21. Lloyd KG, Farley IJ, Deck JHN, Hornykiewicz O. 1974. Serotonin and 5-hydroxyindoleacetic acid in discrete areas of the brainstem of suicide victims and control patients. Adv Biochem Psychopharmacol 11:387-397.
22. Mahadik SP, Laev H, Korenovsky A, Karpiak SE. 1988. Haloperidol alters rat CNS cholinergic system: enzymatic and morphological analyses. Biol Psychiatry 24:199-217.
23. Mann JJ. 2003. Neurobiology of suicidal behaviour. Nat Rev Neurosci 4:819-828.
24. Mann JJ, Malone KM. 1997. Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biol Psychiatry 41:162-171.
25. Mann JJ, Arango V, Marzuk PM, Theccanat S, Reis DJ. 1989. Evidence for the 5-HT hypothesis of suicide. A review of post-mortem studies. Br J Psychiatry Suppl 155 (Suppl 8):7-14.
26. Mann JJ, Malone KM, Sweeney JA, Brown RP, Linnoila M, Stanley B, Stanley M. 1996. Attempted suicide characteristics and cerebrospinal fluid amine metabolites in depressed inpatients. Neuropsychopharmacology 15:576-586.
27. McIntyre IM, Stanley M. 1984. Postmortem and regional changes of serotonin, 5-hydroxyindoleacetic acid, and tryptophan in brain. J Neurochem 42:1588-1592.
28. 2 receptors and suicide. Lancet ii:1256.
29. Palmer AM, Lowe SL, Francis PT, Bowen DM. 1988. Are post-mortem biochemical studies of human brain worthwhile. Biochem Soc Trans 16:472-475.
30. Pare CMB, Yeung DPH, Price K, Stacey RS. 1969. 5-Hydroxytryptamine, noradrenaline, and dopamine in brainstem, hypothalamus, and caudate nucleus of controls and of patients committing suicide by coal-gas poisoning. Lancet ii:133-135.
31. Patel PD, Pontrello C, Burke S. 2004. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biol Psychiatry 55:428-433.
32. Placidi GP, Oquendo MA, Malone KM, Huang YY, Ellis SP, Mann JJ. 2001. Aggressivity, suicide attempts, and depression: relationship to cerebrospinal fluid monoamine metabolite levels. Biol Psychiatry 50:783-791.
33. Shaw DM, Camps FE, Eccleston EG. 1967. 5-Hydroxytryptamine in the hind-brain of depressive suicides. Br J Psychiatry 113:1407-1411.
34. Stanley M, Träskman-Bendz L, Dorovini-Zis K. 1985. Correlations between aminergic metabolites simultaneously obtained from human CSF and brain. Life Sci 37:1279-1286.
35. Träskman L, Åsberg M, Bertilsson L, Sjöstrand L. 1981. Monoamine metabolites in CSF and suicidal behavior. Arch Gen Psychiatry 38:631-636.
36. Underwood MD, Khaibulina AA, Ellis SP, Moran A, Rice PM, Mann JJ, Arango V. 1999. Morphometry of the dorsal raphe nucleus serotonergic neurons in suicide victims. Biol Psychiatry 46:473-483.
37. Zhang X, Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG. 2004. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 305:217.