Exercise boosts hippocampal volume by preventing early age-related gray matter loss

Hippocampus

Volumn 24, Issue 2, 2014, Pages 131-134

  Fuss, Johannes ^a   Biedermann, Sarah V ^a   Falfán Melgoza, Claudia ^a   Auer, Matthias K ^a,b   Zheng, Lei ^c   Steinle, Jörg ^a   Hörner, Felix ^a   Sartorius, Alexander ^a   Ende, Gabriele ^a   Weber Fahr, Wolfgang ^a   Gass, Peter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Aging; Brain matter; Hippocampus; Mice; Sports; Wheel running

Indexed keywords

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN SIZE; CELL DISRUPTION; CELL LOSS; CONTROLLED STUDY; EARLY AGE RELATED GRAY MATTER LOSS; EXERCISE; HIPPOCAMPUS; HUMAN; IRRADIATION; MALE; MOUSE; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RUNNING; SPORT; VOXEL BASED MORPHOMETRY; WHEEL RUNNING;

AGING; BRAIN MATTER; HIPPOCAMPUS; MICE; SPORTS; WHEEL RUNNING;

AGING; ANIMALS; CRANIAL IRRADIATION; HIPPOCAMPUS; IMAGING, THREE-DIMENSIONAL; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED C57BL; PHYSICAL CONDITIONING, ANIMAL; RUNNING;

EID: 84892671408     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.22227     Document Type: Article

References (20)

1. Ben Abdallah NM, Slomianka L, Vyssotski AL, Lipp HP. 2010. Early age-related changes in adult hippocampal neurogenesis in C57 mice. Neurobiol Aging 31:151-161.
2. Biedermann S, Fuss J, Zheng L, Sartorius A, Falfan-Melgoza C, Demirakca T, Gass P, Ende G, Weber-Fahr W. 2012. In vivo voxel based morphometry: Detection of increased hippocampal volume and decreased glutamate levels in exercising mice. Neuroimage 61:1206-1212.
3. Erickson KI, Prakash RS, Voss MW, Chaddock L, Hu L, Morris KS, White SM, Wojcicki TR, McAuley E, Kramer AF. 2009. Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus 19:1030-1039.
4. Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, Kim JS, Heo S, Alves H, White SM, Wojcicki TR, Mailey E, Vieira VJ, Martin SA, Pence BD, Woods JA, McAuley E, Kramer AF. 2011. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA 108:3017-3022.
5. Fuss J, Ben Abdallah NM, Hensley FW, Weber KJ, Hellweg R, Gass P. 2010a. Deletion of running-induced hippocampal neurogenesis by irradiation prevents development of an anxious phenotype in mice. PLoS One 5:0012769.
6. Fuss J, Ben Abdallah NM, Vogt MA, Touma C, Pacifici PG, Palme R, Witzemann V, Hellweg R, Gass P. 2010b. Voluntary exercise induces anxiety-like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis. Hippocampus 20:364-376.
7. Fuss J, Vogt MA, Weber KJ, Burke TF, Gass P, Hensler JG. 2013. Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long term voluntary wheel running. Synapse 67:648-655.
8. Giedd JN, Blumenthal J, Jeffries NO, Castellanos FX, Liu H, Zijdenbos A, Paus T, Evans AC, Rapoport JL. 1999. Brain development during childhood and adolescence: A longitudinal MRI study. Nat Neurosci 2:861-863.
9. Hedman AM, van Haren NE, Schnack HG, Kahn RS, Hulshoff Pol HE. 2012. Human brain changes across the life span: A review of 56 longitudinal magnetic resonance imaging studies. Hum Brain Mapp 33:1987-2002.
10. Ho NF, Hooker JM, Sahay A, Holt DJ, Roffman JL. 2013. In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise. Mol Psychiatry 18:404-416.
11. Holms S. 1979. A simple sequentially rejective multiple test procedure. Scand J Stat 6:65-70.
12. Klauschen F, Goldman A, Barra V, Meyer-Lindenberg A, Lundervold A. 2009. Evaluation of automated brain MR image segmentation and volumetry methods. Hum Brain Mapp 30:1310-1327.
13. Kovacevic N, Henderson JT, Chan E, Lifshitz N, Bishop J, Evans AC, Henkelman RM, Chen XJ. 2005. A three-dimensional MRI atlas of the mouse brain with estimates of the average and variability. Cereb Cortex 15:639-645.
14. Luders E, Steinmetz H, Jancke L. 2002. Brain size and grey matter volume in the healthy human brain. Neuroreport 13:2371-2374.
15. Pajonk FG, Wobrock T, Gruber O, Scherk H, Berner D, Kaizl I, Kierer A, Muller S, Oest M, Meyer T, Backens M, Schneider-Axmann T, Thornton AE, Honer WG, Falkai P. 2010. Hippocampal plasticity in response to exercise in schizophrenia. Arch Gen Psychiatry 67:133-143.
16. Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage FH, Brown TR, Small SA. 2007. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci USA 104:5638-5643.
17. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, Johansen-Berg H, Bannister PR, De Luca M, Drobnjak I, Flitney DE, Niazy RK, Saunders J, Vickers J, Zhang Y, De Stefano N, Brady JM, Matthews PM. 2004. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23 (Suppl 1), S208-S219.
18. Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA. 2011. Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 476:458-461.
19. van Praag H, Kempermann G, Gage FH. 1999. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 2:266-270.
20. van Praag H, Shubert T, Zhao C, Gage FH. 2005. Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 25:8680-8685.