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Volumn 217, Issue 2-3, 2014, Pages 271-278

Urinary phthalate metabolites and male reproductive function parameters in Chongqing general population, China

Author keywords

DAN damage; Hormone; Human; Male; Metabolites; Phthalate; Reproduction; Semen; Sperm

Indexed keywords

HORMONE; PHTHALIC ACID; PHTHALIC ACID DERIVATIVE; SEX HORMONE;

EID: 84892670232     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2013.06.006     Document Type: Article
Times cited : (78)

References (46)
  • 1
    • 63649102703 scopus 로고    scopus 로고
    • Maternal urinary metabolites of di-(2-ethlhexyl) phthalate in relation to the timing of labor in a US multicenter pregnancy cohort study
    • Adibi J.J., Hauser R., Williams P.L., Whyatt R.M., Calafat A.M., Nelson H., Herrick R., Swan S.H. Maternal urinary metabolites of di-(2-ethlhexyl) phthalate in relation to the timing of labor in a US multicenter pregnancy cohort study. Am. J. Epidemiol. 2009, 169:1015-1024.
    • (2009) Am. J. Epidemiol. , vol.169 , pp. 1015-1024
    • Adibi, J.J.1    Hauser, R.2    Williams, P.L.3    Whyatt, R.M.4    Calafat, A.M.5    Nelson, H.6    Herrick, R.7    Swan, S.H.8
  • 2
    • 84892674212 scopus 로고
    • Agency for Toxic Substances and Disease Registry, Toxicological profile for diethyl phthalate (DEP), Available at: (accessed 09.06.07).
    • Agency for Toxic Substances and Disease Registry, Toxicological profile for diethyl phthalate (DEP), 1995. Available at: (accessed 09.06.07). http://www.atsdr.cdc.gov/toxprofiles/tp73.html.
    • (1995)
  • 3
    • 84892672035 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry, Toxicological profile for di-n-butyl phthalate (DBP), Available at: (accessed 09.06.07).
    • Agency for Toxic Substances and Disease Registry, Toxicological profile for di-n-butyl phthalate (DBP), 2001. Available at: (accessed 09.06.07). http://www.atsdr.cdc.gov/toxprofiles/tp135.html.
    • (2001)
  • 4
    • 84892675108 scopus 로고    scopus 로고
    • Agency for Toxic Substances and Disease Registry. Toxicological profile for di(2-ethylhexyl)phthalate (DEHP), Available at: (accessed 09.06.07).
    • Agency for Toxic Substances and Disease Registry. Toxicological profile for di(2-ethylhexyl)phthalate (DEHP), 2002. Available at: (accessed 09.06.07). http://www.atsdr.cdc.gov/toxprofiles/tp9.htm.
    • (2002)
  • 7
    • 67449098265 scopus 로고    scopus 로고
    • Biomonitoring of detoxifying activity as measured by CYP1A1 induction in Yangtze and Jialing Rivers in Chongqing City in China
    • Cui Z., Liu J., Li P., Cao B., Luo C., Cao J. Biomonitoring of detoxifying activity as measured by CYP1A1 induction in Yangtze and Jialing Rivers in Chongqing City in China. J. Toxicol. Environ. Health A 2009, 72:782-788.
    • (2009) J. Toxicol. Environ. Health A , vol.72 , pp. 782-788
    • Cui, Z.1    Liu, J.2    Li, P.3    Cao, B.4    Luo, C.5    Cao, J.6
  • 9
    • 1242275292 scopus 로고    scopus 로고
    • The relationship between environmental exposure to phthalate and computer-aided sperm analysis motion parameters
    • Duty S.M., Calafat A.M., Silva M.J., Brock J.W., Ryan L., Chen Z., Overstreet J., Hauser R. The relationship between environmental exposure to phthalate and computer-aided sperm analysis motion parameters. J. Androl. 2004, 25:293-302.
    • (2004) J. Androl. , vol.25 , pp. 293-302
    • Duty, S.M.1    Calafat, A.M.2    Silva, M.J.3    Brock, J.W.4    Ryan, L.5    Chen, Z.6    Overstreet, J.7    Hauser, R.8
  • 12
    • 0035025368 scopus 로고    scopus 로고
    • Effects of phthalate esters on the developing reproductive tract of male rats
    • Foster P.M., Mylchreest E., Gaido K.W., Sar M. Effects of phthalate esters on the developing reproductive tract of male rats. Hum. Reprod. Update 2001, 7:231-235.
    • (2001) Hum. Reprod. Update , vol.7 , pp. 231-235
    • Foster, P.M.1    Mylchreest, E.2    Gaido, K.W.3    Sar, M.4
  • 14
    • 0034523473 scopus 로고    scopus 로고
    • Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
    • Gray L.E., Ostby J., Furr J., Price M., Veeramachaneni D.N., Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol. Sci. 2000, 58:350-365.
    • (2000) Toxicol. Sci. , vol.58 , pp. 350-365
    • Gray, L.E.1    Ostby, J.2    Furr, J.3    Price, M.4    Veeramachaneni, D.N.5    Parks, L.6
  • 15
    • 55649099700 scopus 로고    scopus 로고
    • The analysis of the persistent organic pollution in the Three Gorges Reservoir in Chongqing
    • [in Chinese]
    • Guo Z., Luo C., Zhang W., Lu Y., Sun J., Cao J. The analysis of the persistent organic pollution in the Three Gorges Reservoir in Chongqing. Environ. Monit. 2006, 4:45-48. [in Chinese].
    • (2006) Environ. Monit. , vol.4 , pp. 45-48
    • Guo, Z.1    Luo, C.2    Zhang, W.3    Lu, Y.4    Sun, J.5    Cao, J.6
  • 16
    • 79955574631 scopus 로고    scopus 로고
    • Phthalate metabolites in urine from China: and implications for human exposures
    • Guo Y., Wu Q., Kannan K. Phthalate metabolites in urine from China: and implications for human exposures. Environ. Int. 2011, 37(July (5)):893-898.
    • (2011) Environ. Int. , vol.37 , Issue.5 JULY , pp. 893-898
    • Guo, Y.1    Wu, Q.2    Kannan, K.3
  • 17
    • 34147163038 scopus 로고    scopus 로고
    • Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human
    • Hallmark N., Walker M., McKinnell C., Mahood I.K., Scott H., Bayne R., Coutts S., Anderson R.A., Greig I., Morris K., Sharpe R.M. Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human. Environ. Health Perspect. 2006, 115:390-396.
    • (2006) Environ. Health Perspect. , vol.115 , pp. 390-396
    • Hallmark, N.1    Walker, M.2    McKinnell, C.3    Mahood, I.K.4    Scott, H.5    Bayne, R.6    Coutts, S.7    Anderson, R.A.8    Greig, I.9    Morris, K.10    Sharpe, R.M.11
  • 18
    • 79955834171 scopus 로고    scopus 로고
    • Association between urinary polycyclic aromatic hydrocarbon metabolites and sperm DNA damage: a population study in Chongqing, China
    • Han X., Zhou N., Cui Z., Ma M., Li L., Cai M., Li Y., Lin H., Li Y., Ao L., Liu J., Cao J. Association between urinary polycyclic aromatic hydrocarbon metabolites and sperm DNA damage: a population study in Chongqing, China. Environ. Health Perspect. 2011, 119:652-657.
    • (2011) Environ. Health Perspect. , vol.119 , pp. 652-657
    • Han, X.1    Zhou, N.2    Cui, Z.3    Ma, M.4    Li, L.5    Cai, M.6    Li, Y.7    Lin, H.8    Li, Y.9    Ao, L.10    Liu, J.11    Cao, J.12
  • 19
    • 40349116033 scopus 로고    scopus 로고
    • Urinary phthalate metabolites and semen quality: a review of a potential biomarker of susceptibility
    • Hauser R. Urinary phthalate metabolites and semen quality: a review of a potential biomarker of susceptibility. Int. J. Androl. 2008, 31:112-117.
    • (2008) Int. J. Androl. , vol.31 , pp. 112-117
    • Hauser, R.1
  • 20
    • 33750482232 scopus 로고    scopus 로고
    • Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites
    • Hauser R., Meeker J.D., Duty S., Silva M.J., Calafat A.M. Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Epidemiology 2006, 17:682-691.
    • (2006) Epidemiology , vol.17 , pp. 682-691
    • Hauser, R.1    Meeker, J.D.2    Duty, S.3    Silva, M.J.4    Calafat, A.M.5
  • 21
    • 10944238528 scopus 로고    scopus 로고
    • Temporal variability of urinary phthalate metabolite levels in men of reproductive age
    • Hauser R., Meeker J.D., Park S., Silva M.J., Calafat A.M. Temporal variability of urinary phthalate metabolite levels in men of reproductive age. Environ. Health Perspect. 2004, 112:1734-1740.
    • (2004) Environ. Health Perspect. , vol.112 , pp. 1734-1740
    • Hauser, R.1    Meeker, J.D.2    Park, S.3    Silva, M.J.4    Calafat, A.M.5
  • 22
    • 34247892413 scopus 로고    scopus 로고
    • DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites
    • Hauser R., Meeker J.D., Singh N.P., Silva M.I., Duty S., Calafat A.M. DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites. Hum. Reprod. 2007, 22:688-695.
    • (2007) Hum. Reprod. , vol.22 , pp. 688-695
    • Hauser, R.1    Meeker, J.D.2    Singh, N.P.3    Silva, M.I.4    Duty, S.5    Calafat, A.M.6
  • 23
    • 18044362709 scopus 로고    scopus 로고
    • Evidence of interaction between polychlorinated biphenyls and phthalates in relation to human sperm motility
    • Hauser R., Williams P., Altshul L., Calafat A.M. Evidence of interaction between polychlorinated biphenyls and phthalates in relation to human sperm motility. Environ. Health Perspect. 2005, 113:425-430.
    • (2005) Environ. Health Perspect. , vol.113 , pp. 425-430
    • Hauser, R.1    Williams, P.2    Altshul, L.3    Calafat, A.M.4
  • 25
    • 62649088559 scopus 로고    scopus 로고
    • Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence
    • Hu G.X., Lian Q.Q., Ge R.S., Hardy D.O., Li X.K. Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence. Trends Endocrinol. Metab. 2009, 20:139-145.
    • (2009) Trends Endocrinol. Metab. , vol.20 , pp. 139-145
    • Hu, G.X.1    Lian, Q.Q.2    Ge, R.S.3    Hardy, D.O.4    Li, X.K.5
  • 27
    • 84858439072 scopus 로고    scopus 로고
    • Phthalate exposure of Chinese reproductive age couples and its effects on male semen quality, a primary study
    • Liu L., Bao H., Liu F., Zhang J., Shen H. Phthalate exposure of Chinese reproductive age couples and its effects on male semen quality, a primary study. Environ. Int. 2012, 42:78-83.
    • (2012) Environ. Int. , vol.42 , pp. 78-83
    • Liu, L.1    Bao, H.2    Liu, F.3    Zhang, J.4    Shen, H.5
  • 28
    • 0033790136 scopus 로고    scopus 로고
    • The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors
    • Møller P., Knudsen L.E., Loft S., Wallin H. The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol. Biomark. Prev. 2000, 9:1005-1015.
    • (2000) Cancer Epidemiol. Biomark. Prev. , vol.9 , pp. 1005-1015
    • Møller, P.1    Knudsen, L.E.2    Loft, S.3    Wallin, H.4
  • 29
    • 20544448920 scopus 로고    scopus 로고
    • Urinary phthalate metabolites and biomarkers of reproductive function in young men
    • Jönsson B.A., Richthoff J., Rylander L., Giwercman A., Hagmar L. Urinary phthalate metabolites and biomarkers of reproductive function in young men. Epidemiology 2005, 16:487-493.
    • (2005) Epidemiology , vol.16 , pp. 487-493
    • Jönsson, B.A.1    Richthoff, J.2    Rylander, L.3    Giwercman, A.4    Hagmar, L.5
  • 30
  • 31
    • 0035140143 scopus 로고    scopus 로고
    • Effect of male age on semen quality and fertility: a review of the literature
    • Kidd S.A., Eskenazi B., Wyrobek A.J. Effect of male age on semen quality and fertility: a review of the literature. Fertil. Steril. 2001, 75:237-248.
    • (2001) Fertil. Steril. , vol.75 , pp. 237-248
    • Kidd, S.A.1    Eskenazi, B.2    Wyrobek, A.J.3
  • 32
    • 22844433529 scopus 로고    scopus 로고
    • New metabolites of di(2-ethylhexyl) phthalate (DEHP) in human urine and serum after a single oral dose of deuterium-labelled DEHP
    • Koch H.M., Bolt H.M., Preuss R., Angerer J. New metabolites of di(2-ethylhexyl) phthalate (DEHP) in human urine and serum after a single oral dose of deuterium-labelled DEHP. Arch. Toxicol. 2005, 79:367-376.
    • (2005) Arch. Toxicol. , vol.79 , pp. 367-376
    • Koch, H.M.1    Bolt, H.M.2    Preuss, R.3    Angerer, J.4
  • 34
    • 33750877092 scopus 로고    scopus 로고
    • Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): across-sectional study in China
    • Pan G., Hanaoka T., Yoshimura M., Zhang S., Wang P., Tsukino H., Inoue K., Nakazawa H., Tsugane S., Takahashi K. Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): across-sectional study in China. Environ. Health Perspect. 2006, 114:1643-1648.
    • (2006) Environ. Health Perspect. , vol.114 , pp. 1643-1648
    • Pan, G.1    Hanaoka, T.2    Yoshimura, M.3    Zhang, S.4    Wang, P.5    Tsukino, H.6    Inoue, K.7    Nakazawa, H.8    Tsugane, S.9    Takahashi, K.10
  • 37
    • 0035004535 scopus 로고    scopus 로고
    • Testiculardysgenesis syndrome: an increasingly common developmental disorder with environmental aspects
    • Skakkebaek N.E., Rajpert-De Meyts E., Main K. Testiculardysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum. Reprod. 2001, 16:972-978.
    • (2001) Hum. Reprod. , vol.16 , pp. 972-978
    • Skakkebaek, N.E.1    Rajpert-De Meyts, E.2    Main, K.3
  • 38
    • 52949101044 scopus 로고    scopus 로고
    • Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans
    • Swan S.H. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ. Res. 2008, 108:177-184.
    • (2008) Environ. Res. , vol.108 , pp. 177-184
    • Swan, S.H.1
  • 40
    • 33747088802 scopus 로고    scopus 로고
    • Organic pollutants in source water in Jialing River and Yangtze River (Chongqing section)
    • [in Chinese]
    • Tian H.J., Shu W.Q., Zhang X.K. Organic pollutants in source water in Jialing River and Yangtze River (Chongqing section). Resour. Environ. Yangtze Basin 2003, 2:118-123. [in Chinese].
    • (2003) Resour. Environ. Yangtze Basin , vol.2 , pp. 118-123
    • Tian, H.J.1    Shu, W.Q.2    Zhang, X.K.3
  • 42
    • 84864313684 scopus 로고    scopus 로고
    • Urinary phthalate monoesters concentration in couples with infertility problems
    • Tranfo G., Caporossi L., Paci E., Aragona C., Romanzi D., Carolis C., et al. Urinary phthalate monoesters concentration in couples with infertility problems. Toxicol. Lett. 2012, 213:15-20.
    • (2012) Toxicol. Lett. , vol.213 , pp. 15-20
    • Tranfo, G.1    Caporossi, L.2    Paci, E.3    Aragona, C.4    Romanzi, D.5    Carolis, C.6
  • 43
    • 84892676978 scopus 로고    scopus 로고
    • Urinary metabolite concentrations of phthalate metabolites in Central Italy healthy volunteers determined by a validated HPLC/MS/MS analytical method
    • DOI: pii: S1438-4639(12)00136-8
    • Tranfo G., Caporossi L., Paci E., Aragona C., Romanzi D., De Carolis C., De Rosa M., Capanna S., Papaleo B., Pera A. Urinary metabolite concentrations of phthalate metabolites in Central Italy healthy volunteers determined by a validated HPLC/MS/MS analytical method. Int. J. Hyg. Environ. Health 2012, DOI: pii: S1438-4639(12)00136-8.
    • (2012) Int. J. Hyg. Environ. Health
    • Tranfo, G.1    Caporossi, L.2    Paci, E.3    Aragona, C.4    Romanzi, D.5    De Carolis, C.6    De Rosa, M.7    Capanna, S.8    Papaleo, B.9    Pera, A.10


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