Wound infections caused by inducible meticillin-resistant Staphylococcus aureus strains

Journal of Global Antimicrobial Resistance

Volumn 1, Issue 2, 2013, Pages 79-83

  Penn, Christopher ^a   Moddrell, Carol ^a   Tickler, Isabella A ^b   Henthorne, Mary Ann ^a   Kehrli, Megan ^a   Goering, Richard V ^c   Tenover, Fred C ^b  

^a Lawrence Memorial Hospital   (United States)

^b CEPHEID   (United States)

^c CREIGHTON UNIVERSITY   (United States)

Author keywords

Cefoxitin screen; MecA; Meticillin resistance; Oxacillin; Staphylococcus aureus

Indexed keywords

CEFOXITIN; CEFTAROLINE; COTRIMOXAZOLE; DAPTOMYCIN; METICILLIN; OXACILLIN; PENICILLIN BINDING PROTEIN 2A; PIPERACILLIN PLUS TAZOBACTAM; STAPHYLOCOCCUS PROTEIN A; SULFAMETHOXAZOLE; TRIMETHOPRIM; VANCOMYCIN;

ABSCESS; ABSCESS DRAINAGE; ADOLESCENT; ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM COLONY; BACTERIUM ISOLATE; CASE REPORT; CELLULITIS; CHILL; CREATININE BLOOD LEVEL; DISK DIFFUSION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; FEVER; GENOTYPE; HEADACHE; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INJECTION SITE ERYTHEMA; LATEX AGGLUTINATION TEST; LEUKOCYTE COUNT; LIVER FUNCTION TEST; LOWER ABDOMINAL PAIN; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MIDDLE AGED; MINIMUM INHIBITORY CONCENTRATION; NAUSEA AND VOMITING; NEUROPATHY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PUS; SKIN ULCER; SUPPURATION; TACHYCARDIA; THROMBOCYTOPENIA; URINE VOLUME; WOUND INFECTION;

EID: 84892666827     PISSN: 22137165     EISSN: 22137173     Source Type: Journal    
DOI: 10.1016/j.jgar.2013.03.009     Document Type: Article

References (24)

1. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; twenty-second informational supplement. Document M100-S22. Wayne, PA: CLSI; 2012.
2. Swenson JM, Williams PP, Killgore G, O'Hara CM, Tenover FC. Performance of eight methods, including two new rapid methods, for detection of oxacillin resistance in a challenge set of Staphylococcus aureus organisms. Journal of Clinical Microbiology 2001;39:3785-8.
3. Felten A, Grandry B, Lagrange PH, Casin I. Evaluation of three techniques for detection of low-level methicillin-resistant Staphylococcus aureus (MRSA): a disk diffusion method with cefoxitin and moxalactam, the Vitek 2 system, and the MRSA-screen latex agglutination test. Journal of Clinical Microbiology 2002;40:2766-71.
4. Wolk DM, Struelens MJ, Pancholi P, Davis T, Della-Latta P, Fuller D, et al. Rapid detection of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in wound specimens and blood cultures: multicenter preclinical evaluation of the Cepheid Xpert MRSA/SA skin and soft tissue and blood culture assays. Journal of Clinical Microbiology 2009;47:823-6.
5. Parta M, Goebel M, Matloobi M, Stager C, Musher DM. Identification of methicillin-resistant or methicillin-susceptible Staphylococcus aureus in blood cultures and wound swabs by GeneXpert. Journal of Clinical Microbiology 2009;47:1609-10.
6. Ubukata K, Yamashita N, Konno M. Occurrence of a b-lactam-inducible penicillin-binding protein in methicillin-resistant staphylococci. Antimicrobial Agents and Chemotherapy 1985;27:851-7.
7. Kampf G, Adena S, Ruden H, Weist K. Inducibility and potential role of mecAgene- positive oxacillin-susceptible Staphylococcus aureus from colonized healthcare workers as a source for nosocomial infections. Journal of Hospital Infection 2003;54:124-9.
8. Ikonomidis A, Michail G, Vasdeki A, Labrou M, Karavasilis V, Stathopoulos C, et al. In vitro and in vivo evaluations of oxacillin efficiency against mecApositive oxacillin-susceptible Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 2008;52:3905-8.
9. Hososaka Y, Hanaki H, Endo H, Suzuki Y, Nagasawa Z, Otsuka Y, et al. Characterization of oxacillin-susceptible mecA-positive Staphylococcus aureus: a new type of MRSA. Journal of Infection and Chemotherapy 2007;13:79-86.
10. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial disk susceptibility tests; approved standard 11th ed. Document M2- A11. Wayne, PA: CLSI; 2012.
11. Pfeltz RF, Schmidt JL, Wilkinson BJ. A microdilution plating method for population analysis of antibiotic-resistant staphylococci. Microbial Drug Resistance 2001;7:289-95.
12. Oliveira DC, de Lencastre H. Methicillin-resistance in Staphylococcus aureus is not affected by the overexpression in trans of the mecA gene repressor: a surprising observation. PLoS One 2011;6:e23287.
13. Shopsin B, Gomez M, Montgomery SO, Smith DH, Waddington M, Dodge DE, et al. Evaluation of protein A gene polymorphic region DNA sequencing for typing of Staphylococcus aureus strains. Journal of Clinical Microbiology 1999;37:3556-63.
14. Chambers HF, Deleo FR. Waves of resistance: Staphylococcus aureus in the antibiotic era. Nature Reviews Microbiology 2009;7:629-41.
15. Garcia-Alvarez L, Holden MT, Lindsay H, Webb CR, Brown DF, Curran MD, et al. Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. Lancet Infectious Diseases 2011;11:595-603.
16. Hackbarth CJ, Chambers HF. BlaI and blaR1 regulate b-lactamase and PBP 2a production in methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 1993;37:1144-9.
17. Hiramatsu K, Asada K, Suzuki E, Okonogi K, Yokota T. Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA). FEBS Letters 1992;298: 133-6.
18. Swenson JM, Lonsway D, McAllister S, Thompson A, Jevitt L, Zhu W, et al. Detection of mecA-mediated resistance using reference and commercial testing methods in a collection of Staphylococcus aureus expressing borderline oxacillin MICs. Diagnostic Microbiology and Infectious Disease 2007;58: 33-9.
19. Rossi L, Tonin E, Cheng YR, Fontana R. Regulation of penicillin-binding protein activity: description of a methicillin-inducible penicillin-binding protein in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 1985;27: 828-31.
20. Ubukata K, Nonoguchi R, Matsuhashi M, Konno M. Expression and inducibility in Staphylococcus aureus of the mecA gene, which encodes a methicillinresistant S. aureus-specific penicillin-binding protein. Journal of Bacteriology 1989;171:2882-5.
21. Bauer KA, West JE, Balada-Llasat JM, Pancholi P, Stevenson KB, Goff DA. An antimicrobial stewardship program's impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus/S. aureus blood culture test in patients with S. aureus bacteremia. Clinical Infectious Diseases 2010;51:1074-80.
22. Dubouix-Bourandy A, de Ladoucette A, Pietri V, Mehdi N, Benzaquen D, Guinand R, et al. Direct detection of Staphylococcus osteoarticular infections by use of Xpert MRSA/SA SSTI real-time PCR. Journal of Clinical Microbiology 2011;49:4225-30.
23. Stamper PD, Cai M, Howard T, Speser S, Carroll KC. Clinical validation of the molecular BD GeneOhm StaphSR assay for direct detection of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in positive blood cultures. Journal of Clinical Microbiology 2007;45:2191-6.
24. Sakoulas G, Gold HS, Venkataraman L, DeGirolami PC, Eliopoulos GM, Qian Q. Methicillin-resistant Staphylococcus aureus: comparison of susceptibility testing methods and analysis of mecA-positive susceptible strains. Journal of Clinical Microbiology 2001;39:3946-51.