Morning free and total testosterone in HIV-infected men: Implications for the assessment of hypogonadism

AIDS Research and Therapy

Volumn 11, Issue 1, 2014, Pages

  Monroe, Anne K ^a   Dobs, Adrian S ^a   Palella, Frank J ^b   Kingsley, Lawrence A ^c   Witt, Mallory D ^d   Brown, Todd T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^d HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

HIV; Hypogonadism; Sex hormone binding globulin; Testosterone

Indexed keywords

SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; ARTICLE; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPOGONADISM; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SUBSTITUTION THERAPY; TANDEM MASS SPECTROMETRY; TESTOSTERONE BLOOD LEVEL;

EID: 84892663855     PISSN: None     EISSN: 17426405     Source Type: Journal    
DOI: 10.1186/1742-6405-11-6     Document Type: Article

References (18)

1. Wunder DM, Bersinger NA, Fux CA, Mueller NJ, Hirschel B, Cavassini M, Elzi L, Schmid P, Bernasconi E, Mueller B, Furrer H, Swiss HIV. Cohort study: hypogonadism in HIV-1-infected men is common and does not resolve during antiretroviral therapy. Antivir Ther 2007, 12:261-265.
2. Rietschel P, Corcoran C, Stanley T, Basgoz N, Klibanski A, Grinspoon S. Prevalence of hypogonadism among men with weight loss related to human immunodeficiency virus infection who were receiving highly active antiretroviral therapy. Clin Infect Dis 2000, 31:1240-1244.
3. Klein RS, Lo Y, Santoro N, Dobs AS. Androgen levels in older men who have or who are at risk of acquiring HIV infection. Clin Infect Dis 2005, 41:1794-1803.
4. Grinspoon S, Corcoran C, Lee K, Burrows B, Hubbard J, Katznelson L, Walsh M, Guccione A, Cannan J, Heller H, Basgoz N, Klibanski A. Loss of lean body and muscle mass correlates with androgen levels in hypogonadal men with acquired immunodeficiency syndrome and wasting. J Clin Endocrinol Metab 1996, 81:4051-4058.
5. Grinspoon S. Androgen deficiency and HIV infection. Clin Infect Dis 2005, 41:1804-1805.
6. Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM. Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2010, 95:2536-2559.
7. Martin ME, Benassayag C, Amiel C. Alterations in the concentrations and binding properties of sex steroid binding protein and corticosteroid-binding globulin in HIV + patients. J Endocrinol Invest 1992, 15:597-603.
8. Monroe AK, Dobs AS, Xu X, Palella FJ, Kingsley LA, Witt MD, Brown TT. Sex hormones, insulin resistance, and diabetes mellitus among men with or at risk for HIV infection. JAIDS 2011, 58:173-180.
9. Waters L, Patterson B, Scourfield A, Hughes A, De Silva S, Gazzard B, Barton S, Asboe D, Pozniak A, Boffito M. A dedicated clinic for HIV-positive individuals over 50 years of age: a multidisciplinary experience. Int J STD AIDS 2012, 23:546-552.
10. Blick G. Optimal diagnostic measures and thresholds for hypogonadism in men with HIV/AIDS: comparison between 2 transdermal testosterone replacement therapy gels. Postgrad Med 2013, 125:30-39.
11. Aberg JA, Gallant JE, Ghanem KG, Emmanuel P, Zingman BS, Horberg MA. Primary care guidelines for the management of persons infected with HIV: 2013 update by the HIV medicine association of the infectious diseases society of America. Clin Infect Dis 2014, 58:e1-e34.
12. Mayer KH, Mylonakis E, Koutkia P. Diagnosis and treatment of androgen deficiency in human immunodeficiency virus-infected men and women. Clin Inf Dis 2001, 33:857-864.
13. Dobs AS, Few WL, Blackman MR, Harman SM, Hoover DR, Graham NM. Serum hormones in men with human immunodeficiency virus-associated wasting. J Clin Endocrinol Metab 1996, 81:4108-4112.
14. Kingsley L, Cuervo-Rojas J, Muñoz A, Palella FJ, Post W, Witt MD, Budoff M, Kuller L. Subclinical coronary atherosclerosis, HIV infection and antiretroviral therapy: multicenter AIDS cohort study. AIDS 2008, 22:1589-1599.
15. Bhasin S, Pencina M, Jasuja GK, Travison TG, Coviello A, Orwoll E, Wang PY, Nielson C, Wu F, Tajar A, Labrie F, Vesper H, Zhang A, Ulloor J, Singh R, D'Agostino R, Vasan RS. Reference ranges for testosterone in men generated using liquid chromatography tandem mass spectrometry in a community-based sample of healthy nonobese young men in the Framingham Heart Study and applied to three geographically distinct cohorts. J Clin Endocrinol Metab 2011, 96:2430-2439.
16. Bhasin S, Travison TG, Storer TW, Lakshman K, Kaushik M, Mazer NA, Ngyuen AH, Davda MN, Jara H, Aakil A, Anderson S, Knapp PE, Hanka S, Mohammed N, Daou P, Miciek R, Ulloor J, Zhang A, Brooks B, Orwoll K, Hede-Brierley L, Eder R, Elmi A, Bhasin G, Collins L, Singh R, Basaria S. Effect of testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production: a randomized controlled trial. JAMA 2012, 307:931-939.
17. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999, 84:3666-3672.
18. Crum-Cianflone NF, Bavaro M, Hale B, Amling C, Truett A, Brandt C, Pope B, Furtek K, Medina S, Wallace MR. Erectile dysfunction and hypogonadism among men with HIV. Aids Patient Care STDS 2007, 21:9-19.