Identification of ML251, a potent inhibitor of T. brucei and T. cruzi phosphofructokinase

ACS Medicinal Chemistry Letters

Volumn 5, Issue 1, 2014, Pages 12-17

  Brimacombe, Kyle R ^a   Walsh, Martin J ^a   Liu, Li ^a   Vásquez Valdivieso, Montserrat G ^b   Morgan, Hugh P ^b   McNae, Iain ^b   Fothergill Gilmore, Linda A ^b   Michels, Paul A M ^c   Auld, Douglas S ^a   Simeonov, Anton ^a   Walkinshaw, Malcolm D ^b   Shen, Min ^a   Boxer, Matthew B ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c DE DUVE INSTITUTE   (Belgium)

Author keywords

glycolysis; high throughput screening; inhibitors; phosphofructokinase; Trypanosoma brucei; Trypanosoma cruzi

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ADENOSINE TRIPHOSPHATE; ANTITRYPANOSOMAL AGENT; GLUCOSE; ML 251; PHOSPHOFRUCTOKINASE INHIBITOR; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ARTICLE; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; GLYCOLYSIS; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

EID: 84892618894     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400259d     Document Type: Article

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