Long-term outcomes after first-generation autologous chondrocyte implantation for cartilage defects of the knee

American Journal of Sports Medicine

Volumn 42, Issue 1, 2014, Pages 150-157

  Niemeyer, Philipp ^a   Porichis, Stella ^a   Steinwachs, Matthias ^b   Erggelet, Christoph ^c   Kreuz, Peter C ^d   Schmal, Hagen ^a   Uhl, Markus ^e   Ghanem, Nadir ^f   Südkamp, Norbert P ^a   Salzmann, Gian ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b SCHULTHESS CLINIC   (Switzerland)

^c Center of Biologic Joint Repair   (Switzerland)

^d ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

^e Institute for Diagnostic Radiology   (Germany)

^f Diagnostic Imaging Center   (Germany)

Author keywords

autologous chondrocyte implantation; cartilage; knee joint; long term outcomes

Indexed keywords

ADULT; ARTHROSCOPY; ARTICLE; ARTICULAR CARTILAGE; AUTOLOGOUS CHONDROCYTE IMPLANTATION; AUTOTRANSPLANTATION; CARTILAGE; CARTILAGE CELL; FEMALE; FOLLOW UP; HUMAN; JOINT CHARACTERISTICS AND FUNCTIONS; KNEE; KNEE OSTEOARTHRITIS; LONG-TERM OUTCOMES; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; ORTHOPEDIC SURGERY; PAIN ASSESSMENT; PATIENT SATISFACTION; TRANSPLANTATION;

AUTOLOGOUS CHONDROCYTE IMPLANTATION; CARTILAGE; KNEE JOINT; LONG-TERM OUTCOMES;

ADULT; ARTHROSCOPY; CARTILAGE, ARTICULAR; CHONDROCYTES; FEMALE; FOLLOW-UP STUDIES; HUMANS; KNEE JOINT; MAGNETIC RESONANCE IMAGING; MALE; ORTHOPEDIC PROCEDURES; OSTEOARTHRITIS, KNEE; PAIN MEASUREMENT; PATIENT SATISFACTION; RANGE OF MOTION, ARTICULAR; TRANSPLANTATION, AUTOLOGOUS;

EID: 84892598097     PISSN: 03635465     EISSN: 15523365     Source Type: Journal    
DOI: 10.1177/0363546513506593     Document Type: Article

References (47)

1. Anders S, Goetz J, Schubert T, Grifka J, Schaumburger J. Treatment of deep articular talus lesions by matrix associated autologous chondrocyte implantation: results at five years. Int Orthop. 2012 ; 36 (11). 2279-2285
2. Bartlett W, Skinner JA, Gooding CR, et al. Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study. J Bone Joint Surg Br. 2005 ; 87 (5). 640-645
3. Behrens P, Bosch U, Bruns J, et al. [Indications and implementation of recommendations of the working group "Tissue Regeneration and Tissue Substitutes" for autologous chondrocyte transplantation (ACT)]. Z Orthop Ihre Grenzgeb. 2004 ; 142 (5). 529-539
4. Bentley G, Biant LC, Vijayan S, Macmull S, Skinner JA, Carrington RW. Minimum ten-year results of a prospective randomised study of autologous chondrocyte implantation versus mosaicplasty for symptomatic articular cartilage lesions of the knee. J Bone Joint Surg Br. 2012 ; 94 (4). 504-509
5. Beris AE, Lykissas MG, Kostas-Agnantis I, Manoudis GN. Treatment of full-thickness chondral defects of the knee with autologous chondrocyte implantation: a functional evaluation with long-term follow-up. Am J Sports Med. 2012 ; 40 (3). 562-567
6. Blackman AJ, Smith MV, Flanigan DC, Matava MJ, Wright RW, Brophy RH. Correlation between magnetic resonance imaging and clinical outcomes after cartilage repair surgery in the knee: a systematic review and meta-analysis. Am J Sports Med. 2013 ; 41 (6). 1426-1434
7. Bode G, Schmal H, Pestka JM, Ogon P, Sudkamp NP, Niemeyer P. A non-randomized controlled clinical trial on autologous chondrocyte implantation (ACI) in cartilage defects of the medial femoral condyle with or without high tibial osteotomy in patients with varus deformity of less than 5 degrees. Arch Orthop Trauma Surg. 2013 ; 133 (1). 43-49
8. Brittberg M. Autologous chondrocyte transplantation. Clin Orthop Relat Res. 1999 ;: S147 - S155
9. BrittbergM. ICRS Clinical Cartilage Injury Evaluation System. Paper presented at: 3rd ICRS Meeting; April 28, 2000; Göteborg, Sweden. Available at: www.cartilage.org/-files/contentmanagement/ICRS-evaluation.pdf. Accessed January 3, 2012.
10. Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994 ; 331 (14). 889-895
11. Choi Y, Potter HG. MR imaging sequences for evaluation of cartilage repair. Radiographics. 2008 ; 28: 1043-1059
12. Cicuttini F, Ding C, Wluka A, Davis S, Ebeling PR, Jones G. Association of cartilage defects with loss of knee cartilage in healthy, middle-age adults: a prospective study. Arthritis Rheum. 2005 ; 52 (7). 2033-2039
13. Cole BJ, Pascual-Garrido C, Grumet RC. Surgical management of articular cartilage defects in the knee. J Bone Joint Surg Am. 2009 ; 91 (7). 1778-1790
14. Corpus KT, Bajaj S, Daley EL, et al. Long-term evaluation of autologous chondrocyte implantation: minimum 7-year follow-up. Cartilage. 2012 ; 3 (4). 342-350
15. de Windt TS, Bekkers JE, Creemers LB, Dhert WJ, Saris DB. Patient profiling in cartilage regeneration: prognostic factors determining success of treatment for cartilage defects. Am J Sports Med. 2009 ; 37: 58S - 62S
16. Ebert JR, Robertson WB, Woodhouse J, et al. Clinical and magnetic resonance imaging-based outcomes to 5 years after matrix-induced autologous chondrocyte implantation to address articular cartilage defects in the knee. Am J Sports Med. 2011 ; 39 (4). 753-763
17. Engen CN, Engebretsen L, Aroen A. Knee cartilage defect patients enrolled in randomized controlled trials are not representative of patients in orthopedic practice. Cartilage. 2010 ; 1 (4). 312-319
18. Genovese E, Ronga M, Angeretti MG, et al. Matrix-induced autologous chondrocyte implantation of the knee: mid-term and long-term follow-up by MR arthrography. Skeletal Radiol. 2011 ; 40 (1). 47-56
19. Gooding CR, Bartlett W, Bentley G, Skinner JA, Carrington R, Flanagan A. A prospective, randomised study comparing two techniques of autologous chondrocyte implantation for osteochondral defects in the knee: periosteum covered versus type I/III collagen covered. Knee. 2006 ; 13 (3). 203-210
20. Harris JD, Siston RA, Brophy RH, Lattermann C, Carey JL, Flanigan DC. Failures, re-operations, and complications after autologous chondrocyte implantation: a systematic review. Osteoarthritis Cartilage. 2011 ; 19 (7). 779-791
21. Heir S, Nerhus TK, Rotterud JH, et al. Focal cartilage defects in the knee impair quality of life as much as severe osteoarthritis: a comparison of Knee Injury and Osteoarthritis Outcome Score in 4 patient categories scheduled for knee surgery. Am J Sports Med. 2010 ; 38 (2). 231-237
22. Jungmann PM, Salzmann GM, Schmal H, Pestka JM, Sudkamp NP, Niemeyer P. Autologous chondrocyte implantation for treatment of cartilage defects of the knee: what predicts the need for reintervention?. Am J Sports Med. 2012 ; 40 (1). 58-67
23. Kon E, Filardo G, Berruto M, et al. Articular cartilage treatment in high-level male soccer players: a prospective comparative study of arthroscopic second-generation autologous chondrocyte implantation versus microfracture. Am J Sports Med. 2011 ; 39 (12). 2549-2557
24. Kreuz PC, Erggelet C, Steinwachs MR, et al. Is microfracture of chondral defects in the knee associated with different results in patients aged 40 years or younger?. Arthroscopy. 2006 ; 22 (11). 1180-1186
25. Krishnan SP, Skinner JA, Bartlett W, et al. Who is the ideal candidate for autologous chondrocyte implantation?. J Bone Joint Surg Br. 2006 ; 88 (1). 61-64
26. Loken S, Ludvigsen TC, Hoysveen T, Holm I, Engebretsen L, Reinholt FP. Autologous chondrocyte implantation to repair knee cartilage injury: ultrastructural evaluation at 2 years and long-term follow-up including muscle strength measurements. Knee Surg Sports Traumatol Arthrosc. 2009 ; 17 (11). 1278-1288
27. Marlovits S, Aldrian S, Wondrasch B, et al. Clinical and radiological outcomes 5 years after matrix-induced autologous chondrocyte implantation in patients with symptomatic, traumatic chondral defects. Am J Sports Med. 2012 ; 40 (10). 2273-2280
28. Marlovits S, Singer P, Zeller P, Mandl I, Haller J, Trattnig S. Magnetic resonance observation of cartilage repair tissue (MOCART) for the evaluation of autologous chondrocyte transplantation: determination of interobserver variability and correlation to clinical outcome after 2 years. Eur J Radiol. 2006 ; 57 (1). 16-23
29. Marlovits S, Zeller P, Singer P, Resinger C, Vecsei V. Cartilage repair: generations of autologous chondrocyte transplantation. Eur J Radiol. 2006 ; 57 (1). 24-31
30. Minas T, Von Keudell A, Bryant T, Gomoll AH. The John Insall Award: a minimum 10-year outcome study of autologous chondrocyte implantation. Clin Orthop Relat Res. :
31. Mithoefer K, McAdams T, Williams RJ, Kreuz PC, Mandelbaum BR. Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis. Am J Sports Med. 2009 ; 37 (10). 2053-2063
32. Mithoefer K, Williams RJ, Warren RF, et al. The microfracture technique for the treatment of articular cartilage lesions in the knee: a prospective cohort study. J Bone Joint Surg Am. 2005 ; 87 (9). 1911-1920
33. Moradi B, Schonit E, Nierhoff C, et al. First-generation autologous chondrocyte implantation in patients with cartilage defects of the knee: 7 to 14 years' clinical and magnetic resonance imaging follow-up evaluation. Arthroscopy. :
34. Moseley JB, Anderson AF, Browne JE, et al. Long-term durability of autologous chondrocyte implantation: a multicenter, observational study in US patients. Am J Sports Med. 2010 ; 38 (2). 238-246
35. Niemeyer P, Andereya S, Angele P, et al. Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: a guideline by the working group "Tissue Regeneration" of the German Society of Orthopaedic Surgery and Traumatology (DGOU) [in German]. Z Orthop Unfall. 2013 ; 151 (1). 38-47
36. Niemeyer P, Pestka JM, Kreuz PC, et al. Characteristic complications after autologous chondrocyte implantation for cartilage defects of the knee joint. Am J Sports Med. 2008 ; 36 (11). 2091-2099
37. Niemeyer P, Salzmann G, Steinwachs M, et al. Presence of subchondral bone marrow edema at the time of treatment represents a negative prognostic factor for early outcome after autologous chondrocyte implantation. Arch Orthop Trauma Surg. 2010 ; 130 (8). 977-983
38. Niemeyer P, Salzmann GM, Hirschmuller A, Sudkamp NP. Factors that influence clinical outcome following autologous chondrocyte implantation for cartilage defects of the knee [in German]. Z Orthop Unfall. 2012 ; 150 (1). 83-88
39. Peterson L, Minas T, Brittberg M, Nilsson A, Sjögren-Jansson E, Lindahl A. Two- to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res. 2000 ; 374: 212-234
40. Peterson L, Vasiliadis HS, Brittberg M, Lindahl A. Autologous chondrocyte implantation: a long-term follow-up. Am J Sports Med. 2010 ; 38 (6). 1117-1124
41. Roos EM, Roos HP, Lohmander LS, Ekdahl C, Beynnon BD. Knee Injury and Osteoarthritis Outcome Score (KOOS): development of a self-administered outcome measure. J Orthop Sports Phys Ther. 1998 ; 28 (2). 88-96
42. Saris DB, Vanlauwe J, Victor J, et al. Characterized chondrocyte implantation results in better structural repair when treating symptomatic cartilage defects of the knee in a randomized controlled trial versus microfracture. Am J Sports Med. 2008 ; 36 (2). 235-246
43. Saris DB, Vanlauwe J, Victor J, et al. Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture. Am J Sports Med. 2009 ;: 10S - 19S
44. Tegner Y, Lysholm J. Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res. 1985 ; 198: 43-49
45. Vanlauwe J, Saris DB, Victor J, Almqvist KF, Bellemans J, Luyten FP. Five-year outcome of characterized chondrocyte implantation versus microfracture for symptomatic cartilage defects of the knee: early treatment matters. Am J Sports Med. 2011 ; 39 (12). 2566-2574
46. Vasiliadis HS, Danielson B, Ljungberg M, McKeon B, Lindahl A, Peterson L. Autologous chondrocyte implantation in cartilage lesions of the knee: long-term evaluation with magnetic resonance imaging and delayed gadolinium-enhanced magnetic resonance imaging technique. Am J Sports Med. 2010 ; 38 (5). 943-949
47. Williamson A, Hoggart B. Pain: a review of three commonly used pain rating scales. J Clin Nurs. 2005 ; 14 (7). 798-804