Improving the plausibility of success with inefficient metrics

ACS Medicinal Chemistry Letters

Volumn 5, Issue 1, 2014, Pages 2-5

  Shultz, Michael D ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

decision making; drug likeness; efficiency metrics; fragment based drug design; Ligand efficiency (LE); lipophilic efficiency (LipE)

Indexed keywords

CARBON; LIGAND;

ATOM; BINDING AFFINITY; DECISION MAKING; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; ENTHALPY; HYDROGEN BOND; LIGAND BINDING; LIPOPHILICITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROBABILITY; REVIEW;

EID: 84892596742     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml4004638     Document Type: Review

References (9)

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