Simultaneous lc-ms/ms analysis of the plasma concentrations of a cocktail of 5 cytochrome p450 substrate drugs and their metabolites

Biological and Pharmaceutical Bulletin

Volumn 37, Issue 1, 2014, Pages 18-25

  Tanaka, Shimako ^a   Uchida, Shinya ^a   Inui, Naoki ^b   Takeuchi, Kazuhiko ^b   Watanabe, Hiroshi ^b   Namiki, Noriyuki ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cocktail; Cytochrome P450; Healthy volunteer; LC MS MS

Indexed keywords

2 BUTYL 4 CHLORO 1 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 5 IMIDAZOLECARBOXYLIC ACID; 5 HYDROXYOMEPRAZOLE; ALPHA HYDROXYMIDAZOLAM; CAFFEINE; DEXTROMETHORPHAN; DEXTRORPHAN; DRUG METABOLITE; LOSARTAN; MIDAZOLAM; OMEPRAZOLE; PARAXANTHINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; DRUG BLOOD LEVEL; DRUG ISOLATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG URINE LEVEL; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIMIT OF QUANTITATION; MASS SPECTROMETRY; NORMAL HUMAN; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; RELIABILITY; VALIDATION PROCESS;

CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; HUMANS; METABOLIC DETOXICATION, DRUG; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84892577345     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b13-00401     Document Type: Article

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