Improved survival in multidrug-resistant tuberculosis patients receiving integrated tuberculosis and antiretroviral treatment in the SAPiT Trial

International Journal of Tuberculosis and Lung Disease

Volumn 18, Issue 2, 2014, Pages 147-154

  Padayatchi, Nesri ^a   Abdool Karim, S S ^a   Naidoo, K ^a   Grobler, A ^a   Friedland, G ^b  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

HIV treatment; MDR TB

Indexed keywords

CYCLOSERINE; DIDANOSINE; EFAVIRENZ; ETHAMBUTOL; ETHAMBUTOL PLUS ISONIAZID PLUS PYRAZINAMIDE PLUS RIFAMPICIN; ETHIONAMIDE; KANAMYCIN; LAMIVUDINE; OFLOXACIN; PYRAZINAMIDE;

ADULT; AGED; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM CULTURE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; FEMALE; FOLLOW UP; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIDRUG RESISTANT TUBERCULOSIS; OPEN STUDY; OUTPATIENT DEPARTMENT; PATIENT COMPLIANCE; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE; TREATMENT INDICATION; TREATMENT OUTCOME;

ADULT; AGED; ANTI-HIV AGENTS; ANTITUBERCULAR AGENTS; CD4 LYMPHOCYTE COUNT; COINFECTION; FEMALE; HIV INFECTIONS; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; SOUTH AFRICA; TIME FACTORS; TREATMENT OUTCOME; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 84892572830     PISSN: 10273719     EISSN: None     Source Type: Journal    
DOI: 10.5588/ijtld.13.0627     Document Type: Article

References (26)

1. World Health Organization. Multidrug and extensively drugresistant TB (M/XDR-TB): 2010 global report on surveillance and response. WHO/HTM/TB/2010.3. Geneva, Switzerland: WHO, 2010
2. World Health Organization. Global tuberculosis report, 2012. WHO/HTM/TB/2012.6. Geneva, Switzerland: WHO, 2013
3. Buthelezi S. Situational analysis of TB drug resistance in KwaZulu-Natal Province, Republic of South Africa. Program and abstracts of the 2nd Global XDR TB Task Force Meeting. Geneva, Switzerland: WHO, 2008
4. Brust J C M, Gandhi N R, Carrara H, Osburn G, Padayatchi N. High treatment failure and default rates for patients with multidrug-resistant tuberculosis in KwaZulu-Natal, South Africa, 2000-2003. Int J Tuberc Lung Dis 2010; 14: 413-419
5. Gandhi N R, Shah N S, Andrews J R, et al. HIV coinfection in multidrug- and extensively drug-resistant tuberculosis results in high early mortality. Am J Respir Crit Care Med 2010; 181: 80-86.
6. Abdool Karim S S, Naidoo K, Grobler A, et al. Timing of initiation of antiretroviral drugs during tuberculosis therapy. N Engl J Med 2010; 362: 697-706
7. Scano F, Vitoria M, Burman W, Harries A D, Gilks C F, Havlir D. Management of HIV-infected patients with MDR- and XDRTB in resource-limited settings. Int J Tuberc Lung Dis 2008; 12: 1370-1375
8. Wells C D, Cegielski J P, Nelson L J, et al. HIV infection and multidrug-resistant tuberculosis: the perfect storm. J Infect Dis 2007; 196 (Suppl 1): S86-S107
9. South African Department of Health. Clinical guidelines for the management of HIV & AIDS in adults and adolescents. Pretoria, South Africa: DoH, 2010. http://www.hiv911.org.za/wp-content/uploads/2010/04/2010-Adult-ART- Guidelines.pdf Accessed November 2013.
10. South African Department of Health. National tuberculosis management guidelines 2008. Pretoria, South Africa: DoH, 2008. http://www.who.int/hiv/pub/ guidelines/south-africa-tb.pdf Accessed November 2013.
11. Oxford Textbook of Palliative Medicine. Karnofsky performance status. Oxford, UK: Oxford University Press, 1993: p 109. http://www.pennmedicine.org/ homecare/hcp/elig-worksheets/Karnofsky-Performance-Status.pdf Accessed November 2013.
12. O'Donnell M R, Padayatchi N, Master I, Osburn G, Horsburgh C R. Improved early results for patients with extensively drug-resistant tuberculosis and HIV in South Africa. Int J Tuberc Lung Dis 2009; 13: 855-861
13. Shenoi S V, Brooks R P, Barbour R, et al. Survival from XDRTB is associated with modifi able clinical characteristics in rural South Africa. PLOS ONE 2012; 7: e31786
14. Sungkanuparph S, Eampokalap B, Chottanapund S, Thongyen S, Manosuthi W. Impact of drug-resistant tuberculosis on the survival of HIV-infected patients. Int J Tuberc Lung Dis 2007; 11: 325-330.
15. Cohen T, Murray M, Wallengren K, Alvarez G G, Samuel E Y, Wilson D. The prevalence and drug sensitivity of tuberculosis among patients dying in hospital in KwaZulu-Natal, South Africa: a postmortem study. PLOS Med 2010; 7: e1000296
16. Dheda K, Shean K, Zumla A, et al. Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study. Lancet 2010; 375: 1798-1807
17. Wells C D. Global impact of multidrug-resistant pulmonary tuberculosis among HIV-infected and other immunocompromised hosts: epidemiology, diagnosis, and strategies for management. Curr Infect Dis Rep 2010; 12: 192-197.
18. Lawn S D, Ayles H, Egwaga S, et al. Potential utility of empirical tuberculosis treatment for HIV-infected patients with advanced immunodefi ciency in high TB-HIV burden settings. Int J Tuberc Lung Dis 2011; 15: 287-295.
19. Brust J C, Lygizos M, Chaiyachati K, et al. Culture conversion among HIV co-infected multidrug-resistant tuberculosis patients in Tugela Ferry, South Africa. PLOS ONE 2011; 6: e15841
20. Hassim S, Shaw P A, Sangweni P, et al. Detection of a substantial rate of multidrug-resistant tuberculosis in an HIV-infected population in South Africa by active monitoring of sputum samples. Clin Infect Dis 2010; 50: 1053-1059
21. Dalton T, Cegielski P, Akksilp S, et al. Prevalence of and risk factors for resistance to second-line drugs in people with multidrug-resistant tuberculosis in eight countries: a prospective cohort study. Lancet 2012; 380: 1406-1417
22. Hoffner S. Unexpected high levels of multidrug-resistant tuberculosis present new challenges for tuberculosis control. Lancet 2012; 380: 1367-1369
23. Andrews J R, Gandhi N R, Moodley P, et al. Exogenous reinfection as a cause of multidrug-resistant and extensively drug-resistant tuberculosis in rural South Africa. J Infect Dis 2008; 198: 1582-1589.
24. Ling D I, Zwerling A A, Pai M. Rapid diagnosis of drug-resistant TB using line probe assays: from evidence to policy. Expert Rev Respir Med 2008; 2: 583-588
25. Perkins M D, Cunningham J. Facing the crisis: improving the diagnosis of tuberculosis in the HIV era. J Infect Dis 2007; 196 (Suppl 1): S15-S27
26. Abdool Karim S S, Naidoo K, Grobler A, et al. Integration of antiretroviral therapy with tuberculosis treatment. N Engl J Med 2011; 365: 1492-1501