Identification of a molecular profile associated with immune status in first-onset schizophrenia patients

Clinical Schizophrenia and Related Psychoses

Volumn 7, Issue 4, 2014, Pages 207-215

  Herberth, Marlis ^a   Rahmoune, Hassan ^a   Schwarz, Emanuel ^a   Koethe, Dagmar ^b   Harris, Laura W ^a   Kranaster, Laura ^b   Witt, Stephanie H ^b   Spain, Michael ^c   Barnes, Anthony ^c   Schmolz, Manfred ^d   Leweke, Markus F ^b   Guest, Paul C ^a   Bahn, Sabine ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^c Rules Based Medicine   (United States)

^d EDI Experimental and Diagnostic Immunology GmbH   (Germany)

Author keywords

Blood cells; Immune system; Multiplex immunoassay; Proteomics; Schizophrenia

Indexed keywords

ALPHA 2 MACROGLOBULIN; ANGIOTENSINOGEN; CREATINE KINASE MB; DIPEPTIDYL CARBOXYPEPTIDASE; EPIDERMAL GROWTH FACTOR; HYDROCORTISONE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 18; INTERLEUKIN 6; LEPTIN; MYELOPEROXIDASE; PLASMINOGEN ACTIVATOR INHIBITOR; PROGESTERONE; STEM CELL FACTOR; STROMELYSIN; THROMBOPOIETIN; THYROTROPIN; THYROXINE BINDING GLOBULIN;

ACUTE PHASE RESPONSE; ADULT; ARTICLE; BLOOD CELL; BLOOD CULTURE; BLOOD SAMPLING; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; EX VIVO STUDY; FEMALE; FIBRINOLYSIS; HUMAN; IMMUNE STATUS; IMMUNOASSAY; IMMUNOCOMPETENT CELL; IN VIVO STUDY; INFLAMMATION; MALE; MENTAL PATIENT; PARANOID SCHIZOPHRENIA; PATIENT IDENTIFICATION; PERIPHERAL BLOOD MONONUCLEAR CELL; SUPERNATANT; T LYMPHOCYTE;

BLOOD CELLS; IMMUNE SYSTEM; MULTIPLEX IMMUNOASSAY; PROTEOMICS; SCHIZOPHRENIA;

ACUTE-PHASE PROTEINS; ADULT; BIOLOGICAL MARKERS; CELLS, CULTURED; COMPUTER SIMULATION; CYTOKINES; FEMALE; FIBRINOLYSIS; HUMANS; IMMUNOASSAY; INDIVIDUALIZED MEDICINE; MALE; PROTEOMICS; SCHIZOPHRENIA; T-LYMPHOCYTES; YOUNG ADULT;

EID: 84892567702     PISSN: 19351232     EISSN: None     Source Type: Journal    
DOI: 10.3371/CSRP.HERA.020113     Document Type: Article

References (31)

1. Rothermundt M, Arolt V, Bayer TA. Review of immunological and immunopathological findings in schizophrenia. Brain Behav Immun 2001;15(4):319-339. (Pubitemid 34044519)
2. Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, et al. Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Eur Arch Psychiatry Clin Neurosci 2009; 259(3):151-163.
3. Arion D, Unger T, Lewis DA, Levitt P, Mirnics K. Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol Psychiatry 2007;62(7):711-721. (Pubitemid 47374650)
4. Schwarz MJ, Chiang S, Muller N, Ackenheil M. T-helper-1 and T-helper-2 responses in psychiatric disorders. Brain Behav Immun 2001;15(4):340-370. (Pubitemid 34044520)
5. Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B. Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry 2011;70(7):663-671.
6. Kim YK, Myint AM, Lee BH, Han CS, Lee HJ, Kim DJ, et al. Th1, Th2 and Th3 cytokine alteration in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2004;28(7):1129-1134.
7. Cazzullo CL, Sacchetti E, Galluzzo A, Panariello A, Colombo F, Zagliani A, et al. Cytokine profiles in drug-naive schizophrenic patients. Schizophr Res 2001;47(2-3):293-298. (Pubitemid 32244114)
8. Edwards D. Immunological effects of tobacco smoking in healthy smokers. COPD 2009;6(1):48-58.
9. Drzyzga L, Obuchowicz E, Marcinowska A, Herman ZS. Cytokines in schizophrenia and the effects of antipsychotic drugs. Brain Behav Immun 2006;20(6):532-545. (Pubitemid 44528954)
10. Kim PK, Deutschman CS. Inflammatory responses and mediators. Surg Clin North Am 2000;80(3):885-894. (Pubitemid 30396977)
11. Guest PC, Wang L, Harris LW, Burling K, Levin Y, Ernst A, et al. Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naive schizophrenia patients. Mol Psychiatry 2010;15(2):118-119.
12. Suzuki K, Nakamura K, Iwata Y, Sekine Y, Kawai M, Sugihara G, et al. Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients. Schizophr Res 2008;98(1-3):148-156. (Pubitemid 350235901)
13. Messamore E. Relationship between the niacin skin flush response and essential fatty acids in schizophrenia. Prostaglandins Leukot Essent Fatty Acids 2003;69(6):413-419. (Pubitemid 37464051)
14. Bertenshaw GP, Yip P, Seshaiah P, Zhao J, Chen TH, Wiggins WS, et al. Multianalyte profiling of serum antigens and autoimmune and infectious disease molecules to identify biomarkers dysregulated in epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev 2008;17(10):2872-2881.
15. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc 1995;57:289-300.
16. Liu XY, Yang JL, Chen LJ, Zhang Y, Yang ML, Wu YY, et al. Comparative proteomics and correlated signaling network of rat hippocampus in the pilocarpine model of temporal lobe epilepsy. Proteomics 2008;8(3):582-603. (Pubitemid 351252015)
17. Sopori ML, Kozak W. Immunomodulatory effects of cigarette smoke. J Neuroimmunol 1998;83(1-2):148-156. (Pubitemid 28280961)
18. Molina-Holgado E, Guaza C, Borrell J, Molina-Holgado F. Effects of cannabinoids on the immune system and central nervous system: therapeutic implications. BioDrugs 1999;12(5):317-326.
19. Moshage H. Cytokines and the hepatic acute phase response. J Pathol 1997;181(3):257-266. (Pubitemid 27156836)
20. Goldberg RB. Cytokine and cytokine-like inflammation markers, endothelial dysfunction and imbalanced coagulation in development of diabetes and its complications. J Clin Endocrinol Metab 2009;94(9):3171-3182.
21. Dinarello CA. The IL-1 family and inflammatory diseases. Clin Exp Rheumatol 2002;20(5 Suppl 27):S1-13.
22. Pietzsch J, Hoppmann S. Human S100A12: a novel key player in inflammation? Amino Acids 2009;36(3):381-389.
23. Ballantyne CM, Nambi V. Markers of inflammation and their clinical significance. Atheroscler Suppl 2005;6(2):21-29.
24. Fujisawa H, Ito H, Kashiwagi S, Nomura S, Toyosawa M. Kallikrein-kinin system in chronic subdural haematomas: its roles in vascular permeability and regulation of fibrinolysis and coagulation. J Neurol Neurosurg Psychiatry 1995;59(4):388-394.
25. Glen AI, Cooper SJ, Rybakowski J, Vaddadi K, Brayshaw N, Horrobin DF. Membrane fatty acids, niacin flushing and clinical parameters. Prostaglandins Leukot Essent Fatty Acids 1996;55(1-2):9-15. (Pubitemid 26321112)
26. Loria V, Dato I, Graziani F, Biasucci LM. Myeloperoxidase: a new biomarker of inflammation in ischemic heart disease and acute coronary syndromes. Mediators Inflamm 2008:135625. doi: 10.1155/2008/135625. (Pubitemid 351697086)
27. Maji D. Hyperthyroidism. J Indian Med Assoc 2006;104(10):563-564, 566-567.
28. de Boer JP, Creasey AA, Chang A, Abbink JJ, Roem D, Eerenberg AJ, et al. Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in sepsis: studies using a baboon model. Infect Immun 1993;61(12):5035-5043. (Pubitemid 23353877)
29. Aghajanian A, Wittchen ES, Allingham MJ, Garrett TA, Burridge K. Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration. J Thromb Haemost 2008;6(9):1453-1460.
30. Pannen BH, Robotham JL. The acute-phase response. New Horiz 1995;3(2):183-197.
31. van Winkel R, Stefanis NC, Myin-Germeys I. Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. Schizophr Bull 2008;34(6):1095-1105.