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Volumn 12, Issue 1, 2014, Pages 25-35

The efficacy of chlorhexidine dentifrice or gel on plaque, clinical parameters of gingival inflammation and tooth discoloration: A systematic review

Author keywords

Chlorhexidine; CHX dentifrice; CHX gel; CHX toothpaste; Plaque; Systematic review; Tooth staining

Indexed keywords

CHLORHEXIDINE; GEL; TOOTHPASTE; TOPICAL ANTIINFECTIVE AGENT;

EID: 84892543210     PISSN: 16015029     EISSN: 16015037     Source Type: Journal    
DOI: 10.1111/idh.12050     Document Type: Review
Times cited : (51)

References (71)
  • 1
    • 0026196539 scopus 로고
    • Public health aspects of periodontal disease in Europe
    • Sheiham A. Public health aspects of periodontal disease in Europe. J Clin Periodontol 1991; 18: 362-369.
    • (1991) J Clin Periodontol , vol.18 , pp. 362-369
    • Sheiham, A.1
  • 2
    • 0028472735 scopus 로고
    • The effect of a dentifrice containing chlorhexidine and zinc on plaque, gingivitis, calculus and tooth staining
    • {black diamond suit} Sanz M, Vallcorba N, Fabregues S, Müller I, Herkströter F. The effect of a dentifrice containing chlorhexidine and zinc on plaque, gingivitis, calculus and tooth staining. J Clin Periodontol 1994; 21: 431-437.
    • (1994) J Clin Periodontol , vol.21 , pp. 431-437
    • Sanz, M.1    Vallcorba, N.2    Fabregues, S.3    Müller, I.4    Herkströter, F.5
  • 3
    • 78650061880 scopus 로고    scopus 로고
    • Oral hygiene in the prevention of periodontal diseases: the evidence
    • Van der Weijden F, Slot DE. Oral hygiene in the prevention of periodontal diseases: the evidence. Periodontol 2000 2011; 55: 104-123.
    • (2011) Periodontol 2000 , vol.55 , pp. 104-123
    • Van der Weijden, F.1    Slot, D.E.2
  • 4
    • 0025810505 scopus 로고
    • Antibacterial dentifrices. Clinical data and relevance with emphasis on zinc/triclosan
    • Gjermo P, Saxton CA. Antibacterial dentifrices. Clinical data and relevance with emphasis on zinc/triclosan. J Clin Periodontol 1991; 18: 469-473.
    • (1991) J Clin Periodontol , vol.18 , pp. 469-473
    • Gjermo, P.1    Saxton, C.A.2
  • 5
    • 0004218253 scopus 로고
    • The effect of suppression of the oral microflora upon the development of dental plaque and gingivitis
    • McHugh WD, ed. Edinburgh, E & S Livingstone
    • Löe H, Schiött CR. The effect of suppression of the oral microflora upon the development of dental plaque and gingivitis. In: McHugh WD, ed. Dental Plaque. Edinburgh, E & S Livingstone, 1970, pp. 247-255.
    • (1970) Dental Plaque , pp. 247-255
    • Löe, H.1    Schiött, C.R.2
  • 6
    • 84867400001 scopus 로고    scopus 로고
    • Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review
    • Van Strydonck DA, Slot DE, Van der Velden U, Van der Weijden F. Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review. J Clin Periodontol 2012; 39: 1042-1055.
    • (2012) J Clin Periodontol , vol.39 , pp. 1042-1055
    • Van Strydonck, D.A.1    Slot, D.E.2    Van der Velden, U.3    Van der Weijden, F.4
  • 8
    • 0016745155 scopus 로고
    • The effect of a chlorhexidine-containing gel on oral cleanliness and gingival health in young adults
    • {black diamond suit} Hansen F, Gjermo P, Eriksen HM. The effect of a chlorhexidine-containing gel on oral cleanliness and gingival health in young adults. J Clin Periodontol 1975; 2: 153-159.
    • (1975) J Clin Periodontol , vol.2 , pp. 153-159
    • Hansen, F.1    Gjermo, P.2    Eriksen, H.M.3
  • 9
    • 84872259606 scopus 로고    scopus 로고
    • The effect of medicated, sugar free chewing gum on plaque and clinical parameters of gingival inflammation: a systematic review
    • Epub ahead of print; doi: 10.1111/idh.12026
    • Keukenmeester RS, Slot DE, Putt MS, Van der Weijden GA. The effect of medicated, sugar free chewing gum on plaque and clinical parameters of gingival inflammation: a systematic review. Int J Dent Hyg 2013. Epub ahead of print; doi: 10.1111/idh.12026.
    • (2013) Int J Dent Hyg
    • Keukenmeester, R.S.1    Slot, D.E.2    Putt, M.S.3    Van der Weijden, G.A.4
  • 10
    • 0027236866 scopus 로고
    • Validation of a 21-day, partial-mouth gingivitis model for evaluating chemotherapeutic dentifrices
    • Putt MS, Van der Weijden GA, Kleber CJ, Saxton CA. Validation of a 21-day, partial-mouth gingivitis model for evaluating chemotherapeutic dentifrices. J Periodontal Res 1993; 28: 301-307.
    • (1993) J Periodontal Res , vol.28 , pp. 301-307
    • Putt, M.S.1    Van der Weijden, G.A.2    Kleber, C.J.3    Saxton, C.A.4
  • 11
    • 84892521884 scopus 로고    scopus 로고
    • PRISMA Statement. Available at: (accessed 01 March 2013)
    • PRISMA Statement. Available at: http://www.prisma-statement.org/ (accessed 01 March 2013).
  • 12
    • 68049122102 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • PRISMA Group
    • Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009; 21: 7: e1000097.
    • (2009) PLoS Med , vol.21 , Issue.7
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 13
    • 84892554404 scopus 로고    scopus 로고
    • American Dental Association. Acceptance Program Guidelines. Chemotherapeutic Products for Control of Gingivitis. American Dental Association, Available at: (accessed 01 March 2013)
    • American Dental Association. Acceptance Program Guidelines. Chemotherapeutic Products for Control of Gingivitis. American Dental Association, 2008. Available at: http://www.ada.org/sections/scienceAndResearch/pdfs/guide_chemo_ging.pdf (accessed 01 March 2013).
    • (2008)
  • 14
    • 84872259606 scopus 로고    scopus 로고
    • The effect of sugar-free chewing gum on plaque and clinical parameters of gingival inflammation: a systematic review
    • Keukenmeester RS, Slot DE, Putt MS, Van der Weijden GA. The effect of sugar-free chewing gum on plaque and clinical parameters of gingival inflammation: a systematic review. Int J Dent Hyg 2013; 11: 2-14.
    • (2013) Int J Dent Hyg , vol.11 , pp. 2-14
    • Keukenmeester, R.S.1    Slot, D.E.2    Putt, M.S.3    Van der Weijden, G.A.4
  • 15
    • 73149085727 scopus 로고    scopus 로고
    • Alveolar bone dimensional changes of post-extraction sockets in humans: a systematic review
    • Van der Weijden F, Dell'Acqua F, Slot DE. Alveolar bone dimensional changes of post-extraction sockets in humans: a systematic review. J Clin Periodontol 2009; 36: 1048-1058.
    • (2009) J Clin Periodontol , vol.36 , pp. 1048-1058
    • Van der Weijden, F.1    Dell'Acqua, F.2    Slot, D.E.3
  • 16
    • 84892522881 scopus 로고    scopus 로고
    • GRADE Working Group. Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group. Available at: (accessed 01 March 2013)
    • GRADE Working Group. Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group. Available at: http://www.gradeworkinggroup.org/index.htm (accessed 01 March 2013).
  • 17
    • 43049113533 scopus 로고    scopus 로고
    • GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
    • Guyatt GH, Oxman AD, Vist GE et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008; 26: 924-926.
    • (2008) BMJ , vol.26 , pp. 924-926
    • Guyatt, G.H.1    Oxman, A.D.2    Vist, G.E.3
  • 18
    • 0018141791 scopus 로고
    • Retention and plaque-inhibiting effect in man of chlorhexidine after multiple mouth rinses and retention and release of chlorhexidine after toothbrushing with a chlorhexidine gel
    • Bonesvoll P. Retention and plaque-inhibiting effect in man of chlorhexidine after multiple mouth rinses and retention and release of chlorhexidine after toothbrushing with a chlorhexidine gel. Arch Oral Biol 1978; 23: 295-300.
    • (1978) Arch Oral Biol , vol.23 , pp. 295-300
    • Bonesvoll, P.1
  • 19
    • 0018772494 scopus 로고
    • Gingival bleeding in an experimental clinical trial design
    • Watts TL, Lennon MA, Davies RM. Gingival bleeding in an experimental clinical trial design. J Clin Periodontol 1979; 6: 15-21.
    • (1979) J Clin Periodontol , vol.6 , pp. 15-21
    • Watts, T.L.1    Lennon, M.A.2    Davies, R.M.3
  • 20
    • 0015113563 scopus 로고
    • Retention of chlorhexidine in the human oral cavity
    • Rölla G, Loe H, Schiott CR. Retention of chlorhexidine in the human oral cavity. Arch Oral Biol 1971; 16: 1109-1116.
    • (1971) Arch Oral Biol , vol.16 , pp. 1109-1116
    • Rölla, G.1    Loe, H.2    Schiott, C.R.3
  • 21
    • 0024274736 scopus 로고
    • Clinical benefits of chlorhexidine in sustaining gingival health following prophylaxis
    • Sturzenberger OP, Bosma ML, Moore DJ, Grossman E. Clinical benefits of chlorhexidine in sustaining gingival health following prophylaxis. J Clin Dent 1988; 1: 24-27.
    • (1988) J Clin Dent , vol.1 , pp. 24-27
    • Sturzenberger, O.P.1    Bosma, M.L.2    Moore, D.J.3    Grossman, E.4
  • 22
    • 4444354745 scopus 로고    scopus 로고
    • The effect of two different dental gels and a mouthwash on plaque and gingival scores: a six-week clinical study
    • Pai MR, Acharya LD, Udupa N. The effect of two different dental gels and a mouthwash on plaque and gingival scores: a six-week clinical study. Int Dent J 2004; 54: 219-223.
    • (2004) Int Dent J , vol.54 , pp. 219-223
    • Pai, M.R.1    Acharya, L.D.2    Udupa, N.3
  • 23
    • 77949396518 scopus 로고    scopus 로고
    • Short-term clinical effects of commercially available gel containing Acacia arabica: a randomized controlled clinical trial
    • Pradeep AR, Happy D, Garg G. Short-term clinical effects of commercially available gel containing Acacia arabica: a randomized controlled clinical trial. Aust Dent J 2010; 55: 65-69.
    • (2010) Aust Dent J , vol.55 , pp. 65-69
    • Pradeep, A.R.1    Happy, D.2    Garg, G.3
  • 24
    • 84871888407 scopus 로고    scopus 로고
    • Efficacy of chlorhexidine, metronidazole and combination gel in the treatment of gingivitis-a randomized clinical trial
    • Pradeep AR, Kumari M, Priyanka N, Naik SB. Efficacy of chlorhexidine, metronidazole and combination gel in the treatment of gingivitis-a randomized clinical trial. J Int Acad Periodontol 2012a; 14: 91-96.
    • (2012) J Int Acad Periodontol , vol.14 , pp. 91-96
    • Pradeep, A.R.1    Kumari, M.2    Priyanka, N.3    Naik, S.B.4
  • 25
    • 84865781571 scopus 로고    scopus 로고
    • Clinical and microbiologic effects of commercially available gel and powder containing Acacia arabica on gingivitis
    • Pradeep AR, Agarwal E, Bajaj P, Naik SB, Shanbhag N, Uma SR. Clinical and microbiologic effects of commercially available gel and powder containing Acacia arabica on gingivitis. Aust Dent J 2012b; 57: 312-318.
    • (2012) Aust Dent J , vol.57 , pp. 312-318
    • Pradeep, A.R.1    Agarwal, E.2    Bajaj, P.3    Naik, S.B.4    Shanbhag, N.5    Uma, S.R.6
  • 26
    • 0016583490 scopus 로고
    • A short-term evaluation of a chlorhexidine gel on plaque deposits and gingival status
    • Lennon MA, Davies RM. A short-term evaluation of a chlorhexidine gel on plaque deposits and gingival status. Pharmacol Ther Dent 1975; 2: 13-19.
    • (1975) Pharmacol Ther Dent , vol.2 , pp. 13-19
    • Lennon, M.A.1    Davies, R.M.2
  • 27
    • 0024216931 scopus 로고
    • Comparative clinical trial with natural herbal mouthwash versus chlorhexidine in gingivitis
    • Serfaty R, Itic J. Comparative clinical trial with natural herbal mouthwash versus chlorhexidine in gingivitis. J Clin Dent 1988; 1: A34-A37.
    • (1988) J Clin Dent , vol.1
    • Serfaty, R.1    Itic, J.2
  • 28
    • 0018081025 scopus 로고
    • The effect of a 1% chlorhexidine gel in the initial therapy of chronic periodontal disease
    • Bain MJ, Strahan JD. The effect of a 1% chlorhexidine gel in the initial therapy of chronic periodontal disease. J Periodontol 1978; 49: 469-474.
    • (1978) J Periodontol , vol.49 , pp. 469-474
    • Bain, M.J.1    Strahan, J.D.2
  • 29
    • 0022916107 scopus 로고
    • Effects of chlorhexidine gel in a group of maintenance-care patients with poor oral hygiene
    • Lie T, Enersen M. Effects of chlorhexidine gel in a group of maintenance-care patients with poor oral hygiene. J Periodontol 1986; 57: 364-369.
    • (1986) J Periodontol , vol.57 , pp. 364-369
    • Lie, T.1    Enersen, M.2
  • 30
    • 0016859009 scopus 로고
    • The toothbrush application of chlorhexidine. A clinical trial
    • Bassiouny MA, Grant AA. The toothbrush application of chlorhexidine. A clinical trial. Br Dent J 1975; 139: 323-327.
    • (1975) Br Dent J , vol.139 , pp. 323-327
    • Bassiouny, M.A.1    Grant, A.A.2
  • 31
    • 0015251615 scopus 로고
    • Effects of chlorhexidine-containing dentifrices
    • Gjermo P, Eriksen H. Effects of chlorhexidine-containing dentifrices. Caries Res 1972; 6: 72-73.
    • (1972) Caries Res , vol.6 , pp. 72-73
    • Gjermo, P.1    Eriksen, H.2
  • 32
    • 0017071754 scopus 로고
    • Chlorhexidine gel (Corsodyl) for gingivitis?
    • Chlorhexidine gel (Corsodyl) for gingivitis? Drug Ther Bull 1976; 14: 47-48.
    • (1976) Drug Ther Bull , vol.14 , pp. 47-48
  • 33
  • 34
    • 35548978767 scopus 로고    scopus 로고
    • A. comparison of two chlorhexidine gel brushing regimens and a conventional toothpaste brushing regimen for the development of tooth staining over a 6-week period
    • {black diamond suit} Claydon NCA, Addy M, Adams G et al. A. comparison of two chlorhexidine gel brushing regimens and a conventional toothpaste brushing regimen for the development of tooth staining over a 6-week period. Int J Dent Hyg 2006; 4: 183-188.
    • (2006) Int J Dent Hyg , vol.4 , pp. 183-188
    • Claydon, N.C.A.1    Addy, M.2    Adams, G.3
  • 35
    • 3142761496 scopus 로고    scopus 로고
    • The effects of a tea tree oil-containing gel on plaque and chronic gingivitis
    • {black diamond suit} Soukoulis S, Hirsch R. The effects of a tea tree oil-containing gel on plaque and chronic gingivitis. Aust Dent J 2004; 49: 78-83.
    • (2004) Aust Dent J , vol.49 , pp. 78-83
    • Soukoulis, S.1    Hirsch, R.2
  • 36
    • 0028379261 scopus 로고
    • The effect of three dentifrices and a dental gel on plaque formation: a six week clinical study
    • {black diamond suit} Smith I, Muir KF, Worthington H, Davies GH. The effect of three dentifrices and a dental gel on plaque formation: a six week clinical study. Int Dent J 1994; 44: 71-74.
    • (1994) Int Dent J , vol.44 , pp. 71-74
    • Smith, I.1    Muir, K.F.2    Worthington, H.3    Davies, G.H.4
  • 37
    • 0027339822 scopus 로고
    • A 6-month home usage trial of a 1% chlorhexidine toothpaste (I). Effects on plaque, gingivitis, calculus and toothstaining
    • {black diamond suit} Yates R, Jenkins S, Newcombe R, Wade W, Moran J, Addy M. A 6-month home usage trial of a 1% chlorhexidine toothpaste (I). Effects on plaque, gingivitis, calculus and toothstaining. J Clin Periodontol 1993; 20: 130-138.
    • (1993) J Clin Periodontol , vol.20 , pp. 130-138
    • Yates, R.1    Jenkins, S.2    Newcombe, R.3    Wade, W.4    Moran, J.5    Addy, M.6
  • 38
    • 84984426128 scopus 로고
    • Effect of toothbrushing with chlorhexidine gel on salivary microflora, oral hygiene, and caries
    • {black diamond suit} Emilson CG, Fornell J. Effect of toothbrushing with chlorhexidine gel on salivary microflora, oral hygiene, and caries. Scand J Dent Res 1976; 84: 308-319.
    • (1976) Scand J Dent Res , vol.84 , pp. 308-319
    • Emilson, C.G.1    Fornell, J.2
  • 39
    • 0017091313 scopus 로고
    • Testing therapeutic measures for controlling chronic gingivitis in man: the results of two studies
    • {black diamond suit} Saxton CA, Cowell CR, Sheiham A, Wagg BJ. Testing therapeutic measures for controlling chronic gingivitis in man: the results of two studies. J Clin Periodontol 1976; 3: 220-232.
    • (1976) J Clin Periodontol , vol.3 , pp. 220-232
    • Saxton, C.A.1    Cowell, C.R.2    Sheiham, A.3    Wagg, B.J.4
  • 40
    • 84984515193 scopus 로고
    • Effect of 2-years' use of chlorhexidine-containing dentifrices on plaque, gingivitis, and caries
    • {black diamond suit} Johansen J, Gjermo P, Eriksen HM. Effect of 2-years' use of chlorhexidine-containing dentifrices on plaque, gingivitis, and caries. Scand J Dent Res 1975; 83: 288-292.
    • (1975) Scand J Dent Res , vol.83 , pp. 288-292
    • Johansen, J.1    Gjermo, P.2    Eriksen, H.M.3
  • 41
    • 84984475943 scopus 로고
    • The plaque-inhibiting effect of chlorhexidine-containing dentifrices
    • {black diamond suit} Gjermo P, Rölla G. The plaque-inhibiting effect of chlorhexidine-containing dentifrices. Scand J Dent Res 1971; 79: 126-132.
    • (1971) Scand J Dent Res , vol.79 , pp. 126-132
    • Gjermo, P.1    Rölla, G.2
  • 42
    • 0003191890 scopus 로고
    • Periodontal disease in pregnancy
    • Silness J, Löe H. Periodontal disease in pregnancy. Acta Odontol Scand 1964; 22: 469-474.
    • (1964) Acta Odontol Scand , vol.22 , pp. 469-474
    • Silness, J.1    Löe, H.2
  • 43
    • 0014155768 scopus 로고
    • The gingival index, the plaque index and the retention index systems
    • Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967; 38: 610-616.
    • (1967) J Periodontol , vol.38 , pp. 610-616
    • Löe, H.1
  • 44
    • 0014706824 scopus 로고
    • Reduced plaque formation by the chloromethyl analogue of Victamine C
    • Turesky S, Gilmore ND, Glickman I. Reduced plaque formation by the chloromethyl analogue of Victamine C. J Periodontol 1970; 41: 41-43.
    • (1970) J Periodontol , vol.41 , pp. 41-43
    • Turesky, S.1    Gilmore, N.D.2    Glickman, I.3
  • 45
    • 73849182583 scopus 로고
    • Comparative cleansing efficiency of manual and power brushing
    • Quigley G, Hein J. Comparative cleansing efficiency of manual and power brushing. J Am Dent Assoc 1962; 65: 26-29.
    • (1962) J Am Dent Assoc , vol.65 , pp. 26-29
    • Quigley, G.1    Hein, J.2
  • 46
    • 0016721015 scopus 로고
    • Testing therapeutic measures for controlling chronic gingivitis in man: a suggested protocol
    • Cowell CR, Saxton CA, Sheiham A, Wagg BJ. Testing therapeutic measures for controlling chronic gingivitis in man: a suggested protocol. J Clin Periodontol 1975; 2: 231-240.
    • (1975) J Clin Periodontol , vol.2 , pp. 231-240
    • Cowell, C.R.1    Saxton, C.A.2    Sheiham, A.3    Wagg, B.J.4
  • 47
    • 17144460186 scopus 로고
    • Current status of indices of plaque
    • Fischman SL. Current status of indices of plaque. J Clin Periodontol 1986; 13: 371-374.
    • (1986) J Clin Periodontol , vol.13 , pp. 371-374
    • Fischman, S.L.1
  • 48
    • 0016655811 scopus 로고
    • Problems and proposals for recording gingivitis and plaque
    • Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975; 25: 229-235.
    • (1975) Int Dent J , vol.25 , pp. 229-235
    • Ainamo, J.1    Bay, I.2
  • 49
    • 0015608103 scopus 로고
    • A clinical system for scoring a patient's oral hygiene performance
    • Lenox JA, Kopczyk RA. A clinical system for scoring a patient's oral hygiene performance. J Am Dent Assoc 1973; 86: 849-852.
    • (1973) J Am Dent Assoc , vol.86 , pp. 849-852
    • Lenox, J.A.1    Kopczyk, R.A.2
  • 50
    • 75549115165 scopus 로고
    • Periodontal disease in pregnancy
    • Löe H, Silness J. Periodontal disease in pregnancy. Acta Odontol Scand 1963; 21: 533-551.
    • (1963) Acta Odontol Scand , vol.21 , pp. 533-551
    • Löe, H.1    Silness, J.2
  • 51
    • 0014345578 scopus 로고
    • Effect of dentifrices on tooth stains with controlled brushing
    • Lobene RR. Effect of dentifrices on tooth stains with controlled brushing. J Am Dent Assoc 1968; 77: 849-855.
    • (1968) J Am Dent Assoc , vol.77 , pp. 849-855
    • Lobene, R.R.1
  • 52
    • 0015734303 scopus 로고
    • Incidence of stained tooth surfaces in students using chlorhexidine-containing dentifrices
    • Eriksen HM, Gjermo P. Incidence of stained tooth surfaces in students using chlorhexidine-containing dentifrices. Scand J Dent Res 1973; 81: 533-537.
    • (1973) Scand J Dent Res , vol.81 , pp. 533-537
    • Eriksen, H.M.1    Gjermo, P.2
  • 53
    • 0020639115 scopus 로고
    • Comparison of plaque accumulation after topical application and mouth rinsing with chlorhexidine gluconate
    • Addy M, Moran J. Comparison of plaque accumulation after topical application and mouth rinsing with chlorhexidine gluconate. J Clin Periodontol 1983; 10: 69-71.
    • (1983) J Clin Periodontol , vol.10 , pp. 69-71
    • Addy, M.1    Moran, J.2
  • 54
    • 0017402341 scopus 로고
    • A new index for measuring extrinsic stain in clinical trials
    • Shaw L, Murray JJ. A new index for measuring extrinsic stain in clinical trials. Community Dent Oral Epidemiol 1977; 5: 116-120.
    • (1977) Community Dent Oral Epidemiol , vol.5 , pp. 116-120
    • Shaw, L.1    Murray, J.J.2
  • 56
    • 0024381872 scopus 로고
    • Studies on the effect of toothpaste rinses on plaque regrowth. (I). Influence of surfactants on chlorhexidine efficacy
    • Addy M, Jenkins S, Newcombe R. Studies on the effect of toothpaste rinses on plaque regrowth. (I). Influence of surfactants on chlorhexidine efficacy. J Clin Periodontol 1989; 16: 380-438.
    • (1989) J Clin Periodontol , vol.16 , pp. 380-438
    • Addy, M.1    Jenkins, S.2    Newcombe, R.3
  • 57
    • 33746854291 scopus 로고    scopus 로고
    • Rinsing with chlorhexidine gluconate solution after brushing and flossing teeth: a systematic review of effectiveness
    • Kolahi J, Soolari A. Rinsing with chlorhexidine gluconate solution after brushing and flossing teeth: a systematic review of effectiveness. Quintessence Int 2006; 37: 605-612.
    • (2006) Quintessence Int , vol.37 , pp. 605-612
    • Kolahi, J.1    Soolari, A.2
  • 58
    • 77950919985 scopus 로고    scopus 로고
    • From randomized controlled trials to evidence grading schemes: current state of evidence-based practice in social sciences
    • Boruch R, Rui N. From randomized controlled trials to evidence grading schemes: current state of evidence-based practice in social sciences. J Evid Based Med 2008; 1: 41-49.
    • (2008) J Evid Based Med , vol.1 , pp. 41-49
    • Boruch, R.1    Rui, N.2
  • 59
    • 85100415918 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions, 2011, version 5.1.0. Available at: (accessed 01 March 2013)
    • Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions, 2011, version 5.1.0. Available at: http://cochrane-handbook.org/ (accessed 01 March 2013).
    • Higgins, J.P.T.1    Green, S.2
  • 60
    • 0025144441 scopus 로고
    • Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis
    • Overholser CD, Meiller TF, DePaola LG, Minah GE, Niehaus C. Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis. J Clin Periodontol 1990; 17: 575-579.
    • (1990) J Clin Periodontol , vol.17 , pp. 575-579
    • Overholser, C.D.1    Meiller, T.F.2    DePaola, L.G.3    Minah, G.E.4    Niehaus, C.5
  • 61
    • 33644853364 scopus 로고    scopus 로고
    • A non-staining chlorhexidine mouthwash? Probably not: a study in vitro
    • Addy M, Sharif N, Moran J. A non-staining chlorhexidine mouthwash? Probably not: a study in vitro. Int J Dent Hyg 2005; 3: 59-63.
    • (2005) Int J Dent Hyg , vol.3 , pp. 59-63
    • Addy, M.1    Sharif, N.2    Moran, J.3
  • 62
    • 0024762546 scopus 로고
    • Comparison of two commercially available chlorhexidine mouthrinses: II. Effects on plaque reformation, gingivitis, and tooth staining
    • Jenkins S, Addy M, Newcombe R. Comparison of two commercially available chlorhexidine mouthrinses: II. Effects on plaque reformation, gingivitis, and tooth staining. Clin Prev Dent 1989; 11: 12-16.
    • (1989) Clin Prev Dent , vol.11 , pp. 12-16
    • Jenkins, S.1    Addy, M.2    Newcombe, R.3
  • 63
    • 84877103548 scopus 로고    scopus 로고
    • The effect of an oxygenating agent on chlorhexidine-induced extrinsic tooth staining: a systematic review
    • Van Maanen-Schakel NW, Slot DE, Bakker EW, Van der Weijden GA. The effect of an oxygenating agent on chlorhexidine-induced extrinsic tooth staining: a systematic review. Int J Dent Hyg 2012; 10: 198-208.
    • (2012) Int J Dent Hyg , vol.10 , pp. 198-208
    • Van Maanen-Schakel, N.W.1    Slot, D.E.2    Bakker, E.W.3    Van der Weijden, G.A.4
  • 64
    • 0021875660 scopus 로고
    • Chemical plaque control and extrinsic tooth discoloration. A review of possible mechanisms
    • Eriksen HM, Nordbø H, Kantanen H, Ellingsen JE. Chemical plaque control and extrinsic tooth discoloration. A review of possible mechanisms. J Clin Periodontol 1985; 12: 345-350.
    • (1985) J Clin Periodontol , vol.12 , pp. 345-350
    • Eriksen, H.M.1    Nordbø, H.2    Kantanen, H.3    Ellingsen, J.E.4
  • 66
    • 33846455842 scopus 로고    scopus 로고
    • A meta-analysis of six-month studies of antiplaque and antigingivitis agents
    • Gunsolley JC. A meta-analysis of six-month studies of antiplaque and antigingivitis agents. J Am Dent Assoc 2006; 137: 1649-1657.
    • (2006) J Am Dent Assoc , vol.137 , pp. 1649-1657
    • Gunsolley, J.C.1
  • 67
    • 34047170939 scopus 로고    scopus 로고
    • The effect of 0.12% chlorhexidine dentifrice gel on plaque accumulation: a 3-day non-brushing model
    • Slot DE, Lindeboom R, Rosema NA, Timmerman MF, van der Weijden GA. The effect of 0.12% chlorhexidine dentifrice gel on plaque accumulation: a 3-day non-brushing model. Int J Dent Hyg 2007; 5: 45-52.
    • (2007) Int J Dent Hyg , vol.5 , pp. 45-52
    • Slot, D.E.1    Lindeboom, R.2    Rosema, N.A.3    Timmerman, M.F.4    van der Weijden, G.A.5
  • 69
    • 0023617128 scopus 로고
    • A comparison of three delivery methods of chlorhexidine in handicapped children. I. Effects on plaque, gingivitis and tooth staining
    • Francis JR, Hunter B, Addy M. A comparison of three delivery methods of chlorhexidine in handicapped children. I. Effects on plaque, gingivitis and tooth staining. J Periodontol 1987; 58: 451-454.
    • (1987) J Periodontol , vol.58 , pp. 451-454
    • Francis, J.R.1    Hunter, B.2    Addy, M.3
  • 70
    • 0013617830 scopus 로고    scopus 로고
    • The use of antiseptics in periodontal therapy
    • Lindhe J ed. Copenhagen, Blackwell Publishing Ltd
    • Addy M, Moran J. The use of antiseptics in periodontal therapy. In: Lindhe J ed. Clinical Periodontology and Implantology. Copenhagen, Blackwell Publishing Ltd, 2008, pp. 464-493.
    • (2008) Clinical Periodontology and Implantology , pp. 464-493
    • Addy, M.1    Moran, J.2
  • 71
    • 84984499013 scopus 로고
    • Intra-oral spread of the antimicrobial effect of a chlorhexidine gel
    • Saxen L, Niemi ML, Ainamo J. Intra-oral spread of the antimicrobial effect of a chlorhexidine gel. Scand J Dent Res 1976; 84: 304-307.
    • (1976) Scand J Dent Res , vol.84 , pp. 304-307
    • Saxen, L.1    Niemi, M.L.2    Ainamo, J.3


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