The relationship between epicardial fat and indices of obesity and the metabolic syndrome: A systematic review and meta-analysis

Metabolic Syndrome and Related Disorders

Volumn 12, Issue 1, 2014, Pages 31-42

  Rabkin, Simon W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ABDOMINAL OBESITY; ADIPOSE TISSUE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CORONARY RISK; DATA EXTRACTION; EPICARDIAL ADIPOSE TISSUE; GLUCOSE BLOOD LEVEL; HUMAN; INTRAABDOMINAL FAT; META ANALYSIS; METABOLIC SYNDROME X; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SYSTEMATIC REVIEW; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADIPOSITY; ADULT; AGED; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; CORONARY ARTERY DISEASE; FEMALE; HUMANS; INTRA-ABDOMINAL FAT; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; OBESITY, ABDOMINAL; PERICARDIUM; RISK FACTORS; TREATMENT OUTCOME; TRIGLYCERIDES; WAIST CIRCUMFERENCE;

EID: 84892532178     PISSN: 15404196     EISSN: 15578518     Source Type: Journal    
DOI: 10.1089/met.2013.0107     Document Type: Review

References (64)

1. Rabkin SW, Mathewson FA, Hsu PH. Relation of body weight to development of ischemic heart disease in a cohort of young North American men after a 26 year observation period: The Manitoba Study. Am J Cardiol 1977;39:452-458 (Pubitemid 8055364)
2. Rabkin SW. Epicardial fat: Properties, function and relationship to obesity. Obes Rev 2007;8:253-261 (Pubitemid 46632691)
3. Xu Y, Cheng X, Hong K, Huang C, et al. How to interpret epicardial adipose tissue as a cause of coronary artery disease: A meta-analysis. Coron Artery Dis 2012; 23:227-233
4. Bornfeldt KE, Tabas I. Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab 2011;14:575-585
5. Landsberg L, Aronne LJ, Beilin LJ, et al. Obesity-related hypertension: Pathogenesis, cardiovascular risk, and treatment: A position paper of The Obesity Society and the American Society of Hypertension. J Clin Hypertens 2013; 15:14-33
6. Subramanian S, Chait A. Hypertriglyceridemia secondary to obesity and diabetes. Biochim Biophys Acta 2012;1821:819-825
7. Haas MJ, Mooradian AD. Regulation of high-density lipoprotein by inflammatory cytokines: Establishing links between immune dysfunction and cardiovascular disease. Diabetes Metab Res Rev 2010;26:90-99
8. Alberti KG, Eckel RH, Grundy SM, et al. International Diabetes Federation Task Force on Epidemiology and Prevention. Hational Heart and Blood Institute.American Heart Association.Wor L. Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International. Circulation2009;120:1640-1645
9. Grundy SM, Cleeman JI, Daniels SR, et al. American Heart Association. National Heart and Blood Institute L. Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112:2735-2752 (Pubitemid 41532612)
10. Mottillo S, Filion KB, Genest J, et al. The metabolic syndrome and cardiovascular risk a systematic review and metaanalysis. J Am Coll Cardiol 2010;56:1113-1132
11. Galassi A, Reynolds K, He J. Metabolic syndrome and risk of cardiovascular disease: A meta-analysis. Am J Med 2006;119: 812-819 (Pubitemid 44415613)
12. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283:2008-2012 (Pubitemid 30214957)
13. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. J Clin Epidemiol 2009;62:1006-1012
14. Field AP. Meta-analysis of correlation coefficients: A Monte Carlo comparison of fixed- and random-effects methods. Psychol Methods 2001;6:161-180 (Pubitemid 33604037)
15. Bettencourt N, Toschke AM, Leite D, et al. Epicardial adipose tissue is an independent predictor of coronary atherosclerotic burden. Int J Cardiol 2012;158:26-32
16. Kim M-K, Tanaka K, Kim M-J, et al. Epicardial fat tissue: Relationship with cardiorespiratory fitness in men. Med Sci Sports Exerc 2010;42:463-469
17. Lai Y-H, Yun C-H, Yang F-S, et al. Epicardial adipose tissue relating to anthropometrics, metabolic derangements and fatty liver disease independently contributes to serum highsensitivity C-reactive protein beyond body fat composition: A study validated with computed tomography. J Am Soc Echocardiogr 2012;25:234-241
18. Gaborit B, Jacquier A, Kober F, et al. Effects of bariatric surgery on cardiac ectopic fat: Lesser decrease in epicardial fat compared to visceral fat loss and no change in myocardial triglyceride content. J Am Coll Cardiol 2012;60:1381-1389
19. Graner M, Siren R, Nyman K, et al. Cardiac steatosis associates with visceral obesity in nondiabetic obese men. J Clin Endocrinol Metab 2013;98:1189-1197
20. Borruel S, Fernandez-Duran E, Alpanes M, et al. Global adiposity and thickness of intraperitoneal and mesenteric adipose tissue depots are increased in women with poly- cystic ovary syndrome (PCOS). J Clin Endocrinol Metab2013;98:1254-1263
21. Kilicaslan B, Ozdogan O, Aydin M, et al. Increased epicardial fat thickness is associated with cardiac functional changes in healthy women. Tohoku J Exp Med 2012;228:119-124
22. Cavalcante JL, Tamarappoo BK, Hachamovitch R, et al. Association of epicardial fat, hypertension, subclinical coronary artery disease, and metabolic syndrome with left ventricular diastolic dysfunction. Am J Cardiol 2012;110:1793-1798
23. Sironi AM, Petz R, De Marchi D, et al. Impact of increased visceral and cardiac fat on cardiometabolic risk and disease. Diabet Med 2012;29:622-627
24. Graner M, Seppala-Lindroos A, Rissanen A, et al. Epicardial fat, cardiac dimensions, and low-grade inflammation in young adult monozygotic twins discordant for obesity. American J Cardiol 2012;109:1295-1302
25. Gaborit B, Kober F, Jacquier A, et al. Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: Relationship to metabolic profile, cardiac function and visceral fat. Int J Obes 2012;36:422-430
26. Yerramasu A, Dey D, Venuraju S, et al. Increased volume of epicardial fat is an independent risk factor for accelerated progression of sub-clinical coronary atherosclerosis. Atherosclerosis2012;220:223-230
27. Karadag B, Ozulu B, Ozturk FY, et al. Comparison of epicardial adipose tissue (EAT) thickness and anthropometric measurements in metabolic syndrome (MS) cases above and under the age of 65. Arch Gerontol Geriatr 2011;52:e79-e84
28. Iacobellis G, Lonn E, Lamy A, et al. Epicardial fat thickness and coronary artery disease correlate independently of obesity. Int J Cardiol 2011;146:452-454
29. Sicari R, Sironi AM, Petz R, et al. Pericardial rather than epicardial fat is a cardiometabolic risk marker: An MRI vs echo study. J Am Soc Echocardiogr 2011;24:1156-1162
30. Malavazos AE, Di Leo G, Secchi F, et al. Relation of echocardiographic epicardial fat thickness and myocardial fat. Am J Cardiol 2010;105:1831-1835
31. Aydin H, Toprak A, Deyneli O, et al. Epicardial fat tissue thickness correlates with endothelial dysfunction and other cardiovascular risk factors in patients with metabolic syndrome. Metab Syndr Relat Disord 2010;8:229-234
32. Wang TD, Lee WJ, Shih FY, et al. Relations of epicardial adipose tissue measured by multidetector computed tomography to components of the metabolic syndrome are region-specific and independent of anthropometric indexes and intraabdominal visceral fat. J Clin Endocrinol Metab2009;94:662-669
33. Okyay K, Balcioglu AS, Tavil Y, et al. A relationship between echocardiographic subepicardial adipose tissue and metabolic syndrome. Int J Cardiovasc Imaging 2008;24:577-583
34. Iacobellis G, Pellicelli AM, Grisorio B, et al. Relation of epicardial fat and alanine aminotransferase in subjects with increased visceral fat. Obesity (Silver Spring) 2008;16:179-183 (Pubitemid 351271969)
35. Iacobellis G, Leonetti F. Epicardial adipose tissue and insulin resistance in obese subjects. J Clin Endocrinol Metab 2005; 90:6300-6302 (Pubitemid 41606560)
36. Iacobellis G, Ribaudo MC, Assael F, et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: A new indicator of cardiovascular risk. J Clin Endocrinol Metab 2003;88:5163-5168 (Pubitemid 37452712)
37. Nakazato R, Rajani R, Cheng VY, et al. Weight change modulates epicardial fat burden: A 4-year serial study with non-contrast computed tomography. Atherosclerosis 2012;220: 139-144
38. Fu C-P, Sheu WH-H, Lee I-T, et al. Effects of weight loss on epicardial adipose tissue thickness and its relationship between serum soluble CD40 ligand levels in obese men. Clin Chim Act 2013;421:98-103
39. Sironi AM, Petz R, De Marchi D, et al. Impact of increased visceral and cardiac fat on cardiometabolic risk and disease. Diabet Med 2012;29:622-627
40. Gaborit B, Jacquier A, Kober F, et al. Effects of bariatric surgery on cardiac ectopic fat: Lesser decrease in epicardial fat compared to visceral fat loss and no change in myocardial triglyceride content. J Am Coll Cardiol 2012;60:1381-1389
41. Stramaglia G, Greco A, Guglielmi G, et al. Echocardiography and dual-energy x-ray absorptiometry in the elderly patients with metabolic syndrome: A comparison of two different tecniques to evaluate visceral fat distribution. J NutrHealth Aging 2010;14:6-10
42. Malavazos AE, Ermetici F, Cereda E, et al. Epicardial fat thickness: Relationship with plasma visfatin and plasminogen activator inhibitor-1 levels in visceral obesity. Nutr Metab Cardiovasc Dis 2008;18:523-530
43. Alberti KG, Zimmet P, Shaw J. IDF Epidemiology Task Force Consensus G. The metabolic syndrome - A new worldwide definition. Lancet 2005;366:1059-1062
44. Yorgun H, Canpolat U, Hazirolan T, et al. Increased epicardial fat tissue is a marker of metabolic syndrome in adult patients. Int J Cardiol 2013;165:308-313
45. Sengul C, Duman D. The association of epicardial fat thickness with blunted heart rate recovery in patients with metabolic syndrome. Tohoku J Exp Med 2011;224:257-262
46. Pierdomenico SD, Pierdomenico AM, Neri M, et al. Epicardial adipose tissue and metabolic syndrome in hypertensive patients with normal body weight and waist circumference. Am J Hypertens 2011;24:1145-1149
47. Iacobellis G, Willens HJ, Barbaro G, et al. Threshold values of high-risk echocardiographic epicardial fat thickness. Obesity (Silver Spring) 2008;16:887-892 (Pubitemid 351465648)
48. Tok D, Cagli K, Kadife I, et al. Impaired coronary flow reserve is associated with increased echocardiographic epicardial fat thickness in metabolic syndrome patients. Coron Artery Dis 2013;24:191-195
49. Liang KW, Tsai IC, Lee WJ, et al. MRI measured epicardial adipose tissue thickness at the right AV groove differentiates inflammatory status in obese men with metabolic syndrome. Obesity 2012;20:525-532
50. Wang CP, Hsu HL, Hung WC, et al. Increased epicardial adipose tissue (EAT) volume in type 2 diabetes mellitus and association with metabolic syndrome and severity of coronary atherosclerosis. Clin Eendocrinol 2009;70:876-882
51. Okyay K, Balcioglu AS, Tavil Y, et al. A relationship between echocardiographic subepicardial adipose tissue and metabolic syndrome. Int J Cardiovasc Imaging 2008;24:577-583
52. Kerr JD, Holden RM, Morton AR, et al. Associations of epicardial fat with coronary calcification, insulin resistance, inflammation, and fibroblast growth factor-23 in stage 3-5chronic kidney disease. BMC Nephrol 2013;14:26-30
53. De Vos AM, Prokop M, Roos CJ, et al. Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and coronary artery calcification in post-menopausal women. Eur Heart J 2008;29:777-783 (Pubitemid 351431011)
54. Willens HJ, Byers P, Chirinos JA, et al. Effects of weight loss after bariatric surgery on epicardial fat measured using echocardiography. Am J Cardiol 2007;99:1242-1245 (Pubitemid 46659864)
55. Marchington JM, Mattacks CA, Pond CM. Adipose tissue in the mammalian heart and pericardium: Structure, foetal development and biochemical properties. Comp Biochem Physiol B 1989;94:225-232
56. Despres J-P. Body fat distribution and risk of cardiovascular disease: An update. Circulation 2012;126:1301-1313
57. Juni P, Holenstein F, Sterne J, et al. Direction and impact of language bias in meta-analyses of controlled trials: Empirical study. Int J Epidemiol 2002;31:115-123 (Pubitemid 34284912)
58. Marwan M, Achenbach S. Quantification of epicardial fat by computed tomography: Why, when and how? J Cardiovasc Comput Tomogr 2013;7:3-10
59. Nakazato R, Rajani R, Cheng VY, et al. Weight change modulates epicardial fat burden: A 4-year serial study with non-contrast computed tomography. Atherosclerosis. 2012; 220:139-144
60. Thanassoulis G, Massaro JM, Hoffmann U, et al. Prevalence, distribution, and risk factor correlates of high pericardial and intrathoracic fat depots in the Framingham heart study. Circ Cardiovasc Imaging 2010;3:559-566
61. Ding J, Hsu FC, Harris TB, et al. The association of pericardial fat with incident coronary heart disease: The Multi- Ethnic Study of Atherosclerosis (MESA). Am J Clin Nutr2009;90:499-504
62. Mazzoccoli G, Dagostino MP, Fontana A, et al. Influence of the Gly1057Asp variant of the insulin receptor substrate 2 (IRS2) on insulin resistance and relationship with epicardial fat thickness in the elderly. Exp Gerontol 2012;47:988-993
63. Shemirani H, Khoshavi M. Correlation of echocardiographic epicardial fat thickness with severity of coronary artery disease-an observational study. Anadolu Kardiyol Derg 2012; 12:200-205
64. Gorter PM, van Lindert AS, de Vos AM, et al. Quantification of epicardial and peri-coronary fat using cardiac computed tomography; reproducibility and relation with obesity and metabolic syndrome in patients suspected of coronary artery disease. Atherosclerosis 2008;197:896-903 (Pubitemid 351417890)