Loss of fat-free mass over four years in adult cystic fibrosis is associated with high serum interleukin-6 levels but not tumour necrosis factor-alpha

Clinical Nutrition

Volumn 33, Issue 1, 2014, Pages 150-155

  King, Susannah J ^a,b,c   Nyulasi, Ibolya B ^a,b   Bailey, Michael ^b   Kotsimbos, Tom ^a,b   Wilson, John W ^a,b  

^a ALFRED HOSPITAL   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c LA TROBE UNIVERSITY   (Australia)

Author keywords

Body composition; Cystic fibrosis; Fat free mass; Interleukin 6; Nutritional status

Indexed keywords

INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALLELE; ARTICLE; BLOOD ANALYSIS; BODY COMPOSITION; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FAT FREE MASS; FEMALE; FOLLOW UP; FORCED EXPIRATORY VOLUME; GENE MUTATION; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL STATUS; PREDICTION; PROTEIN BLOOD LEVEL; UPREGULATION;

BODY COMPOSITION; CYSTIC FIBROSIS; FAT-FREE MASS; INTERLEUKIN-6; NUTRITIONAL STATUS;

ABSORPTIOMETRY, PHOTON; ADULT; BODY COMPOSITION; CYSTIC FIBROSIS; FEMALE; FOLLOW-UP STUDIES; FORCED EXPIRATORY VOLUME; HUMANS; INTERLEUKIN-6; MALE; MALNUTRITION; MOTOR ACTIVITY; NUTRITIONAL STATUS; PROSPECTIVE STUDIES; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84892512169     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2013.04.012     Document Type: Article

References (24)

1. Collins C.E., MacDonald-Wicks L., Rowe S., O'Loughlin E.V., Henry R.L. Normal growth in cystic fibrosis associated with a specialised centre. Arch Dis Child 1999, 81:241-246.
2. Ionescu A.A., Evans W.D., Pettit R.J., Nixon L.S., Stone M.D., Shale D.J. Hidden depletion of fat-free mass and bone mineral density in adults with cystic fibrosis. Chest 2003, 124:2220-2228.
3. Ionescu A.A., Nixon L.S., Evans W.D., Stone M.D., Lewis-Jenkins V., Chatham K., et al. Bone density, body composition, and inflammatory status in cystic fibrosis. Am J Respir Crit Care Med 2000, 162:789-794.
4. Ionescu A.A., Nixon L.S., Luzio S., Lewis-Jenkins V., Evans W.D., Stone M.D., et al. Pulmonary function, body composition, and protein catabolism in adults with cystic fibrosis. Am J Respir Crit Care Med 2002, 165:495-500.
5. Schols A.M.W.J., Broekhuizen R., Weling-Scheepers C.A., Wouters E.F. Body composition and mortality in chronic obstructive pulmonary disease. Am J Clin Nutr 2005, 82:53-59.
6. King S.J., Nyulasi I.B., Strauss B.J.G., Kotsimbos T., Bailey M., Wilson J.W. Fat-free mass depletion in cystic fibrosis: associated with lung disease severity but poorly detected by body mass index. Nutrition 2010, 26:753-759.
7. King S.J., Topliss D.J., Kotsimbos T., Bailey M., Nyulasi I.B., Ebeling P.R., et al. Reduced bone density in cystic fibrosis: deltaF508 mutation is an independent risk factor. Eur Respir J 2005, 25:54-61.
8. Davis P.B. The decline and fall of pulmonary function in cystic fibrosis: new models, new lessons. JPediatr 1997, 131:789-790.
9. Baecke J.A., Burema J., Frijters J.E. Ashort questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr 1982, 36:936-942.
10. National Health and Medical Research Council Nutrient reference values for Australia and New Zealand 2006, Commonwealth of Australia, Canberra, Australia.
11. Cystic Fibrosis Australia Cystic fibrosis in Australia 2003: annual report from the Australasian cystic fibrosis data registry 2006, Cystic Fibrosis Australia, Sydney, Australia.
12. Colombo C., Littlewood J. The implementation of standards of care in Europe: state of the art. JCyst Fibros 2011, 10:S7-S15.
13. Peckham D., Leonard C., Range S., Knox A. Nutritional status and pulmonary function in patients with cystic fibrosis with and without Burkholderia cepacia colonization: role of specialist dietetic support. JHum Nutr Diet 1996, 9:173-179.
14. Sermet-Gaudelus I., Souberbielle J.C., Azhar I., Ruiz J.C., Magnine P., Colomb V., et al. Insulin-like growth factor I correlates with lean body mass in cystic fibrosis patients. Arch Dis Child 2003, 88:956-961.
15. Nixon L.S., Yung B., Bell S.C., Elborn J.S., Shale D.J. Circulating immunoreactive interleukin-6 in cystic fibrosis. Am J Respir Crit Care Med 1998, 157:1764-1769.
16. Kronborg G., Hansen M.B., Svenson M., Fomsgaard A., Hoiby N., Bendtzen K. Cytokines in sputum and serum from patients with cystic fibrosis and chronic Pseudomonas aeruginosa infection as markers of destructive inflammation in the lungs. Pediatr Pulmonol 1993, 15:292-297.
17. Sagel S.D., Accurso F.J. Monitoring inflammation in CF. Cytokines. Clin Rev Allergy Immunol 2002, 23:41-57.
18. Song M., Kellum J.A. Interleukin-6. Crit Care Med 2005, 33:S463-S465.
19. Ionescu A.A., Nixon L.E., Shale D.J. Cellular proteolysis and systemic inflammation during exacerbation in cystic fibrosis. JCyst Fibros 2004, 3:253-258.
20. Creutzberg E.C., Schols A.M., Weling-Scheepers C.A., Buurman W.A., Wouters E.F. Characterization of nonresponse to high caloric oral nutritional therapy in depleted patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000, 161:745-752.
21. Plank L.D. Dual-energy X-ray absorptiometry and body composition. Curr Opin Clin Nutr Metab Care 2005, 8:305-309.
22. Kiebzak G.M., Leamy L.J., Pierson L.M., Nord R.H., Zhang Z.Y. Measurement precision of body composition variables using the Lunar DPX-L densitometer. JClin Densitom 2000, 3:35-41.
23. Walker K.Z., Piers L.S., Putt R.S., Jones J.A., O'Dea K. Effects of regular walking on cardiovascular risk factors and body composition in normoglycemic women and women with type 2 diabetes. Diabetes Care 1999, 22:555-561.
24. Aris R.M., Stephens A.R., Ontjes D.A., Blackwood A.D., Lark R.K., Hensler M.B., et al. Adverse alterations in bone metabolism are associated with lung infection in cystic fibrosis. Am J Respir Crit Care Med 2000, 162:1674-1678.