Increased activation of synapsin 1 and mitogen-activated protein kinases/extracellular signal-regulated kinase in the amygdala of maternal separation rats

CNS Neuroscience and Therapeutics

Volumn 20, Issue 2, 2014, Pages 172-181

  Park, Hae Jeong ^a   Kim, Su Kang ^a   Kang, Won Sub ^a   Chung, Joo Ho ^a   Kim, Jong Woo ^a  

^a Kyung Hee University Hospital   (South Korea)

Author keywords

Amygdala; Early life stress; Maternal separation; Mitogen activated protein kinase; Synapsin 1

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; SYNAPSIN I;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DNA MICROARRAY; DOWN REGULATION; EARLY LIFE STRESS; EMOTION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MATERNAL DEPRIVATION; NEUROMODULATION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RISK FACTOR; SYNAPTIC TRANSMISSION; TRANSCRIPTION INITIATION SITE; WESTERN BLOTTING;

AMYGDALA; EARLY LIFE STRESS; MATERNAL SEPARATION; MITOGEN-ACTIVATED PROTEIN KINASE; SYNAPSIN 1;

AMYGDALA; ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; DNA-CYTOSINE METHYLASES; FEMALE; GENE EXPRESSION PROFILING; IMMUNOPRECIPITATION; MALE; MATERNAL DEPRIVATION; MAZE LEARNING; MITOGEN-ACTIVATED PROTEIN KINASES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; STRESS, PSYCHOLOGICAL; SWIMMING; SYNAPSINS; TRANSCRIPTION INITIATION SITE;

EID: 84892508506     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12202     Document Type: Article

References (44)

1. Ouyang L, Fang X, Mercy J, Perou R, Grosse SD. Attention-deficit/hyperactivity disorder symptoms and child maltreatment: A population-based study. J Pediatr 2008;153:851-856.
2. Heim C, Plotsky PM, Nemeroff CB. Importance of studying the contributions of early adverse experience to neurobiological findings in depression. Neuropsychopharmacology 2004;29:641-648.
3. Carpenter LL, Gawuga CE, Tyrka AR, Lee JK, Anderson GM, Price LH. Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults. Neuropsychopharmacology 2010;35:2617-2623.
4. Bremne JD, Vermetten E. Stress and development: Behavioral and biological consequences. Dev Psychopathol 2001;13:473-489.
5. Heim C, Newport DJ, Heit S, et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA 2000;284:592-597.
6. Aisa B, Tordera R, Lasheras B, Del Rio J, Ramirez MJ. Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology 2007;32:256-266.
7. Wigger A, Neumann ID. Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats. Physiol Behav 1999;66:293-302.
8. Wilber AA, Southwood CJ, Wellman CL. Brief neonatal maternal separation alters extinction of conditioned fear and corticolimbic glucocorticoid and NMDA receptor expression in adult rats. Dev Neurobiol 2009;69:73-87.
9. Plotsky PM, Meaney MJ. Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Brain Res Mol Brain Res 1993;18:195-200.
10. Lee HJ, Kim JW, Yim SV, et al. Fluoxetine enhances cell proliferation and prevents apoptosis in dentate gyrus of maternally separated rats. Mol Psychiatry 2001;6:725-728.
11. Kwak HR, Lee JW, Kwon KJ, et al. Neuronal architecture of the hippocampal formation and cerebral cortex in maternal social separation rats. Clin Psychopharmacol Neurosci 2008;6:65-70.
12. Park HJ, Chae Y, Kim JW, Lee H, Chung JH. Effect of acupuncture on hypothalamic-pituitary-adrenal system in maternal separation rats. Cell Mol Neurobiol 2011;31:1123-1127.
13. Kwak HR, Lee JW, Kwon KJ, et al. Maternal social separation of adolescent rats induces hyperactivity and anxiolytic behavior. Korean J Physiol Pharmacol 2009;13:79-83.
14. Kim MJ, Kim HK, Kim BS, Yim SV. Melatonin increases cell proliferation in the dentate gyrus of maternally separated rats. J Pineal Res 2004;37:193-197.
15. Kim MJ, Kim YO, Chang UJ, et al. Melatonin enhances NADPH-diaphorase activities in the hypothalamus of maternally-separated rats. Neurosci Lett 2006;394:111-116.
16. Park HJ, Chae Y, Jang J, Shim I, Lee H, Lim S. The effect of acupuncture on anxiety and neuropeptide Y expression in the basolateral amygdala of maternally separated rats. Neurosci Lett 2005;377:179-184.
17. Murray EA. The amygdala, reward and emotion. Trends Cogn Sci 2007;11:489-497.
18. Davis M, Rainnie D, Cassell M. Neurotransmission in the rat amygdala related to fear and anxiety. Trends Neurosci 1994;17:208-214.
19. Jacobs RH, Renken R, Aleman A, Cornelissen FW. The amygdala, top-down effects, and selective attention to features. Neurosci Biobehav Rev 2012;36:2069-2084.
20. Siegle GJ, Steinhauer SR, Thase ME, Stenger VA, Carter CS. Can't shake that feeling: Event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biol Psychiatry 2002;51:693-707.
21. Sheline YI, Barch DM, Donnelly JM, Ollinger JM, Snyder AZ, Mintun MA. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: An fMRI study. Biol Psychiatry 2001;50:651-658.
22. Drevets WC. Neuroimaging and neuropathological studies of depression: Implications for the cognitive-emotional features of mood disorders. Curr Opin Neurobiol 2001;11:240-249.
23. Drevets WC, Bogers W, Raichle ME. Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. Eur Neuropsychopharmacol 2002;12:527-544.
24. Parsey RV, Hastings RS, Oquendo MA, et al. Lower serotonin transporter binding potential in the human brain during major depressive episodes. Am J Psychiatry 2006;163:52-58.
25. Zetzsche T, Frodl T, Preuss UW, et al. Amygdala volume and depressive symptoms in patients with borderline personality disorder. Biol Psychiatry 2006;60:302-310.
26. Amaral DG, Insausti R. Retrograde transport of D-[3H]-aspartate injected into the monkey amygdaloid complex. Exp Brain Res 1992;88:375-388.
27. Cesca F, Baldelli P, Valtorta F, Benfenati F. The synapsins: Key actors of synapse function and plasticity. Prog Neurobiol 2010;91:313-348.
28. Bernal-Morales B, Contreras CM, Cueto-Escobedo J. Acute restraint stress produces behavioral despair in weanling rats in the forced swim test. Behav Processes 2009;82:219-222.
29. Porsolt RD, Le Pichon M, Jalfre M. Depression: A new animal model sensitive to antidepressant treatments. Nature 1977;266:730-732.
30. Weber M, Davies JJ, Wittig D, et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet 2005;37:853-862.
31. Bolte S, Cordelieres FP. A guided tour into subcellular colocalization analysis in light microscopy. J Microsc 2006;224:213-232.
32. Manders EMM, Verbeek FJ, Aten JA. Measurement of co-localization of objects in dual-colour confocal images. J Microsc 1992;169:375-382.
33. Elliott E, Ezra-Nevo G, Regev L, Neufeld-Cohen A, Chen A. Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice. Nat Neurosci 2010;13:1351-1353.
34. Murgatroyd C, Patchev AV, Wu Y, et al. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci 2009;12:1559-1566.
35. Boggio EM, Putignano E, Sassoe-Pognetto M, Pizzorusso T, Giustetto M. Visual stimulation activates ERK in synaptic and somatic compartments of rat cortical neurons with parallel kinetics. PLoS ONE 2007;2:e604.
36. Sweatt JD. Mitogen-activated protein kinases in synaptic plasticity and memory. Curr Opin Neurobiol 2004;14:311-317.
37. McGowan PO, Sasaki A, D'Alessio AC, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009;12:342-348.
38. Chi P, Greengard P, Ryan TA. Synapsin dispersion and reclustering during synaptic activity. Nat Neurosci 2001;4:1187-1193.
39. Greengard P, Valtorta F, Czernik AJ, Benfenati F. Synaptic vesicle phosphoproteins and regulation of synaptic function. Science 1993;259:780-785.
40. Hilfiker S, Pieribone VA, Czernik AJ, Kao HT, Augustine GJ, Greengard P. Synapsins as regulators of neurotransmitter release. Philos Trans R Soc Lond B Biol Sci 1999;354:269-279.
41. Hermes G, Li N, Duman C, Duman R. Post-weaning chronic social isolation produces profound behavioral dysregulation with decreases in prefrontal cortex synaptic-associated protein expression in female rats. Physiol Behav 2010;104:354-359.
42. Elizalde N, Pastor PM, Garcia-Garcia AL, et al. Regulation of markers of synaptic function in mouse models of depression: Chronic mild stress and decreased expression of VGLUT1. J Neurochem 2010;114:1302-1314.
43. Henningsen K, Palmfeldt J, Christiansen S, et al. Candidate hippocampal biomarkers of susceptibility and resilience to stress in a rat model of depression. Mol Cell Proteomics 2012;11:M111 016428.
44. Varea E, Guirado R, Gilabert-Juan J, et al. Expression of PSA-NCAM and synaptic proteins in the amygdala of psychiatric disorder patients. J Psychiatr Res 2012;46:189-197.