Characteristics, risk factors, and mortality of cirrhotic patients hospitalized for hepatic encephalopathy with and without acute-on-chronic liver failure (ACLF)

Journal of Hepatology

Volumn 60, Issue 2, 2014, Pages 275-281

  Cordoba, Juan ^a,b   Ventura Cots, Meritxell ^a   Simón Talero, Macarena ^a   Amorós, Àlex ^b,c   Pavesi, Marco ^b,c   Vilstrup, Hendrik ^d   Angeli, Paolo ^e   Domenicali, Marco ^f   Ginés, Pere ^b,g   Bernardi, Mauro ^f   Arroyo, Vicente ^b,g  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c Hospital Clinic   (Spain)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

^e UNIVERSITY OF PADOVA   (Italy)

^f UNIVERSITY OF BOLOGNA   (Italy)

^g UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Acute on chronic liver failure; Cirrhosis; Hepatic encephalopathy; Risk factors

Indexed keywords

BILIRUBIN; CREATININE; SODIUM;

ACUTE ON CHRONIC LIVER FAILURE; ADULT; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; DECOMPENSATED LIVER CIRRHOSIS; DISEASE ASSOCIATION; FEMALE; HEPATIC ENCEPHALOPATHY; HOSPITAL PATIENT; HUMAN; INFLAMMATION; INTERNATIONAL NORMALIZED RATIO; LONG TERM SURVIVAL; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RISK FACTOR; SEVERE HEPATIC IMPAIRMENT; SURVIVAL RATE;

(CLIF); ACLF; ACUTE-ON-CHRONIC LIVER FAILURE; ALANINE AMINOTRANSFERASE; ALT; ASPARTATE AMINOTRANSFERASE; AST; CIRRHOSIS; EASL-CHRONIC LIVER FAILURE; GAMMA-GLUTAMYL TRANSFERASE; GGT; HE; HEPATIC ENCEPHALOPATHY; INR; INTERNATIONAL NORMALIZED RATIO; MELD; MODEL FOR END-STAGE LIVER DISEASE; N.S.; NON SIGNIFICANT; RISK FACTORS; SEQUENTIAL ORGAN FAILURE ASSESSMENT; SOFA; WBC; WHITE BLOOD CELLS;

AGED; END STAGE LIVER DISEASE; FEMALE; HEPATIC ENCEPHALOPATHY; HUMANS; LIVER CIRRHOSIS; LIVER CIRRHOSIS, ALCOHOLIC; LIVER FAILURE, ACUTE; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; SPAIN; TIME FACTORS;

EID: 84892496325     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.10.004     Document Type: Article

References (24)

1. P. Ferenci, A. Lockwood, K. Mullen, R. Tarter, K. Weissenborn, and A.T. Blei Hepatic encephalopathy-definition, nomenclature, diagnosis and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998 Hepatology 35 2002 716 721
2. D. Häussinger, and F. Schliess Pathogenetic mechanisms of hepatic encephalopathy Gut 57 2008 1156 1165
3. M. Stepanova, A. Mishra, C. Venkatesan, and Z.M. Younossi In-hospital mortality and economic burden associated with hepatic encephalopathy in the United States from 2005 to 2009 Clin Gastroenterol Hepatol 10 2012 1034 1041
4. D. Patel, M.J. McPhail, J.F. Cobbold, and S.D. Taylor-Robinson Hepatic encephalopathy Br J Hosp Med (Lond) 73 2012 79 85
5. J. Bustamante, A. Rimola, P.J. Ventura, M. Navasa, I. Cirera, and V. Reggiardo et al. Prognostic significance of hepatic encephalopathy in patients with cirrhosis J Hepatol 30 1999 890 895
6. I. Les, E. Doval, R. García-Martínez, M. Planas, G. Cárdenas, and P. Gómez et al. Effects of branched-chain amino acids supplementation in patients with cirrhosis and a previous episode of hepatic encephalopathy: a randomized study Am J Gastroenterol 106 2011 1081 1088
7. R. Moreau, R. Jalan, P. Gines, M. Pavesi, P. Angeli, J. Cordoba for the CANONIC Study Group Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis Gastroenterology 144 2013 1426 1437
8. H.O. Conn The hepatic encephalopathies H.O. Conn, J. Bircher, Hepatic encephalopathy. Syndromes and therapies 1994 Medi-Ed Press Bloomington, IL 1 12
9. J.P. Fine, and R.J. Gray A proportional hazards model for the subdistribution of a competing risk J Am Stat Assoc 94 1999 496 509
10. R.S. Rahimi, and D.C. Rockey Complications of cirrhosis Curr Opin Gastroenterol 28 2012 223 229
11. J. Cordoba New assessment of hepatic encephalopathy J Hepatol 54 2011 1030 1040
12. M. Guevara, M.E. Baccaro, A. Torre, B. Gómez-Ansón, J. Ríos, and F. Torres et al. Hyponatremia is a risk factor of hepatic encephalopathy in patients with cirrhosis: a prospective study with time-dependent analysis Am J Gastroenterol 104 2009 1382 1389
13. P. Sharma, A. Agrawal, B.C. Sharma, and S.K. Sarin Prophylaxis of hepatic encephalopathy in acute variceal bleed: a randomized controlled trial of lactulose versus no lactulose J Gastroenterol Hepatol 26 2011 996 1003
14. P. Ivarsen, J. Greisen, and H. Vilstrup Acute effects of moderate dehydration on the hepatic conversion of amino nitrogen into urea nitrogen in healthy men Clin Sci (Lond) 101 2001 339 344
15. S. Sherlock, B. Senewiratne, A. Scott, and J.G. Walker Complications of diuretic therapy in hepatic cirrhosis Lancet 14 1966 1050 1052
16. P. Ginés, P. Angeli, K. Lenz, S. Møller, K. Moore, and R. Moreau et al. European Association for the Study of the Liver. EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis J Hepatol 53 2010 397 417
17. N.M. Bass, K.D. Mullen, A. Sanyal, F. Poordad, G. Neff, and C.B. Leevy et al. Rifaximin treatment in hepatic encephalopathy N Engl J Med 362 2010 1071 1081
18. B. Als-Nielsen, L.L. Gluud, and C. Gluud Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trials BMJ 328 2004 1046
19. B.C. Sharma, P. Sharma, A. Agrawal, and S.K. Sarin Secondary prophylaxis of hepatic encephalopathy: an open-label randomized controlled trial of lactulose versus placebo Gastroenterology 137 2009 885 891
20. M. Romero-Gómez, M. Jover, J.A. Del Campo, J.L. Royo, E. Hoyas, and J.J. Galán et al. Variations in the promoter region of the glutaminase gene and the development of hepatic encephalopathy in patients with cirrhosis: a cohort study Ann Intern Med 153 2010 281 288
21. W. Laleman, M. Simon-Talero, G. Maleux, M. Perez, K. Ameloot, G. Soriano the EASL-CLIF-Consortium Embolization of large spontaneous portosystemic shunts for refractory hepatic encephalopathy: a multicenter survey on safety and efficacy Hepatology 57 2013 2448 2457
22. E. Strauss, and M.F. da Costa The importance of bacterial infections as precipating factors of chronic hepatic encephalopathy in cirrhosis Hepatogastroenterology 45 1998 900 904
23. D.L. Shawcross, Y. Sharifi, J.B. Canavan, A.D. Yeoman, R.D. Abeles, and N.J. Taylor et al. Infection and systemic inflammation, not ammonia, are associated with Grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis J Hepatol 54 2011 640 649
24. J. Córdoba, R. García-Martinez, and M. Simón-Talero Hyponatremic and hepatic encephalopathies: similarities, differences and coexistence Metab Brain Dis 25 2010 73 80