메뉴 건너뛰기




Volumn 1, Issue 3, 2012, Pages 83-84

Drug Interaction Studies With CYP3A Substrates: How Much Inhibitor Pre-exposure Is Needed?

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; ERYTHROMYCIN; KETOCONAZOLE; MIDAZOLAM; TRIAZOLAM;

EID: 84892488937     PISSN: 2160763X     EISSN: 21607648     Source Type: Journal    
DOI: 10.1177/2160763X12448745     Document Type: Editorial
Times cited : (5)

References (20)
  • 1
    • 77949351406 scopus 로고    scopus 로고
    • Drug interactions evaluation: an integrated part of risk assessment of therapeutics
    • Zhang L,Reynolds KS,Zhao P,Huang SM.Drug interactions evaluation: an integrated part of risk assessment of therapeutics.Toxicol Appl Pharmacol. 2010;243:134-145.
    • (2010) Toxicol Appl Pharmacol , vol.243 , pp. 134-145
    • Zhang, L.1    Reynolds, K.S.2    Zhao, P.3    Huang, S.M.4
  • 2
    • 84892488819 scopus 로고    scopus 로고
    • Regulatory and scientific aspects of drug-drug interaction studies
    • Greenblatt DJ.Regulatory and scientific aspects of drug-drug interaction studies.Clin Pharmacol Drug Dev. 2012;1:43-44.
    • (2012) Clin Pharmacol Drug Dev , vol.1 , pp. 43-44
    • Greenblatt, D.J.1
  • 3
    • 0034004083 scopus 로고    scopus 로고
    • Effects of the antifungal agents on oxidative drug metabolism in humans: clinical relevance
    • Venkatakrishnan K,von Moltke LL,Greenblatt DJ.Effects of the antifungal agents on oxidative drug metabolism in humans: clinical relevance.Clin Pharmacokinet. 2000;38:111-180.
    • (2000) Clin Pharmacokinet , vol.38 , pp. 111-180
    • Venkatakrishnan, K.1    von Moltke, L.L.2    Greenblatt, D.J.3
  • 4
    • 70849085550 scopus 로고    scopus 로고
    • Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase
    • Greenblatt DJ,Peters DE,Oleson LE, et al.Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase.Br J Clin Pharmacol. 2009;68:920-927.
    • (2009) Br J Clin Pharmacol , vol.68 , pp. 920-927
    • Greenblatt, D.J.1    Peters, D.E.2    Oleson, L.E.3
  • 5
    • 13144257695 scopus 로고    scopus 로고
    • Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences
    • Greenblatt DJ,von Moltke LL,Harmatz JS, et al.Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences.Clin Pharmacol Ther. 1998;64:278-285.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 278-285
    • Greenblatt, D.J.1    von Moltke, L.L.2    Harmatz, J.S.3
  • 6
    • 0029130840 scopus 로고
    • Macrolide antibacterials: drug interactions of clinical significance
    • von Rosensteil NA,Adam D.Macrolide antibacterials: drug interactions of clinical significance.Drug Safety. 1995;13:105-122.
    • (1995) Drug Safety , vol.13 , pp. 105-122
    • von Rosensteil, N.A.1    Adam, D.2
  • 8
    • 0033770638 scopus 로고    scopus 로고
    • Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin
    • Westphal JF.Macrolide-induced clinically relevant drug interactions with cytochrome P-450A (CYP) 3A4: an update focused on clarithromycin, azithromycin and dirithromycin.Br J Clin Pharmacol. 2000;50:285-295.
    • (2000) Br J Clin Pharmacol , vol.50 , pp. 285-295
    • Westphal, J.F.1
  • 9
    • 0030077245 scopus 로고    scopus 로고
    • Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors, and clinical confirmation of a predicted interaction with ketoconazole
    • von Moltke LL,Greenblatt DJ,Harmatz JS, et al.Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors, and clinical confirmation of a predicted interaction with ketoconazole.J Pharmacol Exp Ther. 1996;276:370-379.
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 370-379
    • von Moltke, L.L.1    Greenblatt, D.J.2    Harmatz, J.S.3
  • 10
    • 13144307073 scopus 로고    scopus 로고
    • Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences
    • Greenblatt DJ,Wright CE,von Moltke LL, et al.Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences.Clin Pharmacol Ther. 1998;64:237-247.
    • (1998) Clin Pharmacol Ther , vol.64 , pp. 237-247
    • Greenblatt, D.J.1    Wright, C.E.2    von Moltke, L.L.3
  • 11
    • 63849243096 scopus 로고    scopus 로고
    • Effect of different durations of ketoconazole dosing on the single-dose pharmacokinetics of midazolam: shortening the paradigm
    • Stoch SA,Friedman E,Maes A, et al.Effect of different durations of ketoconazole dosing on the single-dose pharmacokinetics of midazolam: shortening the paradigm.J Clin Pharmacol. 2009;49:398-406.
    • (2009) J Clin Pharmacol , vol.49 , pp. 398-406
    • Stoch, S.A.1    Friedman, E.2    Maes, A.3
  • 14
    • 78751483916 scopus 로고    scopus 로고
    • Mechanism of cytochrome P450-3A inhibition by ketoconazole
    • Greenblatt DJ,Zhao Y,Venkatakrishnan K, et al.Mechanism of cytochrome P450-3A inhibition by ketoconazole.J Pharm Pharmacol. 2011;63:214-221.
    • (2011) J Pharm Pharmacol , vol.63 , pp. 214-221
    • Greenblatt, D.J.1    Zhao, Y.2    Venkatakrishnan, K.3
  • 15
    • 36549059303 scopus 로고    scopus 로고
    • Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring
    • Zhou SF,Xue CC,Yu XQ,Li C,Wang G.Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring.Ther Drug Monit. 2007;29:687-710.
    • (2007) Ther Drug Monit , vol.29 , pp. 687-710
    • Zhou, S.F.1    Xue, C.C.2    Yu, X.Q.3    Li, C.4    Wang, G.5
  • 16
    • 45249121177 scopus 로고    scopus 로고
    • Drugs behave as substrates, inhibitors and inducers of human Cytochrome P450 3A4
    • Zhou SF.Drugs behave as substrates, inhibitors and inducers of human Cytochrome P450 3A4.Curr Drug Metab. 2008;9:310-322.
    • (2008) Curr Drug Metab , vol.9 , pp. 310-322
    • Zhou, S.F.1
  • 17
    • 33644827609 scopus 로고    scopus 로고
    • Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human Cytochrome P4503A substrate
    • Polasek TM,Miners JO.Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human Cytochrome P4503A substrate.Eur J Clin Pharmacol. 2006;62:203-208.
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 203-208
    • Polasek, T.M.1    Miners, J.O.2
  • 18
    • 24944510505 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes mechanism based inhibitors: common sub-structures and reactivity
    • Fontana E,Dansette PM,Poli SM.Cytochrome P450 enzymes mechanism based inhibitors: common sub-structures and reactivity.Curr Drug Metab. 2005;6:413-454.
    • (2005) Curr Drug Metab , vol.6 , pp. 413-454
    • Fontana, E.1    Dansette, P.M.2    Poli, S.M.3
  • 19
    • 34548738229 scopus 로고    scopus 로고
    • Drug-drug interactions via mechanism-based Cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation
    • Venkatakrishnan K,Obach RS.Drug-drug interactions via mechanism-based Cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation.Curr Drug Metab. 2007;8:449-462.
    • (2007) Curr Drug Metab , vol.8 , pp. 449-462
    • Venkatakrishnan, K.1    Obach, R.S.2
  • 20
    • 34548049514 scopus 로고    scopus 로고
    • Effect of the treatment period with erythromycin on Cytochrome P450 3A activity in humans
    • Okudaira T,Kotegawa T,Imai H,Tsutsumi K,Nakano S,Ohashi K.Effect of the treatment period with erythromycin on Cytochrome P450 3A activity in humans.J Clin Pharmacol. 2007;47:871-876.
    • (2007) J Clin Pharmacol , vol.47 , pp. 871-876
    • Okudaira, T.1    Kotegawa, T.2    Imai, H.3    Tsutsumi, K.4    Nakano, S.5    Ohashi, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.