Expression and activity of collagenases in the digital laminae of horses with carbohydrate overload-induced acute laminitis

Journal of Veterinary Internal Medicine

Volumn 28, Issue 1, 2014, Pages 215-222

  Wang, L ^a   Pawlak, E A ^a   Johnson, P J ^b   Belknap, J K ^c   Alfandari, D ^a   Black, S J ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

CHO laminitis; Equine; Matrix metalloproteinases

Indexed keywords

ANIMALIA; EQUIDAE;

MATRIX METALLOPROTEINASE; RNA;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMISTRY; CHO-LAMINITIS; ENZYMOLOGY; EQUIDAE; EXTRACELLULAR MATRIX; FLUORESCENCE MICROSCOPY; FOOT DISEASE; GENE EXPRESSION REGULATION; GENETICS; HOOF AND CLAW; HORSE; HORSE DISEASE; IMMUNOHISTOCHEMISTRY; METABOLISM; NONPARAMETRIC TEST; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

CHO-LAMINITIS; EQUINE; MATRIX METALLOPROTEINASES;

ANIMALS; BLOTTING, WESTERN; EXTRACELLULAR MATRIX; FOOT DISEASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOOF AND CLAW; HORSE DISEASES; HORSES; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASES; MICROSCOPY, FLUORESCENCE; REAL-TIME POLYMERASE CHAIN REACTION; RNA; STATISTICS, NONPARAMETRIC;

EID: 84892488310     PISSN: 08916640     EISSN: 19391676     Source Type: Journal    
DOI: 10.1111/jvim.12252     Document Type: Article

References (28)

1. Pollitt CC. The anatomy and physiology of the suspensory apparatus of the distal phalanx. Vet Clin North Am Equine Pract 2010;26:29-49.
2. Pollitt CC, Daradka M. Equine laminitis basement membrane pathology: Loss of type IV collagen, type VII collagen and laminin immunostaining. Equine Vet J Suppl 1998;26:139-144.
3. Wang L, Pawlak E, Johnson PJ, et al. Effects of cleavage by a disintegrin and metalloproteinase with thrombospondin motifs-4 on gene expression and protein content of versican and aggrecan in the digital laminae of horses with starch gruel-induced laminitis. Am J Vet Res 2012;73:1047-1056.
4. Wang L, Pawlak EA, Johnson PJ, et al. Impact of laminitis on the canonical Wnt signaling pathway in basal epithelial cells of the equine digital laminae. PLoS One 2013;8:e56025.
5. French KR, Pollitt CC. Equine laminitis: Cleavage of laminin 5 associated with basement membrane dysadhesion. Equine Vet J 2004;36:242-247.
6. French KR, Pollitt CC. Equine laminitis: Loss of hemidesmosomes in hoof secondary epidermal lamellae correlates to dose in an oligofructose induction model: An ultrastructural study. Equine Vet J 2004;36:230-235.
7. Visser MB, Pollitt CC. The timeline of lamellar basement membrane changes during equine laminitis development. Equine Vet J 2011;43:471-477.
8. Eades SC. Overview of current laminitis research. Vet Clin North Am Equine Pract 2010;26:51-63.
9. Mungall BA, Pollitt CC. Zymographic analysis of equine laminitis. Histochem Cell Biol 1999;112:467-472.
10. Pollitt CC, Pass MA, Pollitt S. Batimastat (BB-94) inhibits matrix metalloproteinases of equine laminitis. Equine Vet J Suppl 1998;26:119-124.
11. Loftus JP, Belknap JK, Black SJ. Matrix metalloproteinase-9 in laminae of black walnut extract treated horses correlates with neutrophil abundance. Vet Immunol Immunopathol 2006;113:267-276.
12. Loftus JP, Johnson PJ, Belknap JK, et al. Leukocyte-derived and endogenous matrix metalloproteinases in the lamellae of horses with naturally acquired and experimentally induced laminitis. Vet Immunol Immunopathol 2009;129:221-230.
13. Brew K, Nagase H. The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity. Biochim Biophys Acta 2010;1803:55-71.
14. Garner HE, Coffman JR, Hahn AW, et al. Equine laminitis of alimentary origin: An experimental model. Am J Vet Res 1975;36:441-444.
15. Johnson PJ, Kreeger JM, Keeler M, et al. Serum markers of lamellar basement membrane degradation and lamellar histopathological changes in horses affected with laminitis. Equine Vet J 2000;32:462-468.
16. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408.
17. Pawlak E, Wang L, Johnson PJ, et al. Distribution and processing of a disintegrin and metalloproteinase with thrombospondin motifs-4, aggrecan, versican, and hyaluronan in equine digital laminae. Am J Vet Res 2012;73:1035-1046.
18. Hayes NV, Newsam RJ, Baines AJ, et al. Characterization of the cell membrane-associated products of the Neuregulin 4 gene. Oncogene 2008;27:715-720.
19. Nagase H, Visse R, Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc Res 2006;69:562-573.
20. Peake NJ, Khawaja K, Myers A, et al. Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: Relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study. Rheumatology (Oxford) 2005;44:1383-1389.
21. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry. Circ Res 2003;92:827-839.
22. Vincenti MP, Brinckerhoff CE. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: Integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res 2002;4:157-164.
23. Arner EC. Aggrecanase-mediated cartilage degradation. Curr Opin Pharmacol 2002;2:322-329.
24. Faleiros RR, Johnson PJ, Nuovo GJ, et al. Laminar leukocyte accumulation in horses with carbohydrate overload-induced laminitis. J Vet Intern Med 2011;25:107-115.
25. Leise BS, Faleiros RR, Watts M, et al. Laminar inflammatory gene expression in the carbohydrate overload model of equine laminitis. Equine Vet J 2011;43:54-61.
26. Knauper V, Will H, Lopez-Otin C, et al. Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme. J Biol Chem 1996;271:17124-17131.
27. Knauper V, Bailey L, Worley JR, et al. Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13. FEBS Lett 2002;532:127-130.
28. Kyaw-Tanner MT, Wattle O, van Eps AW, et al. Equine laminitis: Membrane type matrix metalloproteinase-1 (MMP-14) is involved in acute phase onset. Equine Vet J 2008;40:482-487.