Lp-PLA2 is associated with structural valve degeneration of bioprostheses

European Journal of Clinical Investigation

Volumn 44, Issue 2, 2014, Pages 136-145

  Mahmut, Ablajan ^a   Mahjoub, Haïfa ^a   Boulanger, Marie Chloé ^a   Fournier, Dominique ^a   Després, Jean Pierre ^a   Pibarot, Philippe ^a   Mathieu, Patrick ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Bioprostheses; Lp PLA2; Structural valve degeneration

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; CD68 ANTIGEN; OXIDIZED LOW DENSITY LIPOPROTEIN;

AGED; AORTA VALVE PROSTHESIS; AORTA VALVE REPLACEMENT; ARTICLE; CONTROLLED STUDY; DOPPLER ECHOCARDIOGRAPHY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; EXPLANT; FEMALE; FOLLOW UP; HEART VALVE BIOPROSTHESIS; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; PROSTHESIS FAILURE; PROSTHETIC VALVE DYSFUNCTION; PROTEIN EXPRESSION; STRUCTURAL VALVE DEGENERATION; TISSUE DEGENERATION; AORTIC VALVE INSUFFICIENCY; AORTIC VALVE STENOSIS; BIOPROSTHESIS; CROSS-SECTIONAL STUDY; GRAFT OCCLUSION, VASCULAR; HEART VALVE PROSTHESIS; PHYSIOLOGY; PROSPECTIVE STUDY;

1-ALKYL-2-ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; AGED; AORTIC VALVE INSUFFICIENCY; AORTIC VALVE STENOSIS; BIOPROSTHESIS; CROSS-SECTIONAL STUDIES; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; GRAFT OCCLUSION, VASCULAR; HEART VALVE PROSTHESIS; HUMANS; MALE; PROSPECTIVE STUDIES; PROSTHESIS FAILURE;

EID: 84892481313     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/eci.12199     Document Type: Article

References (19)

1. Ruel M, Kulik A, Rubens FD, Bedard P, Masters RG, Pipe AL et al. Late incidence and determinants of reoperation in patients with prosthetic heart valves. Eur J Cardiothorac Surg 2004;25:364-70.
2. Briand M, Pibarot P, Despres JP, Voisine P, Dumesnil JG, Dagenais F et al. Metabolic syndrome is associated with faster degeneration of bioprosthetic valves. Circulation 2006;114:I512-7.
3. Mahjoub H, Mathieu P, Senechal M, Larose E, Dumesnil J, Despres JP et al. ApoB/ApoA-I ratio is associated with increased risk of bioprosthetic valve degeneration. J Am Coll Cardiol 2013;61:752-61.
4. Schoen FJ, Levy RJ. Calcification of tissue heart valve substitutes: progress toward understanding and prevention. Ann Thorac Surg 2005;79:1072-80.
5. O'Brien KD. Do bioprosthetic aortic valves deteriorate more rapidly in patients with the metabolic syndrome? Nat Clin Pract Cardiovasc Med 2007;4:192-3.
6. Shetty R, Pibarot P, Audet A, Janvier R, Dagenais F, Perron J et al. Lipid-mediated inflammation and degeneration of bioprosthetic heart valves. Eur J Clin Invest 2009;39:471-80.
7. Yacoub MH, El-Hamamsy I. Valvular disease: the private life of tissue valves. Nat Rev Cardiol 2010;7:424-6.
8. Macphee CH, Nelson JJ, Zalewski A. Lipoprotein-associated phospholipase A2 as a target of therapy. Curr Opin Lipidol 2005;16:442-6.
9. Simera I, Moher D, Hoey J, Schulz KF, Altman DG. A catalogue of reporting guidelines for health research. Eur J Clin Invest 2010;40:35-53.
10. Zoghbi WA, Chambers JB, Dumesnil JG, Foster E, Gottdiener JS, Grayburn PA et al. Recommendations for evaluation of prosthetic valves with echocardiography and doppler ultrasound: a report From the American Society of Echocardiography's Guidelines and Standards Committee and the Task Force on Prosthetic Valves, developed in conjunction with the American College of Cardiology Cardiovascular Imaging Committee, Cardiac Imaging Committee of the American Heart Association, the European Association of Echocardiography, a registered branch of the European Society of Cardiology, the Japanese Society of Echocardiography and the Canadian Society of Echocardiography, endorsed by the American College of Cardiology Foundation, American Heart Association, European Association of Echocardiography, a registered branch of the European Society of Cardiology, the Japanese Society of Echocardiography, and Canadian Society of Echocardiography. J Am Soc Echocardiogr 2009;22:975-1014.
11. Shetty R, Girerd N, Cote N, Arsenault B, Despres JP, Pibarot P et al. Elevated proportion of small, dense low-density lipoprotein particles and lower adiponectin blood levels predict early structural valve degeneration of bioprostheses. Cardiology 2012;121:20-6.
12. Karabina SA, Gora S, Atout R, Ninio E. Extracellular phospholipases in atherosclerosis. Biochimie 2010;92:594-600.
13. Wang WY, Li J, Yang D, Xu W, Zha RP, Wang YP. OxLDL stimulates lipoprotein-associated phospholipase A2 expression in THP-1 monocytes via PI3K and p38 MAPK pathways. Cardiovasc Res 2010;85:845-52.
14. Suchindran S, Rivedal D, Guyton JR, Milledge T, Gao X, Benjamin A et al. Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. PLoS Genet 2010;6:e1000928.
15. Ferguson JF, Hinkle CC, Mehta NN, Bagheri R, Derohannessian SL, Shah R et al. Translational studies of lipoprotein-associated phospholipase A(2) in inflammation and atherosclerosis. J Am Coll Cardiol 2012;59:764-72.
16. Vickers KC, Castro-Chavez F, Morrisett JD. Lyso-phosphatidylcholine induces osteogenic gene expression and phenotype in vascular smooth muscle cells. Atherosclerosis 2010;211:122-9.
17. Mohty D, Pibarot P, Despres JP, Cote C, Arsenault B, Cartier A et al. Association between plasma LDL particle size, valvular accumulation of oxidized LDL, and inflammation in patients with aortic stenosis. Arterioscler Thromb Vasc Biol 2008;28:187-93.
18. Tselepis AD, Dentan C, Karabina SA, Chapman MJ, Ninio E. PAF-degrading acetylhydrolase is preferentially associated with dense LDL and VHDL-1 in human plasma. Catalytic characteristics and relation to the monocyte-derived enzyme. Arterioscler Thromb Vasc Biol 1995;15:1764-73.
19. Wilensky RL, Shi Y, Mohler ER III, Hamamdzic D, Burgert ME, Li J et al. Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development. Nat Med 2008;14:1059-66.